Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | HALLMARK_WNT_BETA_CATENIN_SIGNALING |
| Enrichment Score (ES) | -0.40961048 |
| Normalized Enrichment Score (NES) | -1.2796165 |
| Nominal p-value | 0.12962963 |
| FDR q-value | 0.16087374 |
| FWER p-Value | 0.924 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | DKK1 | NA | DKK1 Entrez, Source | dickkopf homolog 1 (Xenopus laevis) | 175 | 2.353 | 0.0821 | No |
| 2 | JAG1 | NA | JAG1 Entrez, Source | jagged 1 (Alagille syndrome) | 432 | 1.447 | 0.1218 | No |
| 3 | NOTCH1 | NA | NOTCH1 Entrez, Source | Notch homolog 1, translocation-associated (Drosophila) | 971 | 0.909 | 0.1194 | No |
| 4 | AXIN1 | NA | AXIN1 Entrez, Source | axin 1 | 1825 | 0.627 | 0.0828 | No |
| 5 | PPARD | NA | PPARD Entrez, Source | peroxisome proliferative activated receptor, delta | 2085 | 0.571 | 0.0870 | No |
| 6 | JAG2 | NA | JAG2 Entrez, Source | jagged 2 | 2112 | 0.567 | 0.1080 | No |
| 7 | MAML1 | NA | MAML1 Entrez, Source | mastermind-like 1 (Drosophila) | 2616 | 0.482 | 0.0909 | No |
| 8 | NOTCH4 | NA | NOTCH4 Entrez, Source | Notch homolog 4 (Drosophila) | 2650 | 0.476 | 0.1077 | No |
| 9 | KAT2A | NA | 3062 | 0.413 | 0.0945 | No | ||
| 10 | ADAM17 | NA | ADAM17 Entrez, Source | ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) | 3315 | 0.381 | 0.0916 | No |
| 11 | CUL1 | NA | CUL1 Entrez, Source | cullin 1 | 4403 | 0.253 | 0.0230 | No |
| 12 | HDAC2 | NA | HDAC2 Entrez, Source | histone deacetylase 2 | 5155 | 0.176 | -0.0244 | No |
| 13 | RBPJ | NA | 6311 | 0.057 | -0.1058 | No | ||
| 14 | PSEN2 | NA | PSEN2 Entrez, Source | presenilin 2 (Alzheimer disease 4) | 6448 | 0.043 | -0.1139 | No |
| 15 | PTCH1 | NA | PTCH1 Entrez, Source | patched homolog 1 (Drosophila) | 6709 | 0.016 | -0.1321 | No |
| 16 | GNAI1 | NA | GNAI1 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 6771 | 0.010 | -0.1361 | No |
| 17 | HEY2 | NA | HEY2 Entrez, Source | hairy/enhancer-of-split related with YRPW motif 2 | 6946 | -0.009 | -0.1484 | No |
| 18 | NCOR2 | NA | NCOR2 Entrez, Source | nuclear receptor co-repressor 2 | 7018 | -0.016 | -0.1529 | No |
| 19 | NCSTN | NA | NCSTN Entrez, Source | nicastrin | 7131 | -0.026 | -0.1599 | No |
| 20 | FZD1 | NA | FZD1 Entrez, Source | frizzled homolog 1 (Drosophila) | 8193 | -0.136 | -0.2314 | No |
| 21 | NUMB | NA | NUMB Entrez, Source | numb homolog (Drosophila) | 8747 | -0.197 | -0.2635 | No |
| 22 | CCND2 | NA | CCND2 Entrez, Source | cyclin D2 | 8965 | -0.222 | -0.2703 | No |
| 23 | AXIN2 | NA | AXIN2 Entrez, Source | axin 2 (conductin, axil) | 9316 | -0.265 | -0.2850 | No |
| 24 | CSNK1E | NA | CSNK1E Entrez, Source | casein kinase 1, epsilon | 9603 | -0.307 | -0.2934 | No |
| 25 | MYC | NA | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 9860 | -0.346 | -0.2980 | No |
| 26 | SKP2 | NA | SKP2 Entrez, Source | S-phase kinase-associated protein 2 (p45) | 10198 | -0.395 | -0.3065 | No |
| 27 | NKD1 | NA | NKD1 Entrez, Source | naked cuticle homolog 1 (Drosophila) | 11238 | -0.572 | -0.3588 | No |
| 28 | DVL2 | NA | DVL2 Entrez, Source | dishevelled, dsh homolog 2 (Drosophila) | 11740 | -0.681 | -0.3677 | Yes |
| 29 | CTNNB1 | NA | CTNNB1 Entrez, Source | catenin (cadherin-associated protein), beta 1, 88kDa | 12021 | -0.762 | -0.3573 | Yes |
| 30 | TP53 | NA | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 12744 | -1.059 | -0.3670 | Yes |
| 31 | HDAC11 | NA | HDAC11 Entrez, Source | histone deacetylase 11 | 13059 | -1.266 | -0.3388 | Yes |
| 32 | HDAC5 | NA | HDAC5 Entrez, Source | histone deacetylase 5 | 13248 | -1.448 | -0.2941 | Yes |
| 33 | HEY1 | NA | HEY1 Entrez, Source | hairy/enhancer-of-split related with YRPW motif 1 | 13321 | -1.539 | -0.2373 | Yes |
| 34 | TCF7 | NA | TCF7 Entrez, Source | transcription factor 7 (T-cell specific, HMG-box) | 13616 | -2.115 | -0.1735 | Yes |
| 35 | FRAT1 | NA | FRAT1 Entrez, Source | frequently rearranged in advanced T-cell lymphomas | 13669 | -2.334 | -0.0833 | Yes |
| 36 | WNT6 | NA | WNT6 Entrez, Source | wingless-type MMTV integration site family, member 6 | 13676 | -2.364 | 0.0115 | Yes |
