Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION |
| Enrichment Score (ES) | 0.47817233 |
| Normalized Enrichment Score (NES) | 1.9681375 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0050132885 |
| FWER p-Value | 0.013 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CXCL11 | NA | CXCL11 Entrez, Source | chemokine (C-X-C motif) ligand 11 | 1 | 4.764 | 0.0343 | Yes |
| 2 | IL7R | NA | IL7R Entrez, Source | interleukin 7 receptor | 3 | 4.680 | 0.0681 | Yes |
| 3 | CRLF2 | NA | CRLF2 Entrez, Source | cytokine receptor-like factor 2 | 9 | 4.480 | 0.1001 | Yes |
| 4 | CCL5 | NA | CCL5 Entrez, Source | chemokine (C-C motif) ligand 5 | 10 | 4.462 | 0.1323 | Yes |
| 5 | IL6 | NA | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 15 | 4.383 | 0.1637 | Yes |
| 6 | CXCL10 | NA | CXCL10 Entrez, Source | chemokine (C-X-C motif) ligand 10 | 16 | 4.314 | 0.1948 | Yes |
| 7 | IL2RG | NA | IL2RG Entrez, Source | interleukin 2 receptor, gamma (severe combined immunodeficiency) | 79 | 3.132 | 0.2129 | Yes |
| 8 | CCL2 | NA | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 98 | 2.964 | 0.2330 | Yes |
| 9 | TNFRSF8 | NA | TNFRSF8 Entrez, Source | tumor necrosis factor receptor superfamily, member 8 | 118 | 2.706 | 0.2512 | Yes |
| 10 | TNFRSF12A | NA | TNFRSF12A Entrez, Source | tumor necrosis factor receptor superfamily, member 12A | 128 | 2.638 | 0.2696 | Yes |
| 11 | TNFRSF21 | NA | TNFRSF21 Entrez, Source | tumor necrosis factor receptor superfamily, member 21 | 130 | 2.631 | 0.2885 | Yes |
| 12 | CXCL2 | NA | CXCL2 Entrez, Source | chemokine (C-X-C motif) ligand 2 | 162 | 2.420 | 0.3038 | Yes |
| 13 | IL24 | NA | IL24 Entrez, Source | interleukin 24 | 163 | 2.417 | 0.3212 | Yes |
| 14 | IL22RA1 | NA | IL22RA1 Entrez, Source | interleukin 22 receptor, alpha 1 | 215 | 2.127 | 0.3329 | Yes |
| 15 | IL18R1 | NA | IL18R1 Entrez, Source | interleukin 18 receptor 1 | 266 | 1.894 | 0.3429 | Yes |
| 16 | CLCF1 | NA | CLCF1 Entrez, Source | cardiotrophin-like cytokine factor 1 | 309 | 1.735 | 0.3524 | Yes |
| 17 | IL12B | NA | IL12B Entrez, Source | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | 366 | 1.567 | 0.3596 | Yes |
| 18 | CSF2RA | NA | CSF2RA Entrez, Source | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | 378 | 1.539 | 0.3699 | Yes |
| 19 | TNFRSF10A | NA | TNFRSF10A Entrez, Source | tumor necrosis factor receptor superfamily, member 10a | 431 | 1.449 | 0.3766 | Yes |
| 20 | RELT | NA | 510 | 1.299 | 0.3803 | Yes | ||
| 21 | IL21R | NA | IL21R Entrez, Source | interleukin 21 receptor | 544 | 1.260 | 0.3870 | Yes |
| 22 | IL1R1 | NA | IL1R1 Entrez, Source | interleukin 1 receptor, type I | 560 | 1.229 | 0.3947 | Yes |
| 23 | TNFRSF11A | NA | TNFRSF11A Entrez, Source | tumor necrosis factor receptor superfamily, member 11a, NFKB activator | 590 | 1.194 | 0.4012 | Yes |
| 24 | AMHR2 | NA | AMHR2 Entrez, Source | anti-Mullerian hormone receptor, type II | 604 | 1.177 | 0.4088 | Yes |
| 25 | EGFR | NA | EGFR Entrez, Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 637 | 1.150 | 0.4148 | Yes |
| 26 | TGFBR2 | NA | TGFBR2 Entrez, Source | transforming growth factor, beta receptor II (70/80kDa) | 639 | 1.148 | 0.4230 | Yes |
