Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_PEROXISOME |
| Enrichment Score (ES) | -0.44407725 |
| Normalized Enrichment Score (NES) | -1.5690159 |
| Nominal p-value | 0.004830918 |
| FDR q-value | 0.09036981 |
| FWER p-Value | 0.768 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | ACOX2 | NA | ACOX2 Entrez, Source | acyl-Coenzyme A oxidase 2, branched chain | 42 | 3.774 | 0.0833 | No |
| 2 | MPV17L | NA | MPV17L Entrez, Source | MPV17 mitochondrial membrane protein-like | 682 | 1.115 | 0.0623 | No |
| 3 | SOD2 | NA | SOD2 Entrez, Source | superoxide dismutase 2, mitochondrial | 897 | 0.945 | 0.0684 | No |
| 4 | NUDT19 | NA | NUDT19 Entrez, Source | nudix (nucleoside diphosphate linked moiety X)-type motif 19 | 1438 | 0.734 | 0.0460 | No |
| 5 | BAAT | NA | BAAT Entrez, Source | bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase) | 1627 | 0.680 | 0.0479 | No |
| 6 | ACSL4 | NA | ACSL4 Entrez, Source | acyl-CoA synthetase long-chain family member 4 | 3026 | 0.418 | -0.0441 | No |
| 7 | ABCD1 | NA | ABCD1 Entrez, Source | ATP-binding cassette, sub-family D (ALD), member 1 | 3434 | 0.362 | -0.0654 | No |
| 8 | ACSL5 | NA | ACSL5 Entrez, Source | acyl-CoA synthetase long-chain family member 5 | 4128 | 0.284 | -0.1093 | No |
| 9 | SLC25A17 | NA | SLC25A17 Entrez, Source | solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 | 4628 | 0.230 | -0.1403 | No |
| 10 | PEX1 | NA | PEX1 Entrez, Source | peroxisome biogenesis factor 1 | 5215 | 0.170 | -0.1789 | No |
| 11 | PEX16 | NA | PEX16 Entrez, Source | peroxisomal biogenesis factor 16 | 5312 | 0.161 | -0.1822 | No |
| 12 | PEX5 | NA | PEX5 Entrez, Source | peroxisomal biogenesis factor 5 | 5474 | 0.143 | -0.1907 | No |
| 13 | PHYH | NA | PHYH Entrez, Source | phytanoyl-CoA 2-hydroxylase | 5481 | 0.141 | -0.1879 | No |
| 14 | HACL1 | NA | HACL1 Entrez, Source | 2-hydroxyacyl-CoA lyase 1 | 5512 | 0.138 | -0.1869 | No |
| 15 | AGPS | NA | AGPS Entrez, Source | alkylglycerone phosphate synthase | 5700 | 0.116 | -0.1978 | No |
| 16 | PEX10 | NA | PEX10 Entrez, Source | peroxisome biogenesis factor 10 | 5887 | 0.099 | -0.2090 | No |
| 17 | PEX2 | NA | 6578 | 0.030 | -0.2585 | No | ||
| 18 | PEX6 | NA | PEX6 Entrez, Source | peroxisomal biogenesis factor 6 | 7187 | -0.031 | -0.3019 | No |
| 19 | PEX3 | NA | PEX3 Entrez, Source | peroxisomal biogenesis factor 3 | 7248 | -0.039 | -0.3054 | No |
| 20 | PEX12 | NA | PEX12 Entrez, Source | peroxisomal biogenesis factor 12 | 7296 | -0.045 | -0.3078 | No |
| 21 | PMVK | NA | PMVK Entrez, Source | phosphomevalonate kinase | 7324 | -0.047 | -0.3087 | No |
| 22 | PEX14 | NA | PEX14 Entrez, Source | peroxisomal biogenesis factor 14 | 7364 | -0.052 | -0.3103 | No |
