Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1w6a
GeneSetKEGG_FOCAL_ADHESION
Enrichment Score (ES)0.29900357
Normalized Enrichment Score (NES)1.2884587
Nominal p-value0.03236246
FDR q-value0.33729795
FWER p-Value0.999
Table: GSEA Results Summary



Fig 1: Enrichment plot: KEGG_FOCAL_ADHESION   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1THBS1NATHBS1
Entrez,  Source
thrombospondin 1813.1200.0189Yes
2LAMA4NALAMA4
Entrez,  Source
laminin, alpha 41032.9270.0406Yes
3COL5A3NACOL5A3
Entrez,  Source
collagen, type V, alpha 31392.5720.0585Yes
4BIRC3NABIRC3
Entrez,  Source
baculoviral IAP repeat-containing 31522.4950.0774Yes
5ITGA10NAITGA10
Entrez,  Source
integrin, alpha 101642.4150.0958Yes
6ITGA2NAITGA2
Entrez,  Source
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)1922.2660.1118Yes
7PAK6NAPAK6
Entrez,  Source
p21(CDKN1A)-activated kinase 62042.1920.1285Yes
8JUNNAJUN
Entrez,  Source
jun oncogene2361.9960.1420Yes
9LAMC2NALAMC2
Entrez,  Source
laminin, gamma 22601.9310.1557Yes
10RAC2NARAC2
Entrez,  Source
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)3231.7070.1647Yes
11ITGB4NAITGB4
Entrez,  Source
integrin, beta 43271.6960.1780Yes
12ITGA5NAITGA5
Entrez,  Source
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)3901.5190.1855Yes
13MYL5NAMYL5
Entrez,  Source
myosin, light chain 5, regulatory4041.4960.1965Yes
14TNXBNATNXB
Entrez,  Source
tenascin XB4151.4840.2075Yes
15MYLK2NAMYLK2
Entrez,  Source
myosin light chain kinase 2, skeletal muscle4241.4700.2186Yes
16ITGB6NAITGB6
Entrez,  Source
integrin, beta 64561.3960.2274Yes
17CAPN2NACAPN2
Entrez,  Source
calpain 2, (m/II) large subunit4991.3150.2348Yes
18ACTG1NAACTG1
Entrez,  Source
actin, gamma 15831.2010.2383Yes
19ITGB8NAITGB8
Entrez,  Source
integrin, beta 86281.1600.2443Yes
20EGFRNAEGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6371.1500.2528Yes
21FLNANAFLNA
Entrez,  Source
filamin A, alpha (actin binding protein 280)6401.1480.2618Yes
22FLNBNAFLNB
Entrez,  Source
filamin B, beta (actin binding protein 278)7001.0990.2662Yes
23BCAR1NABCAR1
Entrez,  Source
breast cancer anti-estrogen resistance 17611.0400.2701Yes
24ACTN1NAACTN1
Entrez,  Source
actinin, alpha 18490.9780.2715Yes
25VWFNAVWF
Entrez,  Source
von Willebrand factor9190.9330.2739Yes
26ZYXNAZYX
Entrez,  Source
zyxin9600.9160.2782Yes
27ITGA3NAITGA3
Entrez,  Source
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)10150.8840.2813Yes
28CCND1NACCND1
Entrez,  Source
cyclin D110330.8770.2870Yes
29PXNNAPXN
Entrez,  Source
paxillin11180.8440.2876Yes
30ACTBNAACTB
Entrez,  Source
actin, beta11270.8400.2937Yes
31ACTN4NAACTN4
Entrez,  Source
actinin, alpha 412700.7890.2895Yes
32ITGA6NAITGA6
Entrez,  Source
integrin, alpha 613270.7640.2915Yes
33VCLNAVCL
Entrez,  Source
vinculin13440.7580.2964Yes
34PRKCGNAPRKCG
Entrez,  Source
protein kinase C, gamma14140.7400.2972Yes
35SRCNASRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)14690.7240.2990Yes
36PIK3R1NAPIK3R1
Entrez,  Source
phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha)16990.6580.2875No
37MYLKNAMYLK
Entrez,  Source
myosin, light chain kinase18060.6320.2847No
38VAV1NAVAV1
Entrez,  Source
vav 1 oncogene18660.6140.2853No
39FLNCNAFLNC
Entrez,  Source
filamin C, gamma (actin binding protein 280)19620.5940.2831No
40BIRC2NABIRC2
Entrez,  Source
baculoviral IAP repeat-containing 219640.5940.2877No
41COL6A1NACOL6A1
Entrez,  Source
collagen, type VI, alpha 121310.5640.2800No
42HRASNAHRAS
Entrez,  Source
v-Ha-ras Harvey rat sarcoma viral oncogene homolog22530.5410.2755No
43COL4A2NACOL4A2
Entrez,  Source
collagen, type IV, alpha 222710.5380.2785No
