Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | HALLMARK_KRAS_SIGNALING_DN |
| Enrichment Score (ES) | -0.2926745 |
| Normalized Enrichment Score (NES) | -1.1019077 |
| Nominal p-value | 0.24468085 |
| FDR q-value | 0.3611984 |
| FWER p-Value | 1.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | RSAD2 | NA | RSAD2 Entrez, Source | radical S-adenosyl methionine domain containing 2 | 45 | 3.655 | 0.0407 | No |
| 2 | KRT13 | NA | KRT13 Entrez, Source | keratin 13 | 160 | 2.437 | 0.0618 | No |
| 3 | EDN1 | NA | EDN1 Entrez, Source | endothelin 1 | 278 | 1.829 | 0.0753 | No |
| 4 | RYR2 | NA | RYR2 Entrez, Source | ryanodine receptor 2 (cardiac) | 310 | 1.733 | 0.0939 | No |
| 5 | ABCG4 | NA | ABCG4 Entrez, Source | ATP-binding cassette, sub-family G (WHITE), member 4 | 335 | 1.661 | 0.1122 | No |
| 6 | IL12B | NA | IL12B Entrez, Source | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | 366 | 1.567 | 0.1288 | No |
| 7 | LYPD3 | NA | LYPD3 Entrez, Source | LY6/PLAUR domain containing 3 | 405 | 1.495 | 0.1441 | No |
| 8 | KCNN1 | NA | KCNN1 Entrez, Source | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 | 455 | 1.397 | 0.1573 | No |
| 9 | GPR3 | NA | GPR3 Entrez, Source | G protein-coupled receptor 3 | 525 | 1.286 | 0.1678 | No |
| 10 | CDH16 | NA | CDH16 Entrez, Source | cadherin 16, KSP-cadherin | 529 | 1.281 | 0.1830 | No |
| 11 | ALOX12B | NA | ALOX12B Entrez, Source | arachidonate 12-lipoxygenase, 12R type | 551 | 1.245 | 0.1965 | No |
| 12 | ENTPD7 | NA | ENTPD7 Entrez, Source | ectonucleoside triphosphate diphosphohydrolase 7 | 630 | 1.159 | 0.2048 | No |
| 13 | CNTFR | NA | CNTFR Entrez, Source | ciliary neurotrophic factor receptor | 677 | 1.117 | 0.2149 | No |
| 14 | IFI44L | NA | IFI44L Entrez, Source | interferon-induced protein 44-like | 735 | 1.062 | 0.2235 | No |
| 15 | FGGY | NA | 815 | 0.997 | 0.2297 | No | ||
| 16 | KCND1 | NA | KCND1 Entrez, Source | potassium voltage-gated channel, Shal-related subfamily, member 1 | 1225 | 0.802 | 0.2096 | No |
| 17 | MX1 | NA | MX1 Entrez, Source | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | 1246 | 0.795 | 0.2177 | No |
| 18 | TCF7L1 | NA | TCF7L1 Entrez, Source | transcription factor 7-like 1 (T-cell specific, HMG-box) | 1449 | 0.731 | 0.2118 | No |
| 19 | EPHA5 | NA | EPHA5 Entrez, Source | EPH receptor A5 | 1521 | 0.709 | 0.2152 | No |
| 20 | BRDT | NA | BRDT Entrez, Source | bromodomain, testis-specific | 1604 | 0.688 | 0.2175 | No |
| 21 | HNF1A | NA | 1831 | 0.625 | 0.2085 | No | ||
| 22 | CDKAL1 | NA | CDKAL1 Entrez, Source | CDK5 regulatory subunit associated protein 1-like 1 | 2034 | 0.581 | 0.2008 | No |
| 23 | NOS1 | NA | NOS1 Entrez, Source | nitric oxide synthase 1 (neuronal) | 2041 | 0.580 | 0.2074 | No |
| 24 | IDUA | NA | IDUA Entrez, Source | iduronidase, alpha-L- | 2211 | 0.548 | 0.2016 | No |
| 25 | GPRC5C | NA | GPRC5C Entrez, Source | G protein-coupled receptor, family C, group 5, member C | 2376 | 0.520 | 0.1960 | No |
| 26 | SLC29A3 | NA | SLC29A3 Entrez, Source | solute carrier family 29 (nucleoside transporters), member 3 | 2398 | 0.516 | 0.2007 | No |
