Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | HALLMARK_PROTEIN_SECRETION |
| Enrichment Score (ES) | -0.33783123 |
| Normalized Enrichment Score (NES) | -1.2441903 |
| Nominal p-value | 0.12929623 |
| FDR q-value | 0.19471072 |
| FWER p-Value | 0.971 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | EGFR | NA | EGFR Entrez, Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 637 | 1.150 | -0.0089 | No |
| 2 | KRT18 | NA | KRT18 Entrez, Source | keratin 18 | 664 | 1.127 | 0.0260 | No |
| 3 | M6PR | NA | M6PR Entrez, Source | mannose-6-phosphate receptor (cation dependent) | 2168 | 0.558 | -0.0652 | No |
| 4 | GOSR2 | NA | GOSR2 Entrez, Source | golgi SNAP receptor complex member 2 | 2716 | 0.465 | -0.0898 | No |
| 5 | ATP6V1H | NA | ATP6V1H Entrez, Source | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H | 3683 | 0.335 | -0.1492 | No |
| 6 | TMX1 | NA | 3817 | 0.319 | -0.1485 | No | ||
| 7 | DNM1L | NA | DNM1L Entrez, Source | dynamin 1-like | 3859 | 0.315 | -0.1412 | No |
| 8 | CLTA | NA | CLTA Entrez, Source | clathrin, light chain (Lca) | 3984 | 0.298 | -0.1405 | No |
| 9 | RAB14 | NA | RAB14 Entrez, Source | RAB14, member RAS oncogene family | 4348 | 0.260 | -0.1584 | No |
| 10 | NAPG | NA | NAPG Entrez, Source | N-ethylmaleimide-sensitive factor attachment protein, gamma | 4542 | 0.238 | -0.1647 | No |
| 11 | COPE | NA | COPE Entrez, Source | coatomer protein complex, subunit epsilon | 4748 | 0.217 | -0.1726 | No |
| 12 | TPD52 | NA | TPD52 Entrez, Source | tumor protein D52 | 4775 | 0.214 | -0.1675 | No |
| 13 | ATP7A | NA | ATP7A Entrez, Source | ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome) | 4826 | 0.208 | -0.1643 | No |
| 14 | CD63 | NA | CD63 Entrez, Source | CD63 molecule | 4949 | 0.197 | -0.1668 | No |
| 15 | ARF1 | NA | ARF1 Entrez, Source | ADP-ribosylation factor 1 | 4972 | 0.195 | -0.1620 | No |
| 16 | ADAM10 | NA | ADAM10 Entrez, Source | ADAM metallopeptidase domain 10 | 5165 | 0.175 | -0.1703 | No |
| 17 | CLN5 | NA | CLN5 Entrez, Source | ceroid-lipofuscinosis, neuronal 5 | 5317 | 0.161 | -0.1760 | No |
| 18 | RAB5A | NA | RAB5A Entrez, Source | RAB5A, member RAS oncogene family | 5356 | 0.155 | -0.1738 | No |
| 19 | ANP32E | NA | ANP32E Entrez, Source | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 5487 | 0.141 | -0.1786 | No |
| 20 | ZW10 | NA | ZW10 Entrez, Source | ZW10, kinetochore associated, homolog (Drosophila) | 5491 | 0.140 | -0.1743 | No |
| 21 | MON2 | NA | MON2 Entrez, Source | MON2 homolog (S. cerevisiae) | 5637 | 0.123 | -0.1808 | No |
| 22 | YKT6 | NA | YKT6 Entrez, Source | YKT6 v-SNARE homolog (S. cerevisiae) | 5680 | 0.118 | -0.1800 | No |
| 23 | VAMP3 | NA | VAMP3 Entrez, Source | vesicle-associated membrane protein 3 (cellubrevin) | 5789 | 0.108 | -0.1844 | No |
| 24 | RPS6KA3 | NA | RPS6KA3 Entrez, Source | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 5805 | 0.107 | -0.1820 | No |
| 25 | ARFGEF1 | NA | ARFGEF1 Entrez, Source | ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) | 5808 | 0.106 | -0.1787 | No |
| 26 | CLTC | NA | CLTC Entrez, Source | clathrin, heavy chain (Hc) | 5998 | 0.087 | -0.1896 | No |
| 27 | USO1 | NA | 6002 | 0.087 | -0.1870 | No | ||
| 28 | NAPA | NA | NAPA Entrez, Source | N-ethylmaleimide-sensitive factor attachment protein, alpha | 6166 | 0.071 | -0.1965 | No |
| 29 | OCRL | NA | OCRL Entrez, Source | oculocerebrorenal syndrome of Lowe | 6349 | 0.054 | -0.2080 | No |
