Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | KEGG_JAK_STAT_SIGNALING_PATHWAY |
| Enrichment Score (ES) | 0.4481727 |
| Normalized Enrichment Score (NES) | 1.7927003 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.021701405 |
| FWER p-Value | 0.126 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | IL7R | NA | IL7R Entrez, Source | interleukin 7 receptor | 3 | 4.680 | 0.0567 | Yes |
| 2 | CRLF2 | NA | CRLF2 Entrez, Source | cytokine receptor-like factor 2 | 9 | 4.480 | 0.1107 | Yes |
| 3 | IL6 | NA | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 15 | 4.383 | 0.1637 | Yes |
| 4 | IL2RG | NA | IL2RG Entrez, Source | interleukin 2 receptor, gamma (severe combined immunodeficiency) | 79 | 3.132 | 0.1971 | Yes |
| 5 | SPRY4 | NA | SPRY4 Entrez, Source | sprouty homolog 4 (Drosophila) | 129 | 2.632 | 0.2256 | Yes |
| 6 | IL24 | NA | IL24 Entrez, Source | interleukin 24 | 163 | 2.417 | 0.2525 | Yes |
| 7 | IL22RA1 | NA | IL22RA1 Entrez, Source | interleukin 22 receptor, alpha 1 | 215 | 2.127 | 0.2747 | Yes |
| 8 | CLCF1 | NA | CLCF1 Entrez, Source | cardiotrophin-like cytokine factor 1 | 309 | 1.735 | 0.2890 | Yes |
| 9 | IL12B | NA | IL12B Entrez, Source | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | 366 | 1.567 | 0.3040 | Yes |
| 10 | CSF2RA | NA | CSF2RA Entrez, Source | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | 378 | 1.539 | 0.3219 | Yes |
| 11 | SOCS3 | NA | SOCS3 Entrez, Source | suppressor of cytokine signaling 3 | 384 | 1.526 | 0.3401 | Yes |
| 12 | BCL2L1 | NA | BCL2L1 Entrez, Source | BCL2-like 1 | 406 | 1.495 | 0.3567 | Yes |
| 13 | IL21R | NA | IL21R Entrez, Source | interleukin 21 receptor | 544 | 1.260 | 0.3620 | Yes |
| 14 | IL6ST | NA | IL6ST Entrez, Source | interleukin 6 signal transducer (gp130, oncostatin M receptor) | 645 | 1.142 | 0.3686 | Yes |
| 15 | CNTFR | NA | CNTFR Entrez, Source | ciliary neurotrophic factor receptor | 677 | 1.117 | 0.3800 | Yes |
| 16 | IL4R | NA | IL4R Entrez, Source | interleukin 4 receptor | 732 | 1.063 | 0.3890 | Yes |
| 17 | IRF9 | NA | 738 | 1.060 | 0.4015 | Yes | ||
| 18 | LIF | NA | LIF Entrez, Source | leukemia inhibitory factor (cholinergic differentiation factor) | 745 | 1.056 | 0.4139 | Yes |
| 19 | JAK2 | NA | JAK2 Entrez, Source | Janus kinase 2 (a protein tyrosine kinase) | 756 | 1.045 | 0.4259 | Yes |
| 20 | IL11 | NA | IL11 Entrez, Source | interleukin 11 | 773 | 1.035 | 0.4373 | Yes |
| 21 | CREBBP | NA | CREBBP Entrez, Source | CREB binding protein (Rubinstein-Taybi syndrome) | 932 | 0.928 | 0.4370 | Yes |
| 22 | CCND1 | NA | CCND1 Entrez, Source | cyclin D1 | 1033 | 0.877 | 0.4404 | Yes |
| 23 | EP300 | NA | EP300 Entrez, Source | E1A binding protein p300 | 1140 | 0.835 | 0.4429 | Yes |
| 24 | STAT5A | NA | STAT5A Entrez, Source | signal transducer and activator of transcription 5A | 1238 | 0.797 | 0.4455 | Yes |
