Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | HALLMARK_UV_RESPONSE_UP |
| Enrichment Score (ES) | 0.2773916 |
| Normalized Enrichment Score (NES) | 1.1480336 |
| Nominal p-value | 0.16763006 |
| FDR q-value | 0.2636378 |
| FWER p-Value | 0.97 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | IL6 | NA | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 15 | 4.383 | 0.0538 | Yes |
| 2 | CYP1A1 | NA | CYP1A1 Entrez, Source | cytochrome P450, family 1, subfamily A, polypeptide 1 | 122 | 2.664 | 0.0794 | Yes |
| 3 | CXCL2 | NA | CXCL2 Entrez, Source | chemokine (C-X-C motif) ligand 2 | 162 | 2.420 | 0.1069 | Yes |
| 4 | ICAM1 | NA | ICAM1 Entrez, Source | intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | 251 | 1.952 | 0.1249 | Yes |
| 5 | IRF1 | NA | IRF1 Entrez, Source | interferon regulatory factor 1 | 252 | 1.947 | 0.1493 | Yes |
| 6 | GLS | NA | GLS Entrez, Source | glutaminase | 368 | 1.566 | 0.1605 | Yes |
| 7 | TUBA4A | NA | 599 | 1.183 | 0.1585 | Yes | ||
| 8 | IL6ST | NA | IL6ST Entrez, Source | interleukin 6 signal transducer (gp130, oncostatin M receptor) | 645 | 1.142 | 0.1695 | Yes |
| 9 | TAP1 | NA | TAP1 Entrez, Source | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 686 | 1.112 | 0.1805 | Yes |
| 10 | MAOA | NA | MAOA Entrez, Source | monoamine oxidase A | 855 | 0.975 | 0.1805 | Yes |
| 11 | SOD2 | NA | SOD2 Entrez, Source | superoxide dismutase 2, mitochondrial | 897 | 0.945 | 0.1893 | Yes |
| 12 | PPIF | NA | PPIF Entrez, Source | peptidylprolyl isomerase F (cyclophilin F) | 924 | 0.931 | 0.1991 | Yes |
| 13 | DNAJB1 | NA | DNAJB1 Entrez, Source | DnaJ (Hsp40) homolog, subfamily B, member 1 | 933 | 0.928 | 0.2101 | Yes |
| 14 | DDX21 | NA | DDX21 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 | 958 | 0.917 | 0.2198 | Yes |
| 15 | NAT1 | NA | NAT1 Entrez, Source | N-acetyltransferase 1 (arylamine N-acetyltransferase) | 1009 | 0.890 | 0.2273 | Yes |
| 16 | DNAJA1 | NA | DNAJA1 Entrez, Source | DnaJ (Hsp40) homolog, subfamily A, member 1 | 1115 | 0.845 | 0.2303 | Yes |
| 17 | SQSTM1 | NA | SQSTM1 Entrez, Source | sequestosome 1 | 1130 | 0.838 | 0.2397 | Yes |
| 18 | CLTB | NA | CLTB Entrez, Source | clathrin, light chain (Lcb) | 1142 | 0.834 | 0.2494 | Yes |
| 19 | FOSB | NA | FOSB Entrez, Source | FBJ murine osteosarcoma viral oncogene homolog B | 1266 | 0.789 | 0.2503 | Yes |
| 20 | BAK1 | NA | BAK1 Entrez, Source | BCL2-antagonist/killer 1 | 1345 | 0.758 | 0.2541 | Yes |
| 21 | ASNS | NA | ASNS Entrez, Source | asparagine synthetase | 1436 | 0.735 | 0.2567 | Yes |
| 22 | NFKBIA | NA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 1484 | 0.721 | 0.2623 | Yes |
| 23 | MGAT1 | NA | MGAT1 Entrez, Source | mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase | 1543 | 0.703 | 0.2669 | Yes |
| 24 | FKBP4 | NA | FKBP4 Entrez, Source | FK506 binding protein 4, 59kDa | 1589 | 0.692 | 0.2723 | Yes |
| 25 | MARK2 | NA | MARK2 Entrez, Source | MAP/microtubule affinity-regulating kinase 2 | 1676 | 0.666 | 0.2743 | Yes |
