Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_PYRUVATE_METABOLISM |
| Enrichment Score (ES) | -0.6449918 |
| Normalized Enrichment Score (NES) | -1.9307138 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0019444188 |
| FWER p-Value | 0.012 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | ME2 | NA | ME2 Entrez, Source | malic enzyme 2, NAD(+)-dependent, mitochondrial | 4921 | 0.200 | -0.3471 | No |
| 2 | ALDH1B1 | NA | ALDH1B1 Entrez, Source | aldehyde dehydrogenase 1 family, member B1 | 5084 | 0.183 | -0.3502 | No |
| 3 | LDHA | NA | LDHA Entrez, Source | lactate dehydrogenase A | 6424 | 0.047 | -0.4450 | No |
| 4 | LDHAL6A | NA | LDHAL6A Entrez, Source | lactate dehydrogenase A-like 6A | 6986 | -0.013 | -0.4850 | No |
| 5 | ACACB | NA | ACACB Entrez, Source | acetyl-Coenzyme A carboxylase beta | 7907 | -0.105 | -0.5467 | No |
| 6 | ME1 | NA | ME1 Entrez, Source | malic enzyme 1, NADP(+)-dependent, cytosolic | 8293 | -0.146 | -0.5677 | No |
| 7 | DLAT | NA | DLAT Entrez, Source | dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) | 8620 | -0.182 | -0.5828 | No |
| 8 | ME3 | NA | ME3 Entrez, Source | malic enzyme 3, NADP(+)-dependent, mitochondrial | 8773 | -0.200 | -0.5844 | No |
| 9 | GLO1 | NA | GLO1 Entrez, Source | glyoxalase I | 9468 | -0.289 | -0.6211 | No |
| 10 | ALDH3A2 | NA | ALDH3A2 Entrez, Source | aldehyde dehydrogenase 3 family, member A2 | 9636 | -0.312 | -0.6185 | No |
| 11 | DLD | NA | DLD Entrez, Source | dihydrolipoamide dehydrogenase | 9719 | -0.325 | -0.6091 | No |
| 12 | PDHA1 | NA | PDHA1 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 1 | 9820 | -0.339 | -0.6004 | No |
| 13 | ACYP2 | NA | ACYP2 Entrez, Source | acylphosphatase 2, muscle type | 10437 | -0.433 | -0.6246 | Yes |
| 14 | LDHB | NA | LDHB Entrez, Source | lactate dehydrogenase B | 10486 | -0.440 | -0.6073 | Yes |
| 15 | MDH2 | NA | MDH2 Entrez, Source | malate dehydrogenase 2, NAD (mitochondrial) | 10593 | -0.456 | -0.5935 | Yes |
| 16 | ALDH9A1 | NA | ALDH9A1 Entrez, Source | aldehyde dehydrogenase 9 family, member A1 | 10955 | -0.519 | -0.5952 | Yes |
| 17 | ACSS2 | NA | ACSS2 Entrez, Source | acyl-CoA synthetase short-chain family member 2 | 11071 | -0.540 | -0.5780 | Yes |
| 18 | LDHAL6B | NA | LDHAL6B Entrez, Source | lactate dehydrogenase A-like 6B | 11102 | -0.547 | -0.5544 | Yes |
| 19 | GRHPR | NA | GRHPR Entrez, Source | glyoxylate reductase/hydroxypyruvate reductase | 11352 | -0.594 | -0.5445 | Yes |
| 20 | AKR1B1 | NA | AKR1B1 Entrez, Source | aldo-keto reductase family 1, member B1 (aldose reductase) | 11413 | -0.607 | -0.5202 | Yes |
| 21 | HAGH | NA | HAGH Entrez, Source | hydroxyacylglutathione hydrolase | 11999 | -0.756 | -0.5269 | Yes |
| 22 | ALDH7A1 | NA | ALDH7A1 Entrez, Source | aldehyde dehydrogenase 7 family, member A1 | 12010 | -0.760 | -0.4918 | Yes |
| 23 | PDHB | NA | PDHB Entrez, Source | pyruvate dehydrogenase (lipoamide) beta | 12302 | -0.852 | -0.4727 | Yes |
| 24 | ACACA | NA | ACACA Entrez, Source | acetyl-Coenzyme A carboxylase alpha | 12340 | -0.869 | -0.4345 | Yes |
| 25 | MDH1 | NA | MDH1 Entrez, Source | malate dehydrogenase 1, NAD (soluble) | 12448 | -0.914 | -0.3991 | Yes |
| 26 | HAGHL | NA | HAGHL Entrez, Source | hydroxyacylglutathione hydrolase-like | 12474 | -0.927 | -0.3573 | Yes |
| 27 | ACAT2 | NA | ACAT2 Entrez, Source | acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) | 12819 | -1.099 | -0.3304 | Yes |
| 28 | PCK2 | NA | PCK2 Entrez, Source | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 12963 | -1.192 | -0.2846 | Yes |
| 29 | ALDH2 | NA | ALDH2 Entrez, Source | aldehyde dehydrogenase 2 family (mitochondrial) | 13109 | -1.302 | -0.2337 | Yes |
| 30 | ACAT1 | NA | ACAT1 Entrez, Source | acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) | 13202 | -1.396 | -0.1745 | Yes |
| 31 | PC | NA | PC Entrez, Source | pyruvate carboxylase | 13641 | -2.224 | -0.1015 | Yes |
| 32 | LDHD | NA | LDHD Entrez, Source | lactate dehydrogenase D | 13685 | -2.448 | 0.0108 | Yes |