| 25 | SPRY2 | NA | SPRY2 Entrez, Source | sprouty homolog 2 (Drosophila) | 1415 | 0.740 | 0.4417 | Yes |
| 26 | STAM2 | NA | STAM2 Entrez, Source | signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 | 1605 | 0.688 | 0.4363 | Yes |
| 27 | IL15RA | NA | IL15RA Entrez, Source | interleukin 15 receptor, alpha | 1690 | 0.661 | 0.4382 | Yes |
| 28 | PIK3R1 | NA | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 1699 | 0.658 | 0.4456 | Yes |
| 29 | LEP | NA | LEP Entrez, Source | leptin (obesity homolog, mouse) | 1771 | 0.638 | 0.4482 | Yes |
| 30 | IFNAR1 | NA | IFNAR1 Entrez, Source | interferon (alpha, beta and omega) receptor 1 | 2074 | 0.574 | 0.4332 | No |
| 31 | IL12RB2 | NA | IL12RB2 Entrez, Source | interleukin 12 receptor, beta 2 | 2252 | 0.541 | 0.4268 | No |
| 32 | SPRED1 | NA | SPRED1 Entrez, Source | sprouty-related, EVH1 domain containing 1 | 2279 | 0.537 | 0.4315 | No |
| 33 | STAT3 | NA | STAT3 Entrez, Source | signal transducer and activator of transcription 3 (acute-phase response factor) | 2345 | 0.524 | 0.4331 | No |
| 34 | STAT1 | NA | STAT1 Entrez, Source | signal transducer and activator of transcription 1, 91kDa | 2374 | 0.520 | 0.4374 | No |
| 35 | PIAS4 | NA | PIAS4 Entrez, Source | protein inhibitor of activated STAT, 4 | 2498 | 0.500 | 0.4345 | No |
| 36 | IL23A | NA | IL23A Entrez, Source | interleukin 23, alpha subunit p19 | 2610 | 0.483 | 0.4323 | No |
| 37 | SOCS2 | NA | SOCS2 Entrez, Source | suppressor of cytokine signaling 2 | 2713 | 0.466 | 0.4305 | No |
| 38 | JAK1 | NA | JAK1 Entrez, Source | Janus kinase 1 (a protein tyrosine kinase) | 2927 | 0.430 | 0.4203 | No |
| 39 | IL6R | NA | IL6R Entrez, Source | interleukin 6 receptor | 3094 | 0.409 | 0.4131 | No |
| 40 | IL9R | NA | IL9R Entrez, Source | interleukin 9 receptor | 3096 | 0.409 | 0.4180 | No |
| 41 | IFNAR2 | NA | IFNAR2 Entrez, Source | interferon (alpha, beta and omega) receptor 2 | 3310 | 0.381 | 0.4072 | No |
| 42 | IL2RA | NA | IL2RA Entrez, Source | interleukin 2 receptor, alpha | 3404 | 0.367 | 0.4048 | No |
| 43 | CNTF | NA | CNTF Entrez, Source | ciliary neurotrophic factor | 3552 | 0.349 | 0.3984 | No |
| 44 | MPL | NA | MPL Entrez, Source | myeloproliferative leukemia virus oncogene | 3933 | 0.304 | 0.3744 | No |
| 45 | IFNGR1 | NA | IFNGR1 Entrez, Source | interferon gamma receptor 1 | 4135 | 0.284 | 0.3632 | No |
| 46 | IL5RA | NA | IL5RA Entrez, Source | interleukin 5 receptor, alpha | 4957 | 0.196 | 0.3058 | No |
| 47 | SPRED2 | NA | SPRED2 Entrez, Source | sprouty-related, EVH1 domain containing 2 | 5255 | 0.166 | 0.2862 | No |
| 48 | PIK3CB | NA | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 5293 | 0.162 | 0.2855 | No |
| 49 | IL15 | NA | IL15 Entrez, Source | interleukin 15 | 5495 | 0.140 | 0.2726 | No |
| 50 | CISH | NA | CISH Entrez, Source | cytokine inducible SH2-containing protein | 5518 | 0.138 | 0.2726 | No |
