Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | HALLMARK_MYOGENESIS |
| Enrichment Score (ES) | -0.51736164 |
| Normalized Enrichment Score (NES) | -2.0152986 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CACNA1H | NA | CACNA1H Entrez, Source | calcium channel, voltage-dependent, alpha 1H subunit | 55 | 3.423 | 0.0225 | No |
| 2 | FGF2 | NA | FGF2 Entrez, Source | fibroblast growth factor 2 (basic) | 146 | 2.533 | 0.0356 | No |
| 3 | PDLIM7 | NA | PDLIM7 Entrez, Source | PDZ and LIM domain 7 (enigma) | 178 | 2.350 | 0.0516 | No |
| 4 | HBEGF | NA | HBEGF Entrez, Source | heparin-binding EGF-like growth factor | 319 | 1.713 | 0.0546 | No |
| 5 | ITGB4 | NA | ITGB4 Entrez, Source | integrin, beta 4 | 327 | 1.696 | 0.0673 | No |
| 6 | ADAM12 | NA | ADAM12 Entrez, Source | ADAM metallopeptidase domain 12 (meltrin alpha) | 339 | 1.652 | 0.0793 | No |
| 7 | TAGLN | NA | TAGLN Entrez, Source | transgelin | 471 | 1.361 | 0.0803 | No |
| 8 | MYH11 | NA | MYH11 Entrez, Source | myosin, heavy chain 11, smooth muscle | 675 | 1.119 | 0.0741 | No |
| 9 | CNN3 | NA | CNN3 Entrez, Source | calponin 3, acidic | 866 | 0.966 | 0.0678 | No |
| 10 | TEAD4 | NA | TEAD4 Entrez, Source | TEA domain family member 4 | 910 | 0.939 | 0.0719 | No |
| 11 | STC2 | NA | STC2 Entrez, Source | stanniocalcin 2 | 926 | 0.931 | 0.0780 | No |
| 12 | NOTCH1 | NA | NOTCH1 Entrez, Source | Notch homolog 1, translocation-associated (Drosophila) | 971 | 0.909 | 0.0819 | No |
| 13 | IFRD1 | NA | IFRD1 Entrez, Source | interferon-related developmental regulator 1 | 1100 | 0.851 | 0.0791 | No |
| 14 | NCAM1 | NA | NCAM1 Entrez, Source | neural cell adhesion molecule 1 | 1176 | 0.822 | 0.0800 | No |
| 15 | SPHK1 | NA | SPHK1 Entrez, Source | sphingosine kinase 1 | 1198 | 0.814 | 0.0848 | No |
| 16 | MYH3 | NA | MYH3 Entrez, Source | myosin, heavy chain 3, skeletal muscle, embryonic | 1326 | 0.764 | 0.0814 | No |
| 17 | TGFB1 | NA | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 1560 | 0.700 | 0.0699 | No |
| 18 | MYH9 | NA | MYH9 Entrez, Source | myosin, heavy chain 9, non-muscle | 1590 | 0.692 | 0.0731 | No |
| 19 | SVIL | NA | SVIL Entrez, Source | supervillin | 1693 | 0.660 | 0.0708 | No |
| 20 | MYLK | NA | MYLK Entrez, Source | myosin, light chain kinase | 1806 | 0.632 | 0.0675 | No |
| 21 | NOS1 | NA | NOS1 Entrez, Source | nitric oxide synthase 1 (neuronal) | 2041 | 0.580 | 0.0549 | No |
| 22 | COL4A2 | NA | COL4A2 Entrez, Source | collagen, type IV, alpha 2 | 2271 | 0.538 | 0.0423 | No |
| 23 | APOD | NA | APOD Entrez, Source | apolipoprotein D | 2337 | 0.526 | 0.0417 | No |
| 24 | GPX3 | NA | GPX3 Entrez, Source | glutathione peroxidase 3 (plasma) | 2570 | 0.489 | 0.0285 | No |
| 25 | PRNP | NA | PRNP Entrez, Source | prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia) | 2789 | 0.453 | 0.0161 | No |
| 26 | KIFC3 | NA | KIFC3 Entrez, Source | kinesin family member C3 | 2805 | 0.451 | 0.0185 | No |
| 27 | SH3BGR | NA | SH3BGR Entrez, Source | SH3 domain binding glutamic acid-rich protein | 2992 | 0.422 | 0.0082 | No |
| 28 | HSPB8 | NA | HSPB8 Entrez, Source | heat shock 22kDa protein 8 | 3086 | 0.410 | 0.0046 | No |
