Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | HALLMARK_KRAS_SIGNALING_UP |
| Enrichment Score (ES) | 0.49296126 |
| Normalized Enrichment Score (NES) | 2.038286 |
| Nominal p-value | 0.0 |
| FDR q-value | 2.888889E-4 |
| FWER p-Value | 0.001 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | IL7R | NA | IL7R Entrez, Source | interleukin 7 receptor | 3 | 4.680 | 0.0347 | Yes |
| 2 | CXCL10 | NA | CXCL10 Entrez, Source | chemokine (C-X-C motif) ligand 10 | 16 | 4.314 | 0.0660 | Yes |
| 3 | PDCD1LG2 | NA | PDCD1LG2 Entrez, Source | programmed cell death 1 ligand 2 | 38 | 3.812 | 0.0930 | Yes |
| 4 | ALDH1A2 | NA | ALDH1A2 Entrez, Source | aldehyde dehydrogenase 1 family, member A2 | 46 | 3.640 | 0.1196 | Yes |
| 5 | IL2RG | NA | IL2RG Entrez, Source | interleukin 2 receptor, gamma (severe combined immunodeficiency) | 79 | 3.132 | 0.1407 | Yes |
| 6 | TRAF1 | NA | TRAF1 Entrez, Source | TNF receptor-associated factor 1 | 88 | 3.029 | 0.1627 | Yes |
| 7 | CTSS | NA | CTSS Entrez, Source | cathepsin S | 97 | 2.972 | 0.1843 | Yes |
| 8 | GPNMB | NA | GPNMB Entrez, Source | glycoprotein (transmembrane) nmb | 106 | 2.893 | 0.2053 | Yes |
| 9 | DOCK2 | NA | DOCK2 Entrez, Source | dedicator of cytokinesis 2 | 107 | 2.869 | 0.2267 | Yes |
| 10 | TNFAIP3 | NA | TNFAIP3 Entrez, Source | tumor necrosis factor, alpha-induced protein 3 | 112 | 2.804 | 0.2474 | Yes |
| 11 | LAPTM5 | NA | LAPTM5 Entrez, Source | lysosomal associated multispanning membrane protein 5 | 135 | 2.589 | 0.2651 | Yes |
| 12 | RGS16 | NA | RGS16 Entrez, Source | regulator of G-protein signalling 16 | 143 | 2.554 | 0.2836 | Yes |
| 13 | GPRC5B | NA | GPRC5B Entrez, Source | G protein-coupled receptor, family C, group 5, member B | 150 | 2.500 | 0.3018 | Yes |
| 14 | BIRC3 | NA | BIRC3 Entrez, Source | baculoviral IAP repeat-containing 3 | 152 | 2.495 | 0.3204 | Yes |
| 15 | HDAC9 | NA | HDAC9 Entrez, Source | histone deacetylase 9 | 179 | 2.349 | 0.3360 | Yes |
| 16 | PLAUR | NA | PLAUR Entrez, Source | plasminogen activator, urokinase receptor | 187 | 2.308 | 0.3528 | Yes |
| 17 | EPHB2 | NA | EPHB2 Entrez, Source | EPH receptor B2 | 189 | 2.284 | 0.3697 | Yes |
| 18 | F2RL1 | NA | F2RL1 Entrez, Source | coagulation factor II (thrombin) receptor-like 1 | 190 | 2.275 | 0.3867 | Yes |
| 19 | ITGA2 | NA | ITGA2 Entrez, Source | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 192 | 2.266 | 0.4036 | Yes |
| 20 | CFB | NA | CFB Entrez, Source | complement factor B | 282 | 1.804 | 0.4105 | Yes |
| 21 | PPP1R15A | NA | PPP1R15A Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 15A | 286 | 1.797 | 0.4237 | Yes |
| 22 | HKDC1 | NA | HKDC1 Entrez, Source | hexokinase domain containing 1 | 296 | 1.779 | 0.4363 | Yes |
| 23 | HBEGF | NA | HBEGF Entrez, Source | heparin-binding EGF-like growth factor | 319 | 1.713 | 0.4475 | Yes |
| 24 | CSF2RA | NA | CSF2RA Entrez, Source | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | 378 | 1.539 | 0.4548 | Yes |
| 25 | TMEM158 | NA | TMEM158 Entrez, Source | transmembrane protein 158 | 495 | 1.321 | 0.4562 | Yes |
