Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1w6a
GeneSetHALLMARK_MYC_TARGETS_V1
Enrichment Score (ES)0.23658672
Normalized Enrichment Score (NES)1.0306413
Nominal p-value0.37869823
FDR q-value0.48649654
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_MYC_TARGETS_V1   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1ODC1NAODC1
Entrez,  Source
ornithine decarboxylase 16111.172-0.0263Yes
2SRMNASRM
Entrez,  Source
spermidine synthase6791.115-0.0136Yes
3RRP9NA7791.031-0.0046Yes
4HSP90AB1NAHSP90AB1
Entrez,  Source
heat shock protein 90kDa alpha (cytosolic), class B member 18100.9990.0089Yes
5DDX21NADDX21
Entrez,  Source
DEAD (Asp-Glu-Ala-Asp) box polypeptide 219580.9170.0126Yes
6RSL1D1NARSL1D1
Entrez,  Source
ribosomal L1 domain containing 19660.9120.0264Yes
7IFRD1NAIFRD1
Entrez,  Source
interferon-related developmental regulator 111000.8510.0301Yes
8NOLC1NANOLC1
Entrez,  Source
nucleolar and coiled-body phosphoprotein 111490.8300.0397Yes
9TRIM28NATRIM28
Entrez,  Source
tripartite motif-containing 2811930.8140.0494Yes
10NOP16NA12490.7940.0579Yes
11GSPT1NAGSPT1
Entrez,  Source
G1 to S phase transition 113750.7490.0605Yes
12G3BP1NA14760.7230.0646Yes
13CDC20NACDC20
Entrez,  Source
CDC20 cell division cycle 20 homolog (S. cerevisiae)15960.6890.0667Yes
14SF3A1NASF3A1
Entrez,  Source
splicing factor 3a, subunit 1, 120kDa16820.6630.0710Yes
15PSMC4NAPSMC4
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 416960.6590.0804Yes
16EIF1AXNAEIF1AX
Entrez,  Source
eukaryotic translation initiation factor 1A, X-linked19590.5940.0706Yes
17CCT4NACCT4
Entrez,  Source
chaperonin containing TCP1, subunit 4 (delta)20540.5780.0728Yes
18RNPS1NARNPS1
Entrez,  Source
RNA binding protein S1, serine-rich domain20730.5740.0805Yes
19PSMD8NAPSMD8
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 820950.5700.0879Yes
20KPNA2NAKPNA2
Entrez,  Source
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)20970.5700.0969Yes
21SYNCRIPNASYNCRIP
Entrez,  Source
synaptotagmin binding, cytoplasmic RNA interacting protein21140.5670.1046Yes
22NOP56NA21910.5520.1077Yes
23PABPC4NAPABPC4
Entrez,  Source
poly(A) binding protein, cytoplasmic 4 (inducible form)22350.5440.1132Yes
24TCP1NATCP1
Entrez,  Source
t-complex 123110.5320.1161Yes
25RAD23BNARAD23B
Entrez,  Source
RAD23 homolog B (S. cerevisiae)23190.5300.1239Yes
26XPO1NAXPO1
Entrez,  Source
exportin 1 (CRM1 homolog, yeast)24700.5050.1209Yes
27PA2G4NAPA2G4
Entrez,  Source
proliferation-associated 2G4, 38kDa24800.5030.1281Yes
28CCT2NACCT2
Entrez,  Source
chaperonin containing TCP1, subunit 2 (beta)25960.4850.1273Yes
29EIF4ENAEIF4E
Entrez,  Source
eukaryotic translation initiation factor 4E26800.4710.1287Yes
30PSMD1NAPSMD1
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 127010.4670.1346Yes
31EIF2S1NAEIF2S1
Entrez,  Source
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa27180.4650.1407Yes
32SNRPA1NASNRPA1
Entrez,  Source
small nuclear ribonucleoprotein polypeptide A'28430.4440.1386Yes
33EIF4A1NAEIF4A1
Entrez,  Source
eukaryotic translation initiation factor 4A, isoform 129810.4230.1353Yes
34PSMD3NAPSMD3
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 330030.4210.1404Yes
35YWHAQNAYWHAQ
Entrez,  Source
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide30100.4200.1465Yes
36CNBPNACNBP
Entrez,  Source