| 29 | SORBS3 | NA | SORBS3 Entrez, Source | sorbin and SH3 domain containing 3 | 3466 | 0.359 | -0.0203 | No |
| 30 | SMTN | NA | SMTN Entrez, Source | smoothelin | 3502 | 0.354 | -0.0201 | No |
| 31 | SYNGR2 | NA | SYNGR2 Entrez, Source | synaptogyrin 2 | 4398 | 0.253 | -0.0835 | No |
| 32 | GADD45B | NA | GADD45B Entrez, Source | growth arrest and DNA-damage-inducible, beta | 4506 | 0.242 | -0.0894 | No |
| 33 | TPM2 | NA | TPM2 Entrez, Source | tropomyosin 2 (beta) | 4614 | 0.230 | -0.0955 | No |
| 34 | MAPRE3 | NA | MAPRE3 Entrez, Source | microtubule-associated protein, RP/EB family, member 3 | 4618 | 0.230 | -0.0939 | No |
| 35 | FLII | NA | FLII Entrez, Source | flightless I homolog (Drosophila) | 4832 | 0.208 | -0.1078 | No |
| 36 | IGFBP7 | NA | IGFBP7 Entrez, Source | insulin-like growth factor binding protein 7 | 5142 | 0.178 | -0.1290 | No |
| 37 | NQO1 | NA | NQO1 Entrez, Source | NAD(P)H dehydrogenase, quinone 1 | 5265 | 0.165 | -0.1367 | No |
| 38 | AGRN | NA | 5397 | 0.151 | -0.1451 | No | ||
| 39 | CDKN1A | NA | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 5707 | 0.115 | -0.1667 | No |
| 40 | ACTN2 | NA | ACTN2 Entrez, Source | actinin, alpha 2 | 5838 | 0.103 | -0.1754 | No |
| 41 | IGFBP3 | NA | IGFBP3 Entrez, Source | insulin-like growth factor binding protein 3 | 5964 | 0.091 | -0.1838 | No |
| 42 | BHLHE40 | NA | 6073 | 0.080 | -0.1911 | No | ||
| 43 | LAMA2 | NA | LAMA2 Entrez, Source | laminin, alpha 2 (merosin, congenital muscular dystrophy) | 6420 | 0.047 | -0.2160 | No |
| 44 | PSEN2 | NA | PSEN2 Entrez, Source | presenilin 2 (Alzheimer disease 4) | 6448 | 0.043 | -0.2177 | No |
| 45 | MEF2A | NA | MEF2A Entrez, Source | MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A) | 6485 | 0.040 | -0.2200 | No |
| 46 | DAPK2 | NA | DAPK2 Entrez, Source | death-associated protein kinase 2 | 6550 | 0.032 | -0.2244 | No |
| 47 | APP | NA | APP Entrez, Source | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | 6652 | 0.022 | -0.2316 | No |
| 48 | MRAS | NA | MRAS Entrez, Source | muscle RAS oncogene homolog | 6692 | 0.018 | -0.2343 | No |
| 49 | TPM3 | NA | TPM3 Entrez, Source | tropomyosin 3 | 6721 | 0.015 | -0.2362 | No |
| 50 | BIN1 | NA | BIN1 Entrez, Source | bridging integrator 1 | 6761 | 0.011 | -0.2390 | No |
| 51 | MEF2C | NA | MEF2C Entrez, Source | MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) | 6920 | -0.006 | -0.2505 | No |
| 52 | MEF2D | NA | MEF2D Entrez, Source | MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D) | 6971 | -0.012 | -0.2540 | No |
| 53 | PICK1 | NA | PICK1 Entrez, Source | protein interacting with PRKCA 1 | 7058 | -0.019 | -0.2602 | No |
| 54 | AKT2 | NA | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 7140 | -0.027 | -0.2659 | No |
| 55 | KLF5 | NA | KLF5 Entrez, Source | Kruppel-like factor 5 (intestinal) | 7151 | -0.028 | -0.2664 | No |
| 56 | SPEG | NA | SPEG Entrez, Source | SPEG complex locus | 7157 | -0.029 | -0.2665 | No |
| 57 | PFKM | NA | PFKM Entrez, Source | phosphofructokinase, muscle | 7219 | -0.035 | -0.2707 | No |
| 58 | PDE4DIP | NA | PDE4DIP Entrez, Source | phosphodiesterase 4D interacting protein (myomegalin) | 7243 | -0.038 | -0.2721 | No |
