Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | HALLMARK_UNFOLDED_PROTEIN_RESPONSE |
| Enrichment Score (ES) | 0.33489594 |
| Normalized Enrichment Score (NES) | 1.3464645 |
| Nominal p-value | 0.019444445 |
| FDR q-value | 0.076176986 |
| FWER p-Value | 0.576 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | IFIT1 | NA | IFIT1 Entrez, Source | interferon-induced protein with tetratricopeptide repeats 1 | 37 | 3.829 | 0.0727 | Yes |
| 2 | CCL2 | NA | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 98 | 2.964 | 0.1267 | Yes |
| 3 | TUBB2A | NA | TUBB2A Entrez, Source | tubulin, beta 2A | 389 | 1.523 | 0.1355 | Yes |
| 4 | HSP90B1 | NA | HSP90B1 Entrez, Source | heat shock protein 90kDa beta (Grp94), member 1 | 478 | 1.351 | 0.1557 | Yes |
| 5 | DNAJA4 | NA | DNAJA4 Entrez, Source | DnaJ (Hsp40) homolog, subfamily A, member 4 | 505 | 1.306 | 0.1796 | Yes |
| 6 | CHAC1 | NA | CHAC1 Entrez, Source | ChaC, cation transport regulator homolog 1 (E. coli) | 687 | 1.111 | 0.1882 | Yes |
| 7 | RRP9 | NA | 779 | 1.031 | 0.2019 | Yes | ||
| 8 | WFS1 | NA | WFS1 Entrez, Source | Wolfram syndrome 1 (wolframin) | 904 | 0.942 | 0.2114 | Yes |
| 9 | STC2 | NA | STC2 Entrez, Source | stanniocalcin 2 | 926 | 0.931 | 0.2282 | Yes |
| 10 | NOLC1 | NA | NOLC1 Entrez, Source | nucleolar and coiled-body phosphoprotein 1 | 1149 | 0.830 | 0.2284 | Yes |
| 11 | HYOU1 | NA | HYOU1 Entrez, Source | hypoxia up-regulated 1 | 1196 | 0.814 | 0.2411 | Yes |
| 12 | NFYA | NA | NFYA Entrez, Source | nuclear transcription factor Y, alpha | 1254 | 0.792 | 0.2525 | Yes |
| 13 | ASNS | NA | ASNS Entrez, Source | asparagine synthetase | 1436 | 0.735 | 0.2538 | Yes |
| 14 | BAG3 | NA | BAG3 Entrez, Source | BCL2-associated athanogene 3 | 1488 | 0.719 | 0.2642 | Yes |
| 15 | EIF4G1 | NA | EIF4G1 Entrez, Source | eukaryotic translation initiation factor 4 gamma, 1 | 1575 | 0.696 | 0.2717 | Yes |
| 16 | NOP14 | NA | 1765 | 0.640 | 0.2705 | Yes | ||
| 17 | SDAD1 | NA | SDAD1 Entrez, Source | SDA1 domain containing 1 | 1943 | 0.598 | 0.2694 | Yes |
| 18 | TATDN2 | NA | TATDN2 Entrez, Source | TatD DNase domain containing 2 | 1958 | 0.594 | 0.2801 | Yes |
| 19 | NOP56 | NA | 2191 | 0.552 | 0.2740 | Yes | ||
| 20 | CEBPB | NA | CEBPB Entrez, Source | CCAAT/enhancer binding protein (C/EBP), beta | 2220 | 0.547 | 0.2828 | Yes |
| 21 | DKC1 | NA | DKC1 Entrez, Source | dyskeratosis congenita 1, dyskerin | 2289 | 0.535 | 0.2883 | Yes |
| 22 | ATP6V0D1 | NA | ATP6V0D1 Entrez, Source | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 | 2464 | 0.506 | 0.2856 | Yes |
| 23 | KHSRP | NA | KHSRP Entrez, Source | KH-type splicing regulatory protein (FUSE binding protein 2) | 2633 | 0.479 | 0.2828 | Yes |
| 24 | EIF4E | NA | EIF4E Entrez, Source | eukaryotic translation initiation factor 4E | 2680 | 0.471 | 0.2888 | Yes |
| 25 | GOSR2 | NA | GOSR2 Entrez, Source | golgi SNAP receptor complex member 2 | 2716 | 0.465 | 0.2954 | Yes |
| 26 | EIF2S1 | NA | EIF2S1 Entrez, Source | eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa | 2718 | 0.465 | 0.3044 | Yes |
