Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | HALLMARK_PEROXISOME |
| Enrichment Score (ES) | -0.3406513 |
| Normalized Enrichment Score (NES) | -1.2386559 |
| Nominal p-value | 0.13374805 |
| FDR q-value | 0.18884732 |
| FWER p-Value | 0.973 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CRABP2 | NA | CRABP2 Entrez, Source | cellular retinoic acid binding protein 2 | 355 | 1.608 | 0.0061 | No |
| 2 | SEMA3C | NA | SEMA3C Entrez, Source | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 448 | 1.410 | 0.0275 | No |
| 3 | HSD3B7 | NA | HSD3B7 Entrez, Source | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | 543 | 1.261 | 0.0457 | No |
| 4 | MVP | NA | MVP Entrez, Source | major vault protein | 861 | 0.970 | 0.0419 | No |
| 5 | SOD2 | NA | SOD2 Entrez, Source | superoxide dismutase 2, mitochondrial | 897 | 0.945 | 0.0581 | No |
| 6 | BCL10 | NA | BCL10 Entrez, Source | B-cell CLL/lymphoma 10 | 1088 | 0.855 | 0.0613 | No |
| 7 | STS | NA | STS Entrez, Source | steroid sulfatase (microsomal), arylsulfatase C, isozyme S | 1158 | 0.828 | 0.0728 | No |
| 8 | CLN6 | NA | CLN6 Entrez, Source | ceroid-lipofuscinosis, neuronal 6, late infantile, variant | 1278 | 0.785 | 0.0797 | No |
| 9 | NUDT19 | NA | NUDT19 Entrez, Source | nudix (nucleoside diphosphate linked moiety X)-type motif 19 | 1438 | 0.734 | 0.0827 | No |
| 10 | CEL | NA | CEL Entrez, Source | carboxyl ester lipase (bile salt-stimulated lipase) | 1636 | 0.677 | 0.0818 | No |
| 11 | ABCB9 | NA | ABCB9 Entrez, Source | ATP-binding cassette, sub-family B (MDR/TAP), member 9 | 2022 | 0.583 | 0.0654 | No |
| 12 | HRAS | NA | HRAS Entrez, Source | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | 2253 | 0.541 | 0.0594 | No |
| 13 | CDK7 | NA | CDK7 Entrez, Source | cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) | 2770 | 0.456 | 0.0310 | No |
| 14 | ACSL4 | NA | ACSL4 Entrez, Source | acyl-CoA synthetase long-chain family member 4 | 3026 | 0.418 | 0.0207 | No |
| 15 | CNBP | NA | CNBP Entrez, Source | CCHC-type zinc finger, nucleic acid binding protein | 3033 | 0.417 | 0.0286 | No |
| 16 | MSH2 | NA | MSH2 Entrez, Source | mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) | 3158 | 0.399 | 0.0275 | No |
| 17 | ABCC5 | NA | ABCC5 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 3192 | 0.395 | 0.0329 | No |
| 18 | ITGB1BP1 | NA | ITGB1BP1 Entrez, Source | integrin beta 1 binding protein 1 | 3342 | 0.377 | 0.0296 | No |
| 19 | ABCD1 | NA | ABCD1 Entrez, Source | ATP-binding cassette, sub-family D (ALD), member 1 | 3434 | 0.362 | 0.0302 | No |
| 20 | LONP2 | NA | 3452 | 0.360 | 0.0361 | No | ||
| 21 | ACSL5 | NA | ACSL5 Entrez, Source | acyl-CoA synthetase long-chain family member 5 | 4128 | 0.284 | -0.0074 | No |
| 22 | PABPC1 | NA | PABPC1 Entrez, Source | poly(A) binding protein, cytoplasmic 1 | 4342 | 0.261 | -0.0177 | No |
| 23 | YWHAH | NA | YWHAH Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | 4514 | 0.241 | -0.0253 | No |
| 24 | SLC25A17 | NA | SLC25A17 Entrez, Source | solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 | 4628 | 0.230 | -0.0290 | No |
| 25 | ERCC3 | NA | ERCC3 Entrez, Source | excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) | 4871 | 0.205 | -0.0425 | No |
| 26 | SLC23A2 | NA | SLC23A2 Entrez, Source | solute carrier family 23 (nucleobase transporters), member 2 | 5054 | 0.186 | -0.0521 | No |