| 51 | PTPN11 | NA | PTPN11 Entrez, Source | protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) | 5619 | 0.125 | 0.2669 | No |
| 52 | PIAS3 | NA | PIAS3 Entrez, Source | protein inhibitor of activated STAT, 3 | 5671 | 0.119 | 0.2646 | No |
| 53 | CCND3 | NA | CCND3 Entrez, Source | cyclin D3 | 5722 | 0.114 | 0.2623 | No |
| 54 | IFNE | NA | 6164 | 0.071 | 0.2311 | No | ||
| 55 | CBL | NA | CBL Entrez, Source | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 6561 | 0.031 | 0.2026 | No |
| 56 | STAT6 | NA | STAT6 Entrez, Source | signal transducer and activator of transcription 6, interleukin-4 induced | 6612 | 0.027 | 0.1993 | No |
| 57 | SOCS7 | NA | SOCS7 Entrez, Source | suppressor of cytokine signaling 7 | 6684 | 0.019 | 0.1944 | No |
| 58 | STAM | NA | STAM Entrez, Source | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 | 6739 | 0.013 | 0.1906 | No |
| 59 | GHR | NA | GHR Entrez, Source | growth hormone receptor | 6889 | -0.002 | 0.1798 | No |
| 60 | IL3RA | NA | IL3RA Entrez, Source | interleukin 3 receptor, alpha (low affinity) | 6957 | -0.010 | 0.1750 | No |
| 61 | AKT2 | NA | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 7140 | -0.027 | 0.1621 | No |
| 62 | SOS1 | NA | SOS1 Entrez, Source | son of sevenless homolog 1 (Drosophila) | 7393 | -0.055 | 0.1444 | No |
| 63 | PIAS1 | NA | PIAS1 Entrez, Source | protein inhibitor of activated STAT, 1 | 7416 | -0.058 | 0.1435 | No |
| 64 | IL19 | NA | IL19 Entrez, Source | interleukin 19 | 7550 | -0.071 | 0.1347 | No |
| 65 | PRLR | NA | PRLR Entrez, Source | prolactin receptor | 7590 | -0.074 | 0.1328 | No |
| 66 | PIAS2 | NA | PIAS2 Entrez, Source | protein inhibitor of activated STAT, 2 | 8077 | -0.123 | 0.0989 | No |
| 67 | STAT5B | NA | STAT5B Entrez, Source | signal transducer and activator of transcription 5B | 8241 | -0.142 | 0.0887 | No |
| 68 | PIK3R3 | NA | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 8472 | -0.166 | 0.0740 | No |
| 69 | GRB2 | NA | GRB2 Entrez, Source | growth factor receptor-bound protein 2 | 8662 | -0.186 | 0.0625 | No |
| 70 | IL10RB | NA | IL10RB Entrez, Source | interleukin 10 receptor, beta | 8678 | -0.188 | 0.0637 | No |
| 71 | IL13RA1 | NA | IL13RA1 Entrez, Source | interleukin 13 receptor, alpha 1 | 8682 | -0.188 | 0.0658 | No |
| 72 | SOCS5 | NA | SOCS5 Entrez, Source | suppressor of cytokine signaling 5 | 8711 | -0.192 | 0.0661 | No |
| 73 | STAT4 | NA | STAT4 Entrez, Source | signal transducer and activator of transcription 4 | 8849 | -0.208 | 0.0586 | No |
| 74 | CCND2 | NA | CCND2 Entrez, Source | cyclin D2 | 8965 | -0.222 | 0.0529 | No |
| 75 | IL2RB | NA | IL2RB Entrez, Source | interleukin 2 receptor, beta | 8981 | -0.223 | 0.0546 | No |
| 76 | LIFR | NA | LIFR Entrez, Source | leukemia inhibitory factor receptor alpha | 8985 | -0.224 | 0.0571 | No |