| 30 | GOLGA4 | NA | GOLGA4 Entrez, Source | golgi autoantigen, golgin subfamily a, 4 | 6352 | 0.054 | -0.2064 | No |
| 31 | SCAMP3 | NA | SCAMP3 Entrez, Source | secretory carrier membrane protein 3 | 6468 | 0.041 | -0.2134 | No |
| 32 | GLA | NA | GLA Entrez, Source | galactosidase, alpha | 6473 | 0.041 | -0.2123 | No |
| 33 | COG2 | NA | COG2 Entrez, Source | component of oligomeric golgi complex 2 | 6476 | 0.041 | -0.2112 | No |
| 34 | AP1G1 | NA | AP1G1 Entrez, Source | adaptor-related protein complex 1, gamma 1 subunit | 6541 | 0.034 | -0.2147 | No |
| 35 | GBF1 | NA | GBF1 Entrez, Source | golgi-specific brefeldin A resistance factor 1 | 6624 | 0.026 | -0.2198 | No |
| 36 | TMED2 | NA | TMED2 Entrez, Source | transmembrane emp24 domain trafficking protein 2 | 6699 | 0.017 | -0.2247 | No |
| 37 | STAM | NA | STAM Entrez, Source | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 | 6739 | 0.013 | -0.2271 | No |
| 38 | STX16 | NA | STX16 Entrez, Source | syntaxin 16 | 7099 | -0.023 | -0.2525 | No |
| 39 | ARCN1 | NA | ARCN1 Entrez, Source | archain 1 | 7110 | -0.024 | -0.2524 | No |
| 40 | AP2S1 | NA | AP2S1 Entrez, Source | adaptor-related protein complex 2, sigma 1 subunit | 7118 | -0.025 | -0.2521 | No |
| 41 | RAB22A | NA | RAB22A Entrez, Source | RAB22A, member RAS oncogene family | 7249 | -0.039 | -0.2603 | No |
| 42 | DOPEY1 | NA | DOPEY1 Entrez, Source | dopey family member 1 | 7371 | -0.053 | -0.2674 | No |
| 43 | ATP1A1 | NA | ATP1A1 Entrez, Source | ATPase, Na+/K+ transporting, alpha 1 polypeptide | 7459 | -0.063 | -0.2716 | No |
| 44 | RAB9A | NA | 7507 | -0.067 | -0.2729 | No | ||
| 45 | AP2B1 | NA | AP2B1 Entrez, Source | adaptor-related protein complex 2, beta 1 subunit | 7533 | -0.069 | -0.2724 | No |
| 46 | STX12 | NA | STX12 Entrez, Source | syntaxin 12 | 7578 | -0.073 | -0.2733 | No |
| 47 | IGF2R | NA | IGF2R Entrez, Source | insulin-like growth factor 2 receptor | 7634 | -0.078 | -0.2747 | No |
| 48 | YIPF6 | NA | YIPF6 Entrez, Source | Yip1 domain family, member 6 | 7703 | -0.084 | -0.2769 | No |
| 49 | CAV2 | NA | CAV2 Entrez, Source | caveolin 2 | 7705 | -0.084 | -0.2742 | No |
| 50 | DST | NA | DST Entrez, Source | dystonin | 7838 | -0.098 | -0.2806 | No |
| 51 | VPS4B | NA | VPS4B Entrez, Source | vacuolar protein sorting 4 homolog B (S. cerevisiae) | 7885 | -0.103 | -0.2806 | No |
| 52 | ARFIP1 | NA | ARFIP1 Entrez, Source | ADP-ribosylation factor interacting protein 1 (arfaptin 1) | 8110 | -0.127 | -0.2928 | No |
| 53 | SEC24D | NA | SEC24D Entrez, Source | SEC24 related gene family, member D (S. cerevisiae) | 8258 | -0.143 | -0.2988 | No |
| 54 | ARFGEF2 | NA | ARFGEF2 Entrez, Source | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 8613 | -0.181 | -0.3187 | No |
| 55 | AP2M1 | NA | AP2M1 Entrez, Source | adaptor-related protein complex 2, mu 1 subunit | 8670 | -0.187 | -0.3167 | No |
| 56 | COPB2 | NA | COPB2 Entrez, Source | coatomer protein complex, subunit beta 2 (beta prime) | 8908 | -0.215 | -0.3269 | No |
| 57 | MAPK1 | NA | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 8973 | -0.222 | -0.3243 | No |
| 58 | PPT1 | NA | PPT1 Entrez, Source | palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile) | 9042 | -0.231 | -0.3217 | No |
| 59 | RAB2A | NA | 9185 | -0.248 | -0.3240 | No | ||
| 60 | RER1 | NA | RER1 Entrez, Source | RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae) | 9257 | -0.258 | -0.3207 | No |