| 59 | SPTAN1 | NA | SPTAN1 Entrez, Source | spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) | 7714 | -0.086 | -0.3058 | No |
| 60 | TSC2 | NA | TSC2 Entrez, Source | tuberous sclerosis 2 | 7745 | -0.089 | -0.3073 | No |
| 61 | COL6A3 | NA | COL6A3 Entrez, Source | collagen, type VI, alpha 3 | 7823 | -0.097 | -0.3121 | No |
| 62 | ABLIM1 | NA | ABLIM1 Entrez, Source | actin binding LIM protein 1 | 7824 | -0.097 | -0.3114 | No |
| 63 | ITGB5 | NA | ITGB5 Entrez, Source | integrin, beta 5 | 7873 | -0.102 | -0.3141 | No |
| 64 | SH2B1 | NA | SH2B1 Entrez, Source | SH2B adaptor protein 1 | 7941 | -0.108 | -0.3182 | No |
| 65 | AGL | NA | AGL Entrez, Source | amylo-1, 6-glucosidase, 4-alpha-glucanotransferase (glycogen debranching enzyme, glycogen storage disease type III) | 7951 | -0.109 | -0.3180 | No |
| 66 | RB1 | NA | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 8006 | -0.115 | -0.3210 | No |
| 67 | LSP1 | NA | LSP1 Entrez, Source | lymphocyte-specific protein 1 | 8428 | -0.160 | -0.3505 | No |
| 68 | ADCY9 | NA | ADCY9 Entrez, Source | adenylate cyclase 9 | 8752 | -0.197 | -0.3726 | No |
| 69 | MYL6B | NA | MYL6B Entrez, Source | myosin, light chain 6B, alkali, smooth muscle and non-muscle | 8764 | -0.198 | -0.3719 | No |
| 70 | TNNI1 | NA | TNNI1 Entrez, Source | troponin I type 1 (skeletal, slow) | 8835 | -0.207 | -0.3754 | No |
| 71 | DMD | NA | DMD Entrez, Source | dystrophin (muscular dystrophy, Duchenne and Becker types) | 8927 | -0.217 | -0.3803 | No |
| 72 | PLXNB2 | NA | PLXNB2 Entrez, Source | plexin B2 | 9319 | -0.266 | -0.4068 | No |
| 73 | PGAM2 | NA | PGAM2 Entrez, Source | phosphoglycerate mutase 2 (muscle) | 9462 | -0.288 | -0.4150 | No |
| 74 | SSPN | NA | SSPN Entrez, Source | sarcospan (Kras oncogene-associated gene) | 9467 | -0.288 | -0.4130 | No |
| 75 | SGCD | NA | SGCD Entrez, Source | sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) | 9478 | -0.290 | -0.4115 | No |
| 76 | MAPK12 | NA | MAPK12 Entrez, Source | mitogen-activated protein kinase 12 | 9483 | -0.292 | -0.4095 | No |
| 77 | MYLPF | NA | MYLPF Entrez, Source | - | 9486 | -0.292 | -0.4074 | No |
| 78 | PTGIS | NA | PTGIS Entrez, Source | prostaglandin I2 (prostacyclin) synthase | 10417 | -0.429 | -0.4720 | No |
| 79 | ITGB1 | NA | ITGB1 Entrez, Source | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 10722 | -0.479 | -0.4905 | No |
| 80 | SIRT2 | NA | SIRT2 Entrez, Source | sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) | 10723 | -0.479 | -0.4868 | No |
| 81 | SGCG | NA | SGCG Entrez, Source | sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) | 10836 | -0.500 | -0.4911 | No |
| 82 | DMPK | NA | DMPK Entrez, Source | dystrophia myotonica-protein kinase | 10884 | -0.507 | -0.4906 | No |
| 83 | EIF4A2 | NA | EIF4A2 Entrez, Source | eukaryotic translation initiation factor 4A, isoform 2 | 10895 | -0.508 | -0.4874 | No |
| 84 | TPD52L1 | NA | TPD52L1 Entrez, Source | tumor protein D52-like 1 | 10974 | -0.522 | -0.4890 | No |
| 85 | GNAO1 | NA | GNAO1 Entrez, Source | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O | 11024 | -0.532 | -0.4885 | No |