| 27 | SRPRB | NA | SRPRB Entrez, Source | signal recognition particle receptor, B subunit | 2862 | 0.441 | 0.3027 | Yes |
| 28 | H2AFX | NA | H2AFX Entrez, Source | H2A histone family, member X | 2873 | 0.438 | 0.3106 | Yes |
| 29 | DDX10 | NA | DDX10 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 | 2918 | 0.432 | 0.3159 | Yes |
| 30 | EIF4A1 | NA | EIF4A1 Entrez, Source | eukaryotic translation initiation factor 4A, isoform 1 | 2981 | 0.423 | 0.3197 | Yes |
| 31 | CNOT4 | NA | CNOT4 Entrez, Source | CCR4-NOT transcription complex, subunit 4 | 3049 | 0.415 | 0.3230 | Yes |
| 32 | HSPA5 | NA | HSPA5 Entrez, Source | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 3161 | 0.399 | 0.3228 | Yes |
| 33 | GEMIN4 | NA | GEMIN4 Entrez, Source | gem (nuclear organelle) associated protein 4 | 3258 | 0.387 | 0.3234 | Yes |
| 34 | PDIA6 | NA | PDIA6 Entrez, Source | protein disulfide isomerase family A, member 6 | 3356 | 0.375 | 0.3237 | Yes |
| 35 | ERN1 | NA | ERN1 Entrez, Source | endoplasmic reticulum to nucleus signalling 1 | 3460 | 0.359 | 0.3233 | Yes |
| 36 | LSM1 | NA | LSM1 Entrez, Source | LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 3472 | 0.358 | 0.3295 | Yes |
| 37 | EXOSC2 | NA | EXOSC2 Entrez, Source | exosome component 2 | 3537 | 0.349 | 0.3317 | Yes |
| 38 | SLC30A5 | NA | SLC30A5 Entrez, Source | solute carrier family 30 (zinc transporter), member 5 | 3738 | 0.329 | 0.3236 | Yes |
| 39 | POP4 | NA | POP4 Entrez, Source | processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae) | 3833 | 0.318 | 0.3230 | Yes |
| 40 | YWHAZ | NA | YWHAZ Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 3862 | 0.315 | 0.3272 | Yes |
| 41 | DCP1A | NA | DCP1A Entrez, Source | DCP1 decapping enzyme homolog A (S. cerevisiae) | 3893 | 0.310 | 0.3311 | Yes |
| 42 | PARN | NA | PARN Entrez, Source | poly(A)-specific ribonuclease (deadenylation nuclease) | 3925 | 0.306 | 0.3349 | Yes |
| 43 | EIF4A3 | NA | 4158 | 0.281 | 0.3235 | No | ||
| 44 | MTHFD2 | NA | MTHFD2 Entrez, Source | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 4284 | 0.267 | 0.3197 | No |
| 45 | EXOSC9 | NA | EXOSC9 Entrez, Source | exosome component 9 | 4446 | 0.249 | 0.3129 | No |
| 46 | EDEM1 | NA | EDEM1 Entrez, Source | ER degradation enhancer, mannosidase alpha-like 1 | 4455 | 0.249 | 0.3172 | No |
| 47 | FUS | NA | FUS Entrez, Source | fusion (involved in t(12;16) in malignant liposarcoma) | 4522 | 0.240 | 0.3171 | No |
| 48 | NPM1 | NA | NPM1 Entrez, Source | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 4781 | 0.214 | 0.3025 | No |
| 49 | EXOSC4 | NA | EXOSC4 Entrez, Source | exosome component 4 | 4809 | 0.211 | 0.3047 | No |
| 50 | CKS1B | NA | CKS1B Entrez, Source | CDC28 protein kinase regulatory subunit 1B | 4868 | 0.205 | 0.3045 | No |
| 51 | CALR | NA | CALR Entrez, Source | calreticulin | 4897 | 0.202 | 0.3065 | No |
| 52 | FKBP14 | NA | FKBP14 Entrez, Source | FK506 binding protein 14, 22 kDa | 5062 | 0.185 | 0.2982 | No |
