Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1gfp
GeneSetKEGG_HUNTINGTONS_DISEASE
Enrichment Score (ES)-0.46860248
Normalized Enrichment Score (NES)-1.8579597
Nominal p-value0.0
FDR q-value0.0069034738
FWER p-Value0.049
Table: GSEA Results Summary



Fig 1: Enrichment plot: KEGG_HUNTINGTONS_DISEASE   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1CREB3L3NACREB3L3
Entrez,  Source
cAMP responsive element binding protein 3-like 31862.3090.0104No
2PLCB4NAPLCB4
Entrez,  Source
phospholipase C, beta 45461.259-0.0027No
3DNAH3NADNAH3
Entrez,  Source
dynein, axonemal, heavy chain 36921.103-0.0018No
4COX6B2NACOX6B2
Entrez,  Source
cytochrome c oxidase subunit VIb polypeptide 2 (testis)8790.955-0.0055No
5CREB5NACREB5
Entrez,  Source
cAMP responsive element binding protein 58840.9530.0042No
6SOD2NASOD2
Entrez,  Source
superoxide dismutase 2, mitochondrial8970.9450.0131No
7CREBBPNACREBBP
Entrez,  Source
CREB binding protein (Rubinstein-Taybi syndrome)9320.9280.0203No
8EP300NAEP300
Entrez,  Source
E1A binding protein p30011400.8350.0139No
9CLTBNACLTB
Entrez,  Source
clathrin, light chain (Lcb)11420.8340.0225No
10PPIDNAPPID
Entrez,  Source
peptidylprolyl isomerase D (cyclophilin D)13770.7490.0132No
11CREB3NACREB3
Entrez,  Source
cAMP responsive element binding protein 316440.6750.0008No
12TBPL1NATBPL1
Entrez,  Source
TBP-like 117370.6470.0008No
13POLR2ANAPOLR2A
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa20430.579-0.0155No
14POLR2DNAPOLR2D
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide D22340.544-0.0237No
15PPARGNAPPARG
Entrez,  Source
peroxisome proliferative activated receptor, gamma22780.537-0.0213No
16TGM2NATGM2
Entrez,  Source
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)23260.529-0.0192No
17BDNFNABDNF
Entrez,  Source
brain-derived neurotrophic factor24650.506-0.0240No
18DNAL1NADNAL1
Entrez,  Source
dynein, axonemal, light chain 125180.497-0.0226No
19CASP3NACASP3
Entrez,  Source
caspase 3, apoptosis-related cysteine peptidase25460.492-0.0195No
20TAF4BNATAF4B
Entrez,  Source
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa31940.394-0.0627No
21POLR2LNAPOLR2L
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa35860.345-0.0877No
22CREB1NACREB1
Entrez,  Source
cAMP responsive element binding protein 139260.306-0.1093No
23CLTANACLTA
Entrez,  Source
clathrin, light chain (Lca)39840.298-0.1103No
24NRF1NANRF1
Entrez,  Source
nuclear respiratory factor 142500.272-0.1269No
25TAF4NATAF4
Entrez,  Source
TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa43010.265-0.1278No
26NDUFB10NANDUFB10
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa43600.259-0.1293No
27POLR2CNAPOLR2C
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide C, 33kDa45240.240-0.1387No
28RESTNAREST
Entrez,  Source
RE1-silencing transcription factor45480.237-0.1379No
29DCTN4NADCTN4
Entrez,  Source
dynactin 4 (p62)47070.221-0.1472No
30POLR2FNAPOLR2F
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide F47460.217-0.1477No
31CASP8NACASP8
Entrez,  Source
caspase 8, apoptosis-related cysteine peptidase50430.187-0.1674No
32VDAC1NAVDAC1
Entrez,  Source
voltage-dependent anion channel 151030.181-0.1698No
33HDAC2NAHDAC2
Entrez,  Source
histone deacetylase 251550.176-0.1717No
34TFAMNATFAM
Entrez,  Source
transcription factor A, mitochondrial55500.134-0.1991No
35CLTCNACLTC
Entrez,  Source
clathrin, heavy chain (Hc)59980.087-0.2309No
36DNAI2NADNAI2
Entrez,  Source
dynein, axonemal, intermediate chain 260090.086-0.2308No
37SIN3ANASIN3A
Entrez,  Source
SIN3 homolog A, transcription regulator (yeast)60260.084-0.2311No
38TBPNATBP
Entrez,  Source
TATA box binding protein62690.060-0.2481No
39VDAC3NAVDAC3
Entrez,  Source
voltage-dependent anion channel 367940.007-0.2864No
40SLC25A4NASLC25A4
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 46960-0.011-0.2983No