| 27 | CPA2 | NA | CPA2 Entrez, Source | carboxypeptidase A2 (pancreatic) | 2437 | 0.510 | 0.2040 | No |
| 28 | TGM1 | NA | TGM1 Entrez, Source | transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) | 2669 | 0.473 | 0.1929 | No |
| 29 | TG | NA | TG Entrez, Source | thyroglobulin | 2996 | 0.421 | 0.1742 | No |
| 30 | SPHK2 | NA | SPHK2 Entrez, Source | sphingosine kinase 2 | 3396 | 0.368 | 0.1496 | No |
| 31 | PDE6B | NA | PDE6B Entrez, Source | phosphodiesterase 6B, cGMP-specific, rod, beta (congenital stationary night blindness 3, autosomal dominant) | 3607 | 0.343 | 0.1384 | No |
| 32 | HTR1D | NA | HTR1D Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 1D | 4048 | 0.292 | 0.1099 | No |
| 33 | EFHD1 | NA | EFHD1 Entrez, Source | EF-hand domain family, member D1 | 4199 | 0.278 | 0.1023 | No |
| 34 | GTF3C5 | NA | GTF3C5 Entrez, Source | general transcription factor IIIC, polypeptide 5, 63kDa | 4327 | 0.263 | 0.0962 | No |
| 35 | SLC5A5 | NA | SLC5A5 Entrez, Source | solute carrier family 5 (sodium iodide symporter), member 5 | 4669 | 0.227 | 0.0741 | No |
| 36 | ABCB11 | NA | ABCB11 Entrez, Source | ATP-binding cassette, sub-family B (MDR/TAP), member 11 | 4695 | 0.223 | 0.0750 | No |
| 37 | TGFB2 | NA | TGFB2 Entrez, Source | transforming growth factor, beta 2 | 4731 | 0.219 | 0.0750 | No |
| 38 | EDN2 | NA | EDN2 Entrez, Source | endothelin 2 | 4913 | 0.201 | 0.0643 | No |
| 39 | COL2A1 | NA | COL2A1 Entrez, Source | collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital) | 5037 | 0.188 | 0.0576 | No |
| 40 | KCNE2 | NA | KCNE2 Entrez, Source | potassium voltage-gated channel, Isk-related family, member 2 | 5395 | 0.151 | 0.0334 | No |
| 41 | CLSTN3 | NA | CLSTN3 Entrez, Source | calsyntenin 3 | 5639 | 0.123 | 0.0171 | No |
| 42 | DTNB | NA | DTNB Entrez, Source | dystrobrevin, beta | 5696 | 0.117 | 0.0145 | No |
| 43 | GRID2 | NA | GRID2 Entrez, Source | glutamate receptor, ionotropic, delta 2 | 5834 | 0.104 | 0.0057 | No |
| 44 | CCDC106 | NA | CCDC106 Entrez, Source | coiled-coil domain containing 106 | 5890 | 0.099 | 0.0029 | No |
| 45 | GP2 | NA | GP2 Entrez, Source | glycoprotein 2 (zymogen granule membrane) | 6031 | 0.084 | -0.0063 | No |
| 46 | SKIL | NA | SKIL Entrez, Source | SKI-like | 6144 | 0.073 | -0.0136 | No |
| 47 | BARD1 | NA | BARD1 Entrez, Source | BRCA1 associated RING domain 1 | 6154 | 0.072 | -0.0133 | No |
| 48 | TNNI3 | NA | TNNI3 Entrez, Source | troponin I type 3 (cardiac) | 6246 | 0.062 | -0.0192 | No |
| 49 | MEFV | NA | MEFV Entrez, Source | Mediterranean fever | 6698 | 0.017 | -0.0519 | No |
| 50 | NR6A1 | NA | NR6A1 Entrez, Source | nuclear receptor subfamily 6, group A, member 1 | 6735 | 0.014 | -0.0543 | No |
| 51 | ASB7 | NA | ASB7 Entrez, Source | ankyrin repeat and SOCS box-containing 7 | 7217 | -0.035 | -0.0890 | No |
| 52 | CLDN16 | NA | CLDN16 Entrez, Source | claudin 16 | 7307 | -0.046 | -0.0949 | No |
| 53 | TFCP2L1 | NA | TFCP2L1 Entrez, Source | transcription factor CP2-like 1 | 7521 | -0.068 | -0.1096 | No |
| 54 | ITGB1BP2 | NA | ITGB1BP2 Entrez, Source | integrin beta 1 binding protein (melusin) 2 | 7524 | -0.068 | -0.1089 | No |
