Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | HALLMARK_UV_RESPONSE_DN |
| Enrichment Score (ES) | -0.34628013 |
| Normalized Enrichment Score (NES) | -1.336845 |
| Nominal p-value | 0.026153846 |
| FDR q-value | 0.10806837 |
| FWER p-Value | 0.804 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CYR61 | NA | CYR61 Entrez, Source | cysteine-rich, angiogenic inducer, 61 | 53 | 3.446 | 0.0333 | No |
| 2 | SERPINE1 | NA | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 109 | 2.840 | 0.0599 | No |
| 3 | F3 | NA | F3 Entrez, Source | coagulation factor III (thromboplastin, tissue factor) | 184 | 2.322 | 0.0795 | No |
| 4 | INPP4B | NA | INPP4B Entrez, Source | inositol polyphosphate-4-phosphatase, type II, 105kDa | 203 | 2.198 | 0.1019 | No |
| 5 | PLCB4 | NA | PLCB4 Entrez, Source | phospholipase C, beta 4 | 546 | 1.259 | 0.0905 | No |
| 6 | IRS1 | NA | IRS1 Entrez, Source | insulin receptor substrate 1 | 587 | 1.198 | 0.1005 | No |
| 7 | RND3 | NA | RND3 Entrez, Source | Rho family GTPase 3 | 597 | 1.187 | 0.1126 | No |
| 8 | TGFBR2 | NA | TGFBR2 Entrez, Source | transforming growth factor, beta receptor II (70/80kDa) | 639 | 1.148 | 0.1220 | No |
| 9 | ANXA2 | NA | ANXA2 Entrez, Source | annexin A2 | 674 | 1.119 | 0.1316 | No |
| 10 | RUNX1 | NA | RUNX1 Entrez, Source | runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) | 772 | 1.035 | 0.1357 | No |
| 11 | KCNMA1 | NA | KCNMA1 Entrez, Source | potassium large conductance calcium-activated channel, subfamily M, alpha member 1 | 790 | 1.014 | 0.1454 | No |
| 12 | LDLR | NA | LDLR Entrez, Source | low density lipoprotein receptor (familial hypercholesterolemia) | 803 | 1.007 | 0.1554 | No |
| 13 | MAP1B | NA | MAP1B Entrez, Source | microtubule-associated protein 1B | 986 | 0.901 | 0.1518 | No |
| 14 | SMAD3 | NA | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 1025 | 0.881 | 0.1585 | No |
| 15 | NRP1 | NA | NRP1 Entrez, Source | neuropilin 1 | 1103 | 0.850 | 0.1621 | No |
| 16 | NEK7 | NA | NEK7 Entrez, Source | NIMA (never in mitosis gene a)-related kinase 7 | 1228 | 0.801 | 0.1617 | No |
| 17 | ABCC1 | NA | ABCC1 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | 1245 | 0.795 | 0.1691 | No |
| 18 | SCAF8 | NA | 1259 | 0.791 | 0.1766 | No | ||
| 19 | PDLIM5 | NA | PDLIM5 Entrez, Source | PDZ and LIM domain 5 | 1269 | 0.789 | 0.1845 | No |
| 20 | PRKCE | NA | PRKCE Entrez, Source | protein kinase C, epsilon | 1306 | 0.771 | 0.1902 | No |
| 21 | SYNJ2 | NA | SYNJ2 Entrez, Source | synaptojanin 2 | 1325 | 0.765 | 0.1971 | No |
| 22 | SYNE1 | NA | SYNE1 Entrez, Source | spectrin repeat containing, nuclear envelope 1 | 1544 | 0.703 | 0.1888 | No |
| 23 | NOTCH2 | NA | NOTCH2 Entrez, Source | Notch homolog 2 (Drosophila) | 1656 | 0.674 | 0.1879 | No |
| 24 | FZD2 | NA | FZD2 Entrez, Source | frizzled homolog 2 (Drosophila) | 1749 | 0.644 | 0.1882 | No |
| 25 | CDK13 | NA | 1933 | 0.599 | 0.1813 | No | ||
