Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_PARKINSONS_DISEASE |
| Enrichment Score (ES) | -0.59438413 |
| Normalized Enrichment Score (NES) | -2.1961699 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | UBA7 | NA | 345 | 1.631 | 0.0006 | No | ||
| 2 | COX6B2 | NA | COX6B2 Entrez, Source | cytochrome c oxidase subunit VIb polypeptide 2 (testis) | 879 | 0.955 | -0.0231 | No |
| 3 | PPID | NA | PPID Entrez, Source | peptidylprolyl isomerase D (cyclophilin D) | 1377 | 0.749 | -0.0475 | No |
| 4 | CASP3 | NA | CASP3 Entrez, Source | caspase 3, apoptosis-related cysteine peptidase | 2546 | 0.492 | -0.1247 | No |
| 5 | UBE2G2 | NA | UBE2G2 Entrez, Source | ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast) | 3053 | 0.415 | -0.1550 | No |
| 6 | UBE2J2 | NA | UBE2J2 Entrez, Source | ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast) | 3872 | 0.314 | -0.2096 | No |
| 7 | UBE2G1 | NA | UBE2G1 Entrez, Source | ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) | 4164 | 0.281 | -0.2264 | No |
| 8 | NDUFB10 | NA | NDUFB10 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa | 4360 | 0.259 | -0.2365 | No |
| 9 | UBE2L3 | NA | UBE2L3 Entrez, Source | ubiquitin-conjugating enzyme E2L 3 | 4865 | 0.205 | -0.2699 | No |
| 10 | VDAC1 | NA | VDAC1 Entrez, Source | voltage-dependent anion channel 1 | 5103 | 0.181 | -0.2843 | No |
| 11 | UBE2L6 | NA | UBE2L6 Entrez, Source | ubiquitin-conjugating enzyme E2L 6 | 6768 | 0.010 | -0.4053 | No |
| 12 | VDAC3 | NA | VDAC3 Entrez, Source | voltage-dependent anion channel 3 | 6794 | 0.007 | -0.4070 | No |
| 13 | SLC25A4 | NA | SLC25A4 Entrez, Source | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 | 6960 | -0.011 | -0.4189 | No |
| 14 | ATP5D | NA | ATP5D Entrez, Source | ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit | 7257 | -0.040 | -0.4398 | No |
| 15 | UBA1 | NA | 7369 | -0.053 | -0.4470 | No | ||
| 16 | NDUFV3 | NA | NDUFV3 Entrez, Source | NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa | 7412 | -0.057 | -0.4492 | No |
| 17 | UQCR11 | NA | 7644 | -0.079 | -0.4648 | No | ||
| 18 | NDUFB7 | NA | NDUFB7 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa | 7777 | -0.092 | -0.4729 | No |
| 19 | NDUFB9 | NA | NDUFB9 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa | 7937 | -0.107 | -0.4828 | No |
| 20 | SLC25A5 | NA | SLC25A5 Entrez, Source | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | 7986 | -0.112 | -0.4845 | No |
| 21 | APAF1 | NA | APAF1 Entrez, Source | apoptotic peptidase activating factor | 8206 | -0.138 | -0.4983 | No |
| 22 | UQCRFS1 | NA | UQCRFS1 Entrez, Source | ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 | 8783 | -0.200 | -0.5371 | No |
| 23 | NDUFV2 | NA | NDUFV2 Entrez, Source | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 8825 | -0.206 | -0.5368 | No |
| 24 | NDUFA8 | NA | NDUFA8 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa | 9017 | -0.228 | -0.5471 | No |
| 25 | NDUFS7 | NA | NDUFS7 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) | 9133 | -0.241 | -0.5517 | No |
| 26 | UBE2J1 | NA | UBE2J1 Entrez, Source | ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast) | 9353 | -0.272 | -0.5633 | No |
| 27 | COX7A2L | NA | COX7A2L Entrez, Source | cytochrome c oxidase subunit VIIa polypeptide 2 like | 9489 | -0.293 | -0.5685 | No |
| 28 | HTRA2 | NA | HTRA2 Entrez, Source | HtrA serine peptidase 2 | 9497 | -0.295 | -0.5644 | No |
| 29 | NDUFB2 | NA | NDUFB2 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa | 9548 | -0.300 | -0.5633 | No |
| 30 | NDUFAB1 | NA | NDUFAB1 Entrez, Source | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa | 9593 | -0.305 | -0.5617 | No |
| 31 | VDAC2 | NA | VDAC2 Entrez, Source | voltage-dependent anion channel 2 | 9826 | -0.340 | -0.5732 | No |
| 32 | NDUFS8 | NA | NDUFS8 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) | 9879 | -0.348 | -0.5715 | No |
| 33 | NDUFS3 | NA | NDUFS3 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) | 9933 | -0.354 | -0.5697 | No |
