Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1gfp
GeneSetKEGG_ALZHEIMERS_DISEASE
Enrichment Score (ES)-0.53713477
Normalized Enrichment Score (NES)-2.1006236
Nominal p-value0.0
FDR q-value0.0
FWER p-Value0.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: KEGG_ALZHEIMERS_DISEASE   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1CAPN2NACAPN2
Entrez,  Source
calpain 2, (m/II) large subunit4991.315-0.0211No
2PLCB4NAPLCB4
Entrez,  Source
phospholipase C, beta 45461.259-0.0098No
3GRIN2DNAGRIN2D
Entrez,  Source
glutamate receptor, ionotropic, N-methyl D-aspartate 2D7681.037-0.0138No
4COX6B2NACOX6B2
Entrez,  Source
cytochrome c oxidase subunit VIb polypeptide 2 (testis)8790.955-0.0107No
5TNFRSF1ANATNFRSF1A
Entrez,  Source
tumor necrosis factor receptor superfamily, member 1A10790.859-0.0152No
6FADDNAFADD
Entrez,  Source
Fas (TNFRSF6)-associated via death domain17270.651-0.0549No
7NOS1NANOS1
Entrez,  Source
nitric oxide synthase 1 (neuronal)20410.580-0.0709No
8ITPR3NAITPR3
Entrez,  Source
inositol 1,4,5-triphosphate receptor, type 322140.548-0.0771No
9ITPR2NAITPR2
Entrez,  Source
inositol 1,4,5-triphosphate receptor, type 224100.514-0.0854No
10CASP3NACASP3
Entrez,  Source
caspase 3, apoptosis-related cysteine peptidase25460.492-0.0895No
11IL1BNAIL1B
Entrez,  Source
interleukin 1, beta25810.487-0.0863No
12NAE1NA30770.411-0.1176No
13PPP3CCNAPPP3CC
Entrez,  Source
protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma)30800.411-0.1130No
14ADAM17NAADAM17
Entrez,  Source
ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme)33150.381-0.1256No
15FASNAFAS
Entrez,  Source
Fas (TNF receptor superfamily, member 6)34570.360-0.1317No
16ERN1NAERN1
Entrez,  Source
endoplasmic reticulum to nucleus signalling 134600.359-0.1277No
17PPP3R1NAPPP3R1
Entrez,  Source
protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)37500.328-0.1449No
18CASP7NACASP7
Entrez,  Source
caspase 7, apoptosis-related cysteine peptidase37570.327-0.1416No
19ATP2A2NAATP2A2
Entrez,  Source
ATPase, Ca++ transporting, cardiac muscle, slow twitch 237680.325-0.1385No
20CDK5R1NACDK5R1
Entrez,  Source
cyclin-dependent kinase 5, regulatory subunit 1 (p35)41300.284-0.1615No
21NDUFB10NANDUFB10
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa43600.259-0.1752No
22CASP8NACASP8
Entrez,  Source
caspase 8, apoptosis-related cysteine peptidase50430.187-0.2228No
23ADAM10NAADAM10
Entrez,  Source
ADAM metallopeptidase domain 1051650.175-0.2296No
24CALM2NACALM2
Entrez,  Source
calmodulin 2 (phosphorylase kinase, delta)52240.169-0.2319No
25PSEN1NAPSEN1
Entrez,  Source
presenilin 1 (Alzheimer disease 3)53610.155-0.2400No
26HSD17B10NA61770.069-0.2987No
27ATF6NAATF6
Entrez,  Source
activating transcription factor 663310.055-0.3093No
28PSEN2NAPSEN2
Entrez,  Source
presenilin 2 (Alzheimer disease 4)64480.043-0.3172No
29CAPN1NACAPN1
Entrez,  Source
calpain 1, (mu/I) large subunit64670.042-0.3181No
30APPNAAPP
Entrez,  Source
amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)66520.022-0.3312No
31APH1ANAAPH1A
Entrez,  Source
anterior pharynx defective 1 homolog A (C. elegans)6934-0.008-0.3517No
32CALM3NACALM3
Entrez,  Source
calmodulin 3 (phosphorylase kinase, delta)7094-0.022-0.3630No
33NCSTNNANCSTN
Entrez,  Source
nicastrin7131-0.026-0.3653No
34CDK5NACDK5
Entrez,  Source
cyclin-dependent kinase 57175-0.030-0.3681No
35CALM1NACALM1
Entrez,  Source
