Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1w6a
GeneSetHALLMARK_P53_PATHWAY
Enrichment Score (ES)0.2647454
Normalized Enrichment Score (NES)1.1394843
Nominal p-value0.17088607
FDR q-value0.2634583
FWER p-Value0.977
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_P53_PATHWAY   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1KRT17NAKRT17
Entrez,  Source
keratin 171212.6860.0131Yes
2RGS16NARGS16
Entrez,  Source
regulator of G-protein signalling 161432.5540.0324Yes
3GADD45ANAGADD45A
Entrez,  Source
growth arrest and DNA-damage-inducible, alpha1612.4290.0511Yes
4EPHA2NAEPHA2
Entrez,  Source
EPH receptor A21962.2510.0670Yes
5JUNNAJUN
Entrez,  Source
jun oncogene2361.9960.0804Yes
6MXD1NAMXD1
Entrez,  Source
MAX dimerization protein 12561.9380.0949Yes
7PPP1R15ANAPPP1R15A
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 15A2861.7970.1075Yes
8HBEGFNAHBEGF
Entrez,  Source
heparin-binding EGF-like growth factor3191.7130.1191Yes
9ITGB4NAITGB4
Entrez,  Source
integrin, beta 43271.6960.1325Yes
10IER5NAIER5
Entrez,  Source
immediate early response 55061.3000.1301Yes
11RNF19BNA5071.3000.1407Yes
12S100A10NAS100A10
Entrez,  Source
S100 calcium binding protein A105371.2650.1489Yes
13KLF4NAKLF4
Entrez,  Source
Kruppel-like factor 4 (gut)5661.2220.1569Yes
14VDRNAVDR
Entrez,  Source
vitamin D (1,25- dihydroxyvitamin D3) receptor5701.2190.1666Yes
15SLC7A11NASLC7A11
Entrez,  Source
solute carrier family 7, (cationic amino acid transporter, y+ system) member 115861.1980.1753Yes
16AENNA6431.1460.1806Yes
17PLK3NAPLK3
Entrez,  Source
polo-like kinase 3 (Drosophila)6811.1150.1870Yes
18TAP1NATAP1
Entrez,  Source
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)6861.1120.1958Yes
19LIFNALIF
Entrez,  Source
leukemia inhibitory factor (cholinergic differentiation factor)7451.0560.2002Yes
20PLK2NAPLK2
Entrez,  Source
polo-like kinase 2 (Drosophila)7781.0330.2063Yes
21BAIAP2NABAIAP2
Entrez,  Source
BAI1-associated protein 27981.0090.2132Yes
22DDIT3NADDIT3
Entrez,  Source
DNA-damage-inducible transcript 38880.9490.2144Yes
23IRAK1NAIRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 19180.9340.2199Yes
24ZFP36L1NAZFP36L1
Entrez,  Source
zinc finger protein 36, C3H type-like 19690.9100.2237Yes
25NOTCH1NANOTCH1
Entrez,  Source
Notch homolog 1, translocation-associated (Drosophila)9710.9090.2311Yes
26IL1ANAIL1A
Entrez,  Source
interleukin 1, alpha9770.9040.2381Yes
27TGFANATGFA
Entrez,  Source
transforming growth factor, alpha11210.8420.2345Yes
28DNTTIP2NADNTTIP2
Entrez,  Source
deoxynucleotidyltransferase, terminal, interacting protein 211290.8390.2408Yes
29DRAM1NA11360.8360.2472Yes
30SPHK1NASPHK1
Entrez,  Source
sphingosine kinase 111980.8140.2494Yes
31TCN2NATCN2
Entrez,  Source
transcobalamin II; macrocytic anemia12020.8120.2559Yes
32POM121NAPOM121
Entrez,  Source
POM121 membrane glycoprotein (rat)12440.7950.2594Yes
33IER3NAIER3
Entrez,  Source
immediate early response 312720.7880.2638Yes
34BAK1NABAK1
Entrez,  Source
BCL2-antagonist/killer 113450.7580.2647Yes
35TGFB1NATGFB1