| 23 | XDH | NA | XDH Entrez, Source | xanthine dehydrogenase | 7686 | -0.083 | -0.3317 | No |
| 24 | PEX19 | NA | PEX19 Entrez, Source | peroxisomal biogenesis factor 19 | 8046 | -0.120 | -0.3551 | No |
| 25 | CROT | NA | CROT Entrez, Source | carnitine O-octanoyltransferase | 8051 | -0.121 | -0.3526 | No |
| 26 | PRDX1 | NA | PRDX1 Entrez, Source | peroxiredoxin 1 | 8396 | -0.157 | -0.3740 | No |
| 27 | ABCD4 | NA | ABCD4 Entrez, Source | ATP-binding cassette, sub-family D (ALD), member 4 | 8527 | -0.171 | -0.3795 | No |
| 28 | ACAA1 | NA | ACAA1 Entrez, Source | acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase) | 8688 | -0.190 | -0.3868 | No |
| 29 | MLYCD | NA | MLYCD Entrez, Source | malonyl-CoA decarboxylase | 8788 | -0.201 | -0.3894 | No |
| 30 | ACSL3 | NA | ACSL3 Entrez, Source | acyl-CoA synthetase long-chain family member 3 | 8881 | -0.212 | -0.3913 | No |
| 31 | GNPAT | NA | GNPAT Entrez, Source | glyceronephosphate O-acyltransferase | 9189 | -0.248 | -0.4079 | No |
| 32 | ACSL6 | NA | ACSL6 Entrez, Source | acyl-CoA synthetase long-chain family member 6 | 9191 | -0.248 | -0.4023 | No |
| 33 | PEX11B | NA | PEX11B Entrez, Source | peroxisomal biogenesis factor 11B | 9374 | -0.275 | -0.4092 | No |
| 34 | FAR2 | NA | 9531 | -0.298 | -0.4137 | No | ||
| 35 | ACOX3 | NA | ACOX3 Entrez, Source | acyl-Coenzyme A oxidase 3, pristanoyl | 9583 | -0.304 | -0.4105 | No |
| 36 | ABCD3 | NA | ABCD3 Entrez, Source | ATP-binding cassette, sub-family D (ALD), member 3 | 9890 | -0.349 | -0.4247 | No |
| 37 | SLC27A2 | NA | SLC27A2 Entrez, Source | solute carrier family 27 (fatty acid transporter), member 2 | 9957 | -0.357 | -0.4213 | No |
| 38 | PEX26 | NA | PEX26 Entrez, Source | peroxisome biogenesis factor 26 | 10002 | -0.364 | -0.4162 | No |
| 39 | NOS2 | NA | 10051 | -0.372 | -0.4112 | No | ||
| 40 | ECI2 | NA | 10219 | -0.397 | -0.4142 | No | ||
| 41 | PEX13 | NA | PEX13 Entrez, Source | peroxisome biogenesis factor 13 | 10631 | -0.464 | -0.4335 | Yes |
| 42 | SCP2 | NA | SCP2 Entrez, Source | sterol carrier protein 2 | 10711 | -0.477 | -0.4283 | Yes |
| 43 | EHHADH | NA | EHHADH Entrez, Source | enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase | 10749 | -0.483 | -0.4199 | Yes |
| 44 | NUDT12 | NA | NUDT12 Entrez, Source | nudix (nucleoside diphosphate linked moiety X)-type motif 12 | 10774 | -0.488 | -0.4105 | Yes |
| 45 | AMACR | NA | AMACR Entrez, Source | alpha-methylacyl-CoA racemase | 10776 | -0.488 | -0.3994 | Yes |
| 46 | DHRS4 | NA | DHRS4 Entrez, Source | dehydrogenase/reductase (SDR family) member 4 | 10825 | -0.498 | -0.3915 | Yes |
| 47 | PEX11A | NA | PEX11A Entrez, Source | peroxisomal biogenesis factor 11A | 10928 | -0.514 | -0.3872 | Yes |
