Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1w6a
GeneSetHALLMARK_TNFA_SIGNALING_VIA_NFKB
Enrichment Score (ES)0.63695526
Normalized Enrichment Score (NES)2.731225
Nominal p-value0.0
FDR q-value0.0
FWER p-Value0.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_TNFA_SIGNALING_VIA_NFKB   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1CXCL11NACXCL11
Entrez,  Source
chemokine (C-X-C motif) ligand 1114.7640.0224Yes
2IL7RNAIL7R
Entrez,  Source
interleukin 7 receptor34.6800.0445Yes
3CCL5NACCL5
Entrez,  Source
chemokine (C-C motif) ligand 5104.4620.0652Yes
4DDX58NADDX58
Entrez,  Source
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58134.3970.0858Yes
5IL6NAIL6
Entrez,  Source
interleukin 6 (interferon, beta 2)154.3830.1064Yes
6CXCL10NACXCL10
Entrez,  Source
chemokine (C-X-C motif) ligand 10164.3140.1268Yes
7IFIT2NAIFIT2
Entrez,  Source
interferon-induced protein with tetratricopeptide repeats 2244.1400.1459Yes
8CYR61NACYR61
Entrez,  Source
cysteine-rich, angiogenic inducer, 61533.4460.1601Yes
9IFIH1NAIFIH1
Entrez,  Source
interferon induced with helicase C domain 1603.3430.1755Yes
10FOSL1NAFOSL1
Entrez,  Source
FOS-like antigen 1673.2600.1905Yes
11TRAF1NATRAF1
Entrez,  Source
TNF receptor-associated factor 1883.0290.2033Yes
12CCL2NACCL2
Entrez,  Source
chemokine (C-C motif) ligand 2982.9640.2167Yes
13SERPINE1NASERPINE1
Entrez,  Source
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 11092.8400.2294Yes
14TNFAIP3NATNFAIP3
Entrez,  Source
tumor necrosis factor, alpha-induced protein 31122.8040.2425Yes
15AREGNAAREG
Entrez,  Source
amphiregulin (schwannoma-derived growth factor)1132.7700.2556Yes
16RELBNARELB
Entrez,  Source
v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (avian)1162.7100.2682Yes
17SDC4NASDC4
Entrez,  Source
syndecan 4 (amphiglycan, ryudocan)1492.5030.2777Yes
18BIRC3NABIRC3
Entrez,  Source
baculoviral IAP repeat-containing 31522.4950.2894Yes
19PTGER4NAPTGER4
Entrez,  Source
prostaglandin E receptor 4 (subtype EP4)1592.4500.3005Yes
20GADD45ANAGADD45A
Entrez,  Source
growth arrest and DNA-damage-inducible, alpha1612.4290.3119Yes
21CXCL2NACXCL2
Entrez,  Source
chemokine (C-X-C motif) ligand 21622.4200.3234Yes
22NFKB2NANFKB2
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)1722.3690.3339Yes
23F3NAF3
Entrez,  Source
coagulation factor III (thromboplastin, tissue factor)1842.3220.3441Yes
24PLAURNAPLAUR
Entrez,  Source
plasminogen activator, urokinase receptor1872.3080.3549Yes
25F2RL1NAF2RL1
Entrez,  Source
coagulation factor II (thrombin) receptor-like 11902.2750.3655Yes
26PHLDA1NAPHLDA1
Entrez,  Source
pleckstrin homology-like domain, family A, member 11942.2570.3759Yes
27FJX1NAFJX1
Entrez,  Source
four jointed box 1 (Drosophila)2052.1890.3855Yes
28OLR1NAOLR1
Entrez,  Source
oxidised low density lipoprotein (lectin-like) receptor 12092.1710.3956Yes
29JUNNAJUN
Entrez,  Source
jun oncogene2361.9960.4031Yes
30ICAM1NAICAM1
Entrez,  Source
intercellular adhesion molecule 1 (CD54), human rhinovirus receptor2511.9520.4113Yes
31IRF1NAIRF1
Entrez,  Source
interferon regulatory factor 12521.9470.4205Yes
