Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | KEGG_PRIMARY_IMMUNODEFICIENCY |
| Enrichment Score (ES) | 0.4637746 |
| Normalized Enrichment Score (NES) | 1.3378583 |
| Nominal p-value | 0.13768116 |
| FDR q-value | 0.28577682 |
| FWER p-Value | 0.996 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | IL7R | NA | IL7R Entrez, Source | interleukin 7 receptor | 3 | 4.680 | 0.2519 | Yes |
| 2 | IL2RG | NA | IL2RG Entrez, Source | interleukin 2 receptor, gamma (severe combined immunodeficiency) | 79 | 3.132 | 0.4153 | Yes |
| 3 | TAP1 | NA | TAP1 Entrez, Source | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 686 | 1.112 | 0.4313 | Yes |
| 4 | TAP2 | NA | TAP2 Entrez, Source | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) | 930 | 0.929 | 0.4638 | Yes |
| 5 | IKBKG | NA | IKBKG Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 2396 | 0.517 | 0.3856 | No |
| 6 | PTPRC | NA | PTPRC Entrez, Source | protein tyrosine phosphatase, receptor type, C | 3881 | 0.312 | 0.2950 | No |
| 7 | DCLRE1C | NA | DCLRE1C Entrez, Source | DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae) | 5448 | 0.146 | 0.1895 | No |
| 8 | CIITA | NA | CIITA Entrez, Source | class II, major histocompatibility complex, transactivator | 7816 | -0.096 | 0.0233 | No |
| 9 | CD4 | NA | CD4 Entrez, Source | CD4 molecule | 7841 | -0.098 | 0.0268 | No |
| 10 | AIRE | NA | AIRE Entrez, Source | autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) | 8138 | -0.130 | 0.0124 | No |
| 11 | IGLL1 | NA | IGLL1 Entrez, Source | immunoglobulin lambda-like polypeptide 1 | 8276 | -0.145 | 0.0103 | No |
| 12 | RFXANK | NA | RFXANK Entrez, Source | regulatory factor X-associated ankyrin-containing protein | 8768 | -0.199 | -0.0145 | No |
| 13 | RAG1 | NA | RAG1 Entrez, Source | recombination activating gene 1 | 9028 | -0.229 | -0.0209 | No |
| 14 | CD19 | NA | CD19 Entrez, Source | CD19 molecule | 9065 | -0.233 | -0.0110 | No |
| 15 | ADA | NA | ADA Entrez, Source | adenosine deaminase | 10238 | -0.400 | -0.0743 | No |
| 16 | RFXAP | NA | RFXAP Entrez, Source | regulatory factor X-associated protein | 11596 | -0.647 | -0.1376 | No |
| 17 | UNG | NA | UNG Entrez, Source | uracil-DNA glycosylase | 11992 | -0.753 | -0.1256 | No |
| 18 | RFX5 | NA | RFX5 Entrez, Source | regulatory factor X, 5 (influences HLA class II expression) | 12034 | -0.766 | -0.0873 | No |
| 19 | TNFRSF13C | NA | TNFRSF13C Entrez, Source | tumor necrosis factor receptor superfamily, member 13C | 12580 | -0.973 | -0.0743 | No |
| 20 | AICDA | NA | AICDA Entrez, Source | activation-induced cytidine deaminase | 13035 | -1.244 | -0.0401 | No |
| 21 | JAK3 | NA | JAK3 Entrez, Source | Janus kinase 3 (a protein tyrosine kinase, leukocyte) | 13500 | -1.817 | 0.0242 | No |