44BRAFNABRAF
Entrez,  Source
v-raf murine sarcoma viral oncogene homolog B122750.5370.2826No
45PAK2NAPAK2
Entrez,  Source
p21 (CDKN1A)-activated kinase 222760.5370.2868No
46COL4A1NACOL4A1
Entrez,  Source
collagen, type IV, alpha 124080.5140.2813No
47MAPK8NAMAPK8
Entrez,  Source
mitogen-activated protein kinase 827420.4610.2606No
48RASGRF1NARASGRF1
Entrez,  Source
Ras protein-specific guanine nucleotide-releasing factor 128860.4360.2536No
49PIP5K1CNAPIP5K1C
Entrez,  Source
phosphatidylinositol-4-phosphate 5-kinase, type I, gamma30640.4120.2439No
50CAV1NACAV1
Entrez,  Source
caveolin 1, caveolae protein, 22kDa34830.3560.2162No
51ITGA8NAITGA8
Entrez,  Source
integrin, alpha 837560.3270.1989No
52MYL12ANA37670.3260.2007No
53TLN2NATLN2
Entrez,  Source
talin 237760.3240.2027No
54VAV2NAVAV2
Entrez,  Source
vav 2 oncogene38350.3170.2010No
55KDRNAKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)41010.2870.1839No
56PAK1NAPAK1
Entrez,  Source
p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)42580.2710.1746No
57PDGFANAPDGFA
Entrez,  Source
platelet-derived growth factor alpha polypeptide42940.2670.1742No
58ROCK1NAROCK1
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 143700.2570.1707No
59SHC3NASHC3
Entrez,  Source
SHC (Src homology 2 domain containing) transforming protein 344430.2500.1674No
60TNCNATNC
Entrez,  Source
tenascin C (hexabrachion)44570.2480.1685No
61DIAPH1NADIAPH1
Entrez,  Source
diaphanous homolog 1 (Drosophila)44820.2450.1687No
62XIAPNA45490.2370.1657No
63PPP1R12ANAPPP1R12A
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 12A46570.2280.1597No
64ROCK2NAROCK2
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 247240.2190.1566No
65PAK4NAPAK4
Entrez,  Source
p21(CDKN1A)-activated kinase 448110.2100.1520No
66MAP2K1NAMAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 148940.2020.1476No
67VASPNAVASP
Entrez,  Source
vasodilator-stimulated phosphoprotein49500.1970.1451No
68COL2A1NACOL2A1
Entrez,  Source
collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital)50370.1880.1403No
69MYL10NA50670.1850.1397No
70RAPGEF1NARAPGEF1
Entrez,  Source
Rap guanine nucleotide exchange factor (GEF) 151860.1720.1324No
71PIK3CBNAPIK3CB
Entrez,  Source
phosphoinositide-3-kinase, catalytic, beta polypeptide52930.1620.1259No
72LAMA5NALAMA5
Entrez,  Source
laminin, alpha 555490.1340.1083No
73RAC1NARAC1
Entrez,  Source
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)55560.1340.1090No
74SHC4NASHC4
Entrez,  Source
SHC (Src homology 2 domain containing) family, member 455830.1300.1081No
75ITGB7NAITGB7
Entrez,  Source
integrin, beta 757130.1150.0996No
76CCND3NACCND3
Entrez,  Source
cyclin D357220.1140.0999No
77COL11A1NACOL11A1
Entrez,  Source
collagen, type XI, alpha 157340.1130.1000No
78PPP1CCNAPPP1CC
Entrez,  Source
protein phosphatase 1, catalytic subunit, gamma isoform57610.1110.0990No
79ACTN2NAACTN2
Entrez,  Source
actinin, alpha 258380.1030.0942No
80METNAMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)59160.0960.0893No
81FN1NAFN1
Entrez,  Source
fibronectin 161420.0730.0734No
82CRKLNACRKL
Entrez,  Source
v-crk sarcoma virus CT10 oncogene homolog (avian)-like62810.0590.0638No
83LAMB3NALAMB3
Entrez,  Source
laminin, beta 363570.0540.0588No
84CRKNACRK
Entrez,  Source
v-crk sarcoma virus CT10 oncogene homolog (avian)63760.0510.0578No
85LAMA2NALAMA2
Entrez,  Source
laminin, alpha 2 (merosin, congenital muscular dystrophy)64200.0470.0551No
86COL5A1NACOL5A1
Entrez,  Source
collagen, type V, alpha 164990.0390.0497No
87ELK1NAELK1
Entrez,  Source
ELK1, member of ETS oncogene family67560.0120.0310No
