Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1w6a
GeneSetHALLMARK_INTERFERON_GAMMA_RESPONSE
Enrichment Score (ES)0.6385854
Normalized Enrichment Score (NES)2.7096412
Nominal p-value0.0
FDR q-value0.0
FWER p-Value0.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_INTERFERON_GAMMA_RESPONSE   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1CXCL11NACXCL11
Entrez,  Source
chemokine (C-X-C motif) ligand 1114.7640.0269Yes
2IFIT3NAIFIT3
Entrez,  Source
interferon-induced protein with tetratricopeptide repeats 384.4980.0520Yes
3CCL5NACCL5
Entrez,  Source
chemokine (C-C motif) ligand 5104.4620.0772Yes
4OAS2NAOAS2
Entrez,  Source
2'-5'-oligoadenylate synthetase 2, 69/71kDa114.4500.1024Yes
5DDX58NADDX58
Entrez,  Source
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58134.3970.1272Yes
6OASLNAOASL
Entrez,  Source
2'-5'-oligoadenylate synthetase-like144.3940.1521Yes
7IL6NAIL6
Entrez,  Source
interleukin 6 (interferon, beta 2)154.3830.1769Yes
8CXCL10NACXCL10
Entrez,  Source
chemokine (C-X-C motif) ligand 10164.3140.2014Yes
9IFI44NAIFI44
Entrez,  Source
interferon-induced protein 44194.2050.2251Yes
10IFIT2NAIFIT2
Entrez,  Source
interferon-induced protein with tetratricopeptide repeats 2244.1400.2482Yes
11TDRD7NATDRD7
Entrez,  Source
tudor domain containing 7333.8970.2697Yes
12IFIT1NAIFIT1
Entrez,  Source
interferon-induced protein with tetratricopeptide repeats 1373.8290.2912Yes
13RSAD2NARSAD2
Entrez,  Source
radical S-adenosyl methionine domain containing 2453.6550.3114Yes
14DDX60NA543.4350.3302Yes
15ISG20NAISG20
Entrez,  Source
interferon stimulated exonuclease gene 20kDa563.4020.3494Yes
16IFIH1NAIFIH1
Entrez,  Source
interferon induced with helicase C domain 1603.3430.3682Yes
17DHX58NA643.3170.3867Yes
18RTP4NARTP4
Entrez,  Source
receptor transporter protein 4903.0140.4020Yes
19CCL2NACCL2
Entrez,  Source
chemokine (C-C motif) ligand 2982.9640.4183Yes
20HERC6NAHERC6
Entrez,  Source
hect domain and RLD 61052.9080.4343Yes
21TNFAIP3NATNFAIP3
Entrez,  Source
tumor necrosis factor, alpha-induced protein 31122.8040.4497Yes
22WARSNAWARS
Entrez,  Source
tryptophanyl-tRNA synthetase1672.3850.4593Yes
23APOL6NAAPOL6
Entrez,  Source
apolipoprotein L, 62002.2080.4695Yes
24SAMD9LNASAMD9L
Entrez,  Source
sterile alpha motif domain containing 9-like2102.1670.4811Yes
25ISG15NAISG15
Entrez,  Source
ISG15 ubiquitin-like modifier2401.9800.4902Yes
26ZNFX1NAZNFX1
Entrez,  Source
zinc finger, NFX1-type containing 12451.9750.5011Yes
27ICAM1NAICAM1
Entrez,  Source
intercellular adhesion molecule 1 (CD54), human rhinovirus receptor2511.9520.5118Yes
28IRF1NAIRF1
Entrez,  Source
interferon regulatory factor 12521.9470.5228Yes
29SECTM1NASECTM1
Entrez,  Source
secreted and transmembrane 12611.9250.5331Yes
30CFBNACFB
Entrez,  Source
complement factor B2821.8040.5419Yes
31PSMB9NAPSMB9
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)3251.7060.5485Yes
32SOCS3NASOCS3
Entrez,  Source
suppressor of cytokine signaling 33841.5260.5529Yes
33PDE4BNAPDE4B
Entrez,  Source
phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)3881.5230.5613Yes
34MT2ANAMT2A
Entrez,  Source
metallothionein 2A4081.4930.5683Yes
35HLA-BNAHLA-B
Entrez,  Source
major histocompatibility complex, class I, B4211.4740.5758Yes
36IFI27NAIFI27
Entrez,  Source
interferon, alpha-inducible protein 274291.4530.5835Yes
37TRIM26NATRIM26
Entrez,  Source
tripartite motif-containing 264351.4370.5913Yes
38TRIM21NATRIM21
Entrez,  Source
tripartite motif-containing 214631.3740.5971Yes
39USP18NAUSP18
Entrez,  Source
ubiquitin specific peptidase 185401.2620.5987Yes
40OAS3NAOAS3
Entrez,  Source
2'-5'-oligoadenylate synthetase 3, 100kDa5761.2060.6030Yes