41POLR2HNAPOLR2H
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide H7013-0.015-0.3020No
42DNALI1NADNALI1
Entrez,  Source
dynein, axonemal, light intermediate chain 17098-0.023-0.3079No
43AP2S1NAAP2S1
Entrez,  Source
adaptor-related protein complex 2, sigma 1 subunit7118-0.025-0.3090No
44ATP5DNAATP5D
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit7257-0.040-0.3187No
45GPX1NAGPX1
Entrez,  Source
glutathione peroxidase 17302-0.045-0.3214No
46POLR2JNAPOLR2J
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa7312-0.046-0.3216No
47CREB3L2NACREB3L2
Entrez,  Source
cAMP responsive element binding protein 3-like 27321-0.047-0.3217No
48DCTN1NADCTN1
Entrez,  Source
dynactin 1 (p150, glued homolog, Drosophila)7327-0.047-0.3216No
49NDUFV3NANDUFV3
Entrez,  Source
NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa7412-0.057-0.3271No
50AP2B1NAAP2B1
Entrez,  Source
adaptor-related protein complex 2, beta 1 subunit7533-0.069-0.3352No
51UQCR11NA7644-0.079-0.3424No
52NDUFB7NANDUFB7
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa7777-0.092-0.3511No
53POLR2INAPOLR2I
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa7909-0.105-0.3596No
54NDUFB9NANDUFB9
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa7937-0.107-0.3604No
55SLC25A5NASLC25A5
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 57986-0.112-0.3627No
56HTTNA8102-0.126-0.3698No
57POLR2J2NAPOLR2J2
Entrez,  Source
-8109-0.127-0.3690No
58BAXNABAX
Entrez,  Source
BCL2-associated X protein8170-0.133-0.3720No
59RCOR1NARCOR1
Entrez,  Source
REST corepressor 18189-0.135-0.3719No
60APAF1NAAPAF1
Entrez,  Source
apoptotic peptidase activating factor8206-0.138-0.3716No
61POLR2ENAPOLR2E
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide E, 25kDa8289-0.146-0.3761No
62AP2M1NAAP2M1
Entrez,  Source
adaptor-related protein complex 2, mu 1 subunit8670-0.187-0.4019No
63UQCRFS1NAUQCRFS1
Entrez,  Source
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 18783-0.200-0.4080No
64NDUFV2NANDUFV2
Entrez,  Source
NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa8825-0.206-0.4089No
65SP1NASP1
Entrez,  Source
Sp1 transcription factor8912-0.215-0.4129No
66NDUFA8NANDUFA8
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa9017-0.228-0.4182No
67POLR2BNAPOLR2B
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide B, 140kDa9030-0.229-0.4166No
68NDUFS7NANDUFS7
Entrez,  Source
NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)9133-0.241-0.4216No
69COX7A2LNACOX7A2L
Entrez,  Source
cytochrome c oxidase subunit VIIa polypeptide 2 like9489-0.293-0.4445No
70DCTN2NADCTN2
Entrez,  Source
dynactin 2 (p50)9494-0.294-0.4417No
71NDUFB2NANDUFB2
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa9548-0.300-0.4425No
72HDAC1NAHDAC1
Entrez,  Source
histone deacetylase 19558-0.301-0.4400No
73NDUFAB1NANDUFAB1
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa9593-0.305-0.4393No
74AP2A2NAAP2A2
Entrez,  Source
adaptor-related protein complex 2, alpha 2 subunit9675-0.317-0.4419No
75VDAC2NAVDAC2
Entrez,  Source
voltage-dependent anion channel 29826-0.340-0.4493No
76NDUFS8NANDUFS8
Entrez,  Source
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)9879-0.348-0.4495No
77DNAH1NADNAH1
Entrez,  Source
dynein, axonemal, heavy chain 19896-0.349-0.4470No
78HIP1NAHIP1
Entrez,  Source
huntingtin interacting protein 19922-0.353-0.4452No
79NDUFS3NANDUFS3
Entrez,  Source
NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)9933-0.354-0.4422No
80POLR2KNAPOLR2K
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa9963-0.358-0.4406No
81AP2A1NAAP2A1
Entrez,  Source
adaptor-related protein complex 2, alpha 1 subunit10001-0.364-0.4395No
82NDUFA10NANDUFA10
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa10387-0.425-0.4633No
83SDHBNASDHB
Entrez,  Source