CCHC-type zinc finger, nucleic acid binding protein30330.4170.1515Yes
37PSMA6NAPSMA6
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 631020.4080.1529Yes
38DDX18NADDX18
Entrez,  Source
DEAD (Asp-Glu-Ala-Asp) box polypeptide 1831340.4030.1570Yes
39HDDC2NAHDDC2
Entrez,  Source
HD domain containing 231650.3980.1611Yes
40CSTF2NACSTF2
Entrez,  Source
cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa31740.3970.1668Yes
41CCT3NACCT3
Entrez,  Source
chaperonin containing TCP1, subunit 3 (gamma)31800.3960.1727Yes
42KARSNAKARS
Entrez,  Source
lysyl-tRNA synthetase32190.3900.1760Yes
43SNRPB2NASNRPB2
Entrez,  Source
small nuclear ribonucleoprotein polypeptide B''32890.3830.1770Yes
44CCT7NACCT7
Entrez,  Source
chaperonin containing TCP1, subunit 7 (eta)33490.3760.1786Yes
45USP1NAUSP1
Entrez,  Source
ubiquitin specific peptidase 134010.3680.1807Yes
46KPNB1NAKPNB1
Entrez,  Source
karyopherin (importin) beta 134840.3560.1803Yes
47SF3B3NASF3B3
Entrez,  Source
splicing factor 3b, subunit 3, 130kDa35270.3510.1827Yes
48HSPD1NAHSPD1
Entrez,  Source
heat shock 60kDa protein 1 (chaperonin)35280.3510.1882Yes
49SRPK1NASRPK1
Entrez,  Source
SFRS protein kinase 135740.3460.1904Yes
50EIF3JNA36960.3330.1868Yes
51ETF1NAETF1
Entrez,  Source
eukaryotic translation termination factor 137080.3320.1912Yes
52PSMB2NAPSMB2
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 237840.3230.1908Yes
53CCNA2NACCNA2
Entrez,  Source
cyclin A238880.3110.1882Yes
54PSMD14NAPSMD14
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1440180.2950.1834Yes
55PWP1NAPWP1
Entrez,  Source
PWP1 homolog (S. cerevisiae)40520.2920.1855Yes
56LSM7NALSM7
Entrez,  Source
LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)40920.2880.1872Yes
57TFDP1NATFDP1
Entrez,  Source
transcription factor Dp-141050.2860.1909Yes
58EIF4G2NAEIF4G2
Entrez,  Source
eukaryotic translation initiation factor 4 gamma, 241120.2850.1949Yes
59ORC2NA41190.2850.1990Yes
60HSPE1NAHSPE1
Entrez,  Source
heat shock 10kDa protein 1 (chaperonin 10)41450.2830.2016Yes
61PRPF31NAPRPF31
Entrez,  Source
PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae)42570.2710.1977Yes
62PABPC1NAPABPC1
Entrez,  Source
poly(A) binding protein, cytoplasmic 143420.2610.1957Yes
63NAP1L1NANAP1L1
Entrez,  Source
nucleosome assembly protein 1-like 143740.2560.1975Yes
64SETNASET
Entrez,  Source
SET translocation (myeloid leukemia-associated)43830.2550.2009Yes
65CUL1NACUL1
Entrez,  Source
cullin 144030.2530.2035Yes
66ABCE1NAABCE1
Entrez,  Source
ATP-binding cassette, sub-family E (OABP), member 144370.2500.2050Yes
67PPM1GNAPPM1G
Entrez,  Source
protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform44500.2490.2081Yes
68RANBP1NARANBP1
Entrez,  Source
RAN binding protein 144590.2480.2114Yes
69HNRNPDNA44630.2470.2151Yes
70PTGES3NAPTGES3
Entrez,  Source
prostaglandin E synthase 3 (cytosolic)45560.2360.2120Yes
71SRSF1NA45780.2350.2142Yes
72PSMC6NAPSMC6
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 646410.2290.2133Yes
73SERBP1NASERBP1
Entrez,  Source
SERPINE1 mRNA binding protein 146430.2290.2168Yes
74U2AF1NAU2AF1
Entrez,  Source
U2 small nuclear RNA auxiliary factor 146630.2270.2190Yes
75FAM120ANAFAM120A
Entrez,  Source
family with sequence similarity 120A47180.2200.2185Yes
76CADNACAD
Entrez,  Source