| 55 | PTPRJ | NA | PTPRJ Entrez, Source | protein tyrosine phosphatase, receptor type, J | 7710 | -0.085 | -0.1214 | No |
| 56 | HSD11B2 | NA | HSD11B2 Entrez, Source | hydroxysteroid (11-beta) dehydrogenase 2 | 8181 | -0.134 | -0.1540 | No |
| 57 | NPHS1 | NA | NPHS1 Entrez, Source | nephrosis 1, congenital, Finnish type (nephrin) | 8254 | -0.143 | -0.1575 | No |
| 58 | SHOX2 | NA | SHOX2 Entrez, Source | short stature homeobox 2 | 8782 | -0.200 | -0.1935 | No |
| 59 | TEX15 | NA | TEX15 Entrez, Source | testis expressed sequence 15 | 8847 | -0.208 | -0.1957 | No |
| 60 | SIDT1 | NA | SIDT1 Entrez, Source | SID1 transmembrane family, member 1 | 8851 | -0.208 | -0.1934 | No |
| 61 | TAS2R4 | NA | TAS2R4 Entrez, Source | taste receptor, type 2, member 4 | 8911 | -0.215 | -0.1951 | No |
| 62 | BMPR1B | NA | BMPR1B Entrez, Source | bone morphogenetic protein receptor, type IB | 9027 | -0.229 | -0.2007 | No |
| 63 | MFSD6 | NA | 9089 | -0.236 | -0.2023 | No | ||
| 64 | SERPINA10 | NA | SERPINA10 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 | 9245 | -0.256 | -0.2105 | No |
| 65 | CPEB3 | NA | CPEB3 Entrez, Source | cytoplasmic polyadenylation element binding protein 3 | 9360 | -0.273 | -0.2155 | No |
| 66 | LFNG | NA | LFNG Entrez, Source | lunatic fringe homolog (Drosophila) | 9633 | -0.312 | -0.2316 | No |
| 67 | SLC16A7 | NA | SLC16A7 Entrez, Source | solute carrier family 16, member 7 (monocarboxylic acid transporter 2) | 9723 | -0.325 | -0.2342 | No |
| 68 | SNN | NA | SNN Entrez, Source | stannin | 9889 | -0.349 | -0.2420 | No |
| 69 | NRIP2 | NA | NRIP2 Entrez, Source | nuclear receptor interacting protein 2 | 10055 | -0.373 | -0.2495 | No |
| 70 | KRT15 | NA | KRT15 Entrez, Source | keratin 15 | 10080 | -0.376 | -0.2467 | No |
| 71 | YPEL1 | NA | YPEL1 Entrez, Source | yippee-like 1 (Drosophila) | 10088 | -0.377 | -0.2427 | No |
| 72 | MAST3 | NA | MAST3 Entrez, Source | microtubule associated serine/threonine kinase 3 | 10229 | -0.399 | -0.2481 | No |
| 73 | KLK7 | NA | KLK7 Entrez, Source | kallikrein 7 (chymotryptic, stratum corneum) | 10237 | -0.400 | -0.2438 | No |
| 74 | STAG3 | NA | STAG3 Entrez, Source | stromal antigen 3 | 10535 | -0.447 | -0.2601 | No |
| 75 | AKR1B10 | NA | AKR1B10 Entrez, Source | aldo-keto reductase family 1, member B10 (aldose reductase) | 10550 | -0.450 | -0.2557 | No |
| 76 | MTHFR | NA | MTHFR Entrez, Source | 5,10-methylenetetrahydrofolate reductase (NADPH) | 10793 | -0.492 | -0.2674 | No |
| 77 | WNT16 | NA | WNT16 Entrez, Source | wingless-type MMTV integration site family, member 16 | 10962 | -0.520 | -0.2733 | No |
| 78 | PAX3 | NA | PAX3 Entrez, Source | paired box gene 3 (Waardenburg syndrome 1) | 11216 | -0.567 | -0.2850 | Yes |
| 79 | SPTBN2 | NA | SPTBN2 Entrez, Source | spectrin, beta, non-erythrocytic 2 | 11289 | -0.583 | -0.2832 | Yes |
| 80 | MYO15A | NA | MYO15A Entrez, Source | myosin XVA | 11392 | -0.602 | -0.2834 | Yes |
| 81 | UPK3B | NA | UPK3B Entrez, Source | uroplakin 3B | 11452 | -0.615 | -0.2803 | Yes |
| 82 | EGF | NA | EGF Entrez, Source | epidermal growth factor (beta-urogastrone) | 11460 | -0.616 | -0.2733 | Yes |