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)10461-0.436-0.4641Yes
84POLR2GNAPOLR2G
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide G10462-0.436-0.4595Yes
85POLR2J3NAPOLR2J3
Entrez,  Source
-10465-0.436-0.4551Yes
86NDUFS4NANDUFS4
Entrez,  Source
NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)10470-0.437-0.4509Yes
87COX5ANACOX5A
Entrez,  Source
cytochrome c oxidase subunit Va10523-0.445-0.4500Yes
88DLG4NADLG4
Entrez,  Source
discs, large homolog 4 (Drosophila)10572-0.454-0.4488Yes
89ATP5C1NAATP5C1
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 110643-0.467-0.4491Yes
90UQCRC1NAUQCRC1
Entrez,  Source
ubiquinol-cytochrome c reductase core protein I10695-0.475-0.4479Yes
91ATP5G3NAATP5G3
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)10759-0.485-0.4474Yes
92COX4I1NACOX4I1
Entrez,  Source
cytochrome c oxidase subunit IV isoform 110760-0.485-0.4424Yes
93CYCSNACYCS
Entrez,  Source
cytochrome c, somatic10864-0.504-0.4446Yes
94SDHCNASDHC
Entrez,  Source
succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa10930-0.514-0.4440Yes
95ATP5G2NAATP5G2
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9)10959-0.520-0.4407Yes
96NDUFC2NANDUFC2
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa10967-0.521-0.4358Yes
97NDUFS6NANDUFS6
Entrez,  Source
NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)11041-0.535-0.4355Yes
98GRIN1NAGRIN1
Entrez,  Source
glutamate receptor, ionotropic, N-methyl D-aspartate 111077-0.542-0.4324Yes
99PLCB3NAPLCB3
Entrez,  Source
phospholipase C, beta 3 (phosphatidylinositol-specific)11157-0.555-0.4324Yes
100CYC1NACYC1
Entrez,  Source
cytochrome c-111222-0.567-0.4312Yes
101NDUFS5NANDUFS5
Entrez,  Source
NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)11285-0.582-0.4297Yes
102ATP5HNAATP5H
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d11314-0.588-0.4256Yes
103NDUFA9NANDUFA9
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa11386-0.600-0.4245Yes
104GNAQNAGNAQ
Entrez,  Source
guanine nucleotide binding protein (G protein), q polypeptide11449-0.615-0.4227Yes
105NDUFC1NANDUFC1
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa11496-0.623-0.4195Yes
106DNAI1NADNAI1
Entrez,  Source
dynein, axonemal, intermediate chain 111560-0.638-0.4175Yes
107UQCRQNAUQCRQ
Entrez,  Source
ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa11614-0.653-0.4146Yes
108NDUFS2NANDUFS2
Entrez,  Source
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)11651-0.660-0.4103Yes
109NDUFA3NANDUFA3
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa11706-0.672-0.4073Yes
110NDUFA1NANDUFA1
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa11714-0.675-0.4008Yes
111NDUFA6NANDUFA6
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa11745-0.684-0.3958Yes
112SOD1NASOD1
Entrez,  Source
superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))11746-0.684-0.3887Yes
113ATP5ONAATP5O
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (oligomycin sensitivity conferring protein)11766-0.689-0.3829Yes
114COX6A1NACOX6A1
Entrez,  Source
cytochrome c oxidase subunit VIa polypeptide 111769-0.690-0.3759Yes
115ATP5G1NAATP5G1
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9)11772-0.691-0.3688Yes
116COX6CNACOX6C
Entrez,  Source
cytochrome c oxidase subunit VIc11796-0.698-0.3632Yes
117SLC25A6NASLC25A6
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 611809-0.701-0.3568Yes
118NDUFS1NANDUFS1
Entrez,  Source
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)11893-0.722-0.3554Yes
119ATP5BNAATP5B
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide11967-0.744-0.3530Yes
120NDUFB8NANDUFB8
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa12008-0.759-0.3480Yes
121ATP5F1NAATP5F1
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B112053-0.772-0.3431Yes
122NDUFA2NANDUFA2