| 27 | CLN8 | NA | CLN8 Entrez, Source | ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) | 5438 | 0.147 | -0.0770 | No |
| 28 | PEX5 | NA | PEX5 Entrez, Source | peroxisomal biogenesis factor 5 | 5474 | 0.143 | -0.0767 | No |
| 29 | RETSAT | NA | RETSAT Entrez, Source | retinol saturase (all-trans-retinol 13,14-reductase) | 6362 | 0.053 | -0.1401 | No |
| 30 | SLC25A19 | NA | SLC25A19 Entrez, Source | solute carrier family 25 (mitochondrial deoxynucleotide carrier), member 19 | 6528 | 0.036 | -0.1514 | No |
| 31 | PEX2 | NA | 6578 | 0.030 | -0.1544 | No | ||
| 32 | ABCB4 | NA | ABCB4 Entrez, Source | ATP-binding cassette, sub-family B (MDR/TAP), member 4 | 6678 | 0.020 | -0.1612 | No |
| 33 | SLC25A4 | NA | SLC25A4 Entrez, Source | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 | 6960 | -0.011 | -0.1814 | No |
| 34 | PEX6 | NA | PEX6 Entrez, Source | peroxisomal biogenesis factor 6 | 7187 | -0.031 | -0.1972 | No |
| 35 | PEX14 | NA | PEX14 Entrez, Source | peroxisomal biogenesis factor 14 | 7364 | -0.052 | -0.2090 | No |
| 36 | SMARCC1 | NA | SMARCC1 Entrez, Source | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 7486 | -0.065 | -0.2165 | No |
| 37 | IDE | NA | IDE Entrez, Source | insulin-degrading enzyme | 7554 | -0.071 | -0.2200 | No |
| 38 | CTBP1 | NA | CTBP1 Entrez, Source | C-terminal binding protein 1 | 7594 | -0.075 | -0.2213 | No |
| 39 | VPS4B | NA | VPS4B Entrez, Source | vacuolar protein sorting 4 homolog B (S. cerevisiae) | 7885 | -0.103 | -0.2404 | No |
| 40 | HSD11B2 | NA | HSD11B2 Entrez, Source | hydroxysteroid (11-beta) dehydrogenase 2 | 8181 | -0.134 | -0.2592 | No |
| 41 | DHCR24 | NA | DHCR24 Entrez, Source | 24-dehydrocholesterol reductase | 8270 | -0.144 | -0.2627 | No |
| 42 | PRDX1 | NA | PRDX1 Entrez, Source | peroxiredoxin 1 | 8396 | -0.157 | -0.2687 | No |
| 43 | ELOVL5 | NA | ELOVL5 Entrez, Source | ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast) | 8468 | -0.166 | -0.2705 | No |
| 44 | ERCC1 | NA | ERCC1 Entrez, Source | excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) | 8611 | -0.180 | -0.2773 | No |
| 45 | ACAA1 | NA | ACAA1 Entrez, Source | acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase) | 8688 | -0.190 | -0.2790 | No |
| 46 | RDH11 | NA | RDH11 Entrez, Source | retinol dehydrogenase 11 (all-trans/9-cis/11-cis) | 8706 | -0.192 | -0.2765 | No |
| 47 | MLYCD | NA | MLYCD Entrez, Source | malonyl-CoA decarboxylase | 8788 | -0.201 | -0.2784 | No |
| 48 | GNPAT | NA | GNPAT Entrez, Source | glyceronephosphate O-acyltransferase | 9189 | -0.248 | -0.3025 | No |
| 49 | TOP2A | NA | TOP2A Entrez, Source | topoisomerase (DNA) II alpha 170kDa | 9333 | -0.268 | -0.3076 | No |
| 50 | PEX11B | NA | PEX11B Entrez, Source | peroxisomal biogenesis factor 11B | 9374 | -0.275 | -0.3051 | No |
| 51 | ISOC1 | NA | ISOC1 Entrez, Source | isochorismatase domain containing 1 | 9741 | -0.327 | -0.3252 | No |
| 52 | SIAH1 | NA | SIAH1 Entrez, Source | seven in absentia homolog 1 (Drosophila) | 9876 | -0.348 | -0.3280 | No |
| 53 | ABCD3 | NA | ABCD3 Entrez, Source | ATP-binding cassette, sub-family D (ALD), member 3 | 9890 | -0.349 | -0.3220 | No |
| 54 | SLC27A2 | NA | SLC27A2 Entrez, Source | solute carrier family 27 (fatty acid transporter), member 2 | 9957 | -0.357 | -0.3197 | No |
| 55 | SLC35B2 | NA | SLC35B2 Entrez, Source | solute carrier family 35, member B2 | 10077 | -0.375 | -0.3209 | No |