| 86 | RIT1 | NA | RIT1 Entrez, Source | Ras-like without CAAX 1 | 11082 | -0.543 | -0.4884 | No |
| 87 | KCNH1 | NA | KCNH1 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 1 | 11094 | -0.545 | -0.4850 | No |
| 88 | IGF1 | NA | IGF1 Entrez, Source | insulin-like growth factor 1 (somatomedin C) | 11398 | -0.605 | -0.5024 | No |
| 89 | GAA | NA | GAA Entrez, Source | glucosidase, alpha; acid (Pompe disease, glycogen storage disease type II) | 11441 | -0.612 | -0.5007 | No |
| 90 | MYO1C | NA | MYO1C Entrez, Source | myosin IC | 11467 | -0.618 | -0.4978 | No |
| 91 | SPARC | NA | SPARC Entrez, Source | secreted protein, acidic, cysteine-rich (osteonectin) | 11483 | -0.621 | -0.4940 | No |
| 92 | AK1 | NA | AK1 Entrez, Source | adenylate kinase 1 | 11498 | -0.623 | -0.4902 | No |
| 93 | CHRNB1 | NA | CHRNB1 Entrez, Source | cholinergic receptor, nicotinic, beta 1 (muscle) | 11575 | -0.641 | -0.4908 | No |
| 94 | NAV2 | NA | NAV2 Entrez, Source | neuron navigator 2 | 11729 | -0.678 | -0.4967 | No |
| 95 | CD36 | NA | CD36 Entrez, Source | CD36 molecule (thrombospondin receptor) | 11998 | -0.756 | -0.5104 | No |
| 96 | TNNT1 | NA | TNNT1 Entrez, Source | troponin T type 1 (skeletal, slow) | 12094 | -0.784 | -0.5113 | Yes |
| 97 | ATP6AP1 | NA | ATP6AP1 Entrez, Source | ATPase, H+ transporting, lysosomal accessory protein 1 | 12153 | -0.805 | -0.5093 | Yes |
| 98 | GABARAPL2 | NA | GABARAPL2 Entrez, Source | GABA(A) receptor-associated protein-like 2 | 12225 | -0.829 | -0.5080 | Yes |
| 99 | SORBS1 | NA | SORBS1 Entrez, Source | sorbin and SH3 domain containing 1 | 12303 | -0.852 | -0.5070 | Yes |
| 100 | GSN | NA | GSN Entrez, Source | gelsolin (amyloidosis, Finnish type) | 12312 | -0.856 | -0.5010 | Yes |
| 101 | WWTR1 | NA | WWTR1 Entrez, Source | WW domain containing transcription regulator 1 | 12325 | -0.864 | -0.4952 | Yes |
| 102 | ITGA7 | NA | ITGA7 Entrez, Source | integrin, alpha 7 | 12379 | -0.885 | -0.4922 | Yes |
| 103 | ANKRD2 | NA | ANKRD2 Entrez, Source | ankyrin repeat domain 2 (stretch responsive muscle) | 12471 | -0.925 | -0.4916 | Yes |
| 104 | FDPS | NA | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 12663 | -1.017 | -0.4977 | Yes |
| 105 | SLC6A8 | NA | SLC6A8 Entrez, Source | solute carrier family 6 (neurotransmitter transporter, creatine), member 8 | 12717 | -1.043 | -0.4935 | Yes |
| 106 | LDB3 | NA | LDB3 Entrez, Source | LIM domain binding 3 | 12745 | -1.059 | -0.4872 | Yes |
| 107 | CFD | NA | CFD Entrez, Source | complement factor D (adipsin) | 12784 | -1.080 | -0.4816 | Yes |
| 108 | ST5 | NA | ST5 Entrez, Source | suppression of tumorigenicity 5 | 12808 | -1.095 | -0.4748 | Yes |
| 109 | ATP2A1 | NA | ATP2A1 Entrez, Source | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 | 12821 | -1.099 | -0.4672 | Yes |
| 110 | BAG1 | NA | BAG1 Entrez, Source | BCL2-associated athanogene | 13066 | -1.272 | -0.4751 | Yes |
| 111 | LPIN1 | NA | LPIN1 Entrez, Source | lipin 1 | 13100 | -1.298 | -0.4675 | Yes |
| 112 | COL15A1 | NA | COL15A1 Entrez, Source | collagen, type XV, alpha 1 | 13119 | -1.313 | -0.4586 | Yes |