| 34 | PARK7 | NA | PARK7 Entrez, Source | Parkinson disease (autosomal recessive, early onset) 7 | 10079 | -0.376 | -0.5744 | No |
| 35 | UBB | NA | UBB Entrez, Source | ubiquitin B | 10355 | -0.418 | -0.5878 | Yes |
| 36 | NDUFA10 | NA | NDUFA10 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa | 10387 | -0.425 | -0.5833 | Yes |
| 37 | SDHB | NA | SDHB Entrez, Source | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) | 10461 | -0.436 | -0.5818 | Yes |
| 38 | NDUFS4 | NA | NDUFS4 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) | 10470 | -0.437 | -0.5754 | Yes |
| 39 | COX5A | NA | COX5A Entrez, Source | cytochrome c oxidase subunit Va | 10523 | -0.445 | -0.5722 | Yes |
| 40 | ATP5C1 | NA | ATP5C1 Entrez, Source | ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 | 10643 | -0.467 | -0.5735 | Yes |
| 41 | UQCRC1 | NA | UQCRC1 Entrez, Source | ubiquinol-cytochrome c reductase core protein I | 10695 | -0.475 | -0.5697 | Yes |
| 42 | ATP5G3 | NA | ATP5G3 Entrez, Source | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9) | 10759 | -0.485 | -0.5666 | Yes |
| 43 | COX4I1 | NA | COX4I1 Entrez, Source | cytochrome c oxidase subunit IV isoform 1 | 10760 | -0.485 | -0.5590 | Yes |
| 44 | CYCS | NA | CYCS Entrez, Source | cytochrome c, somatic | 10864 | -0.504 | -0.5585 | Yes |
| 45 | SDHC | NA | SDHC Entrez, Source | succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa | 10930 | -0.514 | -0.5551 | Yes |
| 46 | ATP5G2 | NA | ATP5G2 Entrez, Source | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9) | 10959 | -0.520 | -0.5490 | Yes |
| 47 | NDUFC2 | NA | NDUFC2 Entrez, Source | NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa | 10967 | -0.521 | -0.5413 | Yes |
| 48 | NDUFS6 | NA | NDUFS6 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) | 11041 | -0.535 | -0.5381 | Yes |
| 49 | CYC1 | NA | CYC1 Entrez, Source | cytochrome c-1 | 11222 | -0.567 | -0.5423 | Yes |
| 50 | NDUFS5 | NA | NDUFS5 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) | 11285 | -0.582 | -0.5376 | Yes |
| 51 | ATP5H | NA | ATP5H Entrez, Source | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d | 11314 | -0.588 | -0.5303 | Yes |
| 52 | NDUFA9 | NA | NDUFA9 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa | 11386 | -0.600 | -0.5260 | Yes |
| 53 | NDUFC1 | NA | NDUFC1 Entrez, Source | NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa | 11496 | -0.623 | -0.5241 | Yes |
| 54 | SLC18A2 | NA | SLC18A2 Entrez, Source | solute carrier family 18 (vesicular monoamine), member 2 | 11583 | -0.643 | -0.5202 | Yes |
| 55 | UQCRQ | NA | UQCRQ Entrez, Source | ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa | 11614 | -0.653 | -0.5121 | Yes |
| 56 | NDUFS2 | NA | NDUFS2 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) | 11651 | -0.660 | -0.5043 | Yes |
| 57 | NDUFA3 | NA | NDUFA3 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa | 11706 | -0.672 | -0.4976 | Yes |
| 58 | NDUFA1 | NA | NDUFA1 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa | 11714 | -0.675 | -0.4875 | Yes |
| 59 | NDUFA6 | NA | NDUFA6 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa | 11745 | -0.684 | -0.4789 | Yes |
| 60 | ATP5O | NA | ATP5O Entrez, Source | ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (oligomycin sensitivity conferring protein) | 11766 | -0.689 | -0.4695 | Yes |
| 61 | COX6A1 | NA | COX6A1 Entrez, Source | cytochrome c oxidase subunit VIa polypeptide 1 | 11769 | -0.690 | -0.4587 | Yes |
| 62 | ATP5G1 | NA | ATP5G1 Entrez, Source | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9) | 11772 | -0.691 | -0.4479 | Yes |
| 63 | COX6C | NA | COX6C Entrez, Source | cytochrome c oxidase subunit VIc | 11796 | -0.698 | -0.4386 | Yes |
| 64 | SLC25A6 | NA | SLC25A6 Entrez, Source | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | 11809 | -0.701 | -0.4284 | Yes |
| 65 | NDUFS1 | NA | NDUFS1 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) | 11893 | -0.722 | -0.4230 | Yes |
| 66 | ATP5B | NA | ATP5B Entrez, Source | ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide | 11967 | -0.744 | -0.4166 | Yes |
