Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_CARDIAC_MUSCLE_CONTRACTION |
| Enrichment Score (ES) | -0.49427947 |
| Normalized Enrichment Score (NES) | -1.6011045 |
| Nominal p-value | 0.011744967 |
| FDR q-value | 0.08088725 |
| FWER p-Value | 0.671 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CACNB1 | NA | CACNB1 Entrez, Source | calcium channel, voltage-dependent, beta 1 subunit | 197 | 2.244 | 0.0432 | No |
| 2 | RYR2 | NA | RYR2 Entrez, Source | ryanodine receptor 2 (cardiac) | 310 | 1.733 | 0.0794 | No |
| 3 | SLC8A1 | NA | SLC8A1 Entrez, Source | solute carrier family 8 (sodium/calcium exchanger), member 1 | 484 | 1.336 | 0.1011 | No |
| 4 | SLC9A1 | NA | SLC9A1 Entrez, Source | solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive) | 713 | 1.086 | 0.1123 | No |
| 5 | COX6B2 | NA | COX6B2 Entrez, Source | cytochrome c oxidase subunit VIb polypeptide 2 (testis) | 879 | 0.955 | 0.1248 | No |
| 6 | TPM1 | NA | TPM1 Entrez, Source | tropomyosin 1 (alpha) | 2298 | 0.534 | 0.0356 | No |
| 7 | TPM4 | NA | TPM4 Entrez, Source | tropomyosin 4 | 2917 | 0.432 | 0.0018 | No |
| 8 | ATP1B1 | NA | ATP1B1 Entrez, Source | ATPase, Na+/K+ transporting, beta 1 polypeptide | 2977 | 0.424 | 0.0084 | No |
| 9 | ATP1A2 | NA | ATP1A2 Entrez, Source | ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide | 3226 | 0.390 | 0.0004 | No |
| 10 | ATP2A2 | NA | ATP2A2 Entrez, Source | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 3768 | 0.325 | -0.0305 | No |
| 11 | TPM2 | NA | TPM2 Entrez, Source | tropomyosin 2 (beta) | 4614 | 0.230 | -0.0859 | No |
| 12 | CACNB3 | NA | CACNB3 Entrez, Source | calcium channel, voltage-dependent, beta 3 subunit | 5154 | 0.176 | -0.1205 | No |
| 13 | CACNG8 | NA | CACNG8 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 8 | 5602 | 0.127 | -0.1497 | No |
| 14 | TNNI3 | NA | TNNI3 Entrez, Source | troponin I type 3 (cardiac) | 6246 | 0.062 | -0.1947 | No |
| 15 | ATP1B2 | NA | ATP1B2 Entrez, Source | ATPase, Na+/K+ transporting, beta 2 polypeptide | 6341 | 0.055 | -0.2001 | No |
| 16 | SLC9A6 | NA | SLC9A6 Entrez, Source | solute carrier family 9 (sodium/hydrogen exchanger), member 6 | 6616 | 0.027 | -0.2193 | No |
| 17 | TPM3 | NA | TPM3 Entrez, Source | tropomyosin 3 | 6721 | 0.015 | -0.2265 | No |
| 18 | ATP1B4 | NA | ATP1B4 Entrez, Source | ATPase, (Na+)/K+ transporting, beta 4 polypeptide | 7164 | -0.029 | -0.2578 | No |
| 19 | ATP1A1 | NA | ATP1A1 Entrez, Source | ATPase, Na+/K+ transporting, alpha 1 polypeptide | 7459 | -0.063 | -0.2775 | No |
| 20 | UQCR11 | NA | 7644 | -0.079 | -0.2889 | No | ||
| 21 | CACNA2D2 | NA | CACNA2D2 Entrez, Source | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | 7839 | -0.098 | -0.3004 | No |
| 22 | CACNB4 | NA | CACNB4 Entrez, Source | calcium channel, voltage-dependent, beta 4 subunit | 8125 | -0.128 | -0.3178 | No |
| 23 | UQCRFS1 | NA | UQCRFS1 Entrez, Source | ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 | 8783 | -0.200 | -0.3603 | No |
| 24 | COX7A2L | NA | COX7A2L Entrez, Source | cytochrome c oxidase subunit VIIa polypeptide 2 like | 9489 | -0.293 | -0.4040 | No |
