Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION |
| Enrichment Score (ES) | 0.38171932 |
| Normalized Enrichment Score (NES) | 1.4788322 |
| Nominal p-value | 0.0125 |
| FDR q-value | 0.14032169 |
| FWER p-Value | 0.904 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | NCF2 | NA | NCF2 Entrez, Source | neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2) | 6 | 4.659 | 0.0693 | Yes |
| 2 | CDH5 | NA | CDH5 Entrez, Source | cadherin 5, type 2, VE-cadherin (vascular epithelium) | 110 | 2.836 | 0.1042 | Yes |
| 3 | CLDN4 | NA | CLDN4 Entrez, Source | claudin 4 | 120 | 2.696 | 0.1439 | Yes |
| 4 | ICAM1 | NA | ICAM1 Entrez, Source | intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | 251 | 1.952 | 0.1637 | Yes |
| 5 | CLDN1 | NA | CLDN1 Entrez, Source | claudin 1 | 306 | 1.751 | 0.1860 | Yes |
| 6 | RAC2 | NA | RAC2 Entrez, Source | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) | 323 | 1.707 | 0.2103 | Yes |
| 7 | CYBB | NA | CYBB Entrez, Source | cytochrome b-245, beta polypeptide (chronic granulomatous disease) | 344 | 1.631 | 0.2333 | Yes |
| 8 | PLCG2 | NA | PLCG2 Entrez, Source | phospholipase C, gamma 2 (phosphatidylinositol-specific) | 361 | 1.581 | 0.2558 | Yes |
| 9 | TXK | NA | TXK Entrez, Source | TXK tyrosine kinase | 365 | 1.569 | 0.2791 | Yes |
| 10 | MYL5 | NA | MYL5 Entrez, Source | myosin, light chain 5, regulatory | 404 | 1.496 | 0.2987 | Yes |
| 11 | RAPGEF3 | NA | RAPGEF3 Entrez, Source | Rap guanine nucleotide exchange factor (GEF) 3 | 479 | 1.350 | 0.3135 | Yes |
| 12 | ACTG1 | NA | ACTG1 Entrez, Source | actin, gamma 1 | 583 | 1.201 | 0.3240 | Yes |
| 13 | ITGAM | NA | ITGAM Entrez, Source | integrin, alpha M (complement component 3 receptor 3 subunit) | 696 | 1.100 | 0.3323 | Yes |
| 14 | BCAR1 | NA | BCAR1 Entrez, Source | breast cancer anti-estrogen resistance 1 | 761 | 1.040 | 0.3432 | Yes |
| 15 | ACTN1 | NA | ACTN1 Entrez, Source | actinin, alpha 1 | 849 | 0.978 | 0.3515 | Yes |
| 16 | PXN | NA | PXN Entrez, Source | paxillin | 1118 | 0.844 | 0.3446 | Yes |
| 17 | ACTB | NA | ACTB Entrez, Source | actin, beta | 1127 | 0.840 | 0.3566 | Yes |
| 18 | ACTN4 | NA | ACTN4 Entrez, Source | actinin, alpha 4 | 1270 | 0.789 | 0.3581 | Yes |
| 19 | MSN | NA | MSN Entrez, Source | moesin | 1316 | 0.768 | 0.3663 | Yes |
| 20 | VCL | NA | VCL Entrez, Source | vinculin | 1344 | 0.758 | 0.3757 | Yes |
| 21 | PRKCG | NA | PRKCG Entrez, Source | protein kinase C, gamma | 1414 | 0.740 | 0.3817 | Yes |
| 22 | PIK3R1 | NA | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 1699 | 0.658 | 0.3709 | No |
| 23 | VAV1 | NA | VAV1 Entrez, Source | vav 1 oncogene | 1866 | 0.614 | 0.3680 | No |
| 24 | ESAM | NA | ESAM Entrez, Source | endothelial cell adhesion molecule | 2544 | 0.493 | 0.3261 | No |
| 25 | MMP2 | NA | MMP2 Entrez, Source | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | 2663 | 0.473 | 0.3246 | No |
| 26 | CLDN23 | NA | CLDN23 Entrez, Source | claudin 23 | 3040 | 0.416 | 0.3035 | No |
| 27 | EZR | NA | 3287 | 0.383 | 0.2913 | No | ||
| 28 | JAM2 | NA | JAM2 Entrez, Source | junctional adhesion molecule 2 | 3358 | 0.375 | 0.2919 | No |
| 29 | GNAI3 | NA | GNAI3 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 3439 | 0.361 | 0.2914 | No |
| 30 | CLDN20 | NA | CLDN20 Entrez, Source | claudin 20 | 3512 | 0.353 | 0.2915 | No |