32MXD1NAMXD1
Entrez,  Source
MAX dimerization protein 12561.9380.4295Yes
33EDN1NAEDN1
Entrez,  Source
endothelin 12781.8290.4366Yes
34DUSP5NADUSP5
Entrez,  Source
dual specificity phosphatase 52801.8140.4451Yes
35PPP1R15ANAPPP1R15A
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 15A2861.7970.4532Yes
36TNIP1NATNIP1
Entrez,  Source
TNFAIP3 interacting protein 12951.7800.4610Yes
37CLCF1NACLCF1
Entrez,  Source
cardiotrophin-like cytokine factor 13091.7350.4683Yes
38HBEGFNAHBEGF
Entrez,  Source
heparin-binding EGF-like growth factor3191.7130.4757Yes
39CD44NACD44
Entrez,  Source
CD44 molecule (Indian blood group)3361.6590.4824Yes
40NFKBIENANFKBIE
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon3401.6480.4900Yes
41IL12BNAIL12B
Entrez,  Source
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)3661.5670.4955Yes
42PANX1NAPANX1
Entrez,  Source
pannexin 13821.5310.5017Yes
43SOCS3NASOCS3
Entrez,  Source
suppressor of cytokine signaling 33841.5260.5088Yes
44PDE4BNAPDE4B
Entrez,  Source
phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)3881.5230.5158Yes
45TUBB2ANATUBB2A
Entrez,  Source
tubulin, beta 2A3891.5230.5230Yes
46SERPINB8NASERPINB8
Entrez,  Source
serpin peptidase inhibitor, clade B (ovalbumin), member 84021.5020.5292Yes
47JAG1NAJAG1
Entrez,  Source
jagged 1 (Alagille syndrome)4321.4470.5339Yes
48B4GALT5NAB4GALT5
Entrez,  Source
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 54531.4050.5391Yes
49IER5NAIER5
Entrez,  Source
immediate early response 55061.3000.5415Yes
50RNF19BNA5071.3000.5476Yes
51FUT4NAFUT4
Entrez,  Source
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)5591.2370.5497Yes
52KLF4NAKLF4
Entrez,  Source
Kruppel-like factor 4 (gut)5661.2220.5551Yes
53MAP2K3NAMAP2K3
Entrez,  Source
mitogen-activated protein kinase kinase 35721.2130.5604Yes
54IL6STNAIL6ST
Entrez,  Source
interleukin 6 signal transducer (gp130, oncostatin M receptor)6451.1420.5606Yes
55ZFP36NAZFP36
Entrez,  Source
zinc finger protein 36, C3H type, homolog (mouse)6461.1400.5659Yes
56TIPARPNATIPARP
Entrez,  Source
TCDD-inducible poly(ADP-ribose) polymerase6491.1380.5712Yes
57MCL1NAMCL1
Entrez,  Source
myeloid cell leukemia sequence 1 (BCL2-related)6841.1130.5740Yes
58TAP1NATAP1
Entrez,  Source
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)6861.1120.5791Yes
59NFAT5NANFAT5
Entrez,  Source
nuclear factor of activated T-cells 5, tonicity-responsive7241.0720.5815Yes
60LIFNALIF
Entrez,  Source
leukemia inhibitory factor (cholinergic differentiation factor)7451.0560.5850Yes
61HES1NAHES1
Entrez,  Source
hairy and enhancer of split 1, (Drosophila)7641.0380.5886Yes
62TNIP2NATNIP2
Entrez,  Source
TNFAIP3 interacting protein 27771.0330.5926Yes
63PLK2NAPLK2
Entrez,  Source
polo-like kinase 2 (Drosophila)7781.0330.5975Yes
64LDLRNALDLR
Entrez,  Source
low density lipoprotein receptor (familial hypercholesterolemia)8031.0070.6005Yes
65IL18NAIL18
Entrez,  Source
interleukin 18 (interferon-gamma-inducing factor)8310.9880.6032Yes
66YRDCNAYRDC
Entrez,  Source
yrdC domain containing (E. coli)8900.9490.6034Yes
67SOD2NASOD2
Entrez,  Source