88PDPK1NAPDPK1
Entrez,  Source
3-phosphoinositide dependent protein kinase-167750.0090.0298No
89LAMC1NALAMC1
Entrez,  Source
laminin, gamma 1 (formerly LAMB2)68620.0010.0235No
90LAMB1NALAMB1
Entrez,  Source
laminin, beta 16938-0.0080.0181No
91PTENNAPTEN
Entrez,  Source
phosphatase and tensin homolog (mutated in multiple advanced cancers 1)6985-0.0130.0148No
92ITGAVNAITGAV
Entrez,  Source
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)7059-0.0190.0096No
93AKT2NAAKT2
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 27140-0.0270.0040No
94LAMA1NALAMA1
Entrez,  Source
laminin, alpha 17314-0.046-0.0083No
95SOS1NASOS1
Entrez,  Source
son of sevenless homolog 1 (Drosophila)7393-0.055-0.0136No
96ARHGAP5NAARHGAP5
Entrez,  Source
Rho GTPase activating protein 57510-0.067-0.0215No
97SHC1NASHC1
Entrez,  Source
SHC (Src homology 2 domain containing) transforming protein 17588-0.074-0.0266No
98ITGB3NAITGB3
Entrez,  Source
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)7628-0.078-0.0288No
99CDC42NACDC42
Entrez,  Source
cell division cycle 42 (GTP binding protein, 25kDa)7674-0.082-0.0315No
100CAV2NACAV2
Entrez,  Source
caveolin 27705-0.084-0.0330No
101VEGFANA7811-0.096-0.0399No
102COL6A3NACOL6A3
Entrez,  Source
collagen, type VI, alpha 37823-0.097-0.0400No
103ITGB5NAITGB5
Entrez,  Source
integrin, beta 57873-0.102-0.0427No
104RHOANARHOA
Entrez,  Source
ras homolog gene family, member A8007-0.115-0.0516No
105PPP1CBNAPPP1CB
Entrez,  Source
protein phosphatase 1, catalytic subunit, beta isoform8008-0.115-0.0506No
106PTK2NAPTK2
Entrez,  Source
PTK2 protein tyrosine kinase 28268-0.144-0.0685No
107RAP1BNARAP1B
Entrez,  Source
RAP1B, member of RAS oncogene family8297-0.146-0.0693No
108TLN1NATLN1
Entrez,  Source
talin 18348-0.151-0.0718No
109DOCK1NADOCK1
Entrez,  Source
dedicator of cytokinesis 18352-0.152-0.0708No
110RAP1ANARAP1A
Entrez,  Source
RAP1A, member of RAS oncogene family8399-0.157-0.0729No
111PIK3R3NAPIK3R3
Entrez,  Source
phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma)8472-0.166-0.0769No
112MYL12BNA8537-0.172-0.0802No
113GRB2NAGRB2
Entrez,  Source
growth factor receptor-bound protein 28662-0.186-0.0878No
114IGF1RNAIGF1R
Entrez,  Source
insulin-like growth factor 1 receptor8663-0.186-0.0863No
115PPP1CANAPPP1CA
Entrez,  Source
protein phosphatase 1, catalytic subunit, alpha isoform8679-0.188-0.0859No
116ILKNAILK
Entrez,  Source
integrin-linked kinase8729-0.194-0.0880No
117GSK3BNAGSK3B
Entrez,  Source
glycogen synthase kinase 3 beta8844-0.207-0.0947No
118FLT1NAFLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)8910-0.215-0.0977No
119CCND2NACCND2
Entrez,  Source
cyclin D28965-0.222-0.0999No
120MAPK1NAMAPK1
Entrez,  Source
mitogen-activated protein kinase 18973-0.222-0.0986No
121BADNABAD
Entrez,  Source
BCL2-antagonist of cell death9149-0.244-0.1095No
122COL4A6NACOL4A6
Entrez,  Source
collagen, type IV, alpha 69256-0.258-0.1152No
123THBS4NATHBS4
Entrez,  Source
thrombospondin 49288-0.261-0.1154No
124LAMC3NALAMC3
Entrez,  Source
laminin, gamma 39430-0.283-0.1235No
125RAF1NARAF1
Entrez,  Source
v-raf-1 murine leukemia viral oncogene homolog 19437-0.284-0.1217No
126MYLPFNAMYLPF
Entrez,  Source
-9486-0.292-0.1228No
127TNNNATNN
Entrez,  Source
tenascin N9624-0.310-0.1304No
128ARHGAP35NA9687-0.319-0.1324No
129PIK3CANAPIK3CA
Entrez,  Source
phosphoinositide-3-kinase, catalytic, alpha polypeptide9727-0.326-0.1327No
130MAPK9NAMAPK9
Entrez,  Source
mitogen-activated protein kinase 99823-0.340-0.1369No
131ERBB2NAERBB2
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)9967-0.359-0.1445No
132AKT1NAAKT1