| 113 | CRAT | NA | CRAT Entrez, Source | carnitine acetyltransferase | 13125 | -1.314 | -0.4488 | Yes |
| 114 | OCEL1 | NA | OCEL1 Entrez, Source | occludin/ELL domain containing 1 | 13130 | -1.318 | -0.4388 | Yes |
| 115 | CKB | NA | CKB Entrez, Source | creatine kinase, brain | 13162 | -1.352 | -0.4306 | Yes |
| 116 | HDAC5 | NA | HDAC5 Entrez, Source | histone deacetylase 5 | 13248 | -1.448 | -0.4256 | Yes |
| 117 | MB | NA | MB Entrez, Source | myoglobin | 13250 | -1.452 | -0.4144 | Yes |
| 118 | DES | NA | DES Entrez, Source | desmin | 13353 | -1.580 | -0.4096 | Yes |
| 119 | GJA5 | NA | GJA5 Entrez, Source | gap junction protein, alpha 5, 40kDa (connexin 40) | 13375 | -1.616 | -0.3986 | Yes |
| 120 | FOXO4 | NA | 13438 | -1.722 | -0.3898 | Yes | ||
| 121 | ERBB3 | NA | ERBB3 Entrez, Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 13454 | -1.742 | -0.3774 | Yes |
| 122 | FABP3 | NA | FABP3 Entrez, Source | fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) | 13532 | -1.895 | -0.3683 | Yes |
| 123 | MYOM1 | NA | MYOM1 Entrez, Source | myomesin 1 (skelemin) 185kDa | 13556 | -1.948 | -0.3548 | Yes |
| 124 | CTF1 | NA | CTF1 Entrez, Source | cardiotrophin 1 | 13582 | -2.018 | -0.3410 | Yes |
| 125 | ACSL1 | NA | ACSL1 Entrez, Source | acyl-CoA synthetase long-chain family member 1 | 13590 | -2.037 | -0.3257 | Yes |
| 126 | SCD | NA | SCD Entrez, Source | stearoyl-CoA desaturase (delta-9-desaturase) | 13591 | -2.038 | -0.3099 | Yes |
| 127 | RYR1 | NA | RYR1 Entrez, Source | ryanodine receptor 1 (skeletal) | 13609 | -2.096 | -0.2949 | Yes |
| 128 | ACTC1 | NA | ACTC1 Entrez, Source | actin, alpha, cardiac muscle 1 | 13620 | -2.138 | -0.2791 | Yes |
| 129 | DTNA | NA | DTNA Entrez, Source | dystrobrevin, alpha | 13629 | -2.169 | -0.2628 | Yes |
| 130 | PPP1R3C | NA | PPP1R3C Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 3C | 13630 | -2.169 | -0.2460 | Yes |
| 131 | PC | NA | PC Entrez, Source | pyruvate carboxylase | 13641 | -2.224 | -0.2295 | Yes |
| 132 | TNNC1 | NA | TNNC1 Entrez, Source | troponin C type 1 (slow) | 13657 | -2.279 | -0.2129 | Yes |
| 133 | MYOM2 | NA | MYOM2 Entrez, Source | myomesin (M-protein) 2, 165kDa | 13704 | -2.542 | -0.1965 | Yes |
| 134 | COL1A1 | NA | COL1A1 Entrez, Source | collagen, type I, alpha 1 | 13723 | -2.670 | -0.1771 | Yes |
| 135 | PTP4A3 | NA | PTP4A3 Entrez, Source | protein tyrosine phosphatase type IVA, member 3 | 13728 | -2.705 | -0.1565 | Yes |
| 136 | FST | NA | FST Entrez, Source | follistatin | 13733 | -2.740 | -0.1355 | Yes |
| 137 | FHL1 | NA | FHL1 Entrez, Source | four and a half LIM domains 1 | 13746 | -2.831 | -0.1144 | Yes |
| 138 | BDKRB2 | NA | BDKRB2 Entrez, Source | bradykinin receptor B2 | 13750 | -2.866 | -0.0924 | Yes |
| 139 | ENO3 | NA | ENO3 Entrez, Source | enolase 3 (beta, muscle) | 13755 | -2.899 | -0.0702 | Yes |
| 140 | CRYAB | NA | CRYAB Entrez, Source | crystallin, alpha B | 13758 | -2.921 | -0.0477 | Yes |
| 141 | REEP1 | NA | REEP1 Entrez, Source | receptor accessory protein 1 | 13779 | -3.207 | -0.0243 | Yes |
| 142 | COL3A1 | NA | COL3A1 Entrez, Source | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | 13796 | -3.638 | 0.0028 | Yes |
