Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY |
| Enrichment Score (ES) | 0.6820716 |
| Normalized Enrichment Score (NES) | 2.1691847 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CCL5 | NA | CCL5 Entrez, Source | chemokine (C-C motif) ligand 5 | 10 | 4.462 | 0.1269 | Yes |
| 2 | DDX58 | NA | DDX58 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 13 | 4.397 | 0.2525 | Yes |
| 3 | IL6 | NA | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 15 | 4.383 | 0.3778 | Yes |
| 4 | CXCL10 | NA | CXCL10 Entrez, Source | chemokine (C-X-C motif) ligand 10 | 16 | 4.314 | 0.5013 | Yes |
| 5 | TMEM173 | NA | TMEM173 Entrez, Source | transmembrane protein 173 | 317 | 1.716 | 0.5286 | Yes |
| 6 | POLR3C | NA | POLR3C Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide C (62kD) | 667 | 1.125 | 0.5355 | Yes |
| 7 | POLR3G | NA | POLR3G Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide G (32kD) | 801 | 1.007 | 0.5547 | Yes |
| 8 | IL18 | NA | IL18 Entrez, Source | interleukin 18 (interferon-gamma-inducing factor) | 831 | 0.988 | 0.5808 | Yes |
| 9 | POLR3H | NA | POLR3H Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) | 1220 | 0.804 | 0.5757 | Yes |
| 10 | POLR3F | NA | POLR3F Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa | 1309 | 0.771 | 0.5914 | Yes |
| 11 | POLR3K | NA | POLR3K Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa | 1368 | 0.750 | 0.6087 | Yes |
| 12 | IKBKE | NA | IKBKE Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 1384 | 0.748 | 0.6290 | Yes |
| 13 | NFKBIA | NA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 1484 | 0.721 | 0.6424 | Yes |
| 14 | RELA | NA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 1570 | 0.698 | 0.6562 | Yes |
| 15 | IRF3 | NA | IRF3 Entrez, Source | interferon regulatory factor 3 | 1819 | 0.628 | 0.6562 | Yes |
| 16 | NFKB1 | NA | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 2004 | 0.585 | 0.6596 | Yes |
| 17 | IL33 | NA | 2250 | 0.542 | 0.6574 | Yes | ||
| 18 | IKBKG | NA | IKBKG Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 2396 | 0.517 | 0.6616 | Yes |
| 19 | IL1B | NA | IL1B Entrez, Source | interleukin 1, beta | 2581 | 0.487 | 0.6622 | Yes |
| 20 | ADAR | NA | ADAR Entrez, Source | adenosine deaminase, RNA-specific | 2817 | 0.449 | 0.6580 | Yes |
| 21 | POLR3A | NA | POLR3A Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide A, 155kDa | 2865 | 0.440 | 0.6672 | Yes |
| 22 | CHUK | NA | CHUK Entrez, Source | conserved helix-loop-helix ubiquitous kinase | 2997 | 0.421 | 0.6698 | Yes |
| 23 | RIPK1 | NA | RIPK1 Entrez, Source | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 3193 | 0.394 | 0.6669 | Yes |
| 24 | POLR1D | NA | POLR1D Entrez, Source | polymerase (RNA) I polypeptide D, 16kDa | 3234 | 0.389 | 0.6752 | Yes |
| 25 | POLR1C | NA | POLR1C Entrez, Source | polymerase (RNA) I polypeptide C, 30kDa | 3291 | 0.383 | 0.6821 | Yes |
| 26 | POLR3B | NA | POLR3B Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide B | 3520 | 0.352 | 0.6756 | No |
| 27 | POLR3D | NA | POLR3D Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide D, 44kDa | 5770 | 0.110 | 0.5158 | No |
| 28 | TBK1 | NA | TBK1 Entrez, Source | TANK-binding kinase 1 | 7031 | -0.017 | 0.4250 | No |
| 29 | ZBP1 | NA | ZBP1 Entrez, Source | Z-DNA binding protein 1 | 8612 | -0.181 | 0.3157 | No |
| 30 | MAVS | NA | 8980 | -0.223 | 0.2955 | No | ||
| 31 | IKBKB | NA | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 9844 | -0.344 | 0.2427 | No |
| 32 | CASP1 | NA | CASP1 Entrez, Source | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 10265 | -0.405 | 0.2239 | No |
| 33 | TREX1 | NA | TREX1 Entrez, Source | three prime repair exonuclease 1 | 10414 | -0.429 | 0.2254 | No |
| 34 | POLR3GL | NA | POLR3GL Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide G (32kD) like | 12082 | -0.780 | 0.1269 | No |