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 110063-0.374-0.1485No
133MAPK10NAMAPK10
Entrez,  Source
mitogen-activated protein kinase 1010142-0.384-0.1512No
134PARVBNAPARVB
Entrez,  Source
parvin, beta10163-0.388-0.1496No
135ITGB1NAITGB1
Entrez,  Source
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)10722-0.479-0.1866No
136BCL2NABCL2
Entrez,  Source
B-cell CLL/lymphoma 210892-0.508-0.1949No
137PIK3R2NAPIK3R2
Entrez,  Source
phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta)11136-0.552-0.2083No
138PARVGNAPARVG
Entrez,  Source
parvin, gamma11209-0.565-0.2091No
139IGF1NAIGF1
Entrez,  Source
insulin-like growth factor 1 (somatomedin C)11398-0.605-0.2181No
140EGFNAEGF
Entrez,  Source
epidermal growth factor (beta-urogastrone)11460-0.616-0.2176No
141PDGFCNAPDGFC
Entrez,  Source
platelet derived growth factor C11490-0.622-0.2148No
142COL11A2NACOL11A2
Entrez,  Source
collagen, type XI, alpha 211979-0.746-0.2446No
143ITGA1NAITGA1
Entrez,  Source
integrin, alpha 111982-0.747-0.2388No
144CTNNB1NACTNNB1
Entrez,  Source
catenin (cadherin-associated protein), beta 1, 88kDa12021-0.762-0.2355No
145PRKCANAPRKCA
Entrez,  Source
protein kinase C, alpha12193-0.818-0.2415No
146PDGFRANAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12202-0.819-0.2356No
147VAV3NAVAV3
Entrez,  Source
vav 3 oncogene12323-0.863-0.2375No
148COL6A6NA12346-0.872-0.2322No
149VEGFBNAVEGFB
Entrez,  Source
vascular endothelial growth factor B12361-0.878-0.2263No
150ITGA7NAITGA7
Entrez,  Source
integrin, alpha 712379-0.885-0.2205No
151CHADNACHAD
Entrez,  Source
chondroadherin12380-0.886-0.2134No
152PDGFBNAPDGFB
Entrez,  Source
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)12572-0.972-0.2197No
153PARVANAPARVA
Entrez,  Source
parvin, alpha12599-0.981-0.2138No
154COL5A2NACOL5A2
Entrez,  Source
collagen, type V, alpha 212707-1.040-0.2134No
155SOS2NASOS2
Entrez,  Source
son of sevenless homolog 2 (Drosophila)12762-1.068-0.2088No
156THBS3NATHBS3
Entrez,  Source
thrombospondin 312840-1.116-0.2056No
157FYNNAFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES13049-1.256-0.2108No
158LAMA3NALAMA3
Entrez,  Source
laminin, alpha 313132-1.319-0.2064No
159RAC3NARAC3
Entrez,  Source
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)13155-1.344-0.1973No
160PIK3CGNAPIK3CG
Entrez,  Source
phosphoinositide-3-kinase, catalytic, gamma polypeptide13175-1.371-0.1878No
161MAPK3NAMAPK3
Entrez,  Source
mitogen-activated protein kinase 313226-1.426-0.1801No
162PDGFRBNAPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide13337-1.562-0.1757No
163LAMB2NALAMB2
Entrez,  Source
laminin, beta 2 (laminin S)13365-1.595-0.1650No
164AKT3NAAKT3
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)13407-1.667-0.1548No
165COL4A4NACOL4A4
Entrez,  Source
collagen, type IV, alpha 413626-2.159-0.1536No
166PRKCBNA13643-2.224-0.1371No
167MYLK3NA13665-2.307-0.1203No
168COL1A1NACOL1A1
Entrez,  Source
collagen, type I, alpha 113723-2.670-0.1032No
169PIK3CDNAPIK3CD
Entrez,  Source
phosphoinositide-3-kinase, catalytic, delta polypeptide13763-3.033-0.0820No
170VTNNAVTN
Entrez,  Source
vitronectin13776-3.164-0.0577No
171COL3A1NACOL3A1
Entrez,  Source
collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant)13796-3.638-0.0302No
172ITGA2BNAITGA2B
Entrez,  Source
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)13815-4.1400.0014No
Table: GSEA details [plain text format]



Fig 2: KEGG_FOCAL_ADHESION   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: KEGG_FOCAL_ADHESION: Random ES distribution   
Gene set null distribution of ES for KEGG_FOCAL_ADHESION