Entrez,  Source
transforming growth factor, beta 1 (Camurati-Engelmann disease)15600.7000.2548No
36CCNKNACCNK
Entrez,  Source
cyclin K15610.7000.2605No
37SFNNASFN
Entrez,  Source
stratifin17230.6520.2541No
38TP63NA18170.6290.2524No
39HIST3H2ANAHIST3H2A
Entrez,  Source
histone cluster 3, H2a19920.5880.2445No
40PHLDA3NAPHLDA3
Entrez,  Source
pleckstrin homology-like domain, family A, member 320610.5760.2442No
41RCHY1NARCHY1
Entrez,  Source
ring finger and CHY zinc finger domain containing 121080.5680.2455No
42JAG2NAJAG2
Entrez,  Source
jagged 221120.5670.2499No
43MAPKAPK3NAMAPKAPK3
Entrez,  Source
mitogen-activated protein kinase-activated protein kinase 321900.5520.2488No
44FBXW7NAFBXW7
Entrez,  Source
F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)22010.5500.2525No
45HRASNAHRAS
Entrez,  Source
v-Ha-ras Harvey rat sarcoma viral oncogene homolog22530.5410.2532No
46STOMNASTOM
Entrez,  Source
stomatin23570.5230.2499No
47STEAP3NASTEAP3
Entrez,  Source
STEAP family member 324190.5120.2497No
48BLCAPNABLCAP
Entrez,  Source
bladder cancer associated protein24300.5110.2531No
49NUDT15NANUDT15
Entrez,  Source
nudix (nucleoside diphosphate linked moiety X)-type motif 1526270.4800.2427No
50RAD51CNARAD51C
Entrez,  Source
RAD51 homolog C (S. cerevisiae)26310.4790.2464No
51NOL8NANOL8
Entrez,  Source
nucleolar protein 826550.4750.2486No
52CSRNP2NA28190.4480.2403No
53INHBBNAINHBB
Entrez,  Source
inhibin, beta B (activin AB beta polypeptide)28330.4460.2430No
54SAT1NASAT1
Entrez,  Source
spermidine/spermine N1-acetyltransferase 129430.4280.2385No
55MDM2NAMDM2
Entrez,  Source
Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse)30990.4080.2305No
56ABCC5NAABCC5
Entrez,  Source
ATP-binding cassette, sub-family C (CFTR/MRP), member 531920.3950.2270No
57HSPA4LNAHSPA4L
Entrez,  Source
heat shock 70kDa protein 4-like32090.3920.2290No
58CGRRF1NACGRRF1
Entrez,  Source
cell growth regulator with ring finger domain 132290.3900.2308No
59FASNAFAS
Entrez,  Source
Fas (TNF receptor superfamily, member 6)34570.3600.2171No
60RRP8NA35040.3540.2167No
61F2RNAF2R
Entrez,  Source
coagulation factor II (thrombin) receptor35980.3440.2127No
62SEC61A1NASEC61A1
Entrez,  Source
Sec61 alpha 1 subunit (S. cerevisiae)37940.3210.2010No
63PRKAB1NAPRKAB1
Entrez,  Source
protein kinase, AMP-activated, beta 1 non-catalytic subunit39900.2980.1892No
64CDK5R1NACDK5R1
Entrez,  Source
cyclin-dependent kinase 5, regulatory subunit 1 (p35)41300.2840.1813No
65ACVR1BNAACVR1B
Entrez,  Source
activin A receptor, type IB41870.2790.1795No
66PERPNAPERP
Entrez,  Source
PERP, TP53 apoptosis effector42200.2750.1794No
67PDGFANAPDGFA
Entrez,  Source
platelet-derived growth factor alpha polypeptide42940.2670.1762No
68SERTAD3NASERTAD3
Entrez,  Source
SERTA domain containing 344210.2520.1691No
69SLC35D1NASLC35D1
Entrez,  Source
solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D145170.2410.1641No
70CDKN2AIPNA45390.2380.1645No
71CCP110NA47090.2210.1539No
72PPM1DNAPPM1D
Entrez,  Source