| 77 | SOCS4 | NA | SOCS4 Entrez, Source | suppressor of cytokine signaling 4 | 9421 | -0.282 | 0.0288 | No |
| 78 | IL23R | NA | IL23R Entrez, Source | interleukin 23 receptor | 9490 | -0.293 | 0.0274 | No |
| 79 | IFNGR2 | NA | IFNGR2 Entrez, Source | interferon gamma receptor 2 (interferon gamma transducer 1) | 9538 | -0.299 | 0.0276 | No |
| 80 | PIK3CA | NA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 9727 | -0.326 | 0.0179 | No |
| 81 | MYC | NA | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 9860 | -0.346 | 0.0125 | No |
| 82 | OSMR | NA | OSMR Entrez, Source | oncostatin M receptor | 9965 | -0.359 | 0.0093 | No |
| 83 | STAT2 | NA | STAT2 Entrez, Source | signal transducer and activator of transcription 2, 113kDa | 10036 | -0.369 | 0.0087 | No |
| 84 | AKT1 | NA | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 10063 | -0.374 | 0.0113 | No |
| 85 | LEPR | NA | LEPR Entrez, Source | leptin receptor | 10086 | -0.377 | 0.0143 | No |
| 86 | SPRY3 | NA | SPRY3 Entrez, Source | sprouty homolog 3 (Drosophila) | 10405 | -0.428 | -0.0037 | No |
| 87 | IL10 | NA | IL10 Entrez, Source | interleukin 10 | 10658 | -0.469 | -0.0163 | No |
| 88 | PIK3R2 | NA | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 11136 | -0.552 | -0.0443 | No |
| 89 | EPOR | NA | EPOR Entrez, Source | erythropoietin receptor | 11843 | -0.711 | -0.0871 | No |
| 90 | SPRY1 | NA | SPRY1 Entrez, Source | sprouty homolog 1, antagonist of FGF signaling (Drosophila) | 11884 | -0.721 | -0.0813 | No |
| 91 | TYK2 | NA | TYK2 Entrez, Source | tyrosine kinase 2 | 11932 | -0.735 | -0.0758 | No |
| 92 | PIM1 | NA | PIM1 Entrez, Source | pim-1 oncogene | 11968 | -0.744 | -0.0693 | No |
| 93 | IFNW1 | NA | IFNW1 Entrez, Source | interferon, omega 1 | 12674 | -1.025 | -0.1081 | No |
| 94 | SOS2 | NA | SOS2 Entrez, Source | son of sevenless homolog 2 (Drosophila) | 12762 | -1.068 | -0.1015 | No |
| 95 | PTPN6 | NA | PTPN6 Entrez, Source | protein tyrosine phosphatase, non-receptor type 6 | 12791 | -1.084 | -0.0904 | No |
| 96 | CBLB | NA | CBLB Entrez, Source | Cas-Br-M (murine) ecotropic retroviral transforming sequence b | 13073 | -1.275 | -0.0953 | No |
| 97 | PIK3CG | NA | PIK3CG Entrez, Source | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 13175 | -1.371 | -0.0860 | No |
| 98 | AKT3 | NA | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 13407 | -1.667 | -0.0826 | No |
| 99 | JAK3 | NA | JAK3 Entrez, Source | Janus kinase 3 (a protein tyrosine kinase, leukocyte) | 13500 | -1.817 | -0.0672 | No |
| 100 | CTF1 | NA | CTF1 Entrez, Source | cardiotrophin 1 | 13582 | -2.018 | -0.0486 | No |
| 101 | IL20RB | NA | IL20RB Entrez, Source | interleukin 20 receptor beta | 13691 | -2.460 | -0.0265 | No |
| 102 | PIK3CD | NA | PIK3CD Entrez, Source | phosphoinositide-3-kinase, catalytic, delta polypeptide | 13763 | -3.033 | 0.0052 | No |