41PARP12NAPARP12
Entrez,  Source
poly (ADP-ribose) polymerase family, member 126731.1200.6023Yes
42TAP1NATAP1
Entrez,  Source
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)6861.1120.6077Yes
43IL4RNAIL4R
Entrez,  Source
interleukin 4 receptor7321.0630.6104Yes
44IFI44LNAIFI44L
Entrez,  Source
interferon-induced protein 44-like7351.0620.6163Yes
45IRF9NA7381.0600.6222Yes
46PMLNAPML
Entrez,  Source
promyelocytic leukemia7551.0460.6269Yes
47JAK2NAJAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)7561.0450.6328Yes
48MVPNAMVP
Entrez,  Source
major vault protein8610.9700.6307Yes
49SOD2NASOD2
Entrez,  Source
superoxide dismutase 2, mitochondrial8970.9450.6335Yes
50PTGS2NAPTGS2
Entrez,  Source
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)9020.9450.6386Yes
51MYD88NAMYD88
Entrez,  Source
myeloid differentiation primary response gene (88)10720.8610.6311No
52NMINANMI
Entrez,  Source
N-myc (and STAT) interactor11850.8170.6275No
53MX1NAMX1
Entrez,  Source
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)12460.7950.6276No
54CASP4NACASP4
Entrez,  Source
caspase 4, apoptosis-related cysteine peptidase12760.7850.6300No
55NAMPTNA14390.7340.6223No
56NFKBIANANFKBIA
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha14840.7210.6231No
57PNPT1NAPNPT1
Entrez,  Source
polyribonucleotide nucleotidyltransferase 115260.7080.6242No
58PLSCR1NAPLSCR1
Entrez,  Source
phospholipid scramblase 115270.7080.6282No
59IL15RANAIL15RA
Entrez,  Source
interleukin 15 receptor, alpha16900.6610.6201No
60EIF2AK2NAEIF2AK2
Entrez,  Source
eukaryotic translation initiation factor 2-alpha kinase 217080.6560.6225No
61NUP93NANUP93
Entrez,  Source
nucleoporin 93kDa17360.6480.6242No
62PTPN2NAPTPN2
Entrez,  Source
protein tyrosine phosphatase, non-receptor type 218670.6140.6182No
63HIF1ANAHIF1A
Entrez,  Source
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)18710.6130.6214No
64TRIM14NATRIM14
Entrez,  Source
tripartite motif-containing 1419340.5990.6203No
65NFKB1NANFKB1
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)20040.5850.6186No
66PSMB10NAPSMB10
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 1020300.5810.6200No
67PFKPNAPFKP
Entrez,  Source
phosphofructokinase, platelet22870.5350.6043No
68PNPNA23330.5270.6040No
69TAPBPNATAPBP
Entrez,  Source
TAP binding protein (tapasin)23390.5260.6066No
70STAT3NASTAT3
Entrez,  Source
signal transducer and activator of transcription 3 (acute-phase response factor)23450.5240.6093No
71NLRC5NA23630.5220.6110No
72STAT1NASTAT1
Entrez,  Source
signal transducer and activator of transcription 1, 91kDa23740.5200.6132No
73SP110NASP110
Entrez,  Source
SP110 nuclear body protein23810.5200.6157No
74CASP3NACASP3
Entrez,  Source
caspase 3, apoptosis-related cysteine peptidase25460.4920.6065No
75GBP6NAGBP6
Entrez,  Source
guanylate binding protein family, member 626430.4760.6022No
76ADARNAADAR
Entrez,  Source
adenosine deaminase, RNA-specific28170.4490.5920No
77ARL4ANAARL4A
Entrez,  Source
ADP-ribosylation factor-like 4A29010.4340.5884No
78PTPN1NAPTPN1
Entrez,  Source
protein tyrosine phosphatase, non-receptor type 130570.4140.5794No
79RIPK1NARIPK1
Entrez,  Source
receptor (TNFRSF)-interacting serine-threonine kinase 131930.3940.5718No
80IFNAR2NAIFNAR2
Entrez,  Source
interferon (alpha, beta and omega) receptor 233100.3810.5655No
81FASNAFAS
Entrez,  Source
Fas (TNF receptor superfamily, member 6)34570.3600.5568No
82IDO1NA36130.3430.5474No
83HLA-ANAHLA-A
Entrez,  Source
major histocompatibility complex, class I, A36590.3370.5460No
84PSME2NAPSME2
Entrez,  Source
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)37360.3290.5423No
85B2MNAB2M
Entrez,  Source
beta-2-microglobulin37520.3280.5431No
