Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | KEGG_NOTCH_SIGNALING_PATHWAY |
| Enrichment Score (ES) | 0.5024152 |
| Normalized Enrichment Score (NES) | 1.683746 |
| Nominal p-value | 0.002570694 |
| FDR q-value | 0.0547407 |
| FWER p-Value | 0.34 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | JAG1 | NA | JAG1 Entrez, Source | jagged 1 (Alagille syndrome) | 432 | 1.447 | 0.0437 | Yes |
| 2 | DTX2 | NA | DTX2 Entrez, Source | deltex homolog 2 (Drosophila) | 504 | 1.307 | 0.1063 | Yes |
| 3 | DTX3L | NA | DTX3L Entrez, Source | deltex 3-like (Drosophila) | 754 | 1.049 | 0.1426 | Yes |
| 4 | HES1 | NA | HES1 Entrez, Source | hairy and enhancer of split 1, (Drosophila) | 764 | 1.038 | 0.1958 | Yes |
| 5 | MAML3 | NA | MAML3 Entrez, Source | mastermind-like 3 (Drosophila) | 895 | 0.946 | 0.2354 | Yes |
| 6 | CREBBP | NA | CREBBP Entrez, Source | CREB binding protein (Rubinstein-Taybi syndrome) | 932 | 0.928 | 0.2809 | Yes |
| 7 | NOTCH1 | NA | NOTCH1 Entrez, Source | Notch homolog 1, translocation-associated (Drosophila) | 971 | 0.909 | 0.3252 | Yes |
| 8 | DLL4 | NA | DLL4 Entrez, Source | delta-like 4 (Drosophila) | 1096 | 0.853 | 0.3605 | Yes |
| 9 | EP300 | NA | EP300 Entrez, Source | E1A binding protein p300 | 1140 | 0.835 | 0.4006 | Yes |
| 10 | NOTCH3 | NA | NOTCH3 Entrez, Source | Notch homolog 3 (Drosophila) | 1282 | 0.781 | 0.4309 | Yes |
| 11 | DLL3 | NA | DLL3 Entrez, Source | delta-like 3 (Drosophila) | 1285 | 0.779 | 0.4711 | Yes |
| 12 | NOTCH2 | NA | NOTCH2 Entrez, Source | Notch homolog 2 (Drosophila) | 1656 | 0.674 | 0.4792 | Yes |
| 13 | JAG2 | NA | JAG2 Entrez, Source | jagged 2 | 2112 | 0.567 | 0.4756 | Yes |
| 14 | MAML1 | NA | MAML1 Entrez, Source | mastermind-like 1 (Drosophila) | 2616 | 0.482 | 0.4641 | Yes |
| 15 | NOTCH4 | NA | NOTCH4 Entrez, Source | Notch homolog 4 (Drosophila) | 2650 | 0.476 | 0.4863 | Yes |
| 16 | MAML2 | NA | MAML2 Entrez, Source | mastermind-like 2 (Drosophila) | 2850 | 0.443 | 0.4949 | Yes |
| 17 | KAT2A | NA | 3062 | 0.413 | 0.5010 | Yes | ||
| 18 | ADAM17 | NA | ADAM17 Entrez, Source | ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) | 3315 | 0.381 | 0.5024 | Yes |
| 19 | DVL1 | NA | DVL1 Entrez, Source | dishevelled, dsh homolog 1 (Drosophila) | 4706 | 0.221 | 0.4131 | No |
| 20 | HDAC2 | NA | HDAC2 Entrez, Source | histone deacetylase 2 | 5155 | 0.176 | 0.3897 | No |
| 21 | PSEN1 | NA | PSEN1 Entrez, Source | presenilin 1 (Alzheimer disease 3) | 5361 | 0.155 | 0.3829 | No |
| 22 | NUMBL | NA | NUMBL Entrez, Source | numb homolog (Drosophila)-like | 5624 | 0.124 | 0.3703 | No |
| 23 | RBPJ | NA | 6311 | 0.057 | 0.3235 | No | ||
| 24 | DTX4 | NA | DTX4 Entrez, Source | deltex 4 homolog (Drosophila) | 6353 | 0.054 | 0.3234 | No |
| 25 | SNW1 | NA | SNW1 Entrez, Source | SNW domain containing 1 | 6370 | 0.052 | 0.3249 | No |
| 26 | PSEN2 | NA | PSEN2 Entrez, Source | presenilin 2 (Alzheimer disease 4) | 6448 | 0.043 | 0.3216 | No |
| 27 | APH1A | NA | APH1A Entrez, Source | anterior pharynx defective 1 homolog A (C. elegans) | 6934 | -0.008 | 0.2868 | No |
| 28 | NCOR2 | NA | NCOR2 Entrez, Source | nuclear receptor co-repressor 2 | 7018 | -0.016 | 0.2816 | No |
| 29 | CTBP2 | NA | CTBP2 Entrez, Source | C-terminal binding protein 2 | 7064 | -0.020 | 0.2794 | No |
| 30 | NCSTN | NA | NCSTN Entrez, Source | nicastrin | 7131 | -0.026 | 0.2760 | No |
| 31 | RFNG | NA | RFNG Entrez, Source | radical fringe homolog (Drosophila) | 7245 | -0.038 | 0.2698 | No |
| 32 | CTBP1 | NA | CTBP1 Entrez, Source | C-terminal binding protein 1 | 7594 | -0.075 | 0.2484 | No |
| 33 | DVL3 | NA | DVL3 Entrez, Source | dishevelled, dsh homolog 3 (Drosophila) | 8045 | -0.120 | 0.2220 | No |
| 34 | PSENEN | NA | PSENEN Entrez, Source | presenilin enhancer 2 homolog (C. elegans) | 8118 | -0.127 | 0.2234 | No |
| 35 | PTCRA | NA | PTCRA Entrez, Source | pre T-cell antigen receptor alpha | 8563 | -0.175 | 0.2003 | No |
| 36 | CIR1 | NA | 8655 | -0.186 | 0.2033 | No | ||
| 37 | NUMB | NA | NUMB Entrez, Source | numb homolog (Drosophila) | 8747 | -0.197 | 0.2069 | No |
| 38 | HDAC1 | NA | HDAC1 Entrez, Source | histone deacetylase 1 | 9558 | -0.301 | 0.1638 | No |
| 39 | LFNG | NA | LFNG Entrez, Source | lunatic fringe homolog (Drosophila) | 9633 | -0.312 | 0.1746 | No |
| 40 | MFNG | NA | MFNG Entrez, Source | manic fringe homolog (Drosophila) | 9901 | -0.350 | 0.1734 | No |
| 41 | DVL2 | NA | DVL2 Entrez, Source | dishevelled, dsh homolog 2 (Drosophila) | 11740 | -0.681 | 0.0754 | No |
| 42 | KAT2B | NA | 13263 | -1.472 | 0.0414 | No |
