Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1gfp
GeneSetHALLMARK_XENOBIOTIC_METABOLISM
Enrichment Score (ES)-0.3540799
Normalized Enrichment Score (NES)-1.4138869
Nominal p-value0.013867488
FDR q-value0.06392709
FWER p-Value0.542
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_XENOBIOTIC_METABOLISM   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1ACOX2NAACOX2
Entrez,  Source
acyl-Coenzyme A oxidase 2, branched chain423.7740.0300No
2SERPINE1NASERPINE1
Entrez,  Source
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 11092.8400.0501No
3CYP1A1NACYP1A1
Entrez,  Source
cytochrome P450, family 1, subfamily A, polypeptide 11222.6640.0725No
4EPHA2NAEPHA2
Entrez,  Source
EPH receptor A21962.2510.0869No
5IGFBP4NAIGFBP4
Entrez,  Source
insulin-like growth factor binding protein 42671.8880.0984No
6CFBNACFB
Entrez,  Source
complement factor B2821.8040.1131No
7SERTAD1NASERTAD1
Entrez,  Source
SERTA domain containing 13181.7140.1256No
8MT2ANAMT2A
Entrez,  Source
metallothionein 2A4081.4930.1322No
9AOX1NAAOX1
Entrez,  Source
aldehyde oxidase 14491.4090.1416No
10IL1R1NAIL1R1
Entrez,  Source
interleukin 1 receptor, type I5601.2290.1443No
11UGDHNAUGDH
Entrez,  Source
UDP-glucose dehydrogenase5771.2040.1537No
12ACSM1NAACSM1
Entrez,  Source
acyl-CoA synthetase medium-chain family member 16711.1210.1568No
13PTGESNAPTGES
Entrez,  Source
prostaglandin E synthase6901.1070.1651No
14BCAR1NABCAR1
Entrez,  Source
breast cancer anti-estrogen resistance 17611.0400.1691No
15MAOANAMAOA
Entrez,  Source
monoamine oxidase A8550.9750.1709No
16AP4B1NAAP4B1
Entrez,  Source
adaptor-related protein complex 4, beta 1 subunit10510.8710.1643No
17TNFRSF1ANATNFRSF1A
Entrez,  Source
tumor necrosis factor receptor superfamily, member 1A10790.8590.1698No
18PDLIM5NAPDLIM5
Entrez,  Source
PDZ and LIM domain 512690.7890.1629No
19ANGPTL3NAANGPTL3
Entrez,  Source
angiopoietin-like 312790.7830.1691No
20GSTM4NAGSTM4
Entrez,  Source
glutathione S-transferase M414700.7240.1616No
21GCLCNAGCLC
Entrez,  Source
glutamate-cysteine ligase, catalytic subunit14960.7170.1660No
22SLC1A5NASLC1A5
Entrez,  Source
solute carrier family 1 (neutral amino acid transporter), member 516240.6810.1627No
23GCNT2NAGCNT2
Entrez,  Source
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)16510.6750.1667No
24NPC1NANPC1
Entrez,  Source
Niemann-Pick disease, type C118530.6190.1575No
25PSMB10NAPSMB10
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 1020300.5810.1497No
26PPARDNAPPARD
Entrez,  Source
peroxisome proliferative activated receptor, delta20850.5710.1508No
27ALAS1NAALAS1
Entrez,  Source
aminolevulinate, delta-, synthase 121050.5690.1544No
28CNDP2NACNDP2
Entrez,  Source
CNDP dipeptidase 2 (metallopeptidase M20 family)22390.5430.1494No
29SLC35B1NASLC35B1
Entrez,  Source