| 26 | NFKB1 | NA | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 2004 | 0.585 | 0.1825 | No |
| 27 | ATP2B1 | NA | ATP2B1 Entrez, Source | ATPase, Ca++ transporting, plasma membrane 1 | 2127 | 0.565 | 0.1797 | No |
| 28 | EFEMP1 | NA | EFEMP1 Entrez, Source | EGF-containing fibulin-like extracellular matrix protein 1 | 2159 | 0.559 | 0.1834 | No |
| 29 | GRK5 | NA | GRK5 Entrez, Source | G protein-coupled receptor kinase 5 | 2218 | 0.547 | 0.1851 | No |
| 30 | PPARG | NA | PPARG Entrez, Source | peroxisome proliferative activated receptor, gamma | 2278 | 0.537 | 0.1866 | No |
| 31 | BDNF | NA | BDNF Entrez, Source | brain-derived neurotrophic factor | 2465 | 0.506 | 0.1785 | No |
| 32 | TGFBR3 | NA | TGFBR3 Entrez, Source | transforming growth factor, beta receptor III (betaglycan, 300kDa) | 2547 | 0.492 | 0.1779 | No |
| 33 | SLC7A1 | NA | SLC7A1 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 2677 | 0.472 | 0.1735 | No |
| 34 | NR3C1 | NA | NR3C1 Entrez, Source | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 2793 | 0.453 | 0.1700 | No |
| 35 | KALRN | NA | KALRN Entrez, Source | kalirin, RhoGEF kinase | 2870 | 0.439 | 0.1692 | No |
| 36 | CAP2 | NA | CAP2 Entrez, Source | CAP, adenylate cyclase-associated protein, 2 (yeast) | 3340 | 0.377 | 0.1390 | No |
| 37 | DYRK1A | NA | DYRK1A Entrez, Source | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 3412 | 0.366 | 0.1378 | No |
| 38 | CAV1 | NA | CAV1 Entrez, Source | caveolin 1, caveolae protein, 22kDa | 3483 | 0.356 | 0.1365 | No |
| 39 | DDAH1 | NA | DDAH1 Entrez, Source | dimethylarginine dimethylaminohydrolase 1 | 3523 | 0.351 | 0.1375 | No |
| 40 | ADORA2B | NA | ADORA2B Entrez, Source | adenosine A2b receptor | 3803 | 0.320 | 0.1206 | No |
| 41 | VAV2 | NA | VAV2 Entrez, Source | vav 2 oncogene | 3835 | 0.317 | 0.1217 | No |
| 42 | MIOS | NA | 3891 | 0.310 | 0.1211 | No | ||
| 43 | KIT | NA | KIT Entrez, Source | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 4009 | 0.296 | 0.1157 | No |
| 44 | FHL2 | NA | FHL2 Entrez, Source | four and a half LIM domains 2 | 4107 | 0.286 | 0.1117 | No |
| 45 | LTBP1 | NA | LTBP1 Entrez, Source | latent transforming growth factor beta binding protein 1 | 4131 | 0.284 | 0.1131 | No |
| 46 | CITED2 | NA | CITED2 Entrez, Source | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 4508 | 0.242 | 0.0883 | No |
| 47 | ACVR2A | NA | ACVR2A Entrez, Source | activin A receptor, type IIA | 4566 | 0.235 | 0.0867 | No |
| 48 | CELF2 | NA | 4589 | 0.233 | 0.0876 | No | ||
| 49 | TJP1 | NA | TJP1 Entrez, Source | tight junction protein 1 (zona occludens 1) | 4633 | 0.229 | 0.0869 | No |
| 50 | BMPR1A | NA | BMPR1A Entrez, Source | bone morphogenetic protein receptor, type IA | 4667 | 0.227 | 0.0869 | No |
| 51 | MGLL | NA | MGLL Entrez, Source | monoglyceride lipase | 4876 | 0.204 | 0.0740 | No |
| 52 | PTPRM | NA | PTPRM Entrez, Source | protein tyrosine phosphatase, receptor type, M | 5110 | 0.181 | 0.0589 | No |