superoxide dismutase 2, mitochondrial8970.9450.6075Yes
68PTGS2NAPTGS2
Entrez,  Source
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)9020.9450.6116Yes
69IL1ANAIL1A
Entrez,  Source
interleukin 1, alpha9770.9040.6105Yes
70MAFFNAMAFF
Entrez,  Source
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)10230.8820.6114Yes
71SMAD3NASMAD3
Entrez,  Source
SMAD, mothers against DPP homolog 3 (Drosophila)10250.8810.6155Yes
72CCND1NACCND1
Entrez,  Source
cyclin D110330.8770.6191Yes
73PHLDA2NAPHLDA2
Entrez,  Source
pleckstrin homology-like domain, family A, member 210910.8540.6190Yes
74SQSTM1NASQSTM1
Entrez,  Source
sequestosome 111300.8380.6201Yes
75DRAM1NA11360.8360.6237Yes
76KLF10NAKLF10
Entrez,  Source
Kruppel-like factor 1011410.8350.6274Yes
77SPHK1NASPHK1
Entrez,  Source
sphingosine kinase 111980.8140.6271Yes
78STAT5ANASTAT5A
Entrez,  Source
signal transducer and activator of transcription 5A12380.7970.6280Yes
79FOSBNAFOSB
Entrez,  Source
FBJ murine osteosarcoma viral oncogene homolog B12660.7890.6298Yes
80PDLIM5NAPDLIM5
Entrez,  Source
PDZ and LIM domain 512690.7890.6334Yes
81IER3NAIER3
Entrez,  Source
immediate early response 312720.7880.6370Yes
82EHD1NAEHD1
Entrez,  Source
EH-domain containing 113570.7530.6344No
83CCRL2NACCRL2
Entrez,  Source
chemokine (C-C motif) receptor-like 214080.7410.6342No
84NAMPTNA14390.7340.6355No
85NFKBIANANFKBIA
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha14840.7210.6357No
86RELANARELA
Entrez,  Source
v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian)15700.6980.6327No
87IL15RANAIL15RA
Entrez,  Source
interleukin 15 receptor, alpha16900.6610.6272No
88RCAN1NA17890.6360.6230No
89BIRC2NABIRC2
Entrez,  Source
baculoviral IAP repeat-containing 219640.5940.6131No
90NFKB1NANFKB1
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)20040.5850.6130No
91ATP2B1NAATP2B1
Entrez,  Source
ATPase, Ca++ transporting, plasma membrane 121270.5650.6067No
92PFKFB3NAPFKFB3
Entrez,  Source
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 321410.5630.6084No
93CEBPBNACEBPB
Entrez,  Source
CCAAT/enhancer binding protein (C/EBP), beta22200.5470.6053No
94EIF1NAEIF1
Entrez,  Source
eukaryotic translation initiation factor 122490.5420.6058No
95TGIF1NA22990.5340.6047No
96BCL3NABCL3
Entrez,  Source
B-cell CLL/lymphoma 324210.5120.5983No
97FOSL2NAFOSL2
Entrez,  Source
FOS-like antigen 225240.4970.5932No
98IL1BNAIL1B
Entrez,  Source
interleukin 1, beta25810.4870.5914No
99IL23ANAIL23A
Entrez,  Source
interleukin 23, alpha subunit p1926100.4830.5916No
100CXCL3NACXCL3
Entrez,  Source
chemokine (C-X-C motif) ligand 328750.4380.5743No
101SAT1NASAT1
Entrez,  Source
spermidine/spermine N1-acetyltransferase 129430.4280.5715No
102IER2NAIER2
Entrez,  Source
immediate early response 230410.4160.5663No
103KDM6BNA32300.3900.5544No
104NR4A1NANR4A1
Entrez,  Source
nuclear receptor subfamily 4, group A, member 134360.3620.5411No
105TRIP10NATRIP10
Entrez,  Source
thyroid hormone receptor interactor 1040290.2940.4992No
106TNCNATNC
Entrez,  Source
tenascin C (hexabrachion)44570.2480.4691No
107GADD45BNAGADD45B
Entrez,  Source
