Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | KEGG_SPLICEOSOME |
| Enrichment Score (ES) | 0.36757192 |
| Normalized Enrichment Score (NES) | 1.5212247 |
| Nominal p-value | 0.00802139 |
| FDR q-value | 0.11903773 |
| FWER p-Value | 0.803 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | HSPA6 | NA | HSPA6 Entrez, Source | heat shock 70kDa protein 6 (HSP70B') | 315 | 1.718 | 0.0230 | Yes |
| 2 | HSPA1A | NA | HSPA1A Entrez, Source | heat shock 70kDa protein 1A | 370 | 1.563 | 0.0609 | Yes |
| 3 | HSPA1B | NA | HSPA1B Entrez, Source | heat shock 70kDa protein 1B | 467 | 1.369 | 0.0906 | Yes |
| 4 | HSPA8 | NA | HSPA8 Entrez, Source | heat shock 70kDa protein 8 | 634 | 1.157 | 0.1095 | Yes |
| 5 | PQBP1 | NA | PQBP1 Entrez, Source | polyglutamine binding protein 1 | 765 | 1.037 | 0.1277 | Yes |
| 6 | RBMX | NA | RBMX Entrez, Source | RNA binding motif protein, X-linked | 1053 | 0.870 | 0.1301 | Yes |
| 7 | RBM22 | NA | RBM22 Entrez, Source | RNA binding motif protein 22 | 1208 | 0.809 | 0.1405 | Yes |
| 8 | RBM25 | NA | RBM25 Entrez, Source | RNA binding motif protein 25 | 1356 | 0.754 | 0.1500 | Yes |
| 9 | SF3A1 | NA | SF3A1 Entrez, Source | splicing factor 3a, subunit 1, 120kDa | 1682 | 0.663 | 0.1440 | Yes |
| 10 | SF3B4 | NA | SF3B4 Entrez, Source | splicing factor 3b, subunit 4, 49kDa | 1689 | 0.662 | 0.1613 | Yes |
| 11 | MAGOH | NA | MAGOH Entrez, Source | mago-nashi homolog, proliferation-associated (Drosophila) | 1799 | 0.634 | 0.1703 | Yes |
| 12 | PRPF3 | NA | PRPF3 Entrez, Source | PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) | 1814 | 0.629 | 0.1862 | Yes |
| 13 | CTNNBL1 | NA | CTNNBL1 Entrez, Source | catenin, beta like 1 | 1915 | 0.603 | 0.1950 | Yes |
| 14 | SART1 | NA | SART1 Entrez, Source | squamous cell carcinoma antigen recognised by T cells | 2281 | 0.536 | 0.1827 | Yes |
| 15 | DHX16 | NA | DHX16 Entrez, Source | DEAH (Asp-Glu-Ala-His) box polypeptide 16 | 2395 | 0.517 | 0.1883 | Yes |
| 16 | LSM6 | NA | LSM6 Entrez, Source | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 2511 | 0.498 | 0.1933 | Yes |
| 17 | CHERP | NA | CHERP Entrez, Source | calcium homeostasis endoplasmic reticulum protein | 2585 | 0.487 | 0.2010 | Yes |
| 18 | WBP11 | NA | WBP11 Entrez, Source | WW domain binding protein 11 | 2607 | 0.483 | 0.2124 | Yes |
| 19 | U2SURP | NA | 2827 | 0.447 | 0.2084 | Yes | ||
| 20 | SNRPA1 | NA | SNRPA1 Entrez, Source | small nuclear ribonucleoprotein polypeptide A' | 2843 | 0.444 | 0.2192 | Yes |
| 21 | PRPF40A | NA | PRPF40A Entrez, Source | PRP40 pre-mRNA processing factor 40 homolog A (yeast) | 2932 | 0.430 | 0.2242 | Yes |
| 22 | TCERG1 | NA | TCERG1 Entrez, Source | transcription elongation regulator 1 | 2934 | 0.429 | 0.2357 | Yes |
| 23 | BCAS2 | NA | BCAS2 Entrez, Source | breast carcinoma amplified sequence 2 | 2998 | 0.421 | 0.2424 | Yes |
| 24 | SMNDC1 | NA | SMNDC1 Entrez, Source | survival motor neuron domain containing 1 | 3044 | 0.416 | 0.2502 | Yes |
| 25 | PHF5A | NA | PHF5A Entrez, Source | PHD finger protein 5A | 3056 | 0.414 | 0.2605 | Yes |
| 26 | PRPF4 | NA | PRPF4 Entrez, Source | PRP4 pre-mRNA processing factor 4 homolog (yeast) | 3076 | 0.412 | 0.2701 | Yes |