| 53 | CACNA1A | NA | CACNA1A Entrez, Source | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 5115 | 0.180 | 0.0606 | No |
| 54 | APBB2 | NA | APBB2 Entrez, Source | amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like) | 5179 | 0.173 | 0.0578 | No |
| 55 | PTPN21 | NA | PTPN21 Entrez, Source | protein tyrosine phosphatase, non-receptor type 21 | 5225 | 0.169 | 0.0564 | No |
| 56 | MRPS31 | NA | MRPS31 Entrez, Source | mitochondrial ribosomal protein S31 | 5292 | 0.162 | 0.0533 | No |
| 57 | YTHDC1 | NA | YTHDC1 Entrez, Source | YTH domain containing 1 | 5350 | 0.156 | 0.0508 | No |
| 58 | PIAS3 | NA | PIAS3 Entrez, Source | protein inhibitor of activated STAT, 3 | 5671 | 0.119 | 0.0288 | No |
| 59 | COL11A1 | NA | COL11A1 Entrez, Source | collagen, type XI, alpha 1 | 5734 | 0.113 | 0.0255 | No |
| 60 | NR1D2 | NA | NR1D2 Entrez, Source | nuclear receptor subfamily 1, group D, member 2 | 5756 | 0.111 | 0.0251 | No |
| 61 | SPOP | NA | SPOP Entrez, Source | speckle-type POZ protein | 5893 | 0.099 | 0.0163 | No |
| 62 | MET | NA | MET Entrez, Source | met proto-oncogene (hepatocyte growth factor receptor) | 5916 | 0.096 | 0.0157 | No |
| 63 | WDR37 | NA | WDR37 Entrez, Source | WD repeat domain 37 | 6046 | 0.082 | 0.0072 | No |
| 64 | BHLHE40 | NA | 6073 | 0.080 | 0.0061 | No | ||
| 65 | RASA2 | NA | RASA2 Entrez, Source | RAS p21 protein activator 2 | 6459 | 0.042 | -0.0215 | No |
| 66 | ATRN | NA | ATRN Entrez, Source | attractin | 6492 | 0.039 | -0.0234 | No |
| 67 | RXRA | NA | RXRA Entrez, Source | retinoid X receptor, alpha | 6525 | 0.036 | -0.0254 | No |
| 68 | PAPD7 | NA | 6663 | 0.022 | -0.0351 | No | ||
| 69 | LAMC1 | NA | LAMC1 Entrez, Source | laminin, gamma 1 (formerly LAMB2) | 6862 | 0.001 | -0.0496 | No |
| 70 | PRDM2 | NA | PRDM2 Entrez, Source | PR domain containing 2, with ZNF domain | 6949 | -0.009 | -0.0558 | No |
| 71 | DUSP1 | NA | DUSP1 Entrez, Source | dual specificity phosphatase 1 | 6982 | -0.013 | -0.0579 | No |
| 72 | PTEN | NA | PTEN Entrez, Source | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | 6985 | -0.013 | -0.0580 | No |
| 73 | PHF3 | NA | PHF3 Entrez, Source | PHD finger protein 3 | 7150 | -0.028 | -0.0696 | No |
| 74 | CDC42BPA | NA | CDC42BPA Entrez, Source | CDC42 binding protein kinase alpha (DMPK-like) | 7165 | -0.029 | -0.0703 | No |
| 75 | HAS2 | NA | HAS2 Entrez, Source | hyaluronan synthase 2 | 7222 | -0.035 | -0.0740 | No |
| 76 | PEX14 | NA | PEX14 Entrez, Source | peroxisomal biogenesis factor 14 | 7364 | -0.052 | -0.0838 | No |
| 77 | MAPK14 | NA | MAPK14 Entrez, Source | mitogen-activated protein kinase 14 | 7577 | -0.073 | -0.0984 | No |
| 78 | ZMIZ1 | NA | 7627 | -0.078 | -0.1012 | No | ||
| 79 | ITGB3 | NA | ITGB3 Entrez, Source | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 7628 | -0.078 | -0.1003 | No |