| 67 | NDUFB8 | NA | NDUFB8 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa | 12008 | -0.759 | -0.4075 | Yes |
| 68 | ATP5F1 | NA | ATP5F1 Entrez, Source | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1 | 12053 | -0.772 | -0.3986 | Yes |
| 69 | NDUFA2 | NA | NDUFA2 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa | 12064 | -0.777 | -0.3870 | Yes |
| 70 | UQCR10 | NA | 12066 | -0.777 | -0.3748 | Yes | ||
| 71 | COX6B1 | NA | COX6B1 Entrez, Source | cytochrome c oxidase subunit Vib polypeptide 1 (ubiquitous) | 12086 | -0.781 | -0.3639 | Yes |
| 72 | NDUFB6 | NA | NDUFB6 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa | 12106 | -0.789 | -0.3528 | Yes |
| 73 | NDUFA4 | NA | NDUFA4 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa | 12145 | -0.803 | -0.3429 | Yes |
| 74 | UQCRH | NA | UQCRH Entrez, Source | ubiquinol-cytochrome c reductase hinge protein | 12158 | -0.807 | -0.3310 | Yes |
| 75 | SEPT5 | NA | SEPT5 Entrez, Source | septin 5 | 12159 | -0.808 | -0.3183 | Yes |
| 76 | SDHD | NA | SDHD Entrez, Source | succinate dehydrogenase complex, subunit D, integral membrane protein | 12186 | -0.815 | -0.3073 | Yes |
| 77 | NDUFB3 | NA | NDUFB3 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa | 12187 | -0.815 | -0.2944 | Yes |
| 78 | NDUFV1 | NA | NDUFV1 Entrez, Source | NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa | 12219 | -0.825 | -0.2836 | Yes |
| 79 | COX8A | NA | COX8A Entrez, Source | cytochrome c oxidase subunit 8A (ubiquitous) | 12241 | -0.834 | -0.2720 | Yes |
| 80 | ATP5J | NA | ATP5J Entrez, Source | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6 | 12254 | -0.837 | -0.2597 | Yes |
| 81 | NDUFB4 | NA | NDUFB4 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa | 12267 | -0.842 | -0.2473 | Yes |
| 82 | NDUFA5 | NA | NDUFA5 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa | 12296 | -0.850 | -0.2359 | Yes |
| 83 | NDUFA7 | NA | NDUFA7 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa | 12408 | -0.895 | -0.2298 | Yes |
| 84 | COX7A2 | NA | COX7A2 Entrez, Source | cytochrome c oxidase subunit VIIa polypeptide 2 (liver) | 12409 | -0.895 | -0.2157 | Yes |
| 85 | ATP5A1 | NA | ATP5A1 Entrez, Source | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle | 12430 | -0.907 | -0.2028 | Yes |
| 86 | UQCRB | NA | UQCRB Entrez, Source | ubiquinol-cytochrome c reductase binding protein | 12456 | -0.921 | -0.1901 | Yes |
| 87 | NDUFA4L2 | NA | NDUFA4L2 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 | 12458 | -0.922 | -0.1756 | Yes |
| 88 | COX7C | NA | COX7C Entrez, Source | cytochrome c oxidase subunit VIIc | 12481 | -0.929 | -0.1626 | Yes |
| 89 | NDUFB1 | NA | NDUFB1 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa | 12642 | -1.007 | -0.1583 | Yes |
| 90 | SDHA | NA | SDHA Entrez, Source | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) | 12856 | -1.123 | -0.1561 | Yes |
| 91 | COX5B | NA | COX5B Entrez, Source | cytochrome c oxidase subunit Vb | 12858 | -1.125 | -0.1384 | Yes |
| 92 | NDUFB5 | NA | NDUFB5 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa | 12869 | -1.132 | -0.1213 | Yes |
| 93 | COX7B | NA | COX7B Entrez, Source | cytochrome c oxidase subunit VIIb | 12976 | -1.199 | -0.1100 | Yes |
| 94 | UQCRC2 | NA | UQCRC2 Entrez, Source | ubiquinol-cytochrome c reductase core protein II | 12985 | -1.203 | -0.0916 | Yes |
| 95 | UQCRHL | NA | 12995 | -1.213 | -0.0731 | Yes | ||
| 96 | GPR37 | NA | GPR37 Entrez, Source | G protein-coupled receptor 37 (endothelin receptor type B-like) | 13072 | -1.274 | -0.0585 | Yes |
| 97 | PINK1 | NA | PINK1 Entrez, Source | PTEN induced putative kinase 1 | 13178 | -1.374 | -0.0445 | Yes |
| 98 | LRRK2 | NA | LRRK2 Entrez, Source | leucine-rich repeat kinase 2 | 13404 | -1.658 | -0.0347 | Yes |
| 99 | SNCA | NA | SNCA Entrez, Source | synuclein, alpha (non A4 component of amyloid precursor) | 13431 | -1.703 | -0.0097 | Yes |
| 100 | CASP9 | NA | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 13696 | -2.469 | 0.0100 | Yes |