86CASP7NACASP7
Entrez,  Source
caspase 7, apoptosis-related cysteine peptidase37570.3270.5447No
87PSMB2NAPSMB2
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 237840.3230.5446No
88RAPGEF6NARAPGEF6
Entrez,  Source
Rap guanine nucleotide exchange factor (GEF) 638100.3200.5446No
89SAMHD1NASAMHD1
Entrez,  Source
SAM domain and HD domain 139380.3040.5370No
90MTHFD2NAMTHFD2
Entrez,  Source
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase42840.2670.5133No
91MX2NAMX2
Entrez,  Source
myxovirus (influenza virus) resistance 2 (mouse)43470.2610.5102No
92RIPK2NARIPK2
Entrez,  Source
receptor-interacting serine-threonine kinase 245880.2330.4940No
93RNF31NARNF31
Entrez,  Source
ring finger protein 3147510.2160.4834No
94PSME1NAPSME1
Entrez,  Source
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)49470.1970.4702No
95CASP8NACASP8
Entrez,  Source
caspase 8, apoptosis-related cysteine peptidase50430.1870.4643No
96TOR1BNATOR1B
Entrez,  Source
torsin family 1, member B (torsin B)52070.1710.4534No
97GCH1NAGCH1
Entrez,  Source
GTP cyclohydrolase 1 (dopa-responsive dystonia)53040.1610.4473No
98PSMA3NAPSMA3
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 354050.1500.4408No
99IL15NAIL15
Entrez,  Source
interleukin 1554950.1400.4351No
100CDKN1ANACDKN1A
Entrez,  Source
cyclin-dependent kinase inhibitor 1A (p21, Cip1)57070.1150.4203No
101ITGB7NAITGB7
Entrez,  Source
integrin, beta 757130.1150.4206No
102LYSMD2NALYSMD2
Entrez,  Source
LysM, putative peptidoglycan-binding, domain containing 257370.1130.4195No
103IRF2NAIRF2
Entrez,  Source
interferon regulatory factor 257600.1110.4186No
104OGFRNAOGFR
Entrez,  Source
opioid growth factor receptor59970.0870.4018No
105FGL2NAFGL2
Entrez,  Source
fibrinogen-like 264690.0410.3676No
106ST3GAL5NAST3GAL5
Entrez,  Source
ST3 beta-galactoside alpha-2,3-sialyltransferase 565290.0360.3635No
107HLA-GNAHLA-G
Entrez,  Source
HLA-G histocompatibility antigen, class I, G65600.0310.3614No
108XAF1NA65640.0310.3614No
109IFITM3NAIFITM3
Entrez,  Source
interferon induced transmembrane protein 3 (1-8U)66940.0180.3521No
110UBE2L6NAUBE2L6
Entrez,  Source
ubiquitin-conjugating enzyme E2L 667680.0100.3468No
111SLC25A28NASLC25A28
Entrez,  Source
solute carrier family 25, member 2868480.0020.3410No
112PSMA2NAPSMA2
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 27269-0.0410.3105No
113TRIM25NATRIM25
Entrez,  Source
tripartite motif-containing 257512-0.0680.2932No
114LAP3NALAP3
Entrez,  Source
leucine aminopeptidase 37558-0.0720.2903No
115NOD1NA7612-0.0770.2869No
116LATS2NALATS2
Entrez,  Source
LATS, large tumor suppressor, homolog 2 (Drosophila)7731-0.0870.2787No
117CIITANACIITA
Entrez,  Source
class II, major histocompatibility complex, transactivator7816-0.0960.2731No
118ARID5BNAARID5B
Entrez,  Source
AT rich interactive domain 5B (MRF1-like)7932-0.1070.2653No
119NCOA3NANCOA3
Entrez,  Source
nuclear receptor coactivator 38237-0.1420.2439No
120BTG1NABTG1
Entrez,  Source
B-cell translocation gene 1, anti-proliferative8251-0.1430.2437No
121BPGMNABPGM
Entrez,  Source
2,3-bisphosphoglycerate mutase8541-0.1720.2236No
122ZBP1NAZBP1
Entrez,  Source
Z-DNA binding protein 18612-0.1810.2195No
123IRF4NAIRF4
Entrez,  Source
interferon regulatory factor 48687-0.1890.2151No
124IFI35NAIFI35
Entrez,  Source
interferon-induced protein 358748-0.1970.2119No
125TXNIPNATXNIP
Entrez,  Source
thioredoxin interacting protein8817-0.2050.2081No
126STAT4NASTAT4
Entrez,  Source
signal transducer and activator of transcription 48849-0.2080.2070No
127PARP14NAPARP14
Entrez,  Source
poly (ADP-ribose) polymerase family, member 148880-0.2120.2060No
128IL2RBNAIL2RB
Entrez,  Source