| 80 | ATP2C1 | NA | ATP2C1 Entrez, Source | ATPase, Ca++ transporting, type 2C, member 1 | 7646 | -0.079 | -0.1007 | No |
| 81 | SCN8A | NA | SCN8A Entrez, Source | sodium channel, voltage gated, type VIII, alpha | 8380 | -0.155 | -0.1525 | No |
| 82 | PIK3R3 | NA | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 8472 | -0.166 | -0.1574 | No |
| 83 | ATP2B4 | NA | ATP2B4 Entrez, Source | ATPase, Ca++ transporting, plasma membrane 4 | 8524 | -0.171 | -0.1593 | No |
| 84 | LPAR1 | NA | 8547 | -0.173 | -0.1590 | No | ||
| 85 | RBPMS | NA | RBPMS Entrez, Source | RNA binding protein with multiple splicing | 8575 | -0.177 | -0.1591 | No |
| 86 | IGF1R | NA | IGF1R Entrez, Source | insulin-like growth factor 1 receptor | 8663 | -0.186 | -0.1634 | No |
| 87 | ATRX | NA | ATRX Entrez, Source | alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae) | 8803 | -0.203 | -0.1713 | No |
| 88 | MAP2K5 | NA | MAP2K5 Entrez, Source | mitogen-activated protein kinase kinase 5 | 8902 | -0.214 | -0.1762 | No |
| 89 | AGGF1 | NA | AGGF1 Entrez, Source | angiogenic factor with G patch and FHA domains 1 | 8962 | -0.221 | -0.1781 | No |
| 90 | GCNT1 | NA | GCNT1 Entrez, Source | glucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase) | 8988 | -0.224 | -0.1775 | No |
| 91 | SMAD7 | NA | SMAD7 Entrez, Source | SMAD, mothers against DPP homolog 7 (Drosophila) | 9217 | -0.252 | -0.1914 | No |
| 92 | NIPBL | NA | NIPBL Entrez, Source | Nipped-B homolog (Drosophila) | 9479 | -0.291 | -0.2073 | No |
| 93 | PRKAR2B | NA | PRKAR2B Entrez, Source | protein kinase, cAMP-dependent, regulatory, type II, beta | 9706 | -0.322 | -0.2204 | No |
| 94 | MYC | NA | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 9860 | -0.346 | -0.2278 | No |
| 95 | ERBB2 | NA | ERBB2 Entrez, Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 9967 | -0.359 | -0.2317 | No |
| 96 | MTA1 | NA | MTA1 Entrez, Source | metastasis associated 1 | 10006 | -0.365 | -0.2305 | No |
| 97 | NFIB | NA | NFIB Entrez, Source | nuclear factor I/B | 10392 | -0.426 | -0.2540 | No |
| 98 | DLG1 | NA | DLG1 Entrez, Source | discs, large homolog 1 (Drosophila) | 10936 | -0.516 | -0.2881 | No |
| 99 | SRI | NA | SRI Entrez, Source | sorcin | 10970 | -0.522 | -0.2849 | No |
| 100 | PMP22 | NA | PMP22 Entrez, Source | peripheral myelin protein 22 | 11186 | -0.562 | -0.2945 | No |
| 101 | ANXA4 | NA | ANXA4 Entrez, Source | annexin A4 | 11851 | -0.712 | -0.3353 | No |
| 102 | GJA1 | NA | GJA1 Entrez, Source | gap junction protein, alpha 1, 43kDa (connexin 43) | 12003 | -0.758 | -0.3381 | Yes |
| 103 | TFPI | NA | TFPI Entrez, Source | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 12069 | -0.778 | -0.3345 | Yes |
| 104 | ATP5S | NA | ATP5S Entrez, Source | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B) | 12176 | -0.814 | -0.3334 | Yes |
| 105 | PRKCA | NA | PRKCA Entrez, Source | protein kinase C, alpha | 12193 | -0.818 | -0.3258 | Yes |