| 26 | PRPF3 | NA | PRPF3 Entrez, Source | PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) | 1814 | 0.629 | 0.2722 | Yes |
| 27 | GRPEL1 | NA | GRPEL1 Entrez, Source | GrpE-like 1, mitochondrial (E. coli) | 1850 | 0.619 | 0.2774 | Yes |
| 28 | C4BPB | NA | C4BPB Entrez, Source | complement component 4 binding protein, beta | 2011 | 0.583 | 0.2730 | No |
| 29 | ALAS1 | NA | ALAS1 Entrez, Source | aminolevulinate, delta-, synthase 1 | 2105 | 0.569 | 0.2734 | No |
| 30 | EIF5 | NA | EIF5 Entrez, Source | eukaryotic translation initiation factor 5 | 2448 | 0.508 | 0.2548 | No |
| 31 | CASP3 | NA | CASP3 Entrez, Source | caspase 3, apoptosis-related cysteine peptidase | 2546 | 0.492 | 0.2538 | No |
| 32 | NXF1 | NA | NXF1 Entrez, Source | nuclear RNA export factor 1 | 2560 | 0.491 | 0.2590 | No |
| 33 | GPX3 | NA | GPX3 Entrez, Source | glutathione peroxidase 3 (plasma) | 2570 | 0.489 | 0.2645 | No |
| 34 | WIZ | NA | WIZ Entrez, Source | - | 2799 | 0.451 | 0.2535 | No |
| 35 | H2AFX | NA | H2AFX Entrez, Source | H2A histone family, member X | 2873 | 0.438 | 0.2537 | No |
| 36 | EIF2S3 | NA | EIF2S3 Entrez, Source | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | 2947 | 0.427 | 0.2537 | No |
| 37 | HSPA13 | NA | 3149 | 0.400 | 0.2440 | No | ||
| 38 | NR4A1 | NA | NR4A1 Entrez, Source | nuclear receptor subfamily 4, group A, member 1 | 3436 | 0.362 | 0.2277 | No |
| 39 | LYN | NA | LYN Entrez, Source | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 3567 | 0.347 | 0.2225 | No |
| 40 | SLC6A12 | NA | SLC6A12 Entrez, Source | solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 | 3645 | 0.338 | 0.2212 | No |
| 41 | APOM | NA | APOM Entrez, Source | apolipoprotein M | 3734 | 0.329 | 0.2189 | No |
| 42 | MMP14 | NA | MMP14 Entrez, Source | matrix metallopeptidase 14 (membrane-inserted) | 3870 | 0.314 | 0.2129 | No |
| 43 | PSMC3 | NA | PSMC3 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 3 | 4033 | 0.294 | 0.2048 | No |
| 44 | STIP1 | NA | STIP1 Entrez, Source | stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein) | 4127 | 0.284 | 0.2016 | No |
| 45 | CHKA | NA | CHKA Entrez, Source | choline kinase alpha | 4235 | 0.273 | 0.1972 | No |
| 46 | MSX1 | NA | MSX1 Entrez, Source | msh homeobox homolog 1 (Drosophila) | 4265 | 0.271 | 0.1984 | No |
| 47 | UROD | NA | UROD Entrez, Source | uroporphyrinogen decarboxylase | 4365 | 0.258 | 0.1945 | No |
| 48 | CDC34 | NA | CDC34 Entrez, Source | cell division cycle 34 | 4404 | 0.253 | 0.1948 | No |
| 49 | CHRNA5 | NA | CHRNA5 Entrez, Source | cholinergic receptor, nicotinic, alpha 5 | 4490 | 0.245 | 0.1917 | No |
| 50 | STARD3 | NA | STARD3 Entrez, Source | START domain containing 3 | 4823 | 0.209 | 0.1701 | No |
| 51 | CYB5B | NA | CYB5B Entrez, Source | cytochrome b5 type B (outer mitochondrial membrane) | 4841 | 0.208 | 0.1714 | No |
| 52 | AMD1 | NA | AMD1 Entrez, Source | adenosylmethionine decarboxylase 1 | 4867 | 0.205 | 0.1722 | No |
| 53 | CYB5R1 | NA | CYB5R1 Entrez, Source | cytochrome b5 reductase 1 | 4989 | 0.193 | 0.1658 | No |