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase47560.2160.2192Yes
77NPM1NANPM1
Entrez,  Source
nucleophosmin (nucleolar phosphoprotein B23, numatrin)47810.2140.2208Yes
78ILF2NAILF2
Entrez,  Source
interleukin enhancer binding factor 2, 45kDa48350.2080.2202Yes
79C1QBPNAC1QBP
Entrez,  Source
complement component 1, q subcomponent binding protein48420.2080.2230Yes
80UBE2L3NAUBE2L3
Entrez,  Source
ubiquitin-conjugating enzyme E2L 348650.2050.2247Yes
81MRPL9NAMRPL9
Entrez,  Source
mitochondrial ribosomal protein L949260.2000.2234Yes
82NCBP2NANCBP2
Entrez,  Source
nuclear cap binding protein subunit 2, 20kDa49650.1960.2237Yes
83HDGFNAHDGF
Entrez,  Source
hepatoma-derived growth factor (high-mobility group protein 1-like)49660.1960.2268Yes
84POLE3NAPOLE3
Entrez,  Source
polymerase (DNA directed), epsilon 3 (p17 subunit)49900.1930.2281Yes
85CDK4NACDK4
Entrez,  Source
cyclin-dependent kinase 450460.1870.2271Yes
86FBLNAFBL
Entrez,  Source
fibrillarin50600.1850.2290Yes
87SSBP1NASSBP1
Entrez,  Source
single-stranded DNA binding protein 150910.1820.2297Yes
88HNRNPUNA51000.1810.2320Yes
89VDAC1NAVDAC1
Entrez,  Source
voltage-dependent anion channel 151030.1810.2347Yes
90EIF3BNA51380.1780.2350Yes
91HDAC2NAHDAC2
Entrez,  Source
histone deacetylase 251550.1760.2366Yes
92RUVBL2NARUVBL2
Entrez,  Source
RuvB-like 2 (E. coli)52470.1670.2325No
93PHB2NAPHB2
Entrez,  Source
prohibitin 252670.1650.2337No
94STARD7NASTARD7
Entrez,  Source
START domain containing 752690.1640.2363No
95SNRPD1NASNRPD1
Entrez,  Source
small nuclear ribonucleoprotein D1 polypeptide 16kDa54020.1500.2289No
96SRSF3NA54920.1400.2246No
97BUB3NABUB3
Entrez,  Source
BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)55630.1330.2216No
98GOT2NAGOT2
Entrez,  Source
glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)57740.1090.2079No
99HNRNPCNA57820.1090.2091No
100EIF4HNA58140.1050.2085No
101UBA2NAUBA2
Entrez,  Source
-60170.0860.1950No
102TARDBPNATARDBP
Entrez,  Source
TAR DNA binding protein60910.0780.1909No
103GNL3NAGNL3
Entrez,  Source
guanine nucleotide binding protein-like 3 (nucleolar)61480.0720.1880No
104PSMA4NAPSMA4
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 461580.0720.1884No
105CCT5NACCT5
Entrez,  Source
chaperonin containing TCP1, subunit 5 (epsilon)62550.0610.1824No
106CANXNACANX
Entrez,  Source
calnexin64050.0490.1722No
107LDHANALDHA
Entrez,  Source
lactate dehydrogenase A64240.0470.1716No
108EXOSC7NAEXOSC7
Entrez,  Source
exosome component 765680.0310.1616No
109COPS5NACOPS5
Entrez,  Source
COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)65870.0300.1608No
110DEKNADEK
Entrez,  Source
DEK oncogene (DNA binding)66040.0280.1600No
111HNRNPA1NA66370.0240.1580No
112PHBNAPHB
Entrez,  Source
prohibitin66810.0200.1552No
113PSMA7NAPSMA7
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 767180.0150.1528No
114HPRT1NAHPRT1
Entrez,  Source
hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome)67760.0090.1488No
115VDAC3NAVDAC3
Entrez,  Source
voltage-dependent anion channel 367940.0070.1476No
116HNRNPA3NA68400.0020.1444No
117DHX15NADHX15
Entrez,  Source
DEAH (Asp-Glu-Ala-His) box polypeptide 156933-0.0080.1378No
118RANNARAN
Entrez,  Source
RAN, member RAS oncogene family6951-0.0100.1367No
119TRA2BNA6976-0.0120.1351No
120LSM2NALSM2
Entrez,  Source
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)7004-0.0140.1333No
