Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_CITRATE_CYCLE_TCA_CYCLE |
| Enrichment Score (ES) | -0.6065063 |
| Normalized Enrichment Score (NES) | -1.7622203 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.018235778 |
| FWER p-Value | 0.161 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CS | NA | CS Entrez, Source | citrate synthase | 3461 | 0.359 | -0.2319 | No |
| 2 | IDH3A | NA | IDH3A Entrez, Source | isocitrate dehydrogenase 3 (NAD+) alpha | 4655 | 0.228 | -0.3064 | No |
| 3 | DLST | NA | DLST Entrez, Source | dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) | 5346 | 0.157 | -0.3482 | No |
| 4 | OGDH | NA | OGDH Entrez, Source | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | 8538 | -0.172 | -0.5703 | No |
| 5 | DLAT | NA | DLAT Entrez, Source | dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) | 8620 | -0.182 | -0.5667 | No |
| 6 | ACLY | NA | ACLY Entrez, Source | ATP citrate lyase | 9171 | -0.246 | -0.5936 | Yes |
| 7 | SUCLA2 | NA | SUCLA2 Entrez, Source | succinate-CoA ligase, ADP-forming, beta subunit | 9278 | -0.260 | -0.5877 | Yes |
| 8 | IDH3G | NA | IDH3G Entrez, Source | isocitrate dehydrogenase 3 (NAD+) gamma | 9487 | -0.293 | -0.5875 | Yes |
| 9 | FH | NA | FH Entrez, Source | fumarate hydratase | 9680 | -0.318 | -0.5848 | Yes |
| 10 | DLD | NA | DLD Entrez, Source | dihydrolipoamide dehydrogenase | 9719 | -0.325 | -0.5706 | Yes |
| 11 | PDHA1 | NA | PDHA1 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 1 | 9820 | -0.339 | -0.5602 | Yes |
| 12 | SDHB | NA | SDHB Entrez, Source | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) | 10461 | -0.436 | -0.5837 | Yes |
| 13 | MDH2 | NA | MDH2 Entrez, Source | malate dehydrogenase 2, NAD (mitochondrial) | 10593 | -0.456 | -0.5694 | Yes |
| 14 | SUCLG2 | NA | SUCLG2 Entrez, Source | succinate-CoA ligase, GDP-forming, beta subunit | 10808 | -0.494 | -0.5591 | Yes |
| 15 | SDHC | NA | SDHC Entrez, Source | succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa | 10930 | -0.514 | -0.5410 | Yes |
| 16 | ACO1 | NA | ACO1 Entrez, Source | aconitase 1, soluble | 11609 | -0.652 | -0.5560 | Yes |
| 17 | SUCLG1 | NA | SUCLG1 Entrez, Source | succinate-CoA ligase, GDP-forming, alpha subunit | 12083 | -0.781 | -0.5495 | Yes |
| 18 | ACO2 | NA | ACO2 Entrez, Source | aconitase 2, mitochondrial | 12178 | -0.814 | -0.5138 | Yes |
| 19 | SDHD | NA | SDHD Entrez, Source | succinate dehydrogenase complex, subunit D, integral membrane protein | 12186 | -0.815 | -0.4717 | Yes |
| 20 | PDHB | NA | PDHB Entrez, Source | pyruvate dehydrogenase (lipoamide) beta | 12302 | -0.852 | -0.4355 | Yes |
| 21 | MDH1 | NA | MDH1 Entrez, Source | malate dehydrogenase 1, NAD (soluble) | 12448 | -0.914 | -0.3983 | Yes |
| 22 | SDHA | NA | SDHA Entrez, Source | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) | 12856 | -1.123 | -0.3691 | Yes |
| 23 | PCK2 | NA | PCK2 Entrez, Source | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 12963 | -1.192 | -0.3145 | Yes |
| 24 | IDH1 | NA | IDH1 Entrez, Source | isocitrate dehydrogenase 1 (NADP+), soluble | 13083 | -1.285 | -0.2560 | Yes |
| 25 | IDH2 | NA | IDH2 Entrez, Source | isocitrate dehydrogenase 2 (NADP+), mitochondrial | 13440 | -1.724 | -0.1917 | Yes |
| 26 | OGDHL | NA | OGDHL Entrez, Source | oxoglutarate dehydrogenase-like | 13573 | -1.991 | -0.0973 | Yes |
| 27 | PC | NA | PC Entrez, Source | pyruvate carboxylase | 13641 | -2.224 | 0.0140 | Yes |