| 27 | IL6ST | NA | IL6ST Entrez, Source | interleukin 6 signal transducer (gp130, oncostatin M receptor) | 645 | 1.142 | 0.4309 | Yes |
| 28 | CNTFR | NA | CNTFR Entrez, Source | ciliary neurotrophic factor receptor | 677 | 1.117 | 0.4367 | Yes |
| 29 | IL4R | NA | IL4R Entrez, Source | interleukin 4 receptor | 732 | 1.063 | 0.4404 | Yes |
| 30 | LIF | NA | LIF Entrez, Source | leukemia inhibitory factor (cholinergic differentiation factor) | 745 | 1.056 | 0.4472 | Yes |
| 31 | CCL22 | NA | CCL22 Entrez, Source | chemokine (C-C motif) ligand 22 | 758 | 1.042 | 0.4538 | Yes |
| 32 | IL11 | NA | IL11 Entrez, Source | interleukin 11 | 773 | 1.035 | 0.4603 | Yes |
| 33 | PLEKHO2 | NA | 816 | 0.997 | 0.4644 | Yes | ||
| 34 | IL18 | NA | IL18 Entrez, Source | interleukin 18 (interferon-gamma-inducing factor) | 831 | 0.988 | 0.4705 | Yes |
| 35 | IL1A | NA | IL1A Entrez, Source | interleukin 1, alpha | 977 | 0.904 | 0.4665 | Yes |
| 36 | ACVR1 | NA | ACVR1 Entrez, Source | activin A receptor, type I | 990 | 0.898 | 0.4721 | Yes |
| 37 | ACVRL1 | NA | ACVRL1 Entrez, Source | activin A receptor type II-like 1 | 1070 | 0.862 | 0.4725 | Yes |
| 38 | TNFRSF1A | NA | TNFRSF1A Entrez, Source | tumor necrosis factor receptor superfamily, member 1A | 1079 | 0.859 | 0.4782 | Yes |
| 39 | LTBR | NA | LTBR Entrez, Source | lymphotoxin beta receptor (TNFR superfamily, member 3) | 1223 | 0.803 | 0.4735 | No |
| 40 | TNFRSF10B | NA | TNFRSF10B Entrez, Source | tumor necrosis factor receptor superfamily, member 10b | 1294 | 0.775 | 0.4740 | No |
| 41 | TGFB1 | NA | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 1560 | 0.700 | 0.4597 | No |
| 42 | IL15RA | NA | IL15RA Entrez, Source | interleukin 15 receptor, alpha | 1690 | 0.661 | 0.4551 | No |
| 43 | LEP | NA | LEP Entrez, Source | leptin (obesity homolog, mouse) | 1771 | 0.638 | 0.4538 | No |
| 44 | BMP7 | NA | BMP7 Entrez, Source | bone morphogenetic protein 7 (osteogenic protein 1) | 1922 | 0.602 | 0.4472 | No |
| 45 | TNFSF4 | NA | TNFSF4 Entrez, Source | tumor necrosis factor (ligand) superfamily, member 4 (tax-transcriptionally activated glycoprotein 1, 34kDa) | 2016 | 0.583 | 0.4447 | No |
| 46 | IFNAR1 | NA | IFNAR1 Entrez, Source | interferon (alpha, beta and omega) receptor 1 | 2074 | 0.574 | 0.4446 | No |
| 47 | IL12RB2 | NA | IL12RB2 Entrez, Source | interleukin 12 receptor, beta 2 | 2252 | 0.541 | 0.4356 | No |
| 48 | IL1B | NA | IL1B Entrez, Source | interleukin 1, beta | 2581 | 0.487 | 0.4152 | No |
| 49 | IL23A | NA | IL23A Entrez, Source | interleukin 23, alpha subunit p19 | 2610 | 0.483 | 0.4166 | No |
| 50 | INHBB | NA | INHBB Entrez, Source | inhibin, beta B (activin AB beta polypeptide) | 2833 | 0.446 | 0.4036 | No |
| 51 | CXCL3 | NA | CXCL3 Entrez, Source | chemokine (C-X-C motif) ligand 3 | 2875 | 0.438 | 0.4038 | No |
| 52 | CX3CR1 | NA | CX3CR1 Entrez, Source | chemokine (C-X3-C motif) receptor 1 | 3072 | 0.412 | 0.3925 | No |
| 53 | IL6R | NA | IL6R Entrez, Source | interleukin 6 receptor | 3094 | 0.409 | 0.3939 | No |
| 54 | IL9R | NA | IL9R Entrez, Source | interleukin 9 receptor | 3096 | 0.409 | 0.3968 | No |
| 55 | IFNAR2 | NA | IFNAR2 Entrez, Source | interferon (alpha, beta and omega) receptor 2 | 3310 | 0.381 | 0.3840 | No |