121PCBP1NAPCBP1
Entrez,  Source
poly(rC) binding protein 17128-0.0260.1247No
122NCBP1NANCBP1
Entrez,  Source
nuclear cap binding protein subunit 1, 80kDa7207-0.0350.1196No
123SNRPANASNRPA
Entrez,  Source
small nuclear ribonucleoprotein polypeptide A7238-0.0380.1180No
124PSMA2NAPSMA2
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 27269-0.0410.1164No
125PSMD7NAPSMD7
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog)7374-0.0540.1096No
126XPOTNAXPOT
Entrez,  Source
exportin, tRNA (nuclear export receptor for tRNAs)7409-0.0570.1080No
127SMARCC1NASMARCC1
Entrez,  Source
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 17486-0.0650.1035No
128AIMP2NA7609-0.0760.0957No
129ERHNAERH
Entrez,  Source
enhancer of rudimentary homolog (Drosophila)7662-0.0810.0932No
130RPL18NARPL18
Entrez,  Source
ribosomal protein L187716-0.0860.0907No
131EIF3DNA7762-0.0910.0888No
132MCM7NAMCM7
Entrez,  Source
MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)7810-0.0960.0869No
133HNRNPRNA7820-0.0960.0877No
134CBX3NACBX3
Entrez,  Source
chromobox homolog 3 (HP1 gamma homolog, Drosophila)7896-0.1040.0839No
135TYMSNATYMS
Entrez,  Source
thymidylate synthetase7908-0.1050.0847No
136CLNS1ANACLNS1A
Entrez,  Source
chloride channel, nucleotide-sensitive, 1A7915-0.1060.0859No
137MAD2L1NAMAD2L1
Entrez,  Source
MAD2 mitotic arrest deficient-like 1 (yeast)7922-0.1060.0872No
138TXNL4ANATXNL4A
Entrez,  Source
thioredoxin-like 4A7998-0.1140.0835No
139ACP1NAACP1
Entrez,  Source
acid phosphatase 1, soluble8188-0.1350.0717No
140EIF2S2NAEIF2S2
Entrez,  Source
eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa8198-0.1370.0732No
141IMPDH2NAIMPDH2
Entrez,  Source
IMP (inosine monophosphate) dehydrogenase 28201-0.1370.0752No
142MCM2NAMCM2
Entrez,  Source
MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)8382-0.1550.0645No
143SRSF7NA8454-0.1640.0619No
144VBP1NAVBP1
Entrez,  Source
von Hippel-Lindau binding protein 18583-0.1780.0553No
145RPL14NARPL14
Entrez,  Source
ribosomal protein L148596-0.1790.0572No
146SLC25A3NASLC25A3
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 38626-0.1820.0580No
147SNRPGNASNRPG
Entrez,  Source
small nuclear ribonucleoprotein polypeptide G8680-0.1880.0571No
148SSBNASSB
Entrez,  Source
Sjogren syndrome antigen B (autoantigen La)8710-0.1920.0580No
149RPS2NARPS2
Entrez,  Source
ribosomal protein S28777-0.2000.0563No
150APEX1NAAPEX1
Entrez,  Source
APEX nuclease (multifunctional DNA repair enzyme) 18798-0.2030.0580No
151RPS10NARPS10
Entrez,  Source
ribosomal protein S108898-0.2140.0541No
152YWHAENAYWHAE
Entrez,  Source
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide8989-0.2240.0510No
153XRCC6NAXRCC6
Entrez,  Source
X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70kDa)9129-0.2410.0447No
154SRSF2NA9135-0.2410.0481No
155TUFMNATUFM
Entrez,  Source
Tu translation elongation factor, mitochondrial9298-0.2630.0404No
156MRPS18BNAMRPS18B
Entrez,  Source
mitochondrial ribosomal protein S18B9307-0.2640.0439No
157NME1NANME1
Entrez,  Source
non-metastatic cells 1, protein (NM23A) expressed in9382-0.2760.0428No
158PRDX4NAPRDX4
Entrez,  Source
peroxiredoxin 49394-0.2780.0464No
159GLO1NAGLO1
Entrez,  Source
glyoxalase I9468-0.2890.0456No
160EEF1B2NAEEF1B2
Entrez,  Source
