Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_BUTANOATE_METABOLISM |
| Enrichment Score (ES) | -0.6314022 |
| Normalized Enrichment Score (NES) | -1.8278717 |
| Nominal p-value | 0.0016977929 |
| FDR q-value | 0.009885133 |
| FWER p-Value | 0.075 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | ACSM1 | NA | ACSM1 Entrez, Source | acyl-CoA synthetase medium-chain family member 1 | 671 | 1.121 | 0.0095 | No |
| 2 | HMGCS1 | NA | HMGCS1 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | 3649 | 0.338 | -0.1886 | No |
| 3 | ALDH1B1 | NA | ALDH1B1 Entrez, Source | aldehyde dehydrogenase 1 family, member B1 | 5084 | 0.183 | -0.2829 | No |
| 4 | BDH1 | NA | BDH1 Entrez, Source | 3-hydroxybutyrate dehydrogenase, type 1 | 7162 | -0.029 | -0.4319 | No |
| 5 | ALDH5A1 | NA | ALDH5A1 Entrez, Source | aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) | 7180 | -0.031 | -0.4315 | No |
| 6 | L2HGDH | NA | L2HGDH Entrez, Source | L-2-hydroxyglutarate dehydrogenase | 8730 | -0.195 | -0.5336 | No |
| 7 | ALDH3A2 | NA | ALDH3A2 Entrez, Source | aldehyde dehydrogenase 3 family, member A2 | 9636 | -0.312 | -0.5829 | No |
| 8 | PDHA1 | NA | PDHA1 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 1 | 9820 | -0.339 | -0.5786 | No |
| 9 | AKR1B10 | NA | AKR1B10 Entrez, Source | aldo-keto reductase family 1, member B10 (aldose reductase) | 10550 | -0.450 | -0.6081 | Yes |
| 10 | EHHADH | NA | EHHADH Entrez, Source | enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase | 10749 | -0.483 | -0.5974 | Yes |
| 11 | ALDH9A1 | NA | ALDH9A1 Entrez, Source | aldehyde dehydrogenase 9 family, member A1 | 10955 | -0.519 | -0.5853 | Yes |
| 12 | OXCT2 | NA | OXCT2 Entrez, Source | 3-oxoacid CoA transferase 2 | 11125 | -0.550 | -0.5691 | Yes |
| 13 | AACS | NA | AACS Entrez, Source | acetoacetyl-CoA synthetase | 11211 | -0.566 | -0.5459 | Yes |
| 14 | HADH | NA | HADH Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase | 11456 | -0.615 | -0.5317 | Yes |
| 15 | ECHS1 | NA | ECHS1 Entrez, Source | enoyl Coenzyme A hydratase, short chain, 1, mitochondrial | 11963 | -0.742 | -0.5299 | Yes |
| 16 | ALDH7A1 | NA | ALDH7A1 Entrez, Source | aldehyde dehydrogenase 7 family, member A1 | 12010 | -0.760 | -0.4938 | Yes |
| 17 | HADHA | NA | HADHA Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit | 12220 | -0.825 | -0.4661 | Yes |
| 18 | PDHB | NA | PDHB Entrez, Source | pyruvate dehydrogenase (lipoamide) beta | 12302 | -0.852 | -0.4278 | Yes |
| 19 | HMGCL | NA | HMGCL Entrez, Source | 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) | 12509 | -0.943 | -0.3938 | Yes |
| 20 | OXCT1 | NA | OXCT1 Entrez, Source | 3-oxoacid CoA transferase 1 | 12517 | -0.947 | -0.3453 | Yes |
| 21 | ABAT | NA | ABAT Entrez, Source | 4-aminobutyrate aminotransferase | 12624 | -0.996 | -0.3013 | Yes |
| 22 | ACAT2 | NA | ACAT2 Entrez, Source | acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) | 12819 | -1.099 | -0.2584 | Yes |
| 23 | ACADS | NA | ACADS Entrez, Source | acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain | 12961 | -1.190 | -0.2069 | Yes |
| 24 | BDH2 | NA | BDH2 Entrez, Source | 3-hydroxybutyrate dehydrogenase, type 2 | 12982 | -1.203 | -0.1460 | Yes |
| 25 | ALDH2 | NA | ALDH2 Entrez, Source | aldehyde dehydrogenase 2 family (mitochondrial) | 13109 | -1.302 | -0.0877 | Yes |
| 26 | ACSM3 | NA | ACSM3 Entrez, Source | acyl-CoA synthetase medium-chain family member 3 | 13112 | -1.305 | -0.0202 | Yes |
| 27 | ACAT1 | NA | ACAT1 Entrez, Source | acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) | 13202 | -1.396 | 0.0458 | Yes |