| 26 | ETS1 | NA | ETS1 Entrez, Source | v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) | 498 | 1.319 | 0.4659 | Yes |
| 27 | KLF4 | NA | KLF4 Entrez, Source | Kruppel-like factor 4 (gut) | 566 | 1.222 | 0.4701 | Yes |
| 28 | ANXA10 | NA | ANXA10 Entrez, Source | annexin A10 | 624 | 1.161 | 0.4746 | Yes |
| 29 | LIF | NA | LIF Entrez, Source | leukemia inhibitory factor (cholinergic differentiation factor) | 745 | 1.056 | 0.4737 | Yes |
| 30 | MAP3K1 | NA | MAP3K1 Entrez, Source | mitogen-activated protein kinase kinase kinase 1 | 822 | 0.993 | 0.4756 | Yes |
| 31 | YRDC | NA | YRDC Entrez, Source | yrdC domain containing (E. coli) | 890 | 0.949 | 0.4778 | Yes |
| 32 | PTGS2 | NA | PTGS2 Entrez, Source | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 902 | 0.945 | 0.4840 | Yes |
| 33 | GNG11 | NA | GNG11 Entrez, Source | guanine nucleotide binding protein (G protein), gamma 11 | 1003 | 0.893 | 0.4834 | Yes |
| 34 | NRP1 | NA | NRP1 Entrez, Source | neuropilin 1 | 1103 | 0.850 | 0.4825 | Yes |
| 35 | PLEK2 | NA | PLEK2 Entrez, Source | pleckstrin 2 | 1112 | 0.846 | 0.4882 | Yes |
| 36 | ETV4 | NA | ETV4 Entrez, Source | ets variant gene 4 (E1A enhancer binding protein, E1AF) | 1231 | 0.800 | 0.4856 | Yes |
| 37 | EMP1 | NA | EMP1 Entrez, Source | epithelial membrane protein 1 | 1239 | 0.797 | 0.4910 | Yes |
| 38 | ETV5 | NA | ETV5 Entrez, Source | ets variant gene 5 (ets-related molecule) | 1293 | 0.776 | 0.4930 | Yes |
| 39 | SPRY2 | NA | SPRY2 Entrez, Source | sprouty homolog 2 (Drosophila) | 1415 | 0.740 | 0.4896 | No |
| 40 | SPARCL1 | NA | SPARCL1 Entrez, Source | SPARC-like 1 (mast9, hevin) | 1658 | 0.672 | 0.4770 | No |
| 41 | IL33 | NA | 2250 | 0.542 | 0.4379 | No | ||
| 42 | APOD | NA | APOD Entrez, Source | apolipoprotein D | 2337 | 0.526 | 0.4355 | No |
| 43 | WDR33 | NA | WDR33 Entrez, Source | WD repeat domain 33 | 2347 | 0.524 | 0.4388 | No |
| 44 | IL1B | NA | IL1B Entrez, Source | interleukin 1, beta | 2581 | 0.487 | 0.4254 | No |
| 45 | LAT2 | NA | LAT2 Entrez, Source | linker for activation of T cells family, member 2 | 2693 | 0.468 | 0.4208 | No |
| 46 | PTCD2 | NA | PTCD2 Entrez, Source | pentatricopeptide repeat domain 2 | 2810 | 0.450 | 0.4157 | No |
| 47 | EVI5 | NA | EVI5 Entrez, Source | ecotropic viral integration site 5 | 2835 | 0.446 | 0.4173 | No |
| 48 | ETV1 | NA | ETV1 Entrez, Source | ets variant gene 1 | 2959 | 0.426 | 0.4115 | No |
| 49 | MTMR10 | NA | MTMR10 Entrez, Source | myotubularin related protein 10 | 3004 | 0.421 | 0.4114 | No |
| 50 | ZNF639 | NA | ZNF639 Entrez, Source | zinc finger protein 639 | 3123 | 0.405 | 0.4058 | No |
| 51 | PEG3 | NA | PEG3 Entrez, Source | paternally expressed 3 | 3252 | 0.387 | 0.3994 | No |
| 52 | ADAM17 | NA | ADAM17 Entrez, Source | ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) | 3315 | 0.381 | 0.3977 | No |
| 53 | CLEC4A | NA | CLEC4A Entrez, Source | C-type lectin domain family 4, member A | 3331 | 0.378 | 0.3994 | No |
| 54 | AMMECR1 | NA | AMMECR1 Entrez, Source | Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region, gene 1 | 3730 | 0.330 | 0.3728 | No |
