Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM |
| Enrichment Score (ES) | 0.3562956 |
| Normalized Enrichment Score (NES) | 1.2585558 |
| Nominal p-value | 0.119791664 |
| FDR q-value | 0.3587553 |
| FWER p-Value | 1.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | IL6 | NA | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 15 | 4.383 | 0.0813 | Yes |
| 2 | ITGA10 | NA | ITGA10 Entrez, Source | integrin, alpha 10 | 164 | 2.415 | 0.1159 | Yes |
| 3 | ITGA2 | NA | ITGA2 Entrez, Source | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 192 | 2.266 | 0.1565 | Yes |
| 4 | CACNB1 | NA | CACNB1 Entrez, Source | calcium channel, voltage-dependent, beta 1 subunit | 197 | 2.244 | 0.1984 | Yes |
| 5 | RYR2 | NA | RYR2 Entrez, Source | ryanodine receptor 2 (cardiac) | 310 | 1.733 | 0.2228 | Yes |
| 6 | ITGB4 | NA | ITGB4 Entrez, Source | integrin, beta 4 | 327 | 1.696 | 0.2535 | Yes |
| 7 | ITGA5 | NA | ITGA5 Entrez, Source | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 390 | 1.519 | 0.2776 | Yes |
| 8 | ITGB6 | NA | ITGB6 Entrez, Source | integrin, beta 6 | 456 | 1.396 | 0.2991 | Yes |
| 9 | SLC8A1 | NA | SLC8A1 Entrez, Source | solute carrier family 8 (sodium/calcium exchanger), member 1 | 484 | 1.336 | 0.3222 | Yes |
| 10 | ACTG1 | NA | ACTG1 Entrez, Source | actin, gamma 1 | 583 | 1.201 | 0.3377 | Yes |
| 11 | ITGB8 | NA | ITGB8 Entrez, Source | integrin, beta 8 | 628 | 1.160 | 0.3563 | Yes |
| 12 | ITGA3 | NA | ITGA3 Entrez, Source | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 1015 | 0.884 | 0.3449 | No |
| 13 | ACTB | NA | ACTB Entrez, Source | actin, beta | 1127 | 0.840 | 0.3526 | No |
| 14 | ITGA6 | NA | ITGA6 Entrez, Source | integrin, alpha 6 | 1327 | 0.764 | 0.3525 | No |
| 15 | TGFB1 | NA | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 1560 | 0.700 | 0.3488 | No |
| 16 | TPM1 | NA | TPM1 Entrez, Source | tropomyosin 1 (alpha) | 2298 | 0.534 | 0.3054 | No |
| 17 | TPM4 | NA | TPM4 Entrez, Source | tropomyosin 4 | 2917 | 0.432 | 0.2686 | No |
| 18 | LMNA | NA | LMNA Entrez, Source | lamin A/C | 3378 | 0.371 | 0.2422 | No |
| 19 | ITGA8 | NA | ITGA8 Entrez, Source | integrin, alpha 8 | 3756 | 0.327 | 0.2210 | No |
| 20 | ATP2A2 | NA | ATP2A2 Entrez, Source | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 3768 | 0.325 | 0.2263 | No |
| 21 | PRKAB1 | NA | PRKAB1 Entrez, Source | protein kinase, AMP-activated, beta 1 non-catalytic subunit | 3990 | 0.298 | 0.2159 | No |
| 22 | TPM2 | NA | TPM2 Entrez, Source | tropomyosin 2 (beta) | 4614 | 0.230 | 0.1750 | No |
| 23 | TGFB2 | NA | TGFB2 Entrez, Source | transforming growth factor, beta 2 | 4731 | 0.219 | 0.1707 | No |
| 24 | EMD | NA | EMD Entrez, Source | emerin (Emery-Dreifuss muscular dystrophy) | 5150 | 0.176 | 0.1436 | No |
| 25 | CACNB3 | NA | CACNB3 Entrez, Source | calcium channel, voltage-dependent, beta 3 subunit | 5154 | 0.176 | 0.1467 | No |
| 26 | CACNG8 | NA | CACNG8 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 8 | 5602 | 0.127 | 0.1167 | No |
| 27 | ITGB7 | NA | ITGB7 Entrez, Source | integrin, beta 7 | 5713 | 0.115 | 0.1108 | No |
| 28 | TNNI3 | NA | TNNI3 Entrez, Source | troponin I type 3 (cardiac) | 6246 | 0.062 | 0.0734 | No |
| 29 | LAMA2 | NA | LAMA2 Entrez, Source | laminin, alpha 2 (merosin, congenital muscular dystrophy) | 6420 | 0.047 | 0.0617 | No |
| 30 | PRKAB2 | NA | PRKAB2 Entrez, Source | protein kinase, AMP-activated, beta 2 non-catalytic subunit | 6536 | 0.035 | 0.0540 | No |