growth arrest and DNA-damage-inducible, beta45060.2420.4667No
108SPSB1NASPSB1
Entrez,  Source
splA/ryanodine receptor domain and SOCS box containing 145820.2340.4623No
109RIPK2NARIPK2
Entrez,  Source
receptor-interacting serine-threonine kinase 245880.2330.4630No
110TRIB1NATRIB1
Entrez,  Source
tribbles homolog 1 (Drosophila)46790.2250.4575No
111KLF6NAKLF6
Entrez,  Source
Kruppel-like factor 647760.2140.4515No
112TANKNATANK
Entrez,  Source
TRAF family member-associated NFKB activator47900.2130.4516No
113TNFRSF9NATNFRSF9
Entrez,  Source
tumor necrosis factor receptor superfamily, member 952500.1660.4187No
114CCNL1NACCNL1
Entrez,  Source
cyclin L152720.1640.4180No
115GCH1NAGCH1
Entrez,  Source
GTP cyclohydrolase 1 (dopa-responsive dystonia)53040.1610.4165No
116JUNBNAJUNB
Entrez,  Source
jun B proto-oncogene54570.1450.4060No
117DNAJB4NADNAJB4
Entrez,  Source
DnaJ (Hsp40) homolog, subfamily B, member 454790.1420.4052No
118CDKN1ANACDKN1A
Entrez,  Source
cyclin-dependent kinase inhibitor 1A (p21, Cip1)57070.1150.3891No
119EGR1NAEGR1
Entrez,  Source
early growth response 159190.0950.3741No
120BHLHE40NA60730.0800.3633No
121NFE2L2NANFE2L2
Entrez,  Source
nuclear factor (erythroid-derived 2)-like 260870.0790.3627No
122LAMB3NALAMB3
Entrez,  Source
laminin, beta 363570.0540.3432No
123CFLARNACFLAR
Entrez,  Source
CASP8 and FADD-like apoptosis regulator63590.0530.3434No
124ZC3H12ANAZC3H12A
Entrez,  Source
zinc finger CCCH-type containing 12A65980.0280.3261No
125RELNAREL
Entrez,  Source
v-rel reticuloendotheliosis viral oncogene homolog (avian)66030.0280.3260No
126MAP3K8NAMAP3K8
Entrez,  Source
mitogen-activated protein kinase kinase kinase 866080.0270.3258No
127DUSP1NADUSP1
Entrez,  Source
dual specificity phosphatase 16982-0.0130.2986No
128VEGFANA7811-0.0960.2384No
129MARCKSNAMARCKS
Entrez,  Source
myristoylated alanine-rich protein kinase C substrate7910-0.1050.2317No
130PLEKNAPLEK
Entrez,  Source
pleckstrin8123-0.1280.2168No
131BTG1NABTG1
Entrez,  Source
B-cell translocation gene 1, anti-proliferative8251-0.1430.2082No
132GFPT2NAGFPT2
Entrez,  Source
glutamine-fructose-6-phosphate transaminase 28574-0.1770.1854No
133BTG3NABTG3
Entrez,  Source
BTG family, member 38698-0.1910.1773No
134ICOSLGNAICOSLG
Entrez,  Source
inducible T-cell co-stimulator ligand8708-0.1920.1776No
135ETS2NAETS2
Entrez,  Source
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)8936-0.2180.1620No
136TNFAIP8NATNFAIP8
Entrez,  Source
tumor necrosis factor, alpha-induced protein 89099-0.2370.1512No
137TNFAIP2NATNFAIP2
Entrez,  Source
tumor necrosis factor, alpha-induced protein 29418-0.2820.1293No
138IFNGR2NAIFNGR2
Entrez,  Source
interferon gamma receptor 2 (interferon gamma transducer 1)9538-0.2990.1220No
139TSC22D1NATSC22D1
Entrez,  Source
TSC22 domain family, member 19700-0.3210.1117No
140MYCNAMYC
Entrez,  Source
v-myc myelocytomatosis viral oncogene homolog (avian)9860-0.3460.1017No
141SNNNASNN
Entrez,  Source
stannin9889-0.3490.1013No
142BCL6NABCL6
Entrez,  Source
B-cell CLL/lymphoma 6 (zinc finger protein 51)9958-0.3580.0980No
143PER1NAPER1
Entrez,  Source