| 83 | GDNF | NA | GDNF Entrez, Source | glial cell derived neurotrophic factor | 11679 | -0.667 | -0.2812 | Yes |
| 84 | FAM46C | NA | FAM46C Entrez, Source | family with sequence similarity 46, member C | 11751 | -0.685 | -0.2781 | Yes |
| 85 | SYNPO | NA | SYNPO Entrez, Source | synaptopodin | 11821 | -0.704 | -0.2747 | Yes |
| 86 | CAMK1D | NA | CAMK1D Entrez, Source | calcium/calmodulin-dependent protein kinase ID | 11879 | -0.719 | -0.2702 | Yes |
| 87 | CD80 | NA | CD80 Entrez, Source | CD80 molecule | 12189 | -0.816 | -0.2828 | Yes |
| 88 | UGT2B17 | NA | UGT2B17 Entrez, Source | UDP glucuronosyltransferase 2 family, polypeptide B17 | 12227 | -0.829 | -0.2756 | Yes |
| 89 | MSH5 | NA | MSH5 Entrez, Source | mutS homolog 5 (E. coli) | 12306 | -0.853 | -0.2710 | Yes |
| 90 | CELSR2 | NA | CELSR2 Entrez, Source | cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila) | 12334 | -0.868 | -0.2625 | Yes |
| 91 | GAMT | NA | GAMT Entrez, Source | guanidinoacetate N-methyltransferase | 12335 | -0.868 | -0.2520 | Yes |
| 92 | SLC25A23 | NA | SLC25A23 Entrez, Source | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 | 12372 | -0.883 | -0.2440 | Yes |
| 93 | THRB | NA | THRB Entrez, Source | thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian) | 12467 | -0.924 | -0.2397 | Yes |
| 94 | SLC6A14 | NA | SLC6A14 Entrez, Source | solute carrier family 6 (amino acid transporter), member 14 | 12479 | -0.928 | -0.2294 | Yes |
| 95 | SGK1 | NA | 12552 | -0.961 | -0.2230 | Yes | ||
| 96 | MYOT | NA | MYOT Entrez, Source | myotilin | 12609 | -0.985 | -0.2152 | Yes |
| 97 | PLAG1 | NA | PLAG1 Entrez, Source | pleiomorphic adenoma gene 1 | 12720 | -1.045 | -0.2107 | Yes |
| 98 | FGFR3 | NA | FGFR3 Entrez, Source | fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) | 12973 | -1.198 | -0.2146 | Yes |
| 99 | CYP39A1 | NA | CYP39A1 Entrez, Source | cytochrome P450, family 39, subfamily A, polypeptide 1 | 12999 | -1.215 | -0.2018 | Yes |
| 100 | PRODH | NA | PRODH Entrez, Source | proline dehydrogenase (oxidase) 1 | 13092 | -1.293 | -0.1929 | Yes |
| 101 | PDK2 | NA | PDK2 Entrez, Source | pyruvate dehydrogenase kinase, isozyme 2 | 13194 | -1.386 | -0.1836 | Yes |
| 102 | NR4A2 | NA | NR4A2 Entrez, Source | nuclear receptor subfamily 4, group A, member 2 | 13281 | -1.489 | -0.1719 | Yes |
| 103 | GP1BA | NA | GP1BA Entrez, Source | glycoprotein Ib (platelet), alpha polypeptide | 13339 | -1.568 | -0.1572 | Yes |
| 104 | CCNA1 | NA | CCNA1 Entrez, Source | cyclin A1 | 13467 | -1.757 | -0.1453 | Yes |
| 105 | P2RX6 | NA | 13471 | -1.762 | -0.1243 | Yes | ||
| 106 | RYR1 | NA | RYR1 Entrez, Source | ryanodine receptor 1 (skeletal) | 13609 | -2.096 | -0.1090 | Yes |
| 107 | ACTC1 | NA | ACTC1 Entrez, Source | actin, alpha, cardiac muscle 1 | 13620 | -2.138 | -0.0840 | Yes |
| 108 | BTG2 | NA | BTG2 Entrez, Source | BTG family, member 2 | 13659 | -2.285 | -0.0592 | Yes |
| 109 | C5 | NA | C5 Entrez, Source | complement component 5 | 13673 | -2.359 | -0.0318 | Yes |
| 110 | SLC12A3 | NA | SLC12A3 Entrez, Source | solute carrier family 12 (sodium/chloride transporters), member 3 | 13795 | -3.607 | 0.0028 | Yes |