| 55 | USP12 | NA | USP12 Entrez, Source | ubiquitin specific peptidase 12 | 3759 | 0.327 | 0.3732 | No |
| 56 | ALDH1A3 | NA | ALDH1A3 Entrez, Source | aldehyde dehydrogenase 1 family, member A3 | 3877 | 0.313 | 0.3670 | No |
| 57 | TLR8 | NA | TLR8 Entrez, Source | toll-like receptor 8 | 3919 | 0.307 | 0.3663 | No |
| 58 | ADAM8 | NA | ADAM8 Entrez, Source | ADAM metallopeptidase domain 8 | 4041 | 0.293 | 0.3596 | No |
| 59 | SCG3 | NA | SCG3 Entrez, Source | secretogranin III | 4322 | 0.263 | 0.3412 | No |
| 60 | SPON1 | NA | SPON1 Entrez, Source | spondin 1, extracellular matrix protein | 4447 | 0.249 | 0.3340 | No |
| 61 | CAB39L | NA | CAB39L Entrez, Source | calcium binding protein 39-like | 4568 | 0.235 | 0.3270 | No |
| 62 | TRIB1 | NA | TRIB1 Entrez, Source | tribbles homolog 1 (Drosophila) | 4679 | 0.225 | 0.3206 | No |
| 63 | MMP9 | NA | MMP9 Entrez, Source | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 4824 | 0.209 | 0.3117 | No |
| 64 | AVL9 | NA | 4890 | 0.202 | 0.3084 | No | ||
| 65 | ENG | NA | ENG Entrez, Source | endoglin (Osler-Rendu-Weber syndrome 1) | 5056 | 0.186 | 0.2978 | No |
| 66 | PLAT | NA | PLAT Entrez, Source | plasminogen activator, tissue | 5083 | 0.183 | 0.2972 | No |
| 67 | DNMBP | NA | DNMBP Entrez, Source | dynamin binding protein | 5139 | 0.178 | 0.2946 | No |
| 68 | ATG10 | NA | ATG10 Entrez, Source | ATG10 autophagy related 10 homolog (S. cerevisiae) | 5190 | 0.172 | 0.2922 | No |
| 69 | TSPAN1 | NA | TSPAN1 Entrez, Source | tetraspanin 1 | 5218 | 0.170 | 0.2915 | No |
| 70 | ZNF277 | NA | ZNF277 Entrez, Source | zinc finger protein 277 | 5328 | 0.160 | 0.2847 | No |
| 71 | NIN | NA | NIN Entrez, Source | ninein (GSK3B interacting protein) | 5357 | 0.155 | 0.2838 | No |
| 72 | MPZL2 | NA | 5486 | 0.141 | 0.2755 | No | ||
| 73 | DUSP6 | NA | DUSP6 Entrez, Source | dual specificity phosphatase 6 | 5614 | 0.125 | 0.2672 | No |
| 74 | EREG | NA | EREG Entrez, Source | epiregulin | 5954 | 0.092 | 0.2431 | No |
| 75 | IGFBP3 | NA | IGFBP3 Entrez, Source | insulin-like growth factor binding protein 3 | 5964 | 0.091 | 0.2432 | No |
| 76 | TOR1AIP2 | NA | TOR1AIP2 Entrez, Source | torsin A interacting protein 2 | 6019 | 0.085 | 0.2398 | No |
| 77 | KIF5C | NA | KIF5C Entrez, Source | kinesin family member 5C | 6137 | 0.073 | 0.2319 | No |
| 78 | LCP1 | NA | LCP1 Entrez, Source | lymphocyte cytosolic protein 1 (L-plastin) | 6149 | 0.072 | 0.2316 | No |
| 79 | PECAM1 | NA | PECAM1 Entrez, Source | platelet/endothelial cell adhesion molecule (CD31 antigen) | 6545 | 0.033 | 0.2030 | No |
| 80 | CBL | NA | CBL Entrez, Source | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 6561 | 0.031 | 0.2021 | No |
| 81 | PIGR | NA | PIGR Entrez, Source | polymeric immunoglobulin receptor | 6569 | 0.031 | 0.2019 | No |
| 82 | CDADC1 | NA | CDADC1 Entrez, Source | cytidine and dCMP deaminase domain containing 1 | 6786 | 0.008 | 0.1861 | No |
| 83 | SDCCAG8 | NA | SDCCAG8 Entrez, Source | serologically defined colon cancer antigen 8 | 6968 | -0.011 | 0.1730 | No |
| 84 | AKT2 | NA | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 7140 | -0.027 | 0.1607 | No |