| 61 | SSPN | NA | SSPN Entrez, Source | sarcospan (Kras oncogene-associated gene) | 9467 | -0.288 | -0.3266 | No |
| 62 | AP3B1 | NA | AP3B1 Entrez, Source | adaptor-related protein complex 3, beta 1 subunit | 9623 | -0.310 | -0.3277 | Yes |
| 63 | CTSC | NA | CTSC Entrez, Source | cathepsin C | 9651 | -0.314 | -0.3195 | Yes |
| 64 | LMAN1 | NA | LMAN1 Entrez, Source | lectin, mannose-binding, 1 | 9794 | -0.336 | -0.3188 | Yes |
| 65 | LAMP2 | NA | LAMP2 Entrez, Source | lysosomal-associated membrane protein 2 | 9988 | -0.362 | -0.3211 | Yes |
| 66 | VAMP4 | NA | VAMP4 Entrez, Source | vesicle-associated membrane protein 4 | 10034 | -0.369 | -0.3123 | Yes |
| 67 | AP3S1 | NA | AP3S1 Entrez, Source | adaptor-related protein complex 3, sigma 1 subunit | 10066 | -0.374 | -0.3024 | Yes |
| 68 | SCRN1 | NA | SCRN1 Entrez, Source | secernin 1 | 10090 | -0.377 | -0.2918 | Yes |
| 69 | BET1 | NA | BET1 Entrez, Source | BET1 homolog (S. cerevisiae) | 10115 | -0.380 | -0.2811 | Yes |
| 70 | KIF1B | NA | KIF1B Entrez, Source | kinesin family member 1B | 10440 | -0.433 | -0.2906 | Yes |
| 71 | ERGIC3 | NA | ERGIC3 Entrez, Source | ERGIC and golgi 3 | 10478 | -0.438 | -0.2790 | Yes |
| 72 | TSG101 | NA | TSG101 Entrez, Source | tumor susceptibility gene 101 | 10617 | -0.461 | -0.2740 | Yes |
| 73 | SGMS1 | NA | 10957 | -0.519 | -0.2818 | Yes | ||
| 74 | VPS45 | NA | 11106 | -0.547 | -0.2747 | Yes | ||
| 75 | VAMP7 | NA | 11294 | -0.583 | -0.2693 | Yes | ||
| 76 | CLCN3 | NA | CLCN3 Entrez, Source | chloride channel 3 | 11420 | -0.608 | -0.2586 | Yes |
| 77 | STX7 | NA | STX7 Entrez, Source | syntaxin 7 | 11425 | -0.609 | -0.2390 | Yes |
| 78 | SH3GL2 | NA | SH3GL2 Entrez, Source | SH3-domain GRB2-like 2 | 11558 | -0.638 | -0.2278 | Yes |
| 79 | PAM | NA | PAM Entrez, Source | peptidylglycine alpha-amidating monooxygenase | 11576 | -0.642 | -0.2081 | Yes |
| 80 | SOD1 | NA | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 11746 | -0.684 | -0.1981 | Yes |
| 81 | SNAP23 | NA | SNAP23 Entrez, Source | synaptosomal-associated protein, 23kDa | 11768 | -0.689 | -0.1772 | Yes |
| 82 | ABCA1 | NA | ABCA1 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 1 | 11871 | -0.716 | -0.1613 | Yes |
| 83 | TOM1L1 | NA | TOM1L1 Entrez, Source | target of myb1-like 1 (chicken) | 11957 | -0.740 | -0.1433 | Yes |
| 84 | BNIP3 | NA | BNIP3 Entrez, Source | BCL2/adenovirus E1B 19kDa interacting protein 3 | 12007 | -0.759 | -0.1222 | Yes |
| 85 | ARFGAP3 | NA | ARFGAP3 Entrez, Source | ADP-ribosylation factor GTPase activating protein 3 | 12050 | -0.772 | -0.1001 | Yes |
| 86 | SNX2 | NA | SNX2 Entrez, Source | sorting nexin 2 | 12218 | -0.825 | -0.0853 | Yes |
| 87 | TMED10 | NA | TMED10 Entrez, Source | transmembrane emp24-like trafficking protein 10 (yeast) | 12466 | -0.924 | -0.0732 | Yes |
| 88 | SEC22B | NA | SEC22B Entrez, Source | SEC22 vesicle trafficking protein homolog B (S. cerevisiae) | 12516 | -0.946 | -0.0459 | Yes |
| 89 | GNAS | NA | GNAS Entrez, Source | GNAS complex locus | 12592 | -0.977 | -0.0195 | Yes |
| 90 | TSPAN8 | NA | TSPAN8 Entrez, Source | tetraspanin 8 | 12652 | -1.010 | 0.0091 | Yes |
| 91 | COPB1 | NA | COPB1 Entrez, Source | coatomer protein complex, subunit beta 1 | 12909 | -1.156 | 0.0282 | Yes |
| 92 | SCAMP1 | NA | SCAMP1 Entrez, Source | secretory carrier membrane protein 1 | 12975 | -1.198 | 0.0625 | Yes |