| 53 | ZBTB17 | NA | ZBTB17 Entrez, Source | zinc finger and BTB domain containing 17 | 5130 | 0.179 | 0.2968 | No |
| 54 | DNAJC3 | NA | DNAJC3 Entrez, Source | DnaJ (Hsp40) homolog, subfamily C, member 3 | 5366 | 0.154 | 0.2827 | No |
| 55 | PSAT1 | NA | PSAT1 Entrez, Source | phosphoserine aminotransferase 1 | 5396 | 0.151 | 0.2836 | No |
| 56 | SKIV2L2 | NA | SKIV2L2 Entrez, Source | superkiller viralicidic activity 2-like 2 (S. cerevisiae) | 5503 | 0.139 | 0.2786 | No |
| 57 | SSR1 | NA | SSR1 Entrez, Source | signal sequence receptor, alpha (translocon-associated protein alpha) | 5537 | 0.136 | 0.2789 | No |
| 58 | KIF5B | NA | KIF5B Entrez, Source | kinesin family member 5B | 5568 | 0.132 | 0.2793 | No |
| 59 | PREB | NA | PREB Entrez, Source | prolactin regulatory element binding | 5631 | 0.123 | 0.2772 | No |
| 60 | SPCS3 | NA | SPCS3 Entrez, Source | signal peptidase complex subunit 3 homolog (S. cerevisiae) | 5683 | 0.118 | 0.2758 | No |
| 61 | BANF1 | NA | BANF1 Entrez, Source | barrier to autointegration factor 1 | 5748 | 0.112 | 0.2733 | No |
| 62 | EDC4 | NA | EDC4 Entrez, Source | enhancer of mRNA decapping 4 | 5925 | 0.095 | 0.2624 | No |
| 63 | HSPA9 | NA | 6075 | 0.079 | 0.2531 | No | ||
| 64 | ATF6 | NA | ATF6 Entrez, Source | activating transcription factor 6 | 6331 | 0.055 | 0.2356 | No |
| 65 | ARFGAP1 | NA | ARFGAP1 Entrez, Source | ADP-ribosylation factor GTPase activating protein 1 | 6687 | 0.019 | 0.2101 | No |
| 66 | IMP3 | NA | IMP3 Entrez, Source | IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast) | 6856 | 0.001 | 0.1979 | No |
| 67 | EXOSC10 | NA | EXOSC10 Entrez, Source | exosome component 10 | 7041 | -0.018 | 0.1848 | No |
| 68 | DCTN1 | NA | DCTN1 Entrez, Source | dynactin 1 (p150, glued homolog, Drosophila) | 7327 | -0.047 | 0.1650 | No |
| 69 | ALDH18A1 | NA | ALDH18A1 Entrez, Source | aldehyde dehydrogenase 18 family, member A1 | 7356 | -0.052 | 0.1640 | No |
| 70 | XPOT | NA | XPOT Entrez, Source | exportin, tRNA (nuclear export receptor for tRNAs) | 7409 | -0.057 | 0.1613 | No |
| 71 | DNAJB9 | NA | DNAJB9 Entrez, Source | DnaJ (Hsp40) homolog, subfamily B, member 9 | 7519 | -0.068 | 0.1547 | No |
| 72 | SHC1 | NA | SHC1 Entrez, Source | SHC (Src homology 2 domain containing) transforming protein 1 | 7588 | -0.074 | 0.1512 | No |
| 73 | EXOSC1 | NA | EXOSC1 Entrez, Source | exosome component 1 | 7701 | -0.084 | 0.1447 | No |
| 74 | VEGFA | NA | 7811 | -0.096 | 0.1387 | No | ||
| 75 | PDIA5 | NA | PDIA5 Entrez, Source | protein disulfide isomerase family A, member 5 | 7883 | -0.103 | 0.1355 | No |
| 76 | EEF2 | NA | EEF2 Entrez, Source | eukaryotic translation elongation factor 2 | 8440 | -0.161 | 0.0982 | No |
| 77 | EXOSC5 | NA | EXOSC5 Entrez, Source | exosome component 5 | 8618 | -0.181 | 0.0889 | No |
| 78 | CNOT2 | NA | CNOT2 Entrez, Source | CCR4-NOT transcription complex, subunit 2 | 8681 | -0.188 | 0.0881 | No |
| 79 | CEBPG | NA | CEBPG Entrez, Source | CCAAT/enhancer binding protein (C/EBP), gamma | 8717 | -0.193 | 0.0893 | No |