| 31 | MYL12A | NA | 3767 | 0.326 | 0.2779 | No | ||
| 32 | VAV2 | NA | VAV2 Entrez, Source | vav 2 oncogene | 3835 | 0.317 | 0.2777 | No |
| 33 | NOX1 | NA | NOX1 Entrez, Source | NADPH oxidase 1 | 3994 | 0.297 | 0.2707 | No |
| 34 | ROCK1 | NA | ROCK1 Entrez, Source | Rho-associated, coiled-coil containing protein kinase 1 | 4370 | 0.257 | 0.2473 | No |
| 35 | ROCK2 | NA | ROCK2 Entrez, Source | Rho-associated, coiled-coil containing protein kinase 2 | 4724 | 0.219 | 0.2248 | No |
| 36 | CLDN18 | NA | CLDN18 Entrez, Source | claudin 18 | 4820 | 0.209 | 0.2211 | No |
| 37 | MMP9 | NA | MMP9 Entrez, Source | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 4824 | 0.209 | 0.2240 | No |
| 38 | VASP | NA | VASP Entrez, Source | vasodilator-stimulated phosphoprotein | 4950 | 0.197 | 0.2178 | No |
| 39 | MYL10 | NA | 5067 | 0.185 | 0.2121 | No | ||
| 40 | PIK3CB | NA | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 5293 | 0.162 | 0.1982 | No |
| 41 | RAC1 | NA | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 5556 | 0.134 | 0.1811 | No |
| 42 | CLDN19 | NA | CLDN19 Entrez, Source | claudin 19 | 5575 | 0.131 | 0.1818 | No |
| 43 | PTPN11 | NA | PTPN11 Entrez, Source | protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) | 5619 | 0.125 | 0.1805 | No |
| 44 | CD99 | NA | CD99 Entrez, Source | CD99 molecule | 5725 | 0.114 | 0.1746 | No |
| 45 | ACTN2 | NA | ACTN2 Entrez, Source | actinin, alpha 2 | 5838 | 0.103 | 0.1680 | No |
| 46 | CLDN9 | NA | CLDN9 Entrez, Source | claudin 9 | 6076 | 0.079 | 0.1519 | No |
| 47 | CLDN11 | NA | CLDN11 Entrez, Source | claudin 11 (oligodendrocyte transmembrane protein) | 6321 | 0.056 | 0.1350 | No |
| 48 | PECAM1 | NA | PECAM1 Entrez, Source | platelet/endothelial cell adhesion molecule (CD31 antigen) | 6545 | 0.033 | 0.1193 | No |
| 49 | GNAI1 | NA | GNAI1 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 6771 | 0.010 | 0.1030 | No |
| 50 | CLDN16 | NA | CLDN16 Entrez, Source | claudin 16 | 7307 | -0.046 | 0.0648 | No |
| 51 | JAM3 | NA | JAM3 Entrez, Source | junctional adhesion molecule 3 | 7360 | -0.052 | 0.0618 | No |
| 52 | ARHGAP5 | NA | ARHGAP5 Entrez, Source | Rho GTPase activating protein 5 | 7510 | -0.067 | 0.0520 | No |
| 53 | MAPK14 | NA | MAPK14 Entrez, Source | mitogen-activated protein kinase 14 | 7577 | -0.073 | 0.0482 | No |
| 54 | CDC42 | NA | CDC42 Entrez, Source | cell division cycle 42 (GTP binding protein, 25kDa) | 7674 | -0.082 | 0.0425 | No |
| 55 | CLDN15 | NA | CLDN15 Entrez, Source | claudin 15 | 7781 | -0.093 | 0.0362 | No |
| 56 | NCF1 | NA | NCF1 Entrez, Source | neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1) | 7956 | -0.109 | 0.0251 | No |
| 57 | CTNND1 | NA | CTNND1 Entrez, Source | catenin (cadherin-associated protein), delta 1 | 7982 | -0.112 | 0.0250 | No |
| 58 | RHOA | NA | RHOA Entrez, Source | ras homolog gene family, member A | 8007 | -0.115 | 0.0250 | No |
| 59 | PTK2 | NA | PTK2 Entrez, Source | PTK2 protein tyrosine kinase 2 | 8268 | -0.144 | 0.0082 | No |
| 60 | RAP1B | NA | RAP1B Entrez, Source | RAP1B, member of RAS oncogene family | 8297 | -0.146 | 0.0083 | No |
| 61 | PLCG1 | NA | PLCG1 Entrez, Source | phospholipase C, gamma 1 | 8316 | -0.148 | 0.0092 | No |
| 62 | RAP1A | NA | RAP1A Entrez, Source | RAP1A, member of RAS oncogene family | 8399 | -0.157 | 0.0056 | No |
