Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY |
| Enrichment Score (ES) | 0.56151015 |
| Normalized Enrichment Score (NES) | 1.9192529 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.008095057 |
| FWER p-Value | 0.03 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | DDX58 | NA | DDX58 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 13 | 4.397 | 0.1153 | Yes |
| 2 | CXCL10 | NA | CXCL10 Entrez, Source | chemokine (C-X-C motif) ligand 10 | 16 | 4.314 | 0.2292 | Yes |
| 3 | IFIH1 | NA | IFIH1 Entrez, Source | interferon induced with helicase C domain 1 | 60 | 3.343 | 0.3144 | Yes |
| 4 | DHX58 | NA | 64 | 3.317 | 0.4018 | Yes | ||
| 5 | ISG15 | NA | ISG15 Entrez, Source | ISG15 ubiquitin-like modifier | 240 | 1.980 | 0.4415 | Yes |
| 6 | TMEM173 | NA | TMEM173 Entrez, Source | transmembrane protein 173 | 317 | 1.716 | 0.4813 | Yes |
| 7 | IL12B | NA | IL12B Entrez, Source | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | 366 | 1.567 | 0.5193 | Yes |
| 8 | MAP3K1 | NA | MAP3K1 Entrez, Source | mitogen-activated protein kinase kinase kinase 1 | 822 | 0.993 | 0.5125 | Yes |
| 9 | IKBKE | NA | IKBKE Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 1384 | 0.748 | 0.4916 | Yes |
| 10 | NFKBIA | NA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 1484 | 0.721 | 0.5035 | Yes |
| 11 | RELA | NA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 1570 | 0.698 | 0.5157 | Yes |
| 12 | DDX3X | NA | DDX3X Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked | 1614 | 0.685 | 0.5307 | Yes |
| 13 | FADD | NA | FADD Entrez, Source | Fas (TNFRSF6)-associated via death domain | 1727 | 0.651 | 0.5398 | Yes |
| 14 | IRF3 | NA | IRF3 Entrez, Source | interferon regulatory factor 3 | 1819 | 0.628 | 0.5498 | Yes |
| 15 | NFKB1 | NA | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 2004 | 0.585 | 0.5519 | Yes |
| 16 | CYLD | NA | CYLD Entrez, Source | cylindromatosis (turban tumor syndrome) | 2081 | 0.572 | 0.5615 | Yes |
| 17 | IKBKG | NA | IKBKG Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 2396 | 0.517 | 0.5524 | No |
| 18 | MAPK8 | NA | MAPK8 Entrez, Source | mitogen-activated protein kinase 8 | 2742 | 0.461 | 0.5395 | No |
| 19 | SIKE1 | NA | 2761 | 0.457 | 0.5503 | No | ||
| 20 | CHUK | NA | CHUK Entrez, Source | conserved helix-loop-helix ubiquitous kinase | 2997 | 0.421 | 0.5444 | No |
| 21 | RIPK1 | NA | RIPK1 Entrez, Source | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 3193 | 0.394 | 0.5407 | No |
| 22 | TRAF3 | NA | TRAF3 Entrez, Source | TNF receptor-associated factor 3 | 3421 | 0.364 | 0.5339 | No |
| 23 | TRAF6 | NA | TRAF6 Entrez, Source | TNF receptor-associated factor 6 | 4423 | 0.251 | 0.4679 | No |
| 24 | TANK | NA | TANK Entrez, Source | TRAF family member-associated NFKB activator | 4790 | 0.213 | 0.4470 | No |
| 25 | CASP8 | NA | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 5043 | 0.187 | 0.4336 | No |
| 26 | OTUD5 | NA | OTUD5 Entrez, Source | OTU domain containing 5 | 5539 | 0.136 | 0.4013 | No |
| 27 | IFNE | NA | 6164 | 0.071 | 0.3580 | No | ||
| 28 | TRAF2 | NA | TRAF2 Entrez, Source | TNF receptor-associated factor 2 | 6274 | 0.060 | 0.3516 | No |
| 29 | TBK1 | NA | TBK1 Entrez, Source | TANK-binding kinase 1 | 7031 | -0.017 | 0.2972 | No |
| 30 | ATG5 | NA | ATG5 Entrez, Source | ATG5 autophagy related 5 homolog (S. cerevisiae) | 7202 | -0.033 | 0.2858 | No |
| 31 | ATG12 | NA | ATG12 Entrez, Source | ATG12 autophagy related 12 homolog (S. cerevisiae) | 7391 | -0.055 | 0.2736 | No |
| 32 | TRADD | NA | TRADD Entrez, Source | TNFRSF1A-associated via death domain | 7408 | -0.057 | 0.2740 | No |
| 33 | TRIM25 | NA | TRIM25 Entrez, Source | tripartite motif-containing 25 | 7512 | -0.068 | 0.2683 | No |
| 34 | MAPK14 | NA | MAPK14 Entrez, Source | mitogen-activated protein kinase 14 | 7577 | -0.073 | 0.2656 | No |
| 35 | MAP3K7 | NA | MAP3K7 Entrez, Source | mitogen-activated protein kinase kinase kinase 7 | 8905 | -0.215 | 0.1750 | No |
| 36 | MAVS | NA | 8980 | -0.223 | 0.1755 | No | ||
| 37 | CASP10 | NA | CASP10 Entrez, Source | caspase 10, apoptosis-related cysteine peptidase | 9150 | -0.244 | 0.1697 | No |
| 38 | MAPK12 | NA | MAPK12 Entrez, Source | mitogen-activated protein kinase 12 | 9483 | -0.292 | 0.1533 | No |
| 39 | MAPK9 | NA | MAPK9 Entrez, Source | mitogen-activated protein kinase 9 | 9823 | -0.340 | 0.1377 | No |
| 40 | IKBKB | NA | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 9844 | -0.344 | 0.1453 | No |
| 41 | MAPK10 | NA | MAPK10 Entrez, Source | mitogen-activated protein kinase 10 | 10142 | -0.384 | 0.1340 | No |
| 42 | PIN1 | NA | PIN1 Entrez, Source | protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1 | 10585 | -0.456 | 0.1139 | No |
| 43 | MAPK11 | NA | MAPK11 Entrez, Source | mitogen-activated protein kinase 11 | 10697 | -0.475 | 0.1184 | No |
| 44 | MAPK13 | NA | MAPK13 Entrez, Source | mitogen-activated protein kinase 13 | 10850 | -0.502 | 0.1207 | No |
| 45 | NLRX1 | NA | 11076 | -0.542 | 0.1187 | No | ||
| 46 | AZI2 | NA | AZI2 Entrez, Source | 5-azacytidine induced 2 | 11381 | -0.600 | 0.1125 | No |
| 47 | IFNW1 | NA | IFNW1 Entrez, Source | interferon, omega 1 | 12674 | -1.025 | 0.0459 | No |
| 48 | RNF125 | NA | RNF125 Entrez, Source | ring finger protein 125 | 13247 | -1.446 | 0.0426 | No |