| 85 | PTBP2 | NA | PTBP2 Entrez, Source | polypyrimidine tract binding protein 2 | 7173 | -0.030 | 0.1586 | No |
| 86 | TNFRSF1B | NA | TNFRSF1B Entrez, Source | tumor necrosis factor receptor superfamily, member 1B | 7244 | -0.038 | 0.1538 | No |
| 87 | ANGPTL4 | NA | ANGPTL4 Entrez, Source | angiopoietin-like 4 | 7970 | -0.111 | 0.1017 | No |
| 88 | CROT | NA | CROT Entrez, Source | carnitine O-octanoyltransferase | 8051 | -0.121 | 0.0968 | No |
| 89 | SCN1B | NA | SCN1B Entrez, Source | sodium channel, voltage-gated, type I, beta | 8060 | -0.121 | 0.0971 | No |
| 90 | BPGM | NA | BPGM Entrez, Source | 2,3-bisphosphoglycerate mutase | 8541 | -0.172 | 0.0633 | No |
| 91 | IKZF1 | NA | IKZF1 Entrez, Source | IKAROS family zinc finger 1 (Ikaros) | 8570 | -0.176 | 0.0626 | No |
| 92 | GFPT2 | NA | GFPT2 Entrez, Source | glutamine-fructose-6-phosphate transaminase 2 | 8574 | -0.177 | 0.0637 | No |
| 93 | MALL | NA | MALL Entrez, Source | mal, T-cell differentiation protein-like | 8659 | -0.186 | 0.0589 | No |
| 94 | CCND2 | NA | CCND2 Entrez, Source | cyclin D2 | 8965 | -0.222 | 0.0383 | No |
| 95 | RBM4 | NA | RBM4 Entrez, Source | RNA binding motif protein 4 | 9095 | -0.236 | 0.0307 | No |
| 96 | GABRA3 | NA | GABRA3 Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, alpha 3 | 9107 | -0.238 | 0.0317 | No |
| 97 | C3AR1 | NA | C3AR1 Entrez, Source | complement component 3a receptor 1 | 9205 | -0.250 | 0.0264 | No |
| 98 | ITGBL1 | NA | ITGBL1 Entrez, Source | integrin, beta-like 1 (with EGF-like repeat domains) | 9424 | -0.283 | 0.0126 | No |
| 99 | FBXO4 | NA | FBXO4 Entrez, Source | F-box protein 4 | 9542 | -0.299 | 0.0063 | No |
| 100 | GLRX | NA | GLRX Entrez, Source | glutaredoxin (thioltransferase) | 9559 | -0.301 | 0.0074 | No |
| 101 | STRN | NA | STRN Entrez, Source | striatin, calmodulin binding protein | 9685 | -0.319 | 0.0007 | No |
| 102 | MAP4K1 | NA | MAP4K1 Entrez, Source | mitogen-activated protein kinase kinase kinase kinase 1 | 9763 | -0.331 | -0.0025 | No |
| 103 | CBX8 | NA | CBX8 Entrez, Source | chromobox homolog 8 (Pc class homolog, Drosophila) | 10116 | -0.380 | -0.0254 | No |
| 104 | CXCR4 | NA | CXCR4 Entrez, Source | chemokine (C-X-C motif) receptor 4 | 10239 | -0.400 | -0.0313 | No |
| 105 | MMD | NA | MMD Entrez, Source | monocyte to macrophage differentiation-associated | 10335 | -0.414 | -0.0351 | No |
| 106 | KCNN4 | NA | KCNN4 Entrez, Source | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 | 10500 | -0.442 | -0.0438 | No |
| 107 | FGF9 | NA | FGF9 Entrez, Source | fibroblast growth factor 9 (glia-activating factor) | 10636 | -0.465 | -0.0502 | No |
| 108 | PSMB8 | NA | PSMB8 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) | 10667 | -0.471 | -0.0489 | No |
| 109 | RABGAP1L | NA | RABGAP1L Entrez, Source | RAB GTPase activating protein 1-like | 10883 | -0.507 | -0.0608 | No |
| 110 | BTBD3 | NA | BTBD3 Entrez, Source | BTB (POZ) domain containing 3 | 10894 | -0.508 | -0.0577 | No |
| 111 | JUP | NA | JUP Entrez, Source | junction plakoglobin | 11011 | -0.531 | -0.0622 | No |