| 54 | POLE3 | NA | POLE3 Entrez, Source | polymerase (DNA directed), epsilon 3 (p17 subunit) | 4990 | 0.193 | 0.1682 | No |
| 55 | COL2A1 | NA | COL2A1 Entrez, Source | collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital) | 5037 | 0.188 | 0.1672 | No |
| 56 | HNRNPU | NA | 5100 | 0.181 | 0.1649 | No | ||
| 57 | PPP1R2 | NA | PPP1R2 Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 2 | 5131 | 0.179 | 0.1650 | No |
| 58 | PDAP1 | NA | PDAP1 Entrez, Source | PDGFA associated protein 1 | 5136 | 0.179 | 0.1669 | No |
| 59 | ATP6V1C1 | NA | ATP6V1C1 Entrez, Source | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 | 5294 | 0.162 | 0.1575 | No |
| 60 | ATP6V1F | NA | ATP6V1F Entrez, Source | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | 5299 | 0.162 | 0.1592 | No |
| 61 | GCH1 | NA | GCH1 Entrez, Source | GTP cyclohydrolase 1 (dopa-responsive dystonia) | 5304 | 0.161 | 0.1610 | No |
| 62 | GRINA | NA | GRINA Entrez, Source | glutamate receptor, ionotropic, N-methyl D-asparate-associated protein 1 (glutamate binding) | 5410 | 0.149 | 0.1552 | No |
| 63 | JUNB | NA | JUNB Entrez, Source | jun B proto-oncogene | 5457 | 0.145 | 0.1536 | No |
| 64 | YKT6 | NA | YKT6 Entrez, Source | YKT6 v-SNARE homolog (S. cerevisiae) | 5680 | 0.118 | 0.1389 | No |
| 65 | CCND3 | NA | CCND3 Entrez, Source | cyclin D3 | 5722 | 0.114 | 0.1373 | No |
| 66 | MAPK8IP2 | NA | MAPK8IP2 Entrez, Source | mitogen-activated protein kinase 8 interacting protein 2 | 5788 | 0.108 | 0.1339 | No |
| 67 | HMOX1 | NA | HMOX1 Entrez, Source | heme oxygenase (decycling) 1 | 5804 | 0.107 | 0.1342 | No |
| 68 | ALDOA | NA | ALDOA Entrez, Source | aldolase A, fructose-bisphosphate | 5880 | 0.100 | 0.1300 | No |
| 69 | PPAT | NA | PPAT Entrez, Source | phosphoribosyl pyrophosphate amidotransferase | 6125 | 0.075 | 0.1131 | No |
| 70 | CDKN2B | NA | CDKN2B Entrez, Source | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | 6229 | 0.064 | 0.1064 | No |
| 71 | TGFBRAP1 | NA | TGFBRAP1 Entrez, Source | transforming growth factor, beta receptor associated protein 1 | 6366 | 0.053 | 0.0971 | No |
| 72 | CDC5L | NA | CDC5L Entrez, Source | CDC5 cell division cycle 5-like (S. pombe) | 6482 | 0.040 | 0.0892 | No |
| 73 | RPN1 | NA | RPN1 Entrez, Source | ribophorin I | 6483 | 0.040 | 0.0897 | No |
| 74 | SLC25A4 | NA | SLC25A4 Entrez, Source | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 | 6960 | -0.011 | 0.0551 | No |
| 75 | BCL2L11 | NA | BCL2L11 Entrez, Source | BCL2-like 11 (apoptosis facilitator) | 6975 | -0.012 | 0.0542 | No |
| 76 | POLR2H | NA | POLR2H Entrez, Source | polymerase (RNA) II (DNA directed) polypeptide H | 7013 | -0.015 | 0.0517 | No |
| 77 | AP2S1 | NA | AP2S1 Entrez, Source | adaptor-related protein complex 2, sigma 1 subunit | 7118 | -0.025 | 0.0445 | No |
| 78 | PARP2 | NA | PARP2 Entrez, Source | poly (ADP-ribose) polymerase family, member 2 | 7432 | -0.060 | 0.0224 | No |
| 79 | CNP | NA | CNP Entrez, Source | 2',3'-cyclic nucleotide 3' phosphodiesterase | 7460 | -0.063 | 0.0212 | No |