interleukin 2 receptor, beta8981-0.2230.1999No
129LGALS3BPNALGALS3BP
Entrez,  Source
lectin, galactoside-binding, soluble, 3 binding protein9055-0.2320.1959No
130MARCH1NAMARCH1
Entrez,  Source
membrane-associated ring finger (C3HC4) 19400-0.2790.1723No
131TNFAIP2NATNFAIP2
Entrez,  Source
tumor necrosis factor, alpha-induced protein 29418-0.2820.1727No
132VCAM1NAVCAM1
Entrez,  Source
vascular cell adhesion molecule 19432-0.2840.1733No
133SSPNNASSPN
Entrez,  Source
sarcospan (Kras oncogene-associated gene)9467-0.2880.1725No
134CD274NACD274
Entrez,  Source
CD274 molecule9469-0.2890.1740No
135TRAFD1NATRAFD1
Entrez,  Source
TRAF-type zinc finger domain containing 19619-0.3100.1649No
136IL18BPNAIL18BP
Entrez,  Source
interleukin 18 binding protein9631-0.3110.1658No
137PELI1NAPELI1
Entrez,  Source
pellino homolog 1 (Drosophila)9718-0.3250.1614No
138ISOC1NAISOC1
Entrez,  Source
isochorismatase domain containing 19741-0.3270.1616No
139STAT2NASTAT2
Entrez,  Source
signal transducer and activator of transcription 2, 113kDa10036-0.3690.1422No
140CASP1NACASP1
Entrez,  Source
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)10265-0.4050.1278No
141IFI30NAIFI30
Entrez,  Source
interferon, gamma-inducible protein 3010399-0.4270.1205No
142EPSTI1NAEPSTI1
Entrez,  Source
epithelial stromal interaction 1 (breast)10657-0.4690.1044No
143PSMB8NAPSMB8
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)10667-0.4710.1064No
144SLAMF7NASLAMF7
Entrez,  Source
SLAM family member 710674-0.4720.1086No
145BST2NABST2
Entrez,  Source
bone marrow stromal cell antigen 210820-0.4960.1008No
146SRINASRI
Entrez,  Source
sorcin10970-0.5220.0929No
147SPPL2ANASPPL2A
Entrez,  Source
-10976-0.5230.0955No
148ST8SIA4NAST8SIA4
Entrez,  Source
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 411534-0.6320.0583No
149PLA2G4ANAPLA2G4A
Entrez,  Source
phospholipase A2, group IVA (cytosolic, calcium-dependent)11551-0.6360.0607No
150LY6ENALY6E
Entrez,  Source
lymphocyte antigen 6 complex, locus E11565-0.6390.0634No
151VAMP8NAVAMP8
Entrez,  Source
vesicle-associated membrane protein 8 (endobrevin)11633-0.6570.0622No
152AUTS2NAAUTS2
Entrez,  Source
autism susceptibility candidate 211808-0.7000.0535No
153IFITM2NAIFITM2
Entrez,  Source
interferon induced transmembrane protein 2 (1-8D)11878-0.7180.0525No
154PIM1NAPIM1
Entrez,  Source
pim-1 oncogene11968-0.7440.0502No
155RBCK1NARBCK1
Entrez,  Source
RanBP-type and C3HC4-type zinc finger containing 112175-0.8130.0397No
156VAMP5NAVAMP5
Entrez,  Source
vesicle-associated membrane protein 5 (myobrevin)12542-0.9580.0184No
157TNFSF10NATNFSF10
Entrez,  Source
tumor necrosis factor (ligand) superfamily, member 1012683-1.0280.0140No
158PTPN6NAPTPN6
Entrez,  Source
protein tyrosine phosphatase, non-receptor type 612791-1.0840.0123No
159GBP4NAGBP4
Entrez,  Source
guanylate binding protein 412904-1.1530.0106No
160EIF4E3NAEIF4E3
Entrez,  Source
eukaryotic translation initiation factor 4E member 312932-1.1700.0153No
161C1SNAC1S
Entrez,  Source
complement component 1, s subcomponent13114-1.3070.0094No
162C1RNAC1R
Entrez,  Source
complement component 1, r subcomponent13304-1.5200.0042No
163SERPING1NASERPING1
Entrez,  Source
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)13330-1.5530.0112No
164CFHNACFH
Entrez,  Source
complement factor H13608-2.0940.0028No
165HLA-DMANAHLA-DMA
Entrez,  Source
major histocompatibility complex, class II, DM alpha13683-2.4120.0110No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_INTERFERON_GAMMA_RESPONSE   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_INTERFERON_GAMMA_RESPONSE: Random ES distribution   
Gene set null distribution of ES for HALLMARK_INTERFERON_GAMMA_RESPONSE