| 56 | TNFSF15 | NA | TNFSF15 Entrez, Source | tumor necrosis factor (ligand) superfamily, member 15 | 3323 | 0.380 | 0.3858 | No |
| 57 | IL2RA | NA | IL2RA Entrez, Source | interleukin 2 receptor, alpha | 3404 | 0.367 | 0.3826 | No |
| 58 | FAS | NA | FAS Entrez, Source | Fas (TNF receptor superfamily, member 6) | 3457 | 0.360 | 0.3814 | No |
| 59 | CNTF | NA | CNTF Entrez, Source | ciliary neurotrophic factor | 3552 | 0.349 | 0.3771 | No |
| 60 | MPL | NA | MPL Entrez, Source | myeloproliferative leukemia virus oncogene | 3933 | 0.304 | 0.3516 | No |
| 61 | KIT | NA | KIT Entrez, Source | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 4009 | 0.296 | 0.3482 | No |
| 62 | KDR | NA | KDR Entrez, Source | kinase insert domain receptor (a type III receptor tyrosine kinase) | 4101 | 0.287 | 0.3436 | No |
| 63 | IFNGR1 | NA | IFNGR1 Entrez, Source | interferon gamma receptor 1 | 4135 | 0.284 | 0.3433 | No |
| 64 | ACVR1B | NA | ACVR1B Entrez, Source | activin A receptor, type IB | 4187 | 0.279 | 0.3416 | No |
| 65 | PDGFA | NA | PDGFA Entrez, Source | platelet-derived growth factor alpha polypeptide | 4294 | 0.267 | 0.3358 | No |
| 66 | ACVR2A | NA | ACVR2A Entrez, Source | activin A receptor, type IIA | 4566 | 0.235 | 0.3177 | No |
| 67 | BMPR1A | NA | BMPR1A Entrez, Source | bone morphogenetic protein receptor, type IA | 4667 | 0.227 | 0.3120 | No |
| 68 | TGFB2 | NA | TGFB2 Entrez, Source | transforming growth factor, beta 2 | 4731 | 0.219 | 0.3090 | No |
| 69 | IL5RA | NA | IL5RA Entrez, Source | interleukin 5 receptor, alpha | 4957 | 0.196 | 0.2940 | No |
| 70 | TNFRSF9 | NA | TNFRSF9 Entrez, Source | tumor necrosis factor receptor superfamily, member 9 | 5250 | 0.166 | 0.2738 | No |
| 71 | IL15 | NA | IL15 Entrez, Source | interleukin 15 | 5495 | 0.140 | 0.2570 | No |
| 72 | TNFRSF25 | NA | TNFRSF25 Entrez, Source | tumor necrosis factor receptor superfamily, member 25 | 5891 | 0.099 | 0.2289 | No |
| 73 | MET | NA | MET Entrez, Source | met proto-oncogene (hepatocyte growth factor receptor) | 5916 | 0.096 | 0.2278 | No |
| 74 | IFNE | NA | 6164 | 0.071 | 0.2103 | No | ||
| 75 | GHR | NA | GHR Entrez, Source | growth hormone receptor | 6889 | -0.002 | 0.1575 | No |
| 76 | TNFRSF19 | NA | TNFRSF19 Entrez, Source | tumor necrosis factor receptor superfamily, member 19 | 6925 | -0.007 | 0.1549 | No |
| 77 | IL3RA | NA | IL3RA Entrez, Source | interleukin 3 receptor, alpha (low affinity) | 6957 | -0.010 | 0.1528 | No |
| 78 | TNFRSF10D | NA | TNFRSF10D Entrez, Source | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 7090 | -0.022 | 0.1433 | No |
| 79 | TNFRSF1B | NA | TNFRSF1B Entrez, Source | tumor necrosis factor receptor superfamily, member 1B | 7244 | -0.038 | 0.1324 | No |
| 80 | AMH | NA | AMH Entrez, Source | anti-Mullerian hormone | 7261 | -0.040 | 0.1315 | No |
| 81 | IL19 | NA | IL19 Entrez, Source | interleukin 19 | 7550 | -0.071 | 0.1110 | No |
| 82 | PRLR | NA | PRLR Entrez, Source | prolactin receptor | 7590 | -0.074 | 0.1087 | No |
| 83 | BMPR2 | NA | BMPR2 Entrez, Source | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 7601 | -0.075 | 0.1085 | No |
| 84 | CCL16 | NA | CCL16 Entrez, Source | chemokine (C-C motif) ligand 16 | 7664 | -0.081 | 0.1045 | No |