eukaryotic translation elongation factor 1 beta 29482-0.2910.0493No
161SNRPD3NASNRPD3
Entrez,  Source
small nuclear ribonucleoprotein D3 polypeptide 18kDa9523-0.2980.0510No
162NDUFAB1NANDUFAB1
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa9593-0.3050.0508No
163PSMB3NAPSMB3
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 39617-0.3100.0540No
164RRM1NARRM1
Entrez,  Source
ribonucleotide reductase M1 polypeptide9641-0.3130.0572No
165HNRNPA2B1NA9673-0.3170.0599No
166MRPL23NAMRPL23
Entrez,  Source
mitochondrial ribosomal protein L239694-0.3200.0635No
167SNRPD2NASNRPD2
Entrez,  Source
small nuclear ribonucleoprotein D2 polypeptide 16.5kDa9756-0.3300.0642No
168IARSNAIARS
Entrez,  Source
isoleucine-tRNA synthetase9759-0.3310.0693No
169MYCNAMYC
Entrez,  Source
v-myc myelocytomatosis viral oncogene homolog (avian)9860-0.3460.0674No
170MCM6NAMCM6
Entrez,  Source
MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)9910-0.3510.0694No
171PRPS2NAPRPS2
Entrez,  Source
phosphoribosyl pyrophosphate synthetase 29915-0.3520.0746No
172PCNANAPCNA
Entrez,  Source
proliferating cell nuclear antigen9955-0.3570.0774No
173MCM4NAMCM4
Entrez,  Source
MCM4 minichromosome maintenance deficient 4 (S. cerevisiae)10015-0.3660.0789No
174AP3S1NAAP3S1
Entrez,  Source
adaptor-related protein complex 3, sigma 1 subunit10066-0.3740.0811No
175POLD2NAPOLD2
Entrez,  Source
polymerase (DNA directed), delta 2, regulatory subunit 50kDa10329-0.4130.0684No
176RPS6NARPS6
Entrez,  Source
ribosomal protein S610359-0.4190.0729No
177RPL6NARPL6
Entrez,  Source
ribosomal protein L610400-0.4270.0767No
178EPRSNAEPRS
Entrez,  Source
glutamyl-prolyl-tRNA synthetase10410-0.4280.0828No
179DUTNADUT
Entrez,  Source
dUTP pyrophosphatase10412-0.4280.0895No
180RPS5NARPS5
Entrez,  Source
ribosomal protein S510425-0.4310.0954No
181NHP2NA10429-0.4320.1020No
182RFC4NARFC4
Entrez,  Source
replication factor C (activator 1) 4, 37kDa10453-0.4350.1071No
183COX5ANACOX5A
Entrez,  Source
cytochrome c oxidase subunit Va10523-0.4450.1091No
184PGK1NAPGK1
Entrez,  Source
phosphoglycerate kinase 110801-0.4930.0965No
185UBE2E1NAUBE2E1
Entrez,  Source
ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)10843-0.5010.1014No
186RPS3NARPS3
Entrez,  Source
ribosomal protein S310849-0.5020.1090No
187RPLP0NARPLP0
Entrez,  Source
ribosomal protein, large, P011023-0.5320.1047No
188H2AFZNAH2AFZ
Entrez,  Source
H2A histone family, member Z11093-0.5450.1082No
189CDK2NACDK2
Entrez,  Source
cyclin-dependent kinase 211096-0.5460.1167No
190CYC1NACYC1
Entrez,  Source
cytochrome c-111222-0.5670.1165No
191RPL34NARPL34
Entrez,  Source
ribosomal protein L3411404-0.6060.1127No
192MCM5NAMCM5
Entrez,  Source
MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)11408-0.6070.1221No
193CDC45NA11553-0.6370.1216No
194PPIANAPPIA
Entrez,  Source
peptidylprolyl isomerase A (cyclophilin A)11715-0.6750.1204No
195PSMA1NAPSMA1
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 111829-0.7050.1233No
196RPL22NARPL22
Entrez,  Source
ribosomal protein L2211926-0.7320.1278No
197PRDX3NAPRDX3
Entrez,  Source
peroxiredoxin 312033-0.7660.1321No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_MYC_TARGETS_V1   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_MYC_TARGETS_V1: Random ES distribution   
Gene set null distribution of ES for HALLMARK_MYC_TARGETS_V1