Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_LYSINE_DEGRADATION |
| Enrichment Score (ES) | -0.5260001 |
| Normalized Enrichment Score (NES) | -1.6503425 |
| Nominal p-value | 0.005154639 |
| FDR q-value | 0.056045685 |
| FWER p-Value | 0.492 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | SETD1A | NA | SETD1A Entrez, Source | SET domain containing 1A | 2300 | 0.533 | -0.1355 | No |
| 2 | SUV39H1 | NA | SUV39H1 Entrez, Source | suppressor of variegation 3-9 homolog 1 (Drosophila) | 3370 | 0.372 | -0.1912 | No |
| 3 | NSD1 | NA | NSD1 Entrez, Source | nuclear receptor binding SET domain protein 1 | 4172 | 0.280 | -0.2328 | No |
| 4 | AASDHPPT | NA | AASDHPPT Entrez, Source | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 4864 | 0.205 | -0.2709 | No |
| 5 | ALDH1B1 | NA | ALDH1B1 Entrez, Source | aldehyde dehydrogenase 1 family, member B1 | 5084 | 0.183 | -0.2760 | No |
| 6 | DLST | NA | DLST Entrez, Source | dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) | 5346 | 0.157 | -0.2858 | No |
| 7 | SETD1B | NA | SETD1B Entrez, Source | SET domain containing 1B | 5529 | 0.137 | -0.2909 | No |
| 8 | SUV39H2 | NA | SUV39H2 Entrez, Source | suppressor of variegation 3-9 homolog 2 (Drosophila) | 5793 | 0.108 | -0.3037 | No |
| 9 | EHMT1 | NA | EHMT1 Entrez, Source | euchromatic histone-lysine N-methyltransferase 1 | 6408 | 0.048 | -0.3454 | No |
| 10 | PLOD2 | NA | PLOD2 Entrez, Source | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 6669 | 0.021 | -0.3630 | No |
| 11 | DOT1L | NA | DOT1L Entrez, Source | DOT1-like, histone H3 methyltransferase (S. cerevisiae) | 7109 | -0.024 | -0.3934 | No |
| 12 | AASDH | NA | AASDH Entrez, Source | - | 7133 | -0.026 | -0.3935 | No |
| 13 | SETDB1 | NA | SETDB1 Entrez, Source | SET domain, bifurcated 1 | 7294 | -0.044 | -0.4025 | No |
| 14 | SETDB2 | NA | SETDB2 Entrez, Source | SET domain, bifurcated 2 | 7475 | -0.064 | -0.4118 | No |
| 15 | EHMT2 | NA | EHMT2 Entrez, Source | euchromatic histone-lysine N-methyltransferase 2 | 7544 | -0.071 | -0.4126 | No |
| 16 | SETMAR | NA | SETMAR Entrez, Source | SET domain and mariner transposase fusion gene | 7921 | -0.106 | -0.4336 | No |
| 17 | PLOD3 | NA | PLOD3 Entrez, Source | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 | 8282 | -0.145 | -0.4512 | No |
| 18 | SETD2 | NA | SETD2 Entrez, Source | SET domain containing 2 | 8478 | -0.167 | -0.4556 | No |
| 19 | OGDH | NA | OGDH Entrez, Source | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | 8538 | -0.172 | -0.4498 | No |
| 20 | ASH1L | NA | ASH1L Entrez, Source | ash1 (absent, small, or homeotic)-like (Drosophila) | 9196 | -0.249 | -0.4828 | No |
| 21 | ALDH3A2 | NA | ALDH3A2 Entrez, Source | aldehyde dehydrogenase 3 family, member A2 | 9636 | -0.312 | -0.4964 | No |
| 22 | AASS | NA | AASS Entrez, Source | aminoadipate-semialdehyde synthase | 10046 | -0.372 | -0.5042 | Yes |
| 23 | PLOD1 | NA | PLOD1 Entrez, Source | procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 | 10170 | -0.389 | -0.4904 | Yes |
| 24 | TMLHE | NA | TMLHE Entrez, Source | trimethyllysine hydroxylase, epsilon | 10407 | -0.428 | -0.4824 | Yes |
| 25 | EHHADH | NA | EHHADH Entrez, Source | enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase | 10749 | -0.483 | -0.4789 | Yes |
| 26 | ALDH9A1 | NA | ALDH9A1 Entrez, Source | aldehyde dehydrogenase 9 family, member A1 | 10955 | -0.519 | -0.4634 | Yes |
| 27 | SETD7 | NA | SETD7 Entrez, Source | SET domain containing (lysine methyltransferase) 7 | 11060 | -0.539 | -0.4394 | Yes |
| 28 | HADH | NA | HADH Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase | 11456 | -0.615 | -0.4320 | Yes |
| 29 | GCDH | NA | GCDH Entrez, Source | glutaryl-Coenzyme A dehydrogenase | 11682 | -0.668 | -0.4092 | Yes |
| 30 | ECHS1 | NA | ECHS1 Entrez, Source | enoyl Coenzyme A hydratase, short chain, 1, mitochondrial | 11963 | -0.742 | -0.3860 | Yes |
| 31 | ALDH7A1 | NA | ALDH7A1 Entrez, Source | aldehyde dehydrogenase 7 family, member A1 | 12010 | -0.760 | -0.3449 | Yes |
| 32 | HADHA | NA | HADHA Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit | 12220 | -0.825 | -0.3117 | Yes |
| 33 | ACAT2 | NA | ACAT2 Entrez, Source | acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) | 12819 | -1.099 | -0.2907 | Yes |
| 34 | ALDH2 | NA | ALDH2 Entrez, Source | aldehyde dehydrogenase 2 family (mitochondrial) | 13109 | -1.302 | -0.2355 | Yes |
| 35 | ACAT1 | NA | ACAT1 Entrez, Source | acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) | 13202 | -1.396 | -0.1604 | Yes |
| 36 | PIPOX | NA | PIPOX Entrez, Source | pipecolic acid oxidase | 13313 | -1.530 | -0.0788 | Yes |
| 37 | OGDHL | NA | OGDHL Entrez, Source | oxoglutarate dehydrogenase-like | 13573 | -1.991 | 0.0189 | Yes |