| 80 | YIF1A | NA | YIF1A Entrez, Source | Yip1 interacting factor homolog A (S. cerevisiae) | 8741 | -0.196 | 0.0915 | No |
| 81 | TSPYL2 | NA | TSPYL2 Entrez, Source | TSPY-like 2 | 8793 | -0.201 | 0.0918 | No |
| 82 | SLC1A4 | NA | SLC1A4 Entrez, Source | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | 9038 | -0.230 | 0.0785 | No |
| 83 | XBP1 | NA | XBP1 Entrez, Source | X-box binding protein 1 | 9068 | -0.233 | 0.0810 | No |
| 84 | PAIP1 | NA | PAIP1 Entrez, Source | poly(A) binding protein interacting protein 1 | 9097 | -0.237 | 0.0836 | No |
| 85 | EIF4EBP1 | NA | EIF4EBP1 Entrez, Source | eukaryotic translation initiation factor 4E binding protein 1 | 9136 | -0.242 | 0.0856 | No |
| 86 | SERP1 | NA | SERP1 Entrez, Source | - | 9188 | -0.248 | 0.0868 | No |
| 87 | IARS | NA | IARS Entrez, Source | isoleucine-tRNA synthetase | 9759 | -0.331 | 0.0518 | No |
| 88 | NFYB | NA | NFYB Entrez, Source | nuclear transcription factor Y, beta | 9956 | -0.357 | 0.0445 | No |
| 89 | EXOC2 | NA | EXOC2 Entrez, Source | exocyst complex component 2 | 10021 | -0.367 | 0.0471 | No |
| 90 | SPCS1 | NA | SPCS1 Entrez, Source | signal peptidase complex subunit 1 homolog (S. cerevisiae) | 10192 | -0.393 | 0.0424 | No |
| 91 | TTC37 | NA | 10195 | -0.393 | 0.0500 | No | ||
| 92 | NHP2 | NA | 10429 | -0.432 | 0.0415 | No | ||
| 93 | CXXC1 | NA | CXXC1 Entrez, Source | CXXC finger 1 (PHD domain) | 10472 | -0.437 | 0.0471 | No |
| 94 | TARS | NA | TARS Entrez, Source | threonyl-tRNA synthetase | 10663 | -0.470 | 0.0425 | No |
| 95 | EIF4A2 | NA | EIF4A2 Entrez, Source | eukaryotic translation initiation factor 4A, isoform 2 | 10895 | -0.508 | 0.0357 | No |
| 96 | SEC11A | NA | 10986 | -0.526 | 0.0395 | No | ||
| 97 | ATF4 | NA | ATF4 Entrez, Source | activating transcription factor 4 (tax-responsive enhancer element B67) | 10995 | -0.527 | 0.0493 | No |
| 98 | RPS14 | NA | RPS14 Entrez, Source | ribosomal protein S14 | 11219 | -0.567 | 0.0442 | No |
| 99 | DCP2 | NA | DCP2 Entrez, Source | DCP2 decapping enzyme homolog (S. cerevisiae) | 11495 | -0.623 | 0.0364 | No |
| 100 | LSM4 | NA | LSM4 Entrez, Source | LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 11929 | -0.734 | 0.0193 | No |
| 101 | HERPUD1 | NA | HERPUD1 Entrez, Source | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 11949 | -0.738 | 0.0325 | No |
| 102 | EIF2AK3 | NA | EIF2AK3 Entrez, Source | eukaryotic translation initiation factor 2-alpha kinase 3 | 12089 | -0.781 | 0.0378 | No |
| 103 | KDELR3 | NA | KDELR3 Entrez, Source | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 | 12326 | -0.864 | 0.0376 | No |
| 104 | WIPI1 | NA | WIPI1 Entrez, Source | WD repeat domain, phosphoinositide interacting 1 | 12589 | -0.976 | 0.0377 | No |
| 105 | SLC7A5 | NA | SLC7A5 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 | 13086 | -1.288 | 0.0270 | No |
| 106 | DDIT4 | NA | DDIT4 Entrez, Source | DNA-damage-inducible transcript 4 | 13200 | -1.395 | 0.0462 | No |