| 106 | ARHGEF9 | NA | ARHGEF9 Entrez, Source | Cdc42 guanine nucleotide exchange factor (GEF) 9 | 12333 | -0.868 | -0.3266 | Yes |
| 107 | ID1 | NA | ID1 Entrez, Source | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 12445 | -0.913 | -0.3248 | Yes |
| 108 | CDKN1B | NA | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 12505 | -0.942 | -0.3190 | Yes |
| 109 | CDON | NA | CDON Entrez, Source | Cdon homolog (mouse) | 12625 | -0.996 | -0.3169 | Yes |
| 110 | COL5A2 | NA | COL5A2 Entrez, Source | collagen, type V, alpha 2 | 12707 | -1.040 | -0.3116 | Yes |
| 111 | SNAI2 | NA | SNAI2 Entrez, Source | snail homolog 2 (Drosophila) | 12785 | -1.082 | -0.3056 | Yes |
| 112 | SIPA1L1 | NA | SIPA1L1 Entrez, Source | signal-induced proliferation-associated 1 like 1 | 12893 | -1.143 | -0.3011 | Yes |
| 113 | SLC22A18 | NA | SLC22A18 Entrez, Source | solute carrier family 22 (organic cation transporter), member 18 | 13002 | -1.216 | -0.2958 | Yes |
| 114 | ADD3 | NA | ADD3 Entrez, Source | adducin 3 (gamma) | 13003 | -1.217 | -0.2827 | Yes |
| 115 | FYN | NA | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 13049 | -1.256 | -0.2725 | Yes |
| 116 | ATXN1 | NA | ATXN1 Entrez, Source | ataxin 1 | 13051 | -1.257 | -0.2590 | Yes |
| 117 | BCKDHB | NA | BCKDHB Entrez, Source | branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease) | 13135 | -1.324 | -0.2508 | Yes |
| 118 | SDC2 | NA | SDC2 Entrez, Source | syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan) | 13234 | -1.433 | -0.2425 | Yes |
| 119 | PDGFRB | NA | PDGFRB Entrez, Source | platelet-derived growth factor receptor, beta polypeptide | 13337 | -1.562 | -0.2331 | Yes |
| 120 | DBP | NA | DBP Entrez, Source | D site of albumin promoter (albumin D-box) binding protein | 13359 | -1.590 | -0.2175 | Yes |
| 121 | IGFBP5 | NA | IGFBP5 Entrez, Source | insulin-like growth factor binding protein 5 | 13390 | -1.640 | -0.2020 | Yes |
| 122 | AKT3 | NA | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 13407 | -1.667 | -0.1852 | Yes |
| 123 | INSIG1 | NA | INSIG1 Entrez, Source | insulin induced gene 1 | 13484 | -1.784 | -0.1715 | Yes |
| 124 | VLDLR | NA | VLDLR Entrez, Source | very low density lipoprotein receptor | 13512 | -1.854 | -0.1535 | Yes |
| 125 | DAB2 | NA | DAB2 Entrez, Source | disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) | 13564 | -1.978 | -0.1359 | Yes |
| 126 | DLC1 | NA | DLC1 Entrez, Source | deleted in liver cancer 1 | 13650 | -2.246 | -0.1179 | Yes |
| 127 | COL1A1 | NA | COL1A1 Entrez, Source | collagen, type I, alpha 1 | 13723 | -2.670 | -0.0943 | Yes |
| 128 | FBLN5 | NA | FBLN5 Entrez, Source | fibulin 5 | 13742 | -2.810 | -0.0653 | Yes |
| 129 | PIK3CD | NA | PIK3CD Entrez, Source | phosphoinositide-3-kinase, catalytic, delta polypeptide | 13763 | -3.033 | -0.0341 | Yes |
| 130 | COL3A1 | NA | COL3A1 Entrez, Source | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | 13796 | -3.638 | 0.0028 | Yes |