| 25 | COX5A | NA | COX5A Entrez, Source | cytochrome c oxidase subunit Va | 10523 | -0.445 | -0.4675 | No |
| 26 | UQCRC1 | NA | UQCRC1 Entrez, Source | ubiquinol-cytochrome c reductase core protein I | 10695 | -0.475 | -0.4678 | No |
| 27 | COX4I1 | NA | COX4I1 Entrez, Source | cytochrome c oxidase subunit IV isoform 1 | 10760 | -0.485 | -0.4600 | No |
| 28 | ATP1B3 | NA | ATP1B3 Entrez, Source | ATPase, Na+/K+ transporting, beta 3 polypeptide | 10869 | -0.505 | -0.4549 | No |
| 29 | CYC1 | NA | CYC1 Entrez, Source | cytochrome c-1 | 11222 | -0.567 | -0.4659 | No |
| 30 | UQCRQ | NA | UQCRQ Entrez, Source | ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa | 11614 | -0.653 | -0.4776 | Yes |
| 31 | ATP1A3 | NA | ATP1A3 Entrez, Source | ATPase, Na+/K+ transporting, alpha 3 polypeptide | 11734 | -0.680 | -0.4688 | Yes |
| 32 | COX6A1 | NA | COX6A1 Entrez, Source | cytochrome c oxidase subunit VIa polypeptide 1 | 11769 | -0.690 | -0.4536 | Yes |
| 33 | COX6C | NA | COX6C Entrez, Source | cytochrome c oxidase subunit VIc | 11796 | -0.698 | -0.4376 | Yes |
| 34 | UQCR10 | NA | 12066 | -0.777 | -0.4372 | Yes | ||
| 35 | COX6B1 | NA | COX6B1 Entrez, Source | cytochrome c oxidase subunit Vib polypeptide 1 (ubiquitous) | 12086 | -0.781 | -0.4186 | Yes |
| 36 | UQCRH | NA | UQCRH Entrez, Source | ubiquinol-cytochrome c reductase hinge protein | 12158 | -0.807 | -0.4031 | Yes |
| 37 | COX8A | NA | COX8A Entrez, Source | cytochrome c oxidase subunit 8A (ubiquitous) | 12241 | -0.834 | -0.3877 | Yes |
| 38 | COX7A2 | NA | COX7A2 Entrez, Source | cytochrome c oxidase subunit VIIa polypeptide 2 (liver) | 12409 | -0.895 | -0.3769 | Yes |
| 39 | UQCRB | NA | UQCRB Entrez, Source | ubiquinol-cytochrome c reductase binding protein | 12456 | -0.921 | -0.3567 | Yes |
| 40 | COX7C | NA | COX7C Entrez, Source | cytochrome c oxidase subunit VIIc | 12481 | -0.929 | -0.3346 | Yes |
| 41 | COX5B | NA | COX5B Entrez, Source | cytochrome c oxidase subunit Vb | 12858 | -1.125 | -0.3331 | Yes |
| 42 | CACNA1D | NA | CACNA1D Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1D subunit | 12921 | -1.162 | -0.3078 | Yes |
| 43 | COX7B | NA | COX7B Entrez, Source | cytochrome c oxidase subunit VIIb | 12976 | -1.199 | -0.2810 | Yes |
| 44 | UQCRC2 | NA | UQCRC2 Entrez, Source | ubiquinol-cytochrome c reductase core protein II | 12985 | -1.203 | -0.2508 | Yes |
| 45 | UQCRHL | NA | 12995 | -1.213 | -0.2204 | Yes | ||
| 46 | CACNG3 | NA | CACNG3 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 3 | 13424 | -1.688 | -0.2082 | Yes |
| 47 | CACNA2D3 | NA | CACNA2D3 Entrez, Source | calcium channel, voltage-dependent, alpha 2/delta 3 subunit | 13597 | -2.058 | -0.1680 | Yes |
| 48 | ACTC1 | NA | ACTC1 Entrez, Source | actin, alpha, cardiac muscle 1 | 13620 | -2.138 | -0.1149 | Yes |
| 49 | TNNC1 | NA | TNNC1 Entrez, Source | troponin C type 1 (slow) | 13657 | -2.279 | -0.0591 | Yes |
| 50 | CACNB2 | NA | CACNB2 Entrez, Source | calcium channel, voltage-dependent, beta 2 subunit | 13741 | -2.808 | 0.0067 | Yes |