| 27 | SRSF4 | NA | 3189 | 0.395 | 0.2725 | Yes | ||
| 28 | SNRPB2 | NA | SNRPB2 Entrez, Source | small nuclear ribonucleoprotein polypeptide B'' | 3289 | 0.383 | 0.2756 | Yes |
| 29 | DDX23 | NA | DDX23 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 | 3508 | 0.353 | 0.2691 | Yes |
| 30 | RBM8A | NA | RBM8A Entrez, Source | RNA binding motif protein 8A | 3509 | 0.353 | 0.2786 | Yes |
| 31 | CCDC12 | NA | CCDC12 Entrez, Source | coiled-coil domain containing 12 | 3515 | 0.352 | 0.2877 | Yes |
| 32 | SF3B3 | NA | SF3B3 Entrez, Source | splicing factor 3b, subunit 3, 130kDa | 3527 | 0.351 | 0.2962 | Yes |
| 33 | SNRPF | NA | SNRPF Entrez, Source | small nuclear ribonucleoprotein polypeptide F | 3615 | 0.342 | 0.2991 | Yes |
| 34 | SF3A3 | NA | SF3A3 Entrez, Source | splicing factor 3a, subunit 3, 60kDa | 3639 | 0.339 | 0.3065 | Yes |
| 35 | DHX38 | NA | DHX38 Entrez, Source | DEAH (Asp-Glu-Ala-His) box polypeptide 38 | 3646 | 0.338 | 0.3151 | Yes |
| 36 | ZMAT2 | NA | ZMAT2 Entrez, Source | zinc finger, matrin type 2 | 3827 | 0.318 | 0.3105 | Yes |
| 37 | RBM17 | NA | RBM17 Entrez, Source | RNA binding motif protein 17 | 3842 | 0.317 | 0.3179 | Yes |
| 38 | ACIN1 | NA | ACIN1 Entrez, Source | apoptotic chromatin condensation inducer 1 | 4088 | 0.289 | 0.3078 | Yes |
| 39 | LSM7 | NA | LSM7 Entrez, Source | LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 4092 | 0.288 | 0.3153 | Yes |
| 40 | U2AF2 | NA | U2AF2 Entrez, Source | U2 small nuclear RNA auxiliary factor 2 | 4121 | 0.285 | 0.3209 | Yes |
| 41 | EIF4A3 | NA | 4158 | 0.281 | 0.3258 | Yes | ||
| 42 | PRPF38B | NA | PRPF38B Entrez, Source | PRP38 pre-mRNA processing factor 38 (yeast) domain containing B | 4176 | 0.280 | 0.3320 | Yes |
| 43 | SF3B2 | NA | SF3B2 Entrez, Source | splicing factor 3b, subunit 2, 145kDa | 4256 | 0.271 | 0.3335 | Yes |
| 44 | PRPF31 | NA | PRPF31 Entrez, Source | PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae) | 4257 | 0.271 | 0.3408 | Yes |
| 45 | BUD31 | NA | BUD31 Entrez, Source | BUD31 homolog (yeast) | 4279 | 0.268 | 0.3464 | Yes |
| 46 | SF3A2 | NA | SF3A2 Entrez, Source | splicing factor 3a, subunit 2, 66kDa | 4376 | 0.256 | 0.3463 | Yes |
| 47 | SRSF1 | NA | 4578 | 0.235 | 0.3379 | Yes | ||
| 48 | SRSF9 | NA | 4609 | 0.231 | 0.3419 | Yes | ||
| 49 | U2AF1 | NA | U2AF1 Entrez, Source | U2 small nuclear RNA auxiliary factor 1 | 4663 | 0.227 | 0.3441 | Yes |
| 50 | SRSF10 | NA | 4692 | 0.224 | 0.3481 | Yes | ||
| 51 | PUF60 | NA | 4696 | 0.223 | 0.3538 | Yes | ||
| 52 | AQR | NA | AQR Entrez, Source | aquarius homolog (mouse) | 4814 | 0.210 | 0.3509 | Yes |
| 53 | HNRNPM | NA | 4854 | 0.206 | 0.3536 | Yes | ||
| 54 | PPIH | NA | PPIH Entrez, Source | peptidylprolyl isomerase H (cyclophilin H) | 4888 | 0.203 | 0.3566 | Yes |
| 55 | XAB2 | NA | XAB2 Entrez, Source | XPA binding protein 2 | 4905 | 0.202 | 0.3608 | Yes |
| 56 | NCBP2 | NA | NCBP2 Entrez, Source | nuclear cap binding protein subunit 2, 20kDa | 4965 | 0.196 | 0.3618 | Yes |
| 57 | EFTUD2 | NA | EFTUD2 Entrez, Source | elongation factor Tu GTP binding domain containing 2 | 5063 | 0.185 | 0.3596 | Yes |