calmodulin 1 (phosphorylase kinase, delta)7251-0.040-0.3731No
36ATP5DNAATP5D
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit7257-0.040-0.3730No
37MAPTNAMAPT
Entrez,  Source
microtubule-associated protein tau7280-0.043-0.3741No
38NDUFV3NANDUFV3
Entrez,  Source
NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa7412-0.057-0.3830No
39GRIN2CNAGRIN2C
Entrez,  Source
glutamate receptor, ionotropic, N-methyl D-aspartate 2C7537-0.070-0.3913No
40IDENAIDE
Entrez,  Source
insulin-degrading enzyme7554-0.071-0.3916No
41UQCR11NA7644-0.079-0.3972No
42PPP3CANAPPP3CA
Entrez,  Source
protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha)7776-0.092-0.4057No
43NDUFB7NANDUFB7
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa7777-0.092-0.4046No
44NDUFB9NANDUFB9
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa7937-0.107-0.4149No
45PSENENNAPSENEN
Entrez,  Source
presenilin enhancer 2 homolog (C. elegans)8118-0.127-0.4266No
46APAF1NAAPAF1
Entrez,  Source
apoptotic peptidase activating factor8206-0.138-0.4313No
47GAPDHNAGAPDH
Entrez,  Source
glyceraldehyde-3-phosphate dehydrogenase8442-0.162-0.4466No
48UQCRFS1NAUQCRFS1
Entrez,  Source
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 18783-0.200-0.4691No
49NDUFV2NANDUFV2
Entrez,  Source
NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa8825-0.206-0.4697No
50GSK3BNAGSK3B
Entrez,  Source
glycogen synthase kinase 3 beta8844-0.207-0.4686No
51RYR3NARYR3
Entrez,  Source
ryanodine receptor 38878-0.212-0.4685No
52BIDNABID
Entrez,  Source
BH3 interacting domain death agonist8885-0.213-0.4665No
53MAPK1NAMAPK1
Entrez,  Source
mitogen-activated protein kinase 18973-0.222-0.4702No
54NDUFA8NANDUFA8
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa9017-0.228-0.4707No
55NDUFS7NANDUFS7
Entrez,  Source
NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)9133-0.241-0.4763No
56BADNABAD
Entrez,  Source
BCL2-antagonist of cell death9149-0.244-0.4745No
57COX7A2LNACOX7A2L
Entrez,  Source
cytochrome c oxidase subunit VIIa polypeptide 2 like9489-0.293-0.4959No
58NDUFB2NANDUFB2
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa9548-0.300-0.4966No
59NDUFAB1NANDUFAB1
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa9593-0.305-0.4963No
60NDUFS8NANDUFS8
Entrez,  Source
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)9879-0.348-0.5130No
61NDUFS3NANDUFS3
Entrez,  Source
NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)9933-0.354-0.5127No
62BACE1NABACE1
Entrez,  Source
beta-site APP-cleaving enzyme 110048-0.372-0.5167No
63PPP3CBNAPPP3CB
Entrez,  Source
protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)10191-0.392-0.5225No
64NDUFA10NANDUFA10
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa10387-0.425-0.5318No
65SDHBNASDHB
Entrez,  Source
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)10461-0.436-0.5320Yes
66NDUFS4NANDUFS4
Entrez,  Source
NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)10470-0.437-0.5275Yes
67COX5ANACOX5A
Entrez,  Source
cytochrome c oxidase subunit Va10523-0.445-0.5261Yes
68ATP5C1NAATP5C1
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 110643-0.467-0.5294Yes
69UQCRC1NAUQCRC1
Entrez,  Source
ubiquinol-cytochrome c reductase core protein I10695-0.475-0.5276Yes
70GRIN2ANAGRIN2A
Entrez,  Source
glutamate receptor, ionotropic, N-methyl D-aspartate 2A10758-0.485-0.5264Yes
71ATP5G3NAATP5G3
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)10759-0.485-0.5208Yes
