Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | HALLMARK_NOTCH_SIGNALING |
| Enrichment Score (ES) | 0.4479759 |
| Normalized Enrichment Score (NES) | 1.3506391 |
| Nominal p-value | 0.08715596 |
| FDR q-value | 0.07864082 |
| FWER p-Value | 0.561 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | JAG1 | NA | JAG1 Entrez, Source | jagged 1 (Alagille syndrome) | 432 | 1.447 | 0.0715 | Yes |
| 2 | DTX2 | NA | DTX2 Entrez, Source | deltex homolog 2 (Drosophila) | 504 | 1.307 | 0.1591 | Yes |
| 3 | HES1 | NA | HES1 Entrez, Source | hairy and enhancer of split 1, (Drosophila) | 764 | 1.038 | 0.2141 | Yes |
| 4 | NOTCH1 | NA | NOTCH1 Entrez, Source | Notch homolog 1, translocation-associated (Drosophila) | 971 | 0.909 | 0.2637 | Yes |
| 5 | CCND1 | NA | CCND1 Entrez, Source | cyclin D1 | 1033 | 0.877 | 0.3216 | Yes |
| 6 | NOTCH3 | NA | NOTCH3 Entrez, Source | Notch homolog 3 (Drosophila) | 1282 | 0.781 | 0.3590 | Yes |
| 7 | NOTCH2 | NA | NOTCH2 Entrez, Source | Notch homolog 2 (Drosophila) | 1656 | 0.674 | 0.3799 | Yes |
| 8 | PPARD | NA | PPARD Entrez, Source | peroxisome proliferative activated receptor, delta | 2085 | 0.571 | 0.3895 | Yes |
| 9 | FZD7 | NA | FZD7 Entrez, Source | frizzled homolog 7 (Drosophila) | 2285 | 0.536 | 0.4131 | Yes |
| 10 | MAML2 | NA | MAML2 Entrez, Source | mastermind-like 2 (Drosophila) | 2850 | 0.443 | 0.4037 | Yes |
| 11 | WNT5A | NA | WNT5A Entrez, Source | wingless-type MMTV integration site family, member 5A | 2963 | 0.425 | 0.4258 | Yes |
| 12 | KAT2A | NA | 3062 | 0.413 | 0.4480 | Yes | ||
| 13 | CUL1 | NA | CUL1 Entrez, Source | cullin 1 | 4403 | 0.253 | 0.3689 | No |
| 14 | SAP30 | NA | SAP30 Entrez, Source | Sin3A-associated protein, 30kDa | 4806 | 0.211 | 0.3548 | No |
| 15 | FBXW11 | NA | FBXW11 Entrez, Source | F-box and WD-40 domain protein 11 | 4825 | 0.208 | 0.3682 | No |
| 16 | DTX4 | NA | DTX4 Entrez, Source | deltex 4 homolog (Drosophila) | 6353 | 0.054 | 0.2615 | No |
| 17 | PSEN2 | NA | PSEN2 Entrez, Source | presenilin 2 (Alzheimer disease 4) | 6448 | 0.043 | 0.2578 | No |
| 18 | APH1A | NA | APH1A Entrez, Source | anterior pharynx defective 1 homolog A (C. elegans) | 6934 | -0.008 | 0.2232 | No |
| 19 | FZD5 | NA | FZD5 Entrez, Source | frizzled homolog 5 (Drosophila) | 7372 | -0.053 | 0.1953 | No |
| 20 | RBX1 | NA | RBX1 Entrez, Source | ring-box 1 | 7996 | -0.113 | 0.1583 | No |
| 21 | PSENEN | NA | PSENEN Entrez, Source | presenilin enhancer 2 homolog (C. elegans) | 8118 | -0.127 | 0.1585 | No |
| 22 | SKP1 | NA | 8163 | -0.133 | 0.1648 | No | ||
| 23 | FZD1 | NA | FZD1 Entrez, Source | frizzled homolog 1 (Drosophila) | 8193 | -0.136 | 0.1723 | No |
| 24 | ARRB1 | NA | ARRB1 Entrez, Source | arrestin, beta 1 | 9244 | -0.256 | 0.1145 | No |
| 25 | LFNG | NA | LFNG Entrez, Source | lunatic fringe homolog (Drosophila) | 9633 | -0.312 | 0.1085 | No |
| 26 | PRKCA | NA | PRKCA Entrez, Source | protein kinase C, alpha | 12193 | -0.818 | -0.0188 | No |
| 27 | ST3GAL6 | NA | ST3GAL6 Entrez, Source | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 12460 | -0.922 | 0.0274 | No |
| 28 | TCF7L2 | NA | TCF7L2 Entrez, Source | transcription factor 7-like 2 (T-cell specific, HMG-box) | 12658 | -1.014 | 0.0852 | No |