| 58 | HNRNPU | NA | 5100 | 0.181 | 0.3619 | Yes | ||
| 59 | SNRPC | NA | SNRPC Entrez, Source | small nuclear ribonucleoprotein polypeptide C | 5137 | 0.178 | 0.3640 | Yes |
| 60 | ISY1 | NA | 5168 | 0.174 | 0.3665 | Yes | ||
| 61 | HSPA1L | NA | HSPA1L Entrez, Source | heat shock 70kDa protein 1-like | 5229 | 0.168 | 0.3666 | Yes |
| 62 | PRPF8 | NA | PRPF8 Entrez, Source | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae) | 5382 | 0.152 | 0.3596 | Yes |
| 63 | SNRPD1 | NA | SNRPD1 Entrez, Source | small nuclear ribonucleoprotein D1 polypeptide 16kDa | 5402 | 0.150 | 0.3622 | Yes |
| 64 | DDX42 | NA | DDX42 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 | 5490 | 0.140 | 0.3596 | Yes |
| 65 | SRSF3 | NA | 5492 | 0.140 | 0.3633 | Yes | ||
| 66 | HNRNPA1L2 | NA | 5532 | 0.137 | 0.3641 | Yes | ||
| 67 | USP39 | NA | USP39 Entrez, Source | ubiquitin specific peptidase 39 | 5536 | 0.136 | 0.3676 | Yes |
| 68 | SNRNP40 | NA | 5730 | 0.113 | 0.3565 | No | ||
| 69 | SNRNP70 | NA | 5764 | 0.110 | 0.3571 | No | ||
| 70 | HNRNPC | NA | 5782 | 0.109 | 0.3587 | No | ||
| 71 | PRPF18 | NA | PRPF18 Entrez, Source | PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae) | 5868 | 0.101 | 0.3553 | No |
| 72 | SRSF6 | NA | 5877 | 0.100 | 0.3573 | No | ||
| 73 | CDC40 | NA | CDC40 Entrez, Source | cell division cycle 40 homolog (S. cerevisiae) | 5991 | 0.088 | 0.3515 | No |
| 74 | DDX5 | NA | DDX5 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 | 6054 | 0.081 | 0.3491 | No |
| 75 | PPIL1 | NA | PPIL1 Entrez, Source | peptidylprolyl isomerase (cyclophilin)-like 1 | 6369 | 0.052 | 0.3276 | No |
| 76 | SNW1 | NA | SNW1 Entrez, Source | SNW domain containing 1 | 6370 | 0.052 | 0.3290 | No |
| 77 | DHX8 | NA | DHX8 Entrez, Source | DEAH (Asp-Glu-Ala-His) box polypeptide 8 | 6462 | 0.042 | 0.3235 | No |
| 78 | THOC1 | NA | THOC1 Entrez, Source | THO complex 1 | 6464 | 0.042 | 0.3245 | No |
| 79 | CDC5L | NA | CDC5L Entrez, Source | CDC5 cell division cycle 5-like (S. pombe) | 6482 | 0.040 | 0.3244 | No |
| 80 | DDX39B | NA | 6537 | 0.035 | 0.3214 | No | ||
| 81 | HNRNPA1 | NA | 6637 | 0.024 | 0.3148 | No | ||
| 82 | PRPF38A | NA | PRPF38A Entrez, Source | PRP38 pre-mRNA processing factor 38 (yeast) domain containing A | 6642 | 0.023 | 0.3151 | No |
| 83 | HNRNPK | NA | 6729 | 0.014 | 0.3092 | No | ||
| 84 | CWC15 | NA | 6764 | 0.011 | 0.3070 | No | ||
| 85 | PLRG1 | NA | PLRG1 Entrez, Source | pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) | 6809 | 0.006 | 0.3040 | No |
| 86 | HNRNPA3 | NA | 6840 | 0.002 | 0.3019 | No | ||
| 87 | DHX15 | NA | DHX15 Entrez, Source | DEAH (Asp-Glu-Ala-His) box polypeptide 15 | 6933 | -0.008 | 0.2954 | No |
| 88 | TRA2B | NA | 6976 | -0.012 | 0.2926 | No | ||
| 89 | LSM2 | NA | LSM2 Entrez, Source | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 7004 | -0.014 | 0.2910 | No |
| 90 | SNRNP27 | NA | 7108 | -0.024 | 0.2842 | No | ||
| 91 | PCBP1 | NA | PCBP1 Entrez, Source | poly(rC) binding protein 1 | 7128 | -0.026 | 0.2835 | No |
| 92 | NCBP1 | NA | NCBP1 Entrez, Source | nuclear cap binding protein subunit 1, 80kDa | 7207 | -0.035 | 0.2787 | No |