| 56 | ECI2 | NA | 10219 | -0.397 | -0.3233 | No | ||
| 57 | TSPO | NA | TSPO Entrez, Source | translocator protein (18kDa) | 10302 | -0.410 | -0.3211 | No |
| 58 | DLG4 | NA | DLG4 Entrez, Source | discs, large homolog 4 (Drosophila) | 10572 | -0.454 | -0.3316 | Yes |
| 59 | PEX13 | NA | PEX13 Entrez, Source | peroxisome biogenesis factor 13 | 10631 | -0.464 | -0.3266 | Yes |
| 60 | HSD17B11 | NA | 10655 | -0.468 | -0.3190 | Yes | ||
| 61 | SCP2 | NA | SCP2 Entrez, Source | sterol carrier protein 2 | 10711 | -0.477 | -0.3135 | Yes |
| 62 | EHHADH | NA | EHHADH Entrez, Source | enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase | 10749 | -0.483 | -0.3066 | Yes |
| 63 | PEX11A | NA | PEX11A Entrez, Source | peroxisomal biogenesis factor 11A | 10928 | -0.514 | -0.3093 | Yes |
| 64 | ALDH9A1 | NA | ALDH9A1 Entrez, Source | aldehyde dehydrogenase 9 family, member A1 | 10955 | -0.519 | -0.3009 | Yes |
| 65 | FIS1 | NA | FIS1 Entrez, Source | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | 11214 | -0.566 | -0.3084 | Yes |
| 66 | GSTK1 | NA | GSTK1 Entrez, Source | glutathione S-transferase kappa 1 | 11268 | -0.579 | -0.3008 | Yes |
| 67 | ACOX1 | NA | ACOX1 Entrez, Source | acyl-Coenzyme A oxidase 1, palmitoyl | 11472 | -0.619 | -0.3032 | Yes |
| 68 | SOD1 | NA | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 11746 | -0.684 | -0.3095 | Yes |
| 69 | HSD17B4 | NA | HSD17B4 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 4 | 11867 | -0.715 | -0.3040 | Yes |
| 70 | PRDX5 | NA | PRDX5 Entrez, Source | peroxiredoxin 5 | 11922 | -0.730 | -0.2934 | Yes |
| 71 | UGT2B17 | NA | UGT2B17 Entrez, Source | UDP glucuronosyltransferase 2 family, polypeptide B17 | 12227 | -0.829 | -0.2991 | Yes |
| 72 | ACOT8 | NA | ACOT8 Entrez, Source | acyl-CoA thioesterase 8 | 12438 | -0.910 | -0.2962 | Yes |
| 73 | HMGCL | NA | HMGCL Entrez, Source | 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) | 12509 | -0.943 | -0.2826 | Yes |
| 74 | CADM1 | NA | 12545 | -0.959 | -0.2661 | Yes | ||
| 75 | FDPS | NA | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 12663 | -1.017 | -0.2544 | Yes |
| 76 | ATXN1 | NA | ATXN1 Entrez, Source | ataxin 1 | 13051 | -1.257 | -0.2575 | Yes |
| 77 | IDI1 | NA | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 13058 | -1.264 | -0.2328 | Yes |
| 78 | FADS1 | NA | FADS1 Entrez, Source | fatty acid desaturase 1 | 13062 | -1.268 | -0.2079 | Yes |
| 79 | IDH1 | NA | IDH1 Entrez, Source | isocitrate dehydrogenase 1 (NADP+), soluble | 13083 | -1.285 | -0.1838 | Yes |
| 80 | CRAT | NA | CRAT Entrez, Source | carnitine acetyltransferase | 13125 | -1.314 | -0.1607 | Yes |
| 81 | ECH1 | NA | ECH1 Entrez, Source | enoyl Coenzyme A hydratase 1, peroxisomal | 13349 | -1.579 | -0.1455 | Yes |
| 82 | DHRS3 | NA | DHRS3 Entrez, Source | dehydrogenase/reductase (SDR family) member 3 | 13396 | -1.646 | -0.1161 | Yes |
| 83 | IDH2 | NA | IDH2 Entrez, Source | isocitrate dehydrogenase 2 (NADP+), mitochondrial | 13440 | -1.724 | -0.0850 | Yes |
| 84 | CAT | NA | CAT Entrez, Source | catalase | 13474 | -1.769 | -0.0522 | Yes |
| 85 | SULT2B1 | NA | SULT2B1 Entrez, Source | sulfotransferase family, cytosolic, 2B, member 1 | 13538 | -1.902 | -0.0190 | Yes |
| 86 | ACSL1 | NA | ACSL1 Entrez, Source | acyl-CoA synthetase long-chain family member 1 | 13590 | -2.037 | 0.0177 | Yes |