protein phosphatase 1D magnesium-dependent, delta isoform48770.2040.1434No
73WRAP73NA49700.1950.1382No
74WWP1NAWWP1
Entrez,  Source
WW domain containing E3 ubiquitin protein ligase 150110.1910.1368No
75RAP2BNARAP2B
Entrez,  Source
RAP2B, member of RAS oncogene family50440.1870.1360No
76HDAC3NAHDAC3
Entrez,  Source
histone deacetylase 350850.1830.1346No
77EI24NAEI24
Entrez,  Source
etoposide induced 2.4 mRNA51350.1790.1325No
78TAX1BP3NATAX1BP3
Entrez,  Source
Tax1 (human T-cell leukemia virus type I) binding protein 352420.1670.1261No
79SDC1NASDC1
Entrez,  Source
syndecan 153890.1520.1166No
80CDKN1ANACDKN1A
Entrez,  Source
cyclin-dependent kinase inhibitor 1A (p21, Cip1)57070.1150.0943No
81CCND3NACCND3
Entrez,  Source
cyclin D357220.1140.0942No
82RPL36NARPL36
Entrez,  Source
ribosomal protein L3657290.1130.0947No
83HMOX1NAHMOX1
Entrez,  Source
heme oxygenase (decycling) 158040.1070.0902No
84DGKANADGKA
Entrez,  Source
diacylglycerol kinase, alpha 80kDa60980.0770.0694No
85RHBDF2NARHBDF2
Entrez,  Source
rhomboid 5 homolog 2 (Drosophila)61200.0750.0684No
86CDKN2BNACDKN2B
Entrez,  Source
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)62290.0640.0611No
87RETSATNARETSAT
Entrez,  Source
retinol saturase (all-trans-retinol 13,14-reductase)63620.0530.0518No
88RXRANARXRA
Entrez,  Source
retinoid X receptor, alpha65250.0360.0403No
89TRAF4NATRAF4
Entrez,  Source
TNF receptor-associated factor 465460.0330.0391No
90POLHNAPOLH
Entrez,  Source
polymerase (DNA directed), eta65590.0310.0384No
91APPNAAPP
Entrez,  Source
amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)66520.0220.0319No
92FOXO3NA6872-0.0010.0159No
93ALOX15BNAALOX15B
Entrez,  Source
arachidonate 15-lipoxygenase, type B6956-0.0100.0099No
94PROCRNAPROCR
Entrez,  Source
protein C receptor, endothelial (EPCR)7498-0.066-0.0292No
95RPL18NARPL18
Entrez,  Source
ribosomal protein L187716-0.086-0.0444No
96EPS8L2NAEPS8L2
Entrez,  Source
EPS8-like 27900-0.104-0.0570No
97TPRKBNATPRKB
Entrez,  Source
TP53RK binding protein7972-0.111-0.0612No
98RB1NARB1
Entrez,  Source
retinoblastoma 1 (including osteosarcoma)8006-0.115-0.0627No
99BAXNABAX
Entrez,  Source
BCL2-associated X protein8170-0.133-0.0736No
100APAF1NAAPAF1
Entrez,  Source
apoptotic peptidase activating factor8206-0.138-0.0750No
101BTG1NABTG1
Entrez,  Source
B-cell translocation gene 1, anti-proliferative8251-0.143-0.0771No
102CD81NACD81
Entrez,  Source
CD81 molecule8271-0.144-0.0773No
103RAD9ANARAD9A
Entrez,  Source
RAD9 homolog A (S. pombe)8395-0.157-0.0850No
104RPS12NARPS12
Entrez,  Source
ribosomal protein S128510-0.170-0.0920No
105ANKRA2NAANKRA2
Entrez,  Source
ankyrin repeat, family A (RFXANK-like), 28766-0.199-0.1090No
106TSPYL2NATSPYL2
Entrez,  Source
TSPY-like 28793-0.201-0.1093No
107HEXIM1NAHEXIM1
Entrez,  Source
hexamethylene bis-acetamide inducible 18801-0.203-0.1081No
108TXNIPNATXNIP
Entrez,  Source
thioredoxin interacting protein8817-0.205-0.1075No
109TNNI1NATNNI1
Entrez,  Source
troponin I type 1 (skeletal, slow)8835-0.207-0.1071No
110SP1NASP1
Entrez,  Source
Sp1 transcription factor8912-0.215-0.1109No