| 80 | RASGRP1 | NA | RASGRP1 Entrez, Source | RAS guanyl releasing protein 1 (calcium and DAG-regulated) | 7522 | -0.068 | 0.0176 | No |
| 81 | HYAL2 | NA | HYAL2 Entrez, Source | hyaluronoglucosaminidase 2 | 7648 | -0.079 | 0.0094 | No |
| 82 | CLCN2 | NA | CLCN2 Entrez, Source | chloride channel 2 | 8028 | -0.117 | -0.0167 | No |
| 83 | TMBIM6 | NA | 8150 | -0.131 | -0.0239 | No | ||
| 84 | BTG1 | NA | BTG1 Entrez, Source | B-cell translocation gene 1, anti-proliferative | 8251 | -0.143 | -0.0295 | No |
| 85 | BSG | NA | BSG Entrez, Source | basigin (Ok blood group) | 8286 | -0.145 | -0.0301 | No |
| 86 | PRKCD | NA | PRKCD Entrez, Source | protein kinase C, delta | 8314 | -0.148 | -0.0302 | No |
| 87 | E2F5 | NA | E2F5 Entrez, Source | E2F transcription factor 5, p130-binding | 8417 | -0.159 | -0.0357 | No |
| 88 | GAL | NA | GAL Entrez, Source | galanin | 8475 | -0.166 | -0.0378 | No |
| 89 | POLG2 | NA | POLG2 Entrez, Source | polymerase (DNA directed), gamma 2, accessory subunit | 8546 | -0.173 | -0.0407 | No |
| 90 | ACAA1 | NA | ACAA1 Entrez, Source | acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase) | 8688 | -0.190 | -0.0486 | No |
| 91 | BTG3 | NA | BTG3 Entrez, Source | BTG family, member 3 | 8698 | -0.191 | -0.0469 | No |
| 92 | CEBPG | NA | CEBPG Entrez, Source | CCAAT/enhancer binding protein (C/EBP), gamma | 8717 | -0.193 | -0.0458 | No |
| 93 | SHOX2 | NA | SHOX2 Entrez, Source | short stature homeobox 2 | 8782 | -0.200 | -0.0479 | No |
| 94 | BID | NA | BID Entrez, Source | BH3 interacting domain death agonist | 8885 | -0.213 | -0.0527 | No |
| 95 | HLA-F | NA | HLA-F Entrez, Source | major histocompatibility complex, class I, F | 8904 | -0.215 | -0.0513 | No |
| 96 | PPT1 | NA | PPT1 Entrez, Source | palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile) | 9042 | -0.231 | -0.0585 | No |
| 97 | LHX2 | NA | LHX2 Entrez, Source | LIM homeobox 2 | 9120 | -0.240 | -0.0611 | No |
| 98 | CCNE1 | NA | CCNE1 Entrez, Source | cyclin E1 | 9355 | -0.272 | -0.0747 | No |
| 99 | SPR | NA | SPR Entrez, Source | sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) | 9612 | -0.308 | -0.0896 | No |
| 100 | MRPL23 | NA | MRPL23 Entrez, Source | mitochondrial ribosomal protein L23 | 9694 | -0.320 | -0.0915 | No |
| 101 | PRKACA | NA | PRKACA Entrez, Source | protein kinase, cAMP-dependent, catalytic, alpha | 10315 | -0.412 | -0.1316 | No |
| 102 | STK25 | NA | STK25 Entrez, Source | serine/threonine kinase 25 (STE20 homolog, yeast) | 10328 | -0.413 | -0.1273 | No |
| 103 | RFC4 | NA | RFC4 Entrez, Source | replication factor C (activator 1) 4, 37kDa | 10453 | -0.435 | -0.1309 | No |
| 104 | CREG1 | NA | CREG1 Entrez, Source | cellular repressor of E1A-stimulated genes 1 | 10469 | -0.437 | -0.1265 | No |
| 105 | HSPA2 | NA | HSPA2 Entrez, Source | heat shock 70kDa protein 2 | 10495 | -0.442 | -0.1228 | No |
| 106 | DLG4 | NA | DLG4 Entrez, Source | discs, large homolog 4 (Drosophila) | 10572 | -0.454 | -0.1227 | No |