| 93 | SNRPA | NA | SNRPA Entrez, Source | small nuclear ribonucleoprotein polypeptide A | 7238 | -0.038 | 0.2775 | No |
| 94 | MAGOHB | NA | 7381 | -0.054 | 0.2686 | No | ||
| 95 | SRSF5 | NA | 7406 | -0.056 | 0.2684 | No | ||
| 96 | SRSF8 | NA | 7500 | -0.066 | 0.2634 | No | ||
| 97 | SF3B1 | NA | SF3B1 Entrez, Source | splicing factor 3b, subunit 1, 155kDa | 7531 | -0.069 | 0.2630 | No |
| 98 | CRNKL1 | NA | CRNKL1 Entrez, Source | Crn, crooked neck-like 1 (Drosophila) | 7606 | -0.076 | 0.2597 | No |
| 99 | SYF2 | NA | SYF2 Entrez, Source | SYF2 homolog, RNA splicing factor (S. cerevisiae) | 7770 | -0.092 | 0.2503 | No |
| 100 | SLU7 | NA | SLU7 Entrez, Source | - | 7845 | -0.098 | 0.2475 | No |
| 101 | LSM5 | NA | LSM5 Entrez, Source | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 7851 | -0.099 | 0.2498 | No |
| 102 | TXNL4A | NA | TXNL4A Entrez, Source | thioredoxin-like 4A | 7998 | -0.114 | 0.2422 | No |
| 103 | PPIE | NA | PPIE Entrez, Source | peptidylprolyl isomerase E (cyclophilin E) | 8073 | -0.123 | 0.2401 | No |
| 104 | SNRPE | NA | SNRPE Entrez, Source | small nuclear ribonucleoprotein polypeptide E | 8113 | -0.127 | 0.2406 | No |
| 105 | PRPF6 | NA | PRPF6 Entrez, Source | PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) | 8156 | -0.132 | 0.2411 | No |
| 106 | SF3B5 | NA | SF3B5 Entrez, Source | splicing factor 3b, subunit 5, 10kDa | 8175 | -0.133 | 0.2433 | No |
| 107 | SRSF7 | NA | 8454 | -0.164 | 0.2274 | No | ||
| 108 | SNRPB | NA | SNRPB Entrez, Source | small nuclear ribonucleoprotein polypeptides B and B1 | 8623 | -0.182 | 0.2201 | No |
| 109 | SNRPG | NA | SNRPG Entrez, Source | small nuclear ribonucleoprotein polypeptide G | 8680 | -0.188 | 0.2210 | No |
| 110 | TRA2A | NA | TRA2A Entrez, Source | - | 8767 | -0.199 | 0.2201 | No |
| 111 | PRPF19 | NA | PRPF19 Entrez, Source | PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae) | 8806 | -0.204 | 0.2227 | No |
| 112 | THOC3 | NA | THOC3 Entrez, Source | THO complex 3 | 8858 | -0.209 | 0.2246 | No |
| 113 | THOC2 | NA | THOC2 Entrez, Source | THO complex 2 | 8901 | -0.214 | 0.2273 | No |
| 114 | DDX46 | NA | DDX46 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | 9103 | -0.238 | 0.2190 | No |
| 115 | SRSF2 | NA | 9135 | -0.241 | 0.2232 | No | ||
| 116 | SNRNP200 | NA | 9409 | -0.280 | 0.2108 | No | ||
| 117 | SNRPD3 | NA | SNRPD3 Entrez, Source | small nuclear ribonucleoprotein D3 polypeptide 18kDa | 9523 | -0.298 | 0.2105 | No |
| 118 | SNRPD2 | NA | SNRPD2 Entrez, Source | small nuclear ribonucleoprotein D2 polypeptide 16.5kDa | 9756 | -0.330 | 0.2024 | No |
| 119 | HSPA2 | NA | HSPA2 Entrez, Source | heat shock 70kDa protein 2 | 10495 | -0.442 | 0.1604 | No |
| 120 | LSM3 | NA | LSM3 Entrez, Source | LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 11164 | -0.557 | 0.1266 | No |
| 121 | NAA38 | NA | 11204 | -0.565 | 0.1389 | No | ||
| 122 | LSM4 | NA | LSM4 Entrez, Source | LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 11929 | -0.734 | 0.1057 | No |
| 123 | PRPF40B | NA | PRPF40B Entrez, Source | PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) | 13024 | -1.237 | 0.0591 | No |