111ISCUNA8913-0.215-0.1091No
112CCND2NACCND2
Entrez,  Source
cyclin D28965-0.222-0.1111No
113CDKN2ANACDKN2A
Entrez,  Source
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)9023-0.228-0.1134No
114PRMT2NAPRMT2
Entrez,  Source
protein arginine methyltransferase 29177-0.247-0.1226No
115SLC19A2NASLC19A2
Entrez,  Source
solute carrier family 19 (thiamine transporter), member 29224-0.253-0.1239No
116TRIAP1NATRIAP1
Entrez,  Source
TP53 regulated inhibitor of apoptosis 19232-0.254-0.1223No
117ERCC5NAERCC5
Entrez,  Source
me))9259-0.258-0.1221No
118PLXNB2NAPLXNB2
Entrez,  Source
plexin B29319-0.266-0.1242No
119GLS2NAGLS2
Entrez,  Source
glutaminase 2 (liver, mitochondrial)9616-0.309-0.1434No
120TRAFD1NATRAFD1
Entrez,  Source
TRAF-type zinc finger domain containing 19619-0.310-0.1410No
121TRIB3NATRIB3
Entrez,  Source
tribbles homolog 3 (Drosophila)9660-0.315-0.1413No
122TSC22D1NATSC22D1
Entrez,  Source
TSC22 domain family, member 19700-0.321-0.1416No
123XPCNAXPC
Entrez,  Source
xeroderma pigmentosum, complementation group C9754-0.329-0.1428No
124PCNANAPCNA
Entrez,  Source
proliferating cell nuclear antigen9955-0.357-0.1545No
125HINT1NAHINT1
Entrez,  Source
histidine triad nucleotide binding protein 110153-0.386-0.1658No
126ADANAADA
Entrez,  Source
adenosine deaminase10238-0.400-0.1686No
127CASP1NACASP1
Entrez,  Source
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)10265-0.405-0.1672No
128PTPN14NAPTPN14
Entrez,  Source
protein tyrosine phosphatase, non-receptor type 1410393-0.426-0.1731No
129IFI30NAIFI30
Entrez,  Source
interferon, gamma-inducible protein 3010399-0.427-0.1699No
130PTPRENAPTPRE
Entrez,  Source
protein tyrosine phosphatase, receptor type, E10421-0.430-0.1679No
131H2AFJNAH2AFJ
Entrez,  Source
H2A histone family, member J10438-0.433-0.1656No
132FAM162ANA10460-0.436-0.1635No
133MKNK2NAMKNK2
Entrez,  Source
MAP kinase interacting serine/threonine kinase 210481-0.438-0.1614No
134LDHBNALDHB
Entrez,  Source
lactate dehydrogenase B10486-0.440-0.1581No
135S100A4NAS100A4
Entrez,  Source
S100 calcium binding protein A410515-0.444-0.1565No
136TNFSF9NATNFSF9
Entrez,  Source
tumor necrosis factor (ligand) superfamily, member 910580-0.455-0.1575No
137EPHX1NAEPHX1
Entrez,  Source
epoxide hydrolase 1, microsomal (xenobiotic)10704-0.476-0.1626No
138DEF6NADEF6
Entrez,  Source
differentially expressed in FDCP 6 homolog (mouse)10775-0.488-0.1638No
139TPD52L1NATPD52L1
Entrez,  Source
tumor protein D52-like 110974-0.522-0.1740No
140RAB40CNARAB40C
Entrez,  Source
RAB40C, member RAS oncogene family11007-0.530-0.1720No
141DCXRNADCXR
Entrez,  Source
dicarbonyl/L-xylulose reductase11049-0.537-0.1706No
142NINJ1NANINJ1
Entrez,  Source
ninjurin 111112-0.548-0.1707No
143RALGDSNARALGDS
Entrez,  Source
ral guanine nucleotide dissociation stimulator11195-0.564-0.1721No
144CTSDNACTSD
Entrez,  Source
cathepsin D (lysosomal aspartyl peptidase)11336-0.592-0.1775No
145CD82NACD82
Entrez,  Source
CD82 molecule11402-0.606-0.1773No
146AK1NAAK1
Entrez,  Source