| 107 | TARS | NA | TARS Entrez, Source | threonyl-tRNA synthetase | 10663 | -0.470 | -0.1234 | No |
| 108 | EPHX1 | NA | EPHX1 Entrez, Source | epoxide hydrolase 1, microsomal (xenobiotic) | 10704 | -0.476 | -0.1203 | No |
| 109 | ARRB2 | NA | ARRB2 Entrez, Source | arrestin, beta 2 | 10738 | -0.482 | -0.1167 | No |
| 110 | SULT1A1 | NA | SULT1A1 Entrez, Source | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 | 10805 | -0.494 | -0.1153 | No |
| 111 | ENO2 | NA | ENO2 Entrez, Source | enolase 2 (gamma, neuronal) | 10819 | -0.496 | -0.1101 | No |
| 112 | TFRC | NA | TFRC Entrez, Source | transferrin receptor (p90, CD71) | 10954 | -0.519 | -0.1134 | No |
| 113 | PTPRD | NA | PTPRD Entrez, Source | protein tyrosine phosphatase, receptor type, D | 11050 | -0.537 | -0.1136 | No |
| 114 | CDK2 | NA | CDK2 Entrez, Source | cyclin-dependent kinase 2 | 11096 | -0.546 | -0.1100 | No |
| 115 | TYRO3 | NA | TYRO3 Entrez, Source | TYRO3 protein tyrosine kinase | 11342 | -0.592 | -0.1205 | No |
| 116 | FURIN | NA | FURIN Entrez, Source | furin (paired basic amino acid cleaving enzyme) | 11593 | -0.646 | -0.1306 | No |
| 117 | SIGMAR1 | NA | 11800 | -0.699 | -0.1369 | No | ||
| 118 | RAB27A | NA | RAB27A Entrez, Source | RAB27A, member RAS oncogene family | 12098 | -0.785 | -0.1488 | No |
| 119 | GGH | NA | GGH Entrez, Source | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) | 12249 | -0.836 | -0.1492 | No |
| 120 | FEN1 | NA | FEN1 Entrez, Source | flap structure-specific endonuclease 1 | 12266 | -0.841 | -0.1399 | No |
| 121 | DGAT1 | NA | DGAT1 Entrez, Source | diacylglycerol O-acyltransferase homolog 1 (mouse) | 12403 | -0.891 | -0.1387 | No |
| 122 | TST | NA | TST Entrez, Source | thiosulfate sulfurtransferase (rhodanese) | 12431 | -0.907 | -0.1293 | No |
| 123 | AQP3 | NA | AQP3 Entrez, Source | aquaporin 3 (Gill blood group) | 12436 | -0.910 | -0.1182 | No |
| 124 | KLHDC3 | NA | KLHDC3 Entrez, Source | kelch domain containing 3 | 12594 | -0.978 | -0.1174 | No |
| 125 | NPTXR | NA | NPTXR Entrez, Source | neuronal pentraxin receptor | 12691 | -1.031 | -0.1115 | No |
| 126 | RXRB | NA | RXRB Entrez, Source | retinoid X receptor, beta | 12697 | -1.034 | -0.0989 | No |
| 127 | SLC6A8 | NA | SLC6A8 Entrez, Source | solute carrier family 6 (neurotransmitter transporter, creatine), member 8 | 12717 | -1.043 | -0.0872 | No |
| 128 | RHOB | NA | RHOB Entrez, Source | ras homolog gene family, member B | 13181 | -1.375 | -0.1038 | No |
| 129 | BMP2 | NA | BMP2 Entrez, Source | bone morphogenetic protein 2 | 13439 | -1.723 | -0.1010 | No |
| 130 | CDKN1C | NA | CDKN1C Entrez, Source | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 13445 | -1.734 | -0.0796 | No |
| 131 | FOS | NA | FOS Entrez, Source | v-fos FBJ murine osteosarcoma viral oncogene homolog | 13543 | -1.911 | -0.0628 | No |
| 132 | BTG2 | NA | BTG2 Entrez, Source | BTG family, member 2 | 13659 | -2.285 | -0.0425 | No |
| 133 | OLFM1 | NA | OLFM1 Entrez, Source | olfactomedin 1 | 13822 | -4.412 | 0.0009 | No |