| 48 | FAR1 | NA | 11058 | -0.539 | -0.3842 | Yes | ||
| 49 | MPV17 | NA | MPV17 Entrez, Source | MpV17 mitochondrial inner membrane protein | 11119 | -0.548 | -0.3760 | Yes |
| 50 | GSTK1 | NA | GSTK1 Entrez, Source | glutathione S-transferase kappa 1 | 11268 | -0.579 | -0.3735 | Yes |
| 51 | ACOX1 | NA | ACOX1 Entrez, Source | acyl-Coenzyme A oxidase 1, palmitoyl | 11472 | -0.619 | -0.3741 | Yes |
| 52 | SOD1 | NA | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 11746 | -0.684 | -0.3783 | Yes |
| 53 | PXMP2 | NA | PXMP2 Entrez, Source | peroxisomal membrane protein 2, 22kDa | 11866 | -0.715 | -0.3706 | Yes |
| 54 | HSD17B4 | NA | HSD17B4 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 4 | 11867 | -0.715 | -0.3542 | Yes |
| 55 | PRDX5 | NA | PRDX5 Entrez, Source | peroxiredoxin 5 | 11922 | -0.730 | -0.3415 | Yes |
| 56 | DDO | NA | DDO Entrez, Source | D-aspartate oxidase | 11943 | -0.737 | -0.3260 | Yes |
| 57 | PEX7 | NA | PEX7 Entrez, Source | peroxisomal biogenesis factor 7 | 12422 | -0.903 | -0.3401 | Yes |
| 58 | ACOT8 | NA | ACOT8 Entrez, Source | acyl-CoA thioesterase 8 | 12438 | -0.910 | -0.3204 | Yes |
| 59 | DECR2 | NA | DECR2 Entrez, Source | 2,4-dienoyl CoA reductase 2, peroxisomal | 12443 | -0.912 | -0.2998 | Yes |
| 60 | HMGCL | NA | HMGCL Entrez, Source | 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) | 12509 | -0.943 | -0.2829 | Yes |
| 61 | PECR | NA | PECR Entrez, Source | peroxisomal trans-2-enoyl-CoA reductase | 12622 | -0.994 | -0.2683 | Yes |
| 62 | MVK | NA | MVK Entrez, Source | mevalonate kinase (mevalonic aciduria) | 12984 | -1.203 | -0.2671 | Yes |
| 63 | IDH1 | NA | IDH1 Entrez, Source | isocitrate dehydrogenase 1 (NADP+), soluble | 13083 | -1.285 | -0.2448 | Yes |
| 64 | CRAT | NA | CRAT Entrez, Source | carnitine acetyltransferase | 13125 | -1.314 | -0.2177 | Yes |
| 65 | PXMP4 | NA | PXMP4 Entrez, Source | peroxisomal membrane protein 4, 24kDa | 13311 | -1.529 | -0.1962 | Yes |
| 66 | PIPOX | NA | PIPOX Entrez, Source | pipecolic acid oxidase | 13313 | -1.530 | -0.1612 | Yes |
| 67 | PEX11G | NA | PEX11G Entrez, Source | peroxisomal biogenesis factor 11 gamma | 13346 | -1.577 | -0.1275 | Yes |
| 68 | ECH1 | NA | ECH1 Entrez, Source | enoyl Coenzyme A hydratase 1, peroxisomal | 13349 | -1.579 | -0.0915 | Yes |
| 69 | IDH2 | NA | IDH2 Entrez, Source | isocitrate dehydrogenase 2 (NADP+), mitochondrial | 13440 | -1.724 | -0.0586 | Yes |
| 70 | CAT | NA | CAT Entrez, Source | catalase | 13474 | -1.769 | -0.0205 | Yes |
| 71 | ACSL1 | NA | ACSL1 Entrez, Source | acyl-CoA synthetase long-chain family member 1 | 13590 | -2.037 | 0.0177 | Yes |