solute carrier family 35, member B125290.4960.1326No
30ABCC2NAABCC2
Entrez,  Source
ATP-binding cassette, sub-family C (CFTR/MRP), member 226130.4820.1308No
31KARSNAKARS
Entrez,  Source
lysyl-tRNA synthetase32190.3900.0900No
32FASNAFAS
Entrez,  Source
Fas (TNF receptor superfamily, member 6)34570.3600.0758No
33ALDH3A1NAALDH3A1
Entrez,  Source
aldehyde dehydrogenase 3 family, memberA134800.3560.0773No
34SLC6A12NASLC6A12
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 1236450.3380.0683No
35ATP2A2NAATP2A2
Entrez,  Source
ATPase, Ca++ transporting, cardiac muscle, slow twitch 237680.3250.0622No
36SLC35D1NASLC35D1
Entrez,  Source
solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D145170.2410.0097No
37ENTPD5NAENTPD5
Entrez,  Source
ectonucleoside triphosphate diphosphohydrolase 545360.2380.0104No
38SSR3NASSR3
Entrez,  Source
signal sequence receptor, gamma (translocon-associated protein gamma)45520.2370.0114No
39PTGES3NAPTGES3
Entrez,  Source
prostaglandin E synthase 3 (cytosolic)45560.2360.0133No
40TGFB2NATGFB2
Entrez,  Source
transforming growth factor, beta 247310.2190.0025No
41PEMTNAPEMT
Entrez,  Source
phosphatidylethanolamine N-methyltransferase47820.2140.0007No
42PTSNAPTS
Entrez,  Source
6-pyruvoyltetrahydropterin synthase51880.172-0.0274No
43NQO1NANQO1
Entrez,  Source
NAD(P)H dehydrogenase, quinone 152650.165-0.0315No
44GCH1NAGCH1
Entrez,  Source
GTP cyclohydrolase 1 (dopa-responsive dystonia)53040.161-0.0329No
45SAR1BNASAR1B
Entrez,  Source
SAR1 gene homolog B (S. cerevisiae)53520.156-0.0350No
46SMOXNASMOX
Entrez,  Source
spermine oxidase54120.149-0.0380No
47HACL1NAHACL1
Entrez,  Source
2-hydroxyacyl-CoA lyase 155120.138-0.0440No
48NMT1NANMT1
Entrez,  Source
N-myristoyltransferase 155350.136-0.0444No
49GNMTNAGNMT
Entrez,  Source
glycine N-methyltransferase55960.128-0.0477No
50GARTNAGART
Entrez,  Source
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase56470.122-0.0502No
51HMOX1NAHMOX1
Entrez,  Source
heme oxygenase (decycling) 158040.107-0.0607No
52FAHNAFAH
Entrez,  Source
fumarylacetoacetate hydrolase (fumarylacetoacetase)58190.105-0.0608No
53GSRNAGSR
Entrez,  Source
glutathione reductase62310.064-0.0903No
54RETSATNARETSAT
Entrez,  Source
retinol saturase (all-trans-retinol 13,14-reductase)63620.053-0.0993No
55AHCYNAAHCY
Entrez,  Source
S-adenosylhomocysteine hydrolase63970.050-0.1014No
56SLC12A4NASLC12A4
Entrez,  Source
solute carrier family 12 (potassium/chloride transporters), member 463980.049-0.1010No
57CBR1NACBR1
Entrez,  Source
carbonyl reductase 164980.039-0.1079No
58GSTO1NAGSTO1
Entrez,  Source
glutathione S-transferase omega 165490.033-0.1112No
59HPRT1NAHPRT1
Entrez,  Source
hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome)67760.009-0.1277No
60COMTNACOMT
Entrez,  Source
catechol-O-methyltransferase68410.002-0.1323No
61G6PCNAG6PC