| 63 | PIK3R3 | NA | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 8472 | -0.166 | 0.0029 | No |
| 64 | MYL12B | NA | 8537 | -0.172 | 0.0008 | No | ||
| 65 | VCAM1 | NA | VCAM1 Entrez, Source | vascular cell adhesion molecule 1 | 9432 | -0.284 | -0.0600 | No |
| 66 | MAPK12 | NA | MAPK12 Entrez, Source | mitogen-activated protein kinase 12 | 9483 | -0.292 | -0.0593 | No |
| 67 | MYLPF | NA | MYLPF Entrez, Source | - | 9486 | -0.292 | -0.0551 | No |
| 68 | ARHGAP35 | NA | 9687 | -0.319 | -0.0648 | No | ||
| 69 | RASSF5 | NA | RASSF5 Entrez, Source | Ras association (RalGDS/AF-6) domain family 5 | 9708 | -0.322 | -0.0615 | No |
| 70 | PIK3CA | NA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 9727 | -0.326 | -0.0579 | No |
| 71 | OCLN | NA | OCLN Entrez, Source | occludin | 9944 | -0.355 | -0.0683 | No |
| 72 | GNAI2 | NA | GNAI2 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | 10025 | -0.368 | -0.0686 | No |
| 73 | CTNNA1 | NA | CTNNA1 Entrez, Source | catenin (cadherin-associated protein), alpha 1, 102kDa | 10049 | -0.372 | -0.0647 | No |
| 74 | CXCR4 | NA | CXCR4 Entrez, Source | chemokine (C-X-C motif) receptor 4 | 10239 | -0.400 | -0.0725 | No |
| 75 | PTK2B | NA | PTK2B Entrez, Source | PTK2B protein tyrosine kinase 2 beta | 10406 | -0.428 | -0.0782 | No |
| 76 | MAPK11 | NA | MAPK11 Entrez, Source | mitogen-activated protein kinase 11 | 10697 | -0.475 | -0.0922 | No |
| 77 | ITGB1 | NA | ITGB1 Entrez, Source | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 10722 | -0.479 | -0.0867 | No |
| 78 | CYBA | NA | CYBA Entrez, Source | cytochrome b-245, alpha polypeptide | 10764 | -0.486 | -0.0825 | No |
| 79 | MAPK13 | NA | MAPK13 Entrez, Source | mitogen-activated protein kinase 13 | 10850 | -0.502 | -0.0811 | No |
| 80 | SIPA1 | NA | SIPA1 Entrez, Source | signal-induced proliferation-associated gene 1 | 10917 | -0.512 | -0.0783 | No |
| 81 | PIK3R2 | NA | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 11136 | -0.552 | -0.0859 | No |
| 82 | ITGAL | NA | ITGAL Entrez, Source | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) | 11792 | -0.695 | -0.1231 | No |
| 83 | ITGB2 | NA | ITGB2 Entrez, Source | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | 11846 | -0.711 | -0.1164 | No |
| 84 | CTNNB1 | NA | CTNNB1 Entrez, Source | catenin (cadherin-associated protein), beta 1, 88kDa | 12021 | -0.762 | -0.1176 | No |
| 85 | PRKCA | NA | PRKCA Entrez, Source | protein kinase C, alpha | 12193 | -0.818 | -0.1178 | No |
| 86 | VAV3 | NA | VAV3 Entrez, Source | vav 3 oncogene | 12323 | -0.863 | -0.1143 | No |
| 87 | CTNNA3 | NA | CTNNA3 Entrez, Source | catenin (cadherin-associated protein), alpha 3 | 12602 | -0.983 | -0.1198 | No |
| 88 | PIK3CG | NA | PIK3CG Entrez, Source | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 13175 | -1.371 | -0.1409 | No |
| 89 | F11R | NA | F11R Entrez, Source | F11 receptor | 13441 | -1.725 | -0.1344 | No |
| 90 | PRKCB | NA | 13643 | -2.224 | -0.1157 | No | ||
| 91 | RAPGEF4 | NA | RAPGEF4 Entrez, Source | Rap guanine nucleotide exchange factor (GEF) 4 | 13687 | -2.453 | -0.0821 | No |
| 92 | PIK3CD | NA | PIK3CD Entrez, Source | phosphoinositide-3-kinase, catalytic, delta polypeptide | 13763 | -3.033 | -0.0422 | No |
| 93 | CLDN7 | NA | CLDN7 Entrez, Source | claudin 7 | 13774 | -3.160 | 0.0044 | No |
