Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_COMPLEMENT_AND_COAGULATION_CASCADES |
| Enrichment Score (ES) | -0.50890785 |
| Normalized Enrichment Score (NES) | -1.627194 |
| Nominal p-value | 0.0067453627 |
| FDR q-value | 0.06651141 |
| FWER p-Value | 0.575 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | SERPINE1 | NA | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 109 | 2.840 | 0.0466 | No |
| 2 | F3 | NA | F3 Entrez, Source | coagulation factor III (thromboplastin, tissue factor) | 184 | 2.322 | 0.0858 | No |
| 3 | PLAUR | NA | PLAUR Entrez, Source | plasminogen activator, urokinase receptor | 187 | 2.308 | 0.1299 | No |
| 4 | CFB | NA | CFB Entrez, Source | complement factor B | 282 | 1.804 | 0.1577 | No |
| 5 | VWF | NA | VWF Entrez, Source | von Willebrand factor | 919 | 0.933 | 0.1295 | No |
| 6 | THBD | NA | THBD Entrez, Source | thrombomodulin | 1044 | 0.873 | 0.1373 | No |
| 7 | BDKRB1 | NA | BDKRB1 Entrez, Source | bradykinin receptor B1 | 1993 | 0.588 | 0.0798 | No |
| 8 | C4BPB | NA | C4BPB Entrez, Source | complement component 4 binding protein, beta | 2011 | 0.583 | 0.0898 | No |
| 9 | SERPINC1 | NA | SERPINC1 Entrez, Source | serpin peptidase inhibitor, clade C (antithrombin), member 1 | 2358 | 0.522 | 0.0747 | No |
| 10 | C8A | NA | C8A Entrez, Source | complement component 8, alpha polypeptide | 2399 | 0.516 | 0.0817 | No |
| 11 | F12 | NA | F12 Entrez, Source | coagulation factor XII (Hageman factor) | 2606 | 0.483 | 0.0761 | No |
| 12 | FGB | NA | FGB Entrez, Source | fibrinogen beta chain | 3451 | 0.360 | 0.0218 | No |
| 13 | F2R | NA | F2R Entrez, Source | coagulation factor II (thrombin) receptor | 3598 | 0.344 | 0.0178 | No |
| 14 | CD55 | NA | CD55 Entrez, Source | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 3945 | 0.303 | -0.0015 | No |
| 15 | PLAT | NA | PLAT Entrez, Source | plasminogen activator, tissue | 5083 | 0.183 | -0.0804 | No |
| 16 | F5 | NA | F5 Entrez, Source | coagulation factor V (proaccelerin, labile factor) | 5393 | 0.151 | -0.0999 | No |
| 17 | C7 | NA | C7 Entrez, Source | complement component 7 | 5609 | 0.127 | -0.1131 | No |
| 18 | C2 | NA | C2 Entrez, Source | complement component 2 | 8029 | -0.117 | -0.2862 | No |
| 19 | C3AR1 | NA | C3AR1 Entrez, Source | complement component 3a receptor 1 | 9205 | -0.250 | -0.3666 | No |
| 20 | CD59 | NA | CD59 Entrez, Source | CD59 molecule, complement regulatory protein | 10017 | -0.367 | -0.4184 | No |
| 21 | C9 | NA | C9 Entrez, Source | complement component 9 | 10832 | -0.499 | -0.4678 | No |
| 22 | F8 | NA | F8 Entrez, Source | coagulation factor VIII, procoagulant component (hemophilia A) | 10971 | -0.522 | -0.4678 | No |
| 23 | CR1 | NA | CR1 Entrez, Source | complement component (3b/4b) receptor 1 (Knops blood group) | 11207 | -0.565 | -0.4740 | No |
| 24 | MASP2 | NA | MASP2 Entrez, Source | mannan-binding lectin serine peptidase 2 | 11465 | -0.618 | -0.4808 | No |
| 25 | CD46 | NA | CD46 Entrez, Source | CD46 molecule, complement regulatory protein | 11815 | -0.703 | -0.4926 | Yes |
| 26 | F10 | NA | F10 Entrez, Source | coagulation factor X | 11889 | -0.721 | -0.4841 | Yes |
| 27 | TFPI | NA | TFPI Entrez, Source | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 12069 | -0.778 | -0.4821 | Yes |
| 28 | PLAU | NA | PLAU Entrez, Source | plasminogen activator, urokinase | 12310 | -0.855 | -0.4831 | Yes |
| 29 | MASP1 | NA | MASP1 Entrez, Source | mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) | 12667 | -1.020 | -0.4893 | Yes |
| 30 | CFD | NA | CFD Entrez, Source | complement factor D (adipsin) | 12784 | -1.080 | -0.4770 | Yes |
| 31 | SERPINF2 | NA | SERPINF2 Entrez, Source | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 | 12795 | -1.087 | -0.4569 | Yes |
| 32 | C4BPA | NA | C4BPA Entrez, Source | complement component 4 binding protein, alpha | 12934 | -1.171 | -0.4444 | Yes |
| 33 | C1S | NA | C1S Entrez, Source | complement component 1, s subcomponent | 13114 | -1.307 | -0.4323 | Yes |
| 34 | C1R | NA | C1R Entrez, Source | complement component 1, r subcomponent | 13304 | -1.520 | -0.4168 | Yes |
| 35 | SERPING1 | NA | SERPING1 Entrez, Source | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | 13330 | -1.553 | -0.3888 | Yes |
| 36 | PLG | NA | PLG Entrez, Source | plasminogen | 13466 | -1.757 | -0.3649 | Yes |
| 37 | C3 | NA | C3 Entrez, Source | complement component 3 | 13533 | -1.896 | -0.3333 | Yes |
| 38 | PROS1 | NA | PROS1 Entrez, Source | protein S (alpha) | 13569 | -1.987 | -0.2977 | Yes |
| 39 | A2M | NA | A2M Entrez, Source | alpha-2-macroglobulin | 13580 | -2.010 | -0.2598 | Yes |
| 40 | CFH | NA | CFH Entrez, Source | complement factor H | 13608 | -2.094 | -0.2216 | Yes |
| 41 | C5 | NA | C5 Entrez, Source | complement component 5 | 13673 | -2.359 | -0.1810 | Yes |
| 42 | C5AR1 | NA | C5AR1 Entrez, Source | complement component 5a receptor 1 | 13729 | -2.709 | -0.1330 | Yes |
| 43 | BDKRB2 | NA | BDKRB2 Entrez, Source | bradykinin receptor B2 | 13750 | -2.866 | -0.0794 | Yes |
| 44 | CFI | NA | CFI Entrez, Source | complement factor I | 13823 | -4.452 | 0.0008 | Yes |
