Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY |
| Enrichment Score (ES) | 0.5638357 |
| Normalized Enrichment Score (NES) | 1.916808 |
| Nominal p-value | 0.0024813896 |
| FDR q-value | 0.006071293 |
| FWER p-Value | 0.03 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CCL5 | NA | CCL5 Entrez, Source | chemokine (C-C motif) ligand 5 | 10 | 4.462 | 0.1156 | Yes |
| 2 | IL6 | NA | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 15 | 4.383 | 0.2296 | Yes |
| 3 | CCL2 | NA | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 98 | 2.964 | 0.3010 | Yes |
| 4 | TNFAIP3 | NA | TNFAIP3 Entrez, Source | tumor necrosis factor, alpha-induced protein 3 | 112 | 2.804 | 0.3732 | Yes |
| 5 | BIRC3 | NA | BIRC3 Entrez, Source | baculoviral IAP repeat-containing 3 | 152 | 2.495 | 0.4354 | Yes |
| 6 | CXCL2 | NA | CXCL2 Entrez, Source | chemokine (C-X-C motif) ligand 2 | 162 | 2.420 | 0.4979 | Yes |
| 7 | HSP90B1 | NA | HSP90B1 Entrez, Source | heat shock protein 90kDa beta (Grp94), member 1 | 478 | 1.351 | 0.5102 | Yes |
| 8 | HSP90AB1 | NA | HSP90AB1 Entrez, Source | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 810 | 0.999 | 0.5123 | Yes |
| 9 | IL18 | NA | IL18 Entrez, Source | interleukin 18 (interferon-gamma-inducing factor) | 831 | 0.988 | 0.5366 | Yes |
| 10 | NLRC4 | NA | 965 | 0.912 | 0.5507 | Yes | ||
| 11 | NFKBIA | NA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 1484 | 0.721 | 0.5320 | Yes |
| 12 | RELA | NA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 1570 | 0.698 | 0.5440 | Yes |
| 13 | CARD6 | NA | CARD6 Entrez, Source | caspase recruitment domain family, member 6 | 1680 | 0.663 | 0.5534 | Yes |
| 14 | BIRC2 | NA | BIRC2 Entrez, Source | baculoviral IAP repeat-containing 2 | 1964 | 0.594 | 0.5483 | Yes |
| 15 | NFKB1 | NA | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 2004 | 0.585 | 0.5608 | Yes |
| 16 | HSP90AA1 | NA | HSP90AA1 Entrez, Source | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 2335 | 0.527 | 0.5506 | Yes |
| 17 | IKBKG | NA | IKBKG Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 2396 | 0.517 | 0.5597 | Yes |
| 18 | IL1B | NA | IL1B Entrez, Source | interleukin 1, beta | 2581 | 0.487 | 0.5590 | Yes |
| 19 | MAPK8 | NA | MAPK8 Entrez, Source | mitogen-activated protein kinase 8 | 2742 | 0.461 | 0.5594 | Yes |
| 20 | TRIP6 | NA | TRIP6 Entrez, Source | thyroid hormone receptor interactor 6 | 2842 | 0.444 | 0.5638 | Yes |
| 21 | CHUK | NA | CHUK Entrez, Source | conserved helix-loop-helix ubiquitous kinase | 2997 | 0.421 | 0.5637 | No |
| 22 | CARD9 | NA | CARD9 Entrez, Source | caspase recruitment domain family, member 9 | 3477 | 0.357 | 0.5382 | No |
| 23 | SUGT1 | NA | SUGT1 Entrez, Source | SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) | 3517 | 0.352 | 0.5446 | No |
| 24 | TRAF6 | NA | TRAF6 Entrez, Source | TNF receptor-associated factor 6 | 4423 | 0.251 | 0.4855 | No |
| 25 | NLRP3 | NA | 4507 | 0.242 | 0.4858 | No | ||
| 26 | XIAP | NA | 4549 | 0.237 | 0.4890 | No | ||
| 27 | RIPK2 | NA | RIPK2 Entrez, Source | receptor-interacting serine-threonine kinase 2 | 4588 | 0.233 | 0.4923 | No |
| 28 | CASP8 | NA | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 5043 | 0.187 | 0.4643 | No |
| 29 | TAB2 | NA | 6033 | 0.083 | 0.3947 | No | ||
| 30 | MEFV | NA | MEFV Entrez, Source | Mediterranean fever | 6698 | 0.017 | 0.3470 | No |
| 31 | TAB1 | NA | 7323 | -0.047 | 0.3030 | No | ||
| 32 | MAPK14 | NA | MAPK14 Entrez, Source | mitogen-activated protein kinase 14 | 7577 | -0.073 | 0.2865 | No |
| 33 | NOD1 | NA | 7612 | -0.077 | 0.2861 | No | ||
| 34 | MAP3K7 | NA | MAP3K7 Entrez, Source | mitogen-activated protein kinase kinase kinase 7 | 8905 | -0.215 | 0.1980 | No |
| 35 | MAPK1 | NA | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 8973 | -0.222 | 0.1989 | No |
| 36 | TAB3 | NA | 9328 | -0.267 | 0.1802 | No | ||
| 37 | MAPK12 | NA | MAPK12 Entrez, Source | mitogen-activated protein kinase 12 | 9483 | -0.292 | 0.1766 | No |
| 38 | NLRP1 | NA | 9527 | -0.298 | 0.1813 | No | ||
| 39 | CARD8 | NA | CARD8 Entrez, Source | caspase recruitment domain family, member 8 | 9712 | -0.324 | 0.1764 | No |
| 40 | MAPK9 | NA | MAPK9 Entrez, Source | mitogen-activated protein kinase 9 | 9823 | -0.340 | 0.1773 | No |
| 41 | IKBKB | NA | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 9844 | -0.344 | 0.1848 | No |
| 42 | MAPK10 | NA | MAPK10 Entrez, Source | mitogen-activated protein kinase 10 | 10142 | -0.384 | 0.1733 | No |
| 43 | CASP1 | NA | CASP1 Entrez, Source | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 10265 | -0.405 | 0.1750 | No |
| 44 | MAPK11 | NA | MAPK11 Entrez, Source | mitogen-activated protein kinase 11 | 10697 | -0.475 | 0.1561 | No |
| 45 | MAPK13 | NA | MAPK13 Entrez, Source | mitogen-activated protein kinase 13 | 10850 | -0.502 | 0.1581 | No |
| 46 | NAIP | NA | NAIP Entrez, Source | - | 12144 | -0.803 | 0.0853 | No |
| 47 | MAPK3 | NA | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 13226 | -1.426 | 0.0441 | No |
