Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_ENDOMETRIAL_CANCER |
| Enrichment Score (ES) | -0.46742946 |
| Normalized Enrichment Score (NES) | -1.5461835 |
| Nominal p-value | 0.01 |
| FDR q-value | 0.104773946 |
| FWER p-Value | 0.818 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | EGFR | NA | EGFR Entrez, Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 637 | 1.150 | -0.0067 | No |
| 2 | CCND1 | NA | CCND1 Entrez, Source | cyclin D1 | 1033 | 0.877 | -0.0053 | No |
| 3 | TCF7L1 | NA | TCF7L1 Entrez, Source | transcription factor 7-like 1 (T-cell specific, HMG-box) | 1449 | 0.731 | -0.0103 | No |
| 4 | PIK3R1 | NA | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 1699 | 0.658 | -0.0058 | No |
| 5 | AXIN1 | NA | AXIN1 Entrez, Source | axin 1 | 1825 | 0.627 | 0.0067 | No |
| 6 | HRAS | NA | HRAS Entrez, Source | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | 2253 | 0.541 | -0.0057 | No |
| 7 | BRAF | NA | BRAF Entrez, Source | v-raf murine sarcoma viral oncogene homolog B1 | 2275 | 0.537 | 0.0112 | No |
| 8 | NRAS | NA | NRAS Entrez, Source | neuroblastoma RAS viral (v-ras) oncogene homolog | 3365 | 0.374 | -0.0550 | No |
| 9 | MAP2K2 | NA | MAP2K2 Entrez, Source | mitogen-activated protein kinase kinase 2 | 3444 | 0.361 | -0.0483 | No |
| 10 | ARAF | NA | ARAF Entrez, Source | v-raf murine sarcoma 3611 viral oncogene homolog | 4818 | 0.209 | -0.1407 | No |
| 11 | MAP2K1 | NA | MAP2K1 Entrez, Source | mitogen-activated protein kinase kinase 1 | 4894 | 0.202 | -0.1392 | No |
| 12 | PIK3CB | NA | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 5293 | 0.162 | -0.1625 | No |
| 13 | CDH1 | NA | CDH1 Entrez, Source | cadherin 1, type 1, E-cadherin (epithelial) | 5859 | 0.102 | -0.2000 | No |
| 14 | ELK1 | NA | ELK1 Entrez, Source | ELK1, member of ETS oncogene family | 6756 | 0.012 | -0.2646 | No |
| 15 | PDPK1 | NA | PDPK1 Entrez, Source | 3-phosphoinositide dependent protein kinase-1 | 6775 | 0.009 | -0.2656 | No |
| 16 | FOXO3 | NA | 6872 | -0.001 | -0.2725 | No | ||
| 17 | PTEN | NA | PTEN Entrez, Source | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | 6985 | -0.013 | -0.2802 | No |
| 18 | APC2 | NA | APC2 Entrez, Source | adenomatosis polyposis coli 2 | 7091 | -0.022 | -0.2871 | No |
| 19 | AKT2 | NA | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 7140 | -0.027 | -0.2896 | No |
| 20 | SOS1 | NA | SOS1 Entrez, Source | son of sevenless homolog 1 (Drosophila) | 7393 | -0.055 | -0.3060 | No |
| 21 | APC | NA | APC Entrez, Source | adenomatosis polyposis coli | 7984 | -0.112 | -0.3450 | No |
| 22 | PIK3R3 | NA | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 8472 | -0.166 | -0.3746 | No |
| 23 | GRB2 | NA | GRB2 Entrez, Source | growth factor receptor-bound protein 2 | 8662 | -0.186 | -0.3819 | No |
| 24 | ILK | NA | ILK Entrez, Source | integrin-linked kinase | 8729 | -0.194 | -0.3800 | No |
| 25 | GSK3B | NA | GSK3B Entrez, Source | glycogen synthase kinase 3 beta | 8844 | -0.207 | -0.3812 | No |
| 26 | MAPK1 | NA | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 8973 | -0.222 | -0.3828 | No |
| 27 | MLH1 | NA | MLH1 Entrez, Source | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) | 9019 | -0.228 | -0.3783 | No |
| 28 | BAD | NA | BAD Entrez, Source | BCL2-antagonist of cell death | 9149 | -0.244 | -0.3793 | No |
| 29 | AXIN2 | NA | AXIN2 Entrez, Source | axin 2 (conductin, axil) | 9316 | -0.265 | -0.3822 | No |
| 30 | RAF1 | NA | RAF1 Entrez, Source | v-raf-1 murine leukemia viral oncogene homolog 1 | 9437 | -0.284 | -0.3812 | No |
| 31 | PIK3CA | NA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 9727 | -0.326 | -0.3910 | No |
| 32 | MYC | NA | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 9860 | -0.346 | -0.3887 | No |
| 33 | ERBB2 | NA | ERBB2 Entrez, Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 9967 | -0.359 | -0.3840 | No |
| 34 | CTNNA1 | NA | CTNNA1 Entrez, Source | catenin (cadherin-associated protein), alpha 1, 102kDa | 10049 | -0.372 | -0.3771 | No |
| 35 | AKT1 | NA | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 10063 | -0.374 | -0.3652 | No |
| 36 | KRAS | NA | KRAS Entrez, Source | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 10540 | -0.448 | -0.3844 | No |
| 37 | PIK3R2 | NA | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 11136 | -0.552 | -0.4086 | No |
| 38 | EGF | NA | EGF Entrez, Source | epidermal growth factor (beta-urogastrone) | 11460 | -0.616 | -0.4109 | No |
| 39 | CTNNB1 | NA | CTNNB1 Entrez, Source | catenin (cadherin-associated protein), beta 1, 88kDa | 12021 | -0.762 | -0.4254 | No |
| 40 | CTNNA3 | NA | CTNNA3 Entrez, Source | catenin (cadherin-associated protein), alpha 3 | 12602 | -0.983 | -0.4337 | Yes |
| 41 | TCF7L2 | NA | TCF7L2 Entrez, Source | transcription factor 7-like 2 (T-cell specific, HMG-box) | 12658 | -1.014 | -0.4029 | Yes |
| 42 | TP53 | NA | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 12744 | -1.059 | -0.3727 | Yes |
| 43 | SOS2 | NA | SOS2 Entrez, Source | son of sevenless homolog 2 (Drosophila) | 12762 | -1.068 | -0.3373 | Yes |
| 44 | PIK3CG | NA | PIK3CG Entrez, Source | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 13175 | -1.371 | -0.3201 | Yes |
| 45 | MAPK3 | NA | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 13226 | -1.426 | -0.2748 | Yes |
| 46 | AKT3 | NA | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 13407 | -1.667 | -0.2307 | Yes |
| 47 | TCF7 | NA | TCF7 Entrez, Source | transcription factor 7 (T-cell specific, HMG-box) | 13616 | -2.115 | -0.1731 | Yes |
| 48 | CASP9 | NA | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 13696 | -2.469 | -0.0941 | Yes |
| 49 | PIK3CD | NA | PIK3CD Entrez, Source | phosphoinositide-3-kinase, catalytic, delta polypeptide | 13763 | -3.033 | 0.0052 | Yes |