| 85 | VEGFA | NA | 7811 | -0.096 | 0.0946 | No | ||
| 86 | FASLG | NA | FASLG Entrez, Source | Fas ligand (TNF superfamily, member 6) | 7920 | -0.106 | 0.0874 | No |
| 87 | IL18RAP | NA | IL18RAP Entrez, Source | interleukin 18 receptor accessory protein | 8072 | -0.123 | 0.0773 | No |
| 88 | IL17RA | NA | IL17RA Entrez, Source | interleukin 17 receptor A | 8245 | -0.143 | 0.0658 | No |
| 89 | IL10RB | NA | IL10RB Entrez, Source | interleukin 10 receptor, beta | 8678 | -0.188 | 0.0356 | No |
| 90 | IL13RA1 | NA | IL13RA1 Entrez, Source | interleukin 13 receptor, alpha 1 | 8682 | -0.188 | 0.0367 | No |
| 91 | FLT1 | NA | FLT1 Entrez, Source | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | 8910 | -0.215 | 0.0217 | No |
| 92 | IL2RB | NA | IL2RB Entrez, Source | interleukin 2 receptor, beta | 8981 | -0.223 | 0.0182 | No |
| 93 | LIFR | NA | LIFR Entrez, Source | leukemia inhibitory factor receptor alpha | 8985 | -0.224 | 0.0196 | No |
| 94 | BMPR1B | NA | BMPR1B Entrez, Source | bone morphogenetic protein receptor, type IB | 9027 | -0.229 | 0.0183 | No |
| 95 | TNFSF14 | NA | TNFSF14 Entrez, Source | tumor necrosis factor (ligand) superfamily, member 14 | 9389 | -0.277 | -0.0061 | No |
| 96 | IL23R | NA | IL23R Entrez, Source | interleukin 23 receptor | 9490 | -0.293 | -0.0113 | No |
| 97 | IFNGR2 | NA | IFNGR2 Entrez, Source | interferon gamma receptor 2 (interferon gamma transducer 1) | 9538 | -0.299 | -0.0126 | No |
| 98 | CD27 | NA | 9882 | -0.348 | -0.0351 | No | ||
| 99 | OSMR | NA | OSMR Entrez, Source | oncostatin M receptor | 9965 | -0.359 | -0.0385 | No |
| 100 | LEPR | NA | LEPR Entrez, Source | leptin receptor | 10086 | -0.377 | -0.0445 | No |
| 101 | CXCR4 | NA | CXCR4 Entrez, Source | chemokine (C-X-C motif) receptor 4 | 10239 | -0.400 | -0.0527 | No |
| 102 | CX3CL1 | NA | CX3CL1 Entrez, Source | chemokine (C-X3-C motif) ligand 1 | 10321 | -0.412 | -0.0557 | No |
| 103 | CD70 | NA | 10418 | -0.429 | -0.0596 | No | ||
| 104 | INHBE | NA | INHBE Entrez, Source | inhibin, beta E | 10420 | -0.429 | -0.0566 | No |
| 105 | CCL28 | NA | CCL28 Entrez, Source | chemokine (C-C motif) ligand 28 | 10565 | -0.453 | -0.0638 | No |
| 106 | TNFSF9 | NA | TNFSF9 Entrez, Source | tumor necrosis factor (ligand) superfamily, member 9 | 10580 | -0.455 | -0.0615 | No |
| 107 | CXCR6 | NA | CXCR6 Entrez, Source | chemokine (C-X-C motif) receptor 6 | 10630 | -0.464 | -0.0618 | No |
| 108 | IL10 | NA | IL10 Entrez, Source | interleukin 10 | 10658 | -0.469 | -0.0604 | No |
| 109 | INHBC | NA | INHBC Entrez, Source | inhibin, beta C | 10924 | -0.513 | -0.0760 | No |
| 110 | TNFSF13 | NA | TNFSF13 Entrez, Source | tumor necrosis factor (ligand) superfamily, member 13 | 10949 | -0.518 | -0.0740 | No |
| 111 | CCR6 | NA | CCR6 Entrez, Source | chemokine (C-C motif) receptor 6 | 11282 | -0.582 | -0.0941 | No |
| 112 | ACVR2B | NA | ACVR2B Entrez, Source | activin A receptor, type IIB | 11332 | -0.591 | -0.0934 | No |
| 113 | EGF | NA | EGF Entrez, Source | epidermal growth factor (beta-urogastrone) | 11460 | -0.616 | -0.0982 | No |
| 114 | KITLG | NA | KITLG Entrez, Source | KIT ligand | 11475 | -0.620 | -0.0947 | No |