adenylate kinase 111498-0.623-0.1792No
147VWA5ANA11529-0.629-0.1762No
148TM7SF3NATM7SF3
Entrez,  Source
transmembrane 7 superfamily member 311535-0.632-0.1714No
149VAMP8NAVAMP8
Entrez,  Source
vesicle-associated membrane protein 8 (endobrevin)11633-0.657-0.1731No
150NUPR1NANUPR1
Entrez,  Source
-11636-0.658-0.1679No
151PITPNC1NAPITPNC1
Entrez,  Source
phosphatidylinositol transfer protein, cytoplasmic 111669-0.665-0.1648No
152RPS27LNARPS27L
Entrez,  Source
ribosomal protein S27-like11673-0.665-0.1596No
153FDXRNAFDXR
Entrez,  Source
ferredoxin reductase11725-0.677-0.1578No
154TOB1NATOB1
Entrez,  Source
transducer of ERBB2, 111787-0.694-0.1566No
155TM4SF1NATM4SF1
Entrez,  Source
transmembrane 4 L six family member 111810-0.701-0.1525No
156IP6K2NA11834-0.707-0.1484No
157GM2ANAGM2A
Entrez,  Source
GM2 ganglioside activator12044-0.771-0.1574No
158HIST1H1CNAHIST1H1C
Entrez,  Source
histone cluster 1, H1c12058-0.774-0.1520No
159SESN1NASESN1
Entrez,  Source
sestrin 112519-0.947-0.1779No
160ABATNAABAT
Entrez,  Source
4-aminobutyrate aminotransferase12624-0.996-0.1774No
161ABHD4NAABHD4
Entrez,  Source
abhydrolase domain containing 412649-1.009-0.1709No
162KIF13BNAKIF13B
Entrez,  Source
kinesin family member 13B12666-1.020-0.1637No
163PMM1NAPMM1
Entrez,  Source
phosphomannomutase 112678-1.026-0.1562No
164CCNG1NACCNG1
Entrez,  Source
cyclin G112706-1.040-0.1496No
165DDB2NADDB2
Entrez,  Source
damage-specific DNA binding protein 2, 48kDa12710-1.041-0.1413No
166TP53NATP53
Entrez,  Source
tumor protein p53 (Li-Fraumeni syndrome)12744-1.059-0.1351No
167SERPINB5NASERPINB5
Entrez,  Source
serpin peptidase inhibitor, clade B (ovalbumin), member 512822-1.100-0.1317No
168FUCA1NAFUCA1
Entrez,  Source
fucosidase, alpha-L- 1, tissue12896-1.146-0.1277No
169SLC3A2NASLC3A2
Entrez,  Source
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 212962-1.191-0.1227No
170MXD4NAMXD4
Entrez,  Source
MAX dimerization protein 412997-1.213-0.1153No
171DDIT4NADDIT4
Entrez,  Source
DNA-damage-inducible transcript 413200-1.395-0.1187No
172BMP2NABMP2
Entrez,  Source
bone morphogenetic protein 213439-1.723-0.1220No
173NDRG1NANDRG1
Entrez,  Source
N-myc downstream regulated gene 113498-1.810-0.1115No
174FOSNAFOS
Entrez,  Source
v-fos FBJ murine osteosarcoma viral oncogene homolog13543-1.911-0.0991No
175ST14NAST14
Entrez,  Source
suppression of tumorigenicity 14 (colon carcinoma)13551-1.938-0.0837No
176CEBPANACEBPA
Entrez,  Source
CCAAT/enhancer binding protein (C/EBP), alpha13632-2.174-0.0718No
177BTG2NABTG2
Entrez,  Source
BTG family, member 213659-2.285-0.0550No
178CTSFNACTSF
Entrez,  Source
cathepsin F13699-2.480-0.0376No
179ZMAT3NAZMAT3
Entrez,  Source
zinc finger, matrin type 313718-2.632-0.0174No
180CLCA2NACLCA2
Entrez,  Source
chloride channel, calcium activated, family member 213773-3.1600.0045No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_P53_PATHWAY   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_P53_PATHWAY: Random ES distribution   
Gene set null distribution of ES for HALLMARK_P53_PATHWAY