72COX4I1NACOX4I1
Entrez,  Source
cytochrome c oxidase subunit IV isoform 110760-0.485-0.5151Yes
73CYCSNACYCS
Entrez,  Source
cytochrome c, somatic10864-0.504-0.5168Yes
74CHP2NA10871-0.505-0.5113Yes
75SDHCNASDHC
Entrez,  Source
succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa10930-0.514-0.5095Yes
76ATP5G2NAATP5G2
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9)10959-0.520-0.5055Yes
77NDUFC2NANDUFC2
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa10967-0.521-0.5000Yes
78NDUFS6NANDUFS6
Entrez,  Source
NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)11041-0.535-0.4990Yes
79GRIN1NAGRIN1
Entrez,  Source
glutamate receptor, ionotropic, N-methyl D-aspartate 111077-0.542-0.4953Yes
80PLCB3NAPLCB3
Entrez,  Source
phospholipase C, beta 3 (phosphatidylinositol-specific)11157-0.555-0.4946Yes
81CYC1NACYC1
Entrez,  Source
cytochrome c-111222-0.567-0.4926Yes
82NDUFS5NANDUFS5
Entrez,  Source
NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)11285-0.582-0.4904Yes
83ATP5HNAATP5H
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d11314-0.588-0.4855Yes
84NDUFA9NANDUFA9
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa11386-0.600-0.4837Yes
85GNAQNAGNAQ
Entrez,  Source
guanine nucleotide binding protein (G protein), q polypeptide11449-0.615-0.4811Yes
86NDUFC1NANDUFC1
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa11496-0.623-0.4772Yes
87UQCRQNAUQCRQ
Entrez,  Source
ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa11614-0.653-0.4781Yes
88NDUFS2NANDUFS2
Entrez,  Source
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)11651-0.660-0.4730Yes
89NDUFA3NANDUFA3
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa11706-0.672-0.4691Yes
90NDUFA1NANDUFA1
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa11714-0.675-0.4618Yes
91NDUFA6NANDUFA6
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa11745-0.684-0.4560Yes
92ATP5ONAATP5O
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (oligomycin sensitivity conferring protein)11766-0.689-0.4494Yes
93COX6A1NACOX6A1
Entrez,  Source
cytochrome c oxidase subunit VIa polypeptide 111769-0.690-0.4415Yes
94ATP5G1NAATP5G1
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9)11772-0.691-0.4336Yes
95COX6CNACOX6C
Entrez,  Source
cytochrome c oxidase subunit VIc11796-0.698-0.4271Yes
96NDUFS1NANDUFS1
Entrez,  Source
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)11893-0.722-0.4257Yes
97ATP5BNAATP5B
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide11967-0.744-0.4224Yes
98NDUFB8NANDUFB8
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa12008-0.759-0.4164Yes
99ATP5F1NAATP5F1
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B112053-0.772-0.4106Yes
100NDUFA2NANDUFA2
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa12064-0.777-0.4023Yes
101UQCR10NA12066-0.777-0.3933Yes
102COX6B1NACOX6B1
Entrez,  Source
cytochrome c oxidase subunit Vib polypeptide 1 (ubiquitous)12086-0.781-0.3856Yes
103EIF2AK3NAEIF2AK3
Entrez,  Source
eukaryotic translation initiation factor 2-alpha kinase 312089-0.781-0.3766Yes
104NDUFB6NANDUFB6
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa12106-0.789-0.3686Yes
105NDUFA4NANDUFA4
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa12145-0.803-0.3620Yes
106UQCRHNAUQCRH
Entrez,  Source
ubiquinol-cytochrome c reductase hinge protein12158-0.807-0.3534Yes
107SDHDNASDHD
Entrez,  Source