period homolog 1 (Drosophila)10119-0.3810.0881No
144LITAFNALITAF
Entrez,  Source
lipopolysaccharide-induced TNF factor10242-0.4010.0811No
145PTPRENAPTPRE
Entrez,  Source
protein tyrosine phosphatase, receptor type, E10421-0.4300.0701No
146TNFSF9NATNFSF9
Entrez,  Source
tumor necrosis factor (ligand) superfamily, member 910580-0.4550.0607No
147NINJ1NANINJ1
Entrez,  Source
ninjurin 111112-0.5480.0244No
148DENND5ANA11166-0.5570.0231No
149CEBPDNACEBPD
Entrez,  Source
CCAAT/enhancer binding protein (C/EBP), delta11371-0.5980.0110No
150DUSP4NADUSP4
Entrez,  Source
dual specificity phosphatase 411499-0.6230.0047No
151EFNA1NAEFNA1
Entrez,  Source
ephrin-A111525-0.6290.0058No
152B4GALT1NAB4GALT1
Entrez,  Source
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 111626-0.6550.0016No
153KYNUNAKYNU
Entrez,  Source
kynureninase (L-kynurenine hydrolase)11707-0.673-0.0011No
154ABCA1NAABCA1
Entrez,  Source
ATP-binding cassette, sub-family A (ABC1), member 111871-0.716-0.0097No
155SLC16A6NASLC16A6
Entrez,  Source
solute carrier family 16, member 6 (monocarboxylic acid transporter 7)11937-0.735-0.0109No
156SIK1NA12035-0.767-0.0144No
157SLC2A6NASLC2A6
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 612151-0.805-0.0190No
158CD80NACD80
Entrez,  Source
CD80 molecule12189-0.816-0.0179No
159PLAUNAPLAU
Entrez,  Source
plasminogen activator, urokinase12310-0.855-0.0226No
160GEMNAGEM
Entrez,  Source
GTP binding protein overexpressed in skeletal muscle12453-0.919-0.0287No
161IRS2NAIRS2
Entrez,  Source
insulin receptor substrate 212470-0.925-0.0255No
162PMEPA1NA12482-0.930-0.0219No
163SGK1NA12552-0.961-0.0224No
164RHOBNARHOB
Entrez,  Source
ras homolog gene family, member B13181-1.375-0.0619No
165NR4A2NANR4A2
Entrez,  Source
nuclear receptor subfamily 4, group A, member 213281-1.489-0.0621No
166NR4A3NANR4A3
Entrez,  Source
nuclear receptor subfamily 4, group A, member 313295-1.507-0.0559No
167SLC2A3NASLC2A3
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 313297-1.509-0.0488No
168KLF9NAKLF9
Entrez,  Source
Kruppel-like factor 913300-1.512-0.0418No
169NFIL3NANFIL3
Entrez,  Source
nuclear factor, interleukin 3 regulated13322-1.542-0.0361No
170ZBTB10NAZBTB10
Entrez,  Source
zinc finger and BTB domain containing 1013360-1.592-0.0313No
171DUSP2NADUSP2
Entrez,  Source
dual specificity phosphatase 213368-1.602-0.0242No
172PNRC1NAPNRC1
Entrez,  Source
proline-rich nuclear receptor coactivator 113437-1.721-0.0211No
173BMP2NABMP2
Entrez,  Source
bone morphogenetic protein 213439-1.723-0.0130No
174FOSNAFOS
Entrez,  Source
v-fos FBJ murine osteosarcoma viral oncogene homolog13543-1.911-0.0115No
175CD83NACD83
Entrez,  Source
CD83 molecule13621-2.139-0.0070No
176BTG2NABTG2
Entrez,  Source
BTG family, member 213659-2.2850.0011No
177ID2NAID2
Entrez,  Source
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein13694-2.4660.0103No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_TNFA_SIGNALING_VIA_NFKB   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_TNFA_SIGNALING_VIA_NFKB: Random ES distribution   
Gene set null distribution of ES for HALLMARK_TNFA_SIGNALING_VIA_NFKB