| 115 | PDGFC | NA | PDGFC Entrez, Source | platelet derived growth factor C | 11490 | -0.622 | -0.0913 | No |
| 116 | EPOR | NA | EPOR Entrez, Source | erythropoietin receptor | 11843 | -0.711 | -0.1118 | No |
| 117 | FLT3LG | NA | FLT3LG Entrez, Source | fms-related tyrosine kinase 3 ligand | 11849 | -0.712 | -0.1070 | No |
| 118 | IL1RAP | NA | IL1RAP Entrez, Source | interleukin 1 receptor accessory protein | 11858 | -0.714 | -0.1025 | No |
| 119 | TNFRSF10C | NA | TNFRSF10C Entrez, Source | tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain | 12060 | -0.775 | -0.1116 | No |
| 120 | CXCL16 | NA | CXCL16 Entrez, Source | chemokine (C-X-C motif) ligand 16 | 12141 | -0.801 | -0.1116 | No |
| 121 | PDGFRA | NA | PDGFRA Entrez, Source | platelet-derived growth factor receptor, alpha polypeptide | 12202 | -0.819 | -0.1101 | No |
| 122 | CXCR2 | NA | 12322 | -0.862 | -0.1125 | No | ||
| 123 | CCR3 | NA | CCR3 Entrez, Source | chemokine (C-C motif) receptor 3 | 12359 | -0.877 | -0.1088 | No |
| 124 | VEGFB | NA | VEGFB Entrez, Source | vascular endothelial growth factor B | 12361 | -0.878 | -0.1026 | No |
| 125 | IL17RB | NA | IL17RB Entrez, Source | interleukin 17 receptor B | 12549 | -0.960 | -0.1093 | No |
| 126 | PDGFB | NA | PDGFB Entrez, Source | platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) | 12572 | -0.972 | -0.1039 | No |
| 127 | TNFRSF13C | NA | TNFRSF13C Entrez, Source | tumor necrosis factor receptor superfamily, member 13C | 12580 | -0.973 | -0.0973 | No |
| 128 | IFNW1 | NA | IFNW1 Entrez, Source | interferon, omega 1 | 12674 | -1.025 | -0.0967 | No |
| 129 | TNFSF10 | NA | TNFSF10 Entrez, Source | tumor necrosis factor (ligand) superfamily, member 10 | 12683 | -1.028 | -0.0899 | No |
| 130 | CSF1R | NA | CSF1R Entrez, Source | colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog | 12807 | -1.094 | -0.0910 | No |
| 131 | TGFB3 | NA | TGFB3 Entrez, Source | transforming growth factor, beta 3 | 12913 | -1.157 | -0.0903 | No |
| 132 | TGFBR1 | NA | TGFBR1 Entrez, Source | transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) | 13312 | -1.530 | -0.1083 | No |
| 133 | PDGFRB | NA | PDGFRB Entrez, Source | platelet-derived growth factor receptor, beta polypeptide | 13337 | -1.562 | -0.0988 | No |
| 134 | TNFRSF6B | NA | TNFRSF6B Entrez, Source | tumor necrosis factor receptor superfamily, member 6b, decoy | 13371 | -1.610 | -0.0895 | No |
| 135 | BMP2 | NA | BMP2 Entrez, Source | bone morphogenetic protein 2 | 13439 | -1.723 | -0.0820 | No |
| 136 | CCR7 | NA | CCR7 Entrez, Source | chemokine (C-C motif) receptor 7 | 13458 | -1.749 | -0.0707 | No |
| 137 | CCR1 | NA | CCR1 Entrez, Source | chemokine (C-C motif) receptor 1 | 13495 | -1.800 | -0.0603 | No |
| 138 | CTF1 | NA | CTF1 Entrez, Source | cardiotrophin 1 | 13582 | -2.018 | -0.0520 | No |
| 139 | CCL21 | NA | CCL21 Entrez, Source | chemokine (C-C motif) ligand 21 | 13605 | -2.084 | -0.0386 | No |
| 140 | CCL26 | NA | CCL26 Entrez, Source | chemokine (C-C motif) ligand 26 | 13610 | -2.100 | -0.0237 | No |
| 141 | IL20RB | NA | IL20RB Entrez, Source | interleukin 20 receptor beta | 13691 | -2.460 | -0.0117 | No |
| 142 | EDA2R | NA | EDA2R Entrez, Source | ectodysplasin A2 receptor | 13768 | -3.061 | 0.0048 | No |