Entrez,  Source
glucose-6-phosphatase, catalytic subunit6941-0.009-0.1395No
62TATNATAT
Entrez,  Source
tyrosine aminotransferase7085-0.022-0.1497No
63FBP1NAFBP1
Entrez,  Source
fructose-1,6-bisphosphatase 17096-0.022-0.1503No
64ACP2NAACP2
Entrez,  Source
acid phosphatase 2, lysosomal7272-0.041-0.1627No
65SLC6A6NASLC6A6
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter, taurine), member 67305-0.046-0.1646No
66CYP2E1NACYP2E1
Entrez,  Source
cytochrome P450, family 2, subfamily E, polypeptide 17418-0.058-0.1723No
67BCAT1NABCAT1
Entrez,  Source
branched chain aminotransferase 1, cytosolic7455-0.062-0.1744No
68ARPP19NA7535-0.069-0.1796No
69ADH5NAADH5
Entrez,  Source
alcohol dehydrogenase 5 (class III), chi polypeptide7549-0.071-0.1799No
70PAPSS2NAPAPSS2
Entrez,  Source
3'-phosphoadenosine 5'-phosphosulfate synthase 27625-0.078-0.1847No
71LEAP2NALEAP2
Entrez,  Source
liver expressed antimicrobial peptide 27661-0.081-0.1866No
72XDHNAXDH
Entrez,  Source
xanthine dehydrogenase7686-0.083-0.1876No
73CASP6NACASP6
Entrez,  Source
caspase 6, apoptosis-related cysteine peptidase7942-0.108-0.2053No
74PGRMC1NAPGRMC1
Entrez,  Source
progesterone receptor membrane component 17946-0.108-0.2046No
75CROTNACROT
Entrez,  Source
carnitine O-octanoyltransferase8051-0.121-0.2111No
76SPINT2NASPINT2
Entrez,  Source
serine peptidase inhibitor, Kunitz type, 28116-0.127-0.2147No
77TMBIM6NA8150-0.131-0.2159No
78ABHD6NAABHD6
Entrez,  Source
abhydrolase domain containing 68159-0.132-0.2154No
79CDANACDA
Entrez,  Source
cytidine deaminase8171-0.133-0.2150No
80ACP1NAACP1
Entrez,  Source
acid phosphatase 1, soluble8188-0.135-0.2150No
81TMEM97NATMEM97
Entrez,  Source
transmembrane protein 978392-0.157-0.2284No
82ELOVL5NAELOVL5
Entrez,  Source
ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)8468-0.166-0.2325No
83RAP1GAPNARAP1GAP
Entrez,  Source
RAP1 GTPase activating protein8482-0.168-0.2320No
84VNN1NAVNN1
Entrez,  Source
vanin 18859-0.209-0.2576No
85CSADNACSAD
Entrez,  Source
cysteine sulfinic acid decarboxylase8877-0.212-0.2570No
86GSSNAGSS
Entrez,  Source
glutathione synthetase8920-0.216-0.2582No
87ETS2NAETS2
Entrez,  Source
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)8936-0.218-0.2574No
88MTHFD1NAMTHFD1
Entrez,  Source
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase8945-0.220-0.2560No
89PGDNAPGD
Entrez,  Source
phosphogluconate dehydrogenase9072-0.234-0.2632No
90DHRS7NADHRS7
Entrez,  Source
dehydrogenase/reductase (SDR family) member 79330-0.268-0.2796No
91SHMT2NASHMT2
Entrez,  Source
serine hydroxymethyltransferase 2 (mitochondrial)9354-0.272-0.2789No
92LCATNALCAT
Entrez,  Source
lecithin-cholesterol acyltransferase9501-0.295-0.2870No
93ACOX3NAACOX3
Entrez,  Source
acyl-Coenzyme A oxidase 3, pristanoyl9583-0.304-0.2902No
94CYP1A2NACYP1A2
Entrez,  Source