| 112 | SATB1 | NA | SATB1 Entrez, Source | special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA's) | 11127 | -0.550 | -0.0665 | No |
| 113 | DCBLD2 | NA | DCBLD2 Entrez, Source | discoidin, CUB and LCCL domain containing 2 | 11464 | -0.617 | -0.0864 | No |
| 114 | VWA5A | NA | 11529 | -0.629 | -0.0864 | No | ||
| 115 | SCG5 | NA | SCG5 Entrez, Source | secretogranin V (7B2 protein) | 11561 | -0.638 | -0.0839 | No |
| 116 | PRDM1 | NA | PRDM1 Entrez, Source | PR domain containing 1, with ZNF domain | 11630 | -0.656 | -0.0840 | No |
| 117 | ST6GAL1 | NA | ST6GAL1 Entrez, Source | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | 11827 | -0.705 | -0.0930 | No |
| 118 | ITGB2 | NA | ITGB2 Entrez, Source | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | 11846 | -0.711 | -0.0890 | No |
| 119 | AKAP12 | NA | AKAP12 Entrez, Source | A kinase (PRKA) anchor protein (gravin) 12 | 11847 | -0.711 | -0.0837 | No |
| 120 | CD37 | NA | CD37 Entrez, Source | CD37 molecule | 11892 | -0.722 | -0.0815 | No |
| 121 | TFPI | NA | TFPI Entrez, Source | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 12069 | -0.778 | -0.0886 | No |
| 122 | CBR4 | NA | CBR4 Entrez, Source | carbonyl reductase 4 | 12276 | -0.846 | -0.0973 | No |
| 123 | PLAU | NA | PLAU Entrez, Source | plasminogen activator, urokinase | 12310 | -0.855 | -0.0933 | No |
| 124 | SLPI | NA | SLPI Entrez, Source | secretory leukocyte peptidase inhibitor | 12406 | -0.894 | -0.0936 | No |
| 125 | PRKG2 | NA | PRKG2 Entrez, Source | protein kinase, cGMP-dependent, type II | 12487 | -0.931 | -0.0925 | No |
| 126 | SNAP25 | NA | SNAP25 Entrez, Source | synaptosomal-associated protein, 25kDa | 12631 | -1.001 | -0.0955 | No |
| 127 | TSPAN13 | NA | TSPAN13 Entrez, Source | tetraspanin 13 | 12693 | -1.032 | -0.0922 | No |
| 128 | SEMA3B | NA | SEMA3B Entrez, Source | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 12853 | -1.122 | -0.0954 | No |
| 129 | FUCA1 | NA | FUCA1 Entrez, Source | fucosidase, alpha-L- 1, tissue | 12896 | -1.146 | -0.0899 | No |
| 130 | MAP7 | NA | MAP7 Entrez, Source | microtubule-associated protein 7 | 13136 | -1.329 | -0.0975 | No |
| 131 | HOXD11 | NA | HOXD11 Entrez, Source | homeobox D11 | 13245 | -1.444 | -0.0946 | No |
| 132 | BMP2 | NA | BMP2 Entrez, Source | bone morphogenetic protein 2 | 13439 | -1.723 | -0.0958 | No |
| 133 | ANKH | NA | ANKH Entrez, Source | ankylosis, progressive homolog (mouse) | 13490 | -1.794 | -0.0861 | No |
| 134 | MAFB | NA | MAFB Entrez, Source | v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) | 13562 | -1.972 | -0.0765 | No |
| 135 | CFH | NA | CFH Entrez, Source | complement factor H | 13608 | -2.094 | -0.0642 | No |
| 136 | ID2 | NA | ID2 Entrez, Source | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 13694 | -2.466 | -0.0520 | No |
| 137 | PTPRR | NA | PTPRR Entrez, Source | protein tyrosine phosphatase, receptor type, R | 13804 | -3.778 | -0.0317 | No |
| 138 | USH1C | NA | USH1C Entrez, Source | Usher syndrome 1C (autosomal recessive, severe) | 13827 | -4.536 | 0.0005 | No |