succinate dehydrogenase complex, subunit D, integral membrane protein12186-0.815-0.3459Yes
108NDUFB3NANDUFB3
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa12187-0.815-0.3364Yes
109NDUFV1NANDUFV1
Entrez,  Source
NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa12219-0.825-0.3290Yes
110COX8ANACOX8A
Entrez,  Source
cytochrome c oxidase subunit 8A (ubiquitous)12241-0.834-0.3208Yes
111ATP5JNAATP5J
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F612254-0.837-0.3119Yes
112NDUFB4NANDUFB4
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa12267-0.842-0.3030Yes
113NDUFA5NANDUFA5
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa12296-0.850-0.2951Yes
114PLCB2NAPLCB2
Entrez,  Source
phospholipase C, beta 212339-0.869-0.2881Yes
115LPLNALPL
Entrez,  Source
lipoprotein lipase12381-0.886-0.2807Yes
116NDUFA7NANDUFA7
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa12408-0.895-0.2722Yes
117COX7A2NACOX7A2
Entrez,  Source
cytochrome c oxidase subunit VIIa polypeptide 2 (liver)12409-0.895-0.2617Yes
118ATP5A1NAATP5A1
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle12430-0.907-0.2526Yes
119UQCRBNAUQCRB
Entrez,  Source
ubiquinol-cytochrome c reductase binding protein12456-0.921-0.2437Yes
120NDUFA4L2NANDUFA4L2
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 212458-0.922-0.2330Yes
121BACE2NABACE2
Entrez,  Source
beta-site APP-cleaving enzyme 212468-0.925-0.2229Yes
122COX7CNACOX7C
Entrez,  Source
cytochrome c oxidase subunit VIIc12481-0.929-0.2129Yes
123NDUFB1NANDUFB1
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa12642-1.007-0.2129Yes
124ATP2A1NAATP2A1
Entrez,  Source
ATPase, Ca++ transporting, cardiac muscle, fast twitch 112821-1.099-0.2130Yes
125SDHANASDHA
Entrez,  Source
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)12856-1.123-0.2024Yes
126COX5BNACOX5B
Entrez,  Source
cytochrome c oxidase subunit Vb12858-1.125-0.1894Yes
127NDUFB5NANDUFB5
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa12869-1.132-0.1769Yes
128CACNA1DNACACNA1D
Entrez,  Source
calcium channel, voltage-dependent, L type, alpha 1D subunit12921-1.162-0.1671Yes
129COX7BNACOX7B
Entrez,  Source
cytochrome c oxidase subunit VIIb12976-1.199-0.1570Yes
130UQCRC2NAUQCRC2
Entrez,  Source
ubiquinol-cytochrome c reductase core protein II12985-1.203-0.1436Yes
131UQCRHLNA12995-1.213-0.1301Yes
132MAPK3NAMAPK3
Entrez,  Source
mitogen-activated protein kinase 313226-1.426-0.1302Yes
133LRP1NALRP1
Entrez,  Source
low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)13358-1.589-0.1212Yes
134SNCANASNCA
Entrez,  Source
synuclein, alpha (non A4 component of amyloid precursor)13431-1.703-0.1066Yes
135ATP2A3NAATP2A3
Entrez,  Source
ATPase, Ca++ transporting, ubiquitous13584-2.022-0.0941Yes
136ITPR1NAITPR1
Entrez,  Source
inositol 1,4,5-triphosphate receptor, type 113645-2.228-0.0725Yes
137MMENAMME
Entrez,  Source
membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase)13674-2.360-0.0470Yes
138CASP9NACASP9
Entrez,  Source
caspase 9, apoptosis-related cysteine peptidase13696-2.469-0.0198Yes
139PLCB1NAPLCB1
Entrez,  Source
phospholipase C, beta 1 (phosphoinositide-specific)13705-2.5530.0094Yes
Table: GSEA details [plain text format]



Fig 2: KEGG_ALZHEIMERS_DISEASE   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: KEGG_ALZHEIMERS_DISEASE: Random ES distribution   
Gene set null distribution of ES for KEGG_ALZHEIMERS_DISEASE