| 31 | TPM3 | NA | TPM3 Entrez, Source | tropomyosin 3 | 6721 | 0.015 | 0.0410 | No |
| 32 | ITGAV | NA | ITGAV Entrez, Source | integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) | 7059 | -0.019 | 0.0169 | No |
| 33 | ITGB3 | NA | ITGB3 Entrez, Source | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 7628 | -0.078 | -0.0229 | No |
| 34 | CACNA2D2 | NA | CACNA2D2 Entrez, Source | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | 7839 | -0.098 | -0.0363 | No |
| 35 | ITGB5 | NA | ITGB5 Entrez, Source | integrin, beta 5 | 7873 | -0.102 | -0.0368 | No |
| 36 | CACNB4 | NA | CACNB4 Entrez, Source | calcium channel, voltage-dependent, beta 4 subunit | 8125 | -0.128 | -0.0526 | No |
| 37 | SGCB | NA | SGCB Entrez, Source | sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) | 8307 | -0.147 | -0.0630 | No |
| 38 | PRKAG1 | NA | PRKAG1 Entrez, Source | protein kinase, AMP-activated, gamma 1 non-catalytic subunit | 8856 | -0.209 | -0.0988 | No |
| 39 | PRKAG2 | NA | PRKAG2 Entrez, Source | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 8926 | -0.217 | -0.0998 | No |
| 40 | DMD | NA | DMD Entrez, Source | dystrophin (muscular dystrophy, Duchenne and Becker types) | 8927 | -0.217 | -0.0957 | No |
| 41 | DAG1 | NA | DAG1 Entrez, Source | dystroglycan 1 (dystrophin-associated glycoprotein 1) | 9334 | -0.268 | -0.1201 | No |
| 42 | SGCD | NA | SGCD Entrez, Source | sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) | 9478 | -0.290 | -0.1250 | No |
| 43 | PRKAA2 | NA | PRKAA2 Entrez, Source | protein kinase, AMP-activated, alpha 2 catalytic subunit | 9992 | -0.363 | -0.1555 | No |
| 44 | PRKAA1 | NA | PRKAA1 Entrez, Source | protein kinase, AMP-activated, alpha 1 catalytic subunit | 10256 | -0.403 | -0.1670 | No |
| 45 | TTN | NA | TTN Entrez, Source | titin | 10380 | -0.422 | -0.1680 | No |
| 46 | ITGB1 | NA | ITGB1 Entrez, Source | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 10722 | -0.479 | -0.1837 | No |
| 47 | SGCG | NA | SGCG Entrez, Source | sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) | 10836 | -0.500 | -0.1825 | No |
| 48 | IGF1 | NA | IGF1 Entrez, Source | insulin-like growth factor 1 (somatomedin C) | 11398 | -0.605 | -0.2119 | No |
| 49 | ITGA1 | NA | ITGA1 Entrez, Source | integrin, alpha 1 | 11982 | -0.747 | -0.2402 | No |
| 50 | ITGA7 | NA | ITGA7 Entrez, Source | integrin, alpha 7 | 12379 | -0.885 | -0.2523 | No |
| 51 | TGFB3 | NA | TGFB3 Entrez, Source | transforming growth factor, beta 3 | 12913 | -1.157 | -0.2692 | No |
| 52 | CACNA1D | NA | CACNA1D Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1D subunit | 12921 | -1.162 | -0.2479 | No |
| 53 | DES | NA | DES Entrez, Source | desmin | 13353 | -1.580 | -0.2495 | No |
| 54 | CACNG3 | NA | CACNG3 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 3 | 13424 | -1.688 | -0.2228 | No |
| 55 | CACNA2D3 | NA | CACNA2D3 Entrez, Source | calcium channel, voltage-dependent, alpha 2/delta 3 subunit | 13597 | -2.058 | -0.1966 | No |
| 56 | ACTC1 | NA | ACTC1 Entrez, Source | actin, alpha, cardiac muscle 1 | 13620 | -2.138 | -0.1581 | No |
| 57 | TNNC1 | NA | TNNC1 Entrez, Source | troponin C type 1 (slow) | 13657 | -2.279 | -0.1179 | No |
| 58 | CACNB2 | NA | CACNB2 Entrez, Source | calcium channel, voltage-dependent, beta 2 subunit | 13741 | -2.808 | -0.0711 | No |
| 59 | ITGA2B | NA | ITGA2B Entrez, Source | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | 13815 | -4.140 | 0.0014 | No |