cytochrome P450, family 1, subfamily A, polypeptide 29656-0.315-0.2928No
95PTGDSNAPTGDS
Entrez,  Source
prostaglandin D2 synthase 21kDa (brain)9658-0.315-0.2901No
96MCCC2NAMCCC2
Entrez,  Source
methylcrotonoyl-Coenzyme A carboxylase 2 (beta)9698-0.321-0.2901No
97MPP2NAMPP2
Entrez,  Source
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)9929-0.354-0.3038No
98LPIN2NALPIN2
Entrez,  Source
lipin 210517-0.444-0.3428No
99NFS1NANFS1
Entrez,  Source
NFS1 nitrogen fixation 1 (S. cerevisiae)10588-0.456-0.3439No
100CYP2S1NACYP2S1
Entrez,  Source
cytochrome P450, family 2, subfamily S, polypeptide 110600-0.457-0.3407No
101ESR1NAESR1
Entrez,  Source
estrogen receptor 110623-0.463-0.3383No
102PYCR1NAPYCR1
Entrez,  Source
pyrroline-5-carboxylate reductase 110641-0.466-0.3354No
103EPHX1NAEPHX1
Entrez,  Source
epoxide hydrolase 1, microsomal (xenobiotic)10704-0.476-0.3358No
104ALDH9A1NAALDH9A1
Entrez,  Source
aldehyde dehydrogenase 9 family, member A110955-0.519-0.3495Yes
105JUPNAJUP
Entrez,  Source
junction plakoglobin11011-0.531-0.3489Yes
106DCXRNADCXR
Entrez,  Source
dicarbonyl/L-xylulose reductase11049-0.537-0.3469Yes
107LONP1NA11074-0.541-0.3439Yes
108DHPSNADHPS
Entrez,  Source
deoxyhypusine synthase11084-0.543-0.3398Yes
109NINJ1NANINJ1
Entrez,  Source
ninjurin 111112-0.548-0.3370Yes
110CYP27A1NACYP27A1
Entrez,  Source
cytochrome P450, family 27, subfamily A, polypeptide 111221-0.567-0.3399Yes
111ASLNAASL
Entrez,  Source
argininosuccinate lyase11227-0.568-0.3353Yes
112GABARAPL1NAGABARAPL1
Entrez,  Source
GABA(A) receptor-associated protein like 111242-0.573-0.3313Yes
113ARG2NAARG2
Entrez,  Source
arginase, type II11318-0.590-0.3316Yes
114IGF1NAIGF1
Entrez,  Source
insulin-like growth factor 1 (somatomedin C)11398-0.605-0.3321Yes
115ACOX1NAACOX1
Entrez,  Source
acyl-Coenzyme A oxidase 1, palmitoyl11472-0.619-0.3320Yes
116BPHLNABPHL
Entrez,  Source
biphenyl hydrolase-like (serine hydrolase; breast epithelial mucin-associated antigen)11508-0.625-0.3291Yes
117HES6NAHES6
Entrez,  Source
hairy and enhancer of split 6 (Drosophila)11585-0.644-0.3290Yes
118KYNUNAKYNU
Entrez,  Source
kynureninase (L-kynurenine hydrolase)11707-0.673-0.3319Yes
119MARCH6NAMARCH6
Entrez,  Source
membrane-associated ring finger (C3HC4) 611842-0.710-0.3355Yes
120HNF4ANAHNF4A
Entrez,  Source
hepatocyte nuclear factor 4, alpha11862-0.714-0.3306Yes
121FBLN1NAFBLN1
Entrez,  Source
fibulin 111872-0.716-0.3250Yes
122DDTNADDT
Entrez,  Source
D-dopachrome tautomerase11882-0.721-0.3193Yes
123F10NAF10
Entrez,  Source
coagulation factor X11889-0.721-0.3135Yes
124CD36NACD36
Entrez,  Source
CD36 molecule (thrombospondin receptor)11998-0.756-0.3147Yes
125ACO2NAACO2
Entrez,  Source
aconitase 2, mitochondrial12178-0.814-0.3207Yes
126ITIH4NAITIH4
Entrez,  Source
inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)12300-0.852-0.3221Yes