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa12064-0.777-0.3358Yes
123UQCR10NA12066-0.777-0.3278Yes
124COX6B1NACOX6B1
Entrez,  Source
cytochrome c oxidase subunit Vib polypeptide 1 (ubiquitous)12086-0.781-0.3210Yes
125NDUFB6NANDUFB6
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa12106-0.789-0.3142Yes
126NDUFA4NANDUFA4
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa12145-0.803-0.3086Yes
127UQCRHNAUQCRH
Entrez,  Source
ubiquinol-cytochrome c reductase hinge protein12158-0.807-0.3011Yes
128SDHDNASDHD
Entrez,  Source
succinate dehydrogenase complex, subunit D, integral membrane protein12186-0.815-0.2946Yes
129NDUFB3NANDUFB3
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa12187-0.815-0.2861Yes
130DNAH2NADNAH2
Entrez,  Source
dynein, axonemal, heavy chain 212210-0.823-0.2791Yes
131NDUFV1NANDUFV1
Entrez,  Source
NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa12219-0.825-0.2711Yes
132COX8ANACOX8A
Entrez,  Source
cytochrome c oxidase subunit 8A (ubiquitous)12241-0.834-0.2640Yes
133ATP5JNAATP5J
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F612254-0.837-0.2561Yes
134NDUFB4NANDUFB4
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa12267-0.842-0.2482Yes
135NDUFA5NANDUFA5
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa12296-0.850-0.2414Yes
136PLCB2NAPLCB2
Entrez,  Source
phospholipase C, beta 212339-0.869-0.2354Yes
137NDUFA7NANDUFA7
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa12408-0.895-0.2311Yes
138COX7A2NACOX7A2
Entrez,  Source
cytochrome c oxidase subunit VIIa polypeptide 2 (liver)12409-0.895-0.2218Yes
139ATP5A1NAATP5A1
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle12430-0.907-0.2138Yes
140UQCRBNAUQCRB
Entrez,  Source
ubiquinol-cytochrome c reductase binding protein12456-0.921-0.2060Yes
141NDUFA4L2NANDUFA4L2
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 212458-0.922-0.1965Yes
142COX7CNACOX7C
Entrez,  Source
cytochrome c oxidase subunit VIIc12481-0.929-0.1884Yes
143NDUFB1NANDUFB1
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa12642-1.007-0.1896Yes
144BBC3NABBC3
Entrez,  Source
BCL2 binding component 312644-1.007-0.1792Yes
145TP53NATP53
Entrez,  Source
tumor protein p53 (Li-Fraumeni syndrome)12744-1.059-0.1754Yes
146SDHANASDHA
Entrez,  Source
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)12856-1.123-0.1718Yes
147COX5BNACOX5B
Entrez,  Source
cytochrome c oxidase subunit Vb12858-1.125-0.1602Yes
148NDUFB5NANDUFB5
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa12869-1.132-0.1492Yes
149COX7BNACOX7B
Entrez,  Source
cytochrome c oxidase subunit VIIb12976-1.199-0.1444Yes
150UQCRC2NAUQCRC2
Entrez,  Source
ubiquinol-cytochrome c reductase core protein II12985-1.203-0.1325Yes
151UQCRHLNA12995-1.213-0.1205Yes
152DNAL4NADNAL4
Entrez,  Source
dynein, axonemal, light chain 413017-1.232-0.1092Yes
153CLTCL1NACLTCL1
Entrez,  Source
clathrin, heavy chain-like 113398-1.647-0.1198Yes
154PPARGC1ANAPPARGC1A
Entrez,  Source
peroxisome proliferative activated receptor, gamma, coactivator 1, alpha13430-1.702-0.1044Yes
155CREB3L4NACREB3L4
Entrez,  Source
cAMP responsive element binding protein 3-like 413436-1.717-0.0868Yes
156ITPR1NAITPR1
Entrez,  Source
inositol 1,4,5-triphosphate receptor, type 113645-2.228-0.0788Yes
157CASP9NACASP9
Entrez,  Source
caspase 9, apoptosis-related cysteine peptidase13696-2.469-0.0568Yes
158PLCB1NAPLCB1
Entrez,  Source
phospholipase C, beta 1 (phosphoinositide-specific)13705-2.553-0.0308Yes
159CREB3L1NACREB3L1
Entrez,  Source
cAMP responsive element binding protein 3-like 113806-3.8530.0020Yes
Table: GSEA details [plain text format]



Fig 2: KEGG_HUNTINGTONS_DISEASE   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: KEGG_HUNTINGTONS_DISEASE: Random ES distribution   
Gene set null distribution of ES for KEGG_HUNTINGTONS_DISEASE