127ETFDHNAETFDH
Entrez,  Source
electron-transferring-flavoprotein dehydrogenase12412-0.897-0.3223Yes
128PORNAPOR
Entrez,  Source
P450 (cytochrome) oxidoreductase12492-0.933-0.3199Yes
129TTPANATTPA
Entrez,  Source
tocopherol (alpha) transfer protein (ataxia (Friedreich-like) with vitamin E deficiency)12501-0.938-0.3123Yes
130BLVRBNABLVRB
Entrez,  Source
biliverdin reductase B (flavin reductase (NADPH))12510-0.944-0.3046Yes
131PTGR1NA12612-0.986-0.3033Yes
132PMM1NAPMM1
Entrez,  Source
phosphomannomutase 112678-1.026-0.2991Yes
133MAN1A1NAMAN1A1
Entrez,  Source
mannosidase, alpha, class 1A, member 112929-1.168-0.3071Yes
134DDAH2NADDAH2
Entrez,  Source
dimethylarginine dimethylaminohydrolase 212972-1.198-0.2997Yes
135ABCC3NAABCC3
Entrez,  Source
ATP-binding cassette, sub-family C (CFTR/MRP), member 313021-1.235-0.2924Yes
136DDCNADDC
Entrez,  Source
dopa decarboxylase (aromatic L-amino acid decarboxylase)13079-1.282-0.2853Yes
137IDH1NAIDH1
Entrez,  Source
isocitrate dehydrogenase 1 (NADP+), soluble13083-1.285-0.2743Yes
138ALDH2NAALDH2
Entrez,  Source
aldehyde dehydrogenase 2 family (mitochondrial)13109-1.302-0.2647Yes
139PINK1NAPINK1
Entrez,  Source
PTEN induced putative kinase 113178-1.374-0.2576Yes
140PDK4NAPDK4
Entrez,  Source
pyruvate dehydrogenase kinase, isozyme 413233-1.433-0.2490Yes
141SLC22A1NASLC22A1
Entrez,  Source
solute carrier family 22 (organic cation transporter), member 113309-1.528-0.2411Yes
142ECH1NAECH1
Entrez,  Source
enoyl Coenzyme A hydratase 1, peroxisomal13349-1.579-0.2301Yes
143DHRS1NADHRS1
Entrez,  Source
dehydrogenase/reductase (SDR family) member 113399-1.648-0.2192Yes
144CYP2C18NACYP2C18
Entrez,  Source
cytochrome P450, family 2, subfamily C, polypeptide 1813427-1.692-0.2064Yes
145PLGNAPLG
Entrez,  Source
plasminogen13466-1.757-0.1938Yes
146CATNACAT
Entrez,  Source
catalase13474-1.769-0.1788Yes
147PROS1NAPROS1
Entrez,  Source
protein S (alpha)13569-1.987-0.1682Yes
148PCNAPC
Entrez,  Source
pyruvate carboxylase13641-2.224-0.1539Yes
149ATOH8NAATOH8
Entrez,  Source
atonal homolog 8 (Drosophila)13652-2.271-0.1347Yes
150ID2NAID2
Entrez,  Source
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein13694-2.466-0.1161Yes
151CES1NACES1
Entrez,  Source
carboxylesterase 1 (monocyte/macrophage serine esterase 1)13727-2.702-0.0948Yes
152VTNNAVTN
Entrez,  Source
vitronectin13776-3.164-0.0706Yes
153NDRG2NANDRG2
Entrez,  Source
NDRG family member 213800-3.735-0.0395Yes
154ENPEPNAENPEP
Entrez,  Source
glutamyl aminopeptidase (aminopeptidase A)13832-4.7830.0001Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_XENOBIOTIC_METABOLISM   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_XENOBIOTIC_METABOLISM: Random ES distribution   
Gene set null distribution of ES for HALLMARK_XENOBIOTIC_METABOLISM