Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | HALLMARK_INTERFERON_ALPHA_RESPONSE |
| Enrichment Score (ES) | 0.7281421 |
| Normalized Enrichment Score (NES) | 2.8624566 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CXCL11 | NA | CXCL11 Entrez, Source | chemokine (C-X-C motif) ligand 11 | 1 | 4.764 | 0.0451 | Yes |
| 2 | IFIT3 | NA | IFIT3 Entrez, Source | interferon-induced protein with tetratricopeptide repeats 3 | 8 | 4.498 | 0.0873 | Yes |
| 3 | OASL | NA | OASL Entrez, Source | 2'-5'-oligoadenylate synthetase-like | 14 | 4.394 | 0.1286 | Yes |
| 4 | CXCL10 | NA | CXCL10 Entrez, Source | chemokine (C-X-C motif) ligand 10 | 16 | 4.314 | 0.1694 | Yes |
| 5 | IFI44 | NA | IFI44 Entrez, Source | interferon-induced protein 44 | 19 | 4.205 | 0.2091 | Yes |
| 6 | IFIT2 | NA | IFIT2 Entrez, Source | interferon-induced protein with tetratricopeptide repeats 2 | 24 | 4.140 | 0.2481 | Yes |
| 7 | TDRD7 | NA | TDRD7 Entrez, Source | tudor domain containing 7 | 33 | 3.897 | 0.2845 | Yes |
| 8 | RSAD2 | NA | RSAD2 Entrez, Source | radical S-adenosyl methionine domain containing 2 | 45 | 3.655 | 0.3183 | Yes |
| 9 | DDX60 | NA | 54 | 3.435 | 0.3503 | Yes | ||
| 10 | ISG20 | NA | ISG20 Entrez, Source | interferon stimulated exonuclease gene 20kDa | 56 | 3.402 | 0.3825 | Yes |
| 11 | IFIH1 | NA | IFIH1 Entrez, Source | interferon induced with helicase C domain 1 | 60 | 3.343 | 0.4139 | Yes |
| 12 | DHX58 | NA | 64 | 3.317 | 0.4452 | Yes | ||
| 13 | RTP4 | NA | RTP4 Entrez, Source | receptor transporter protein 4 | 90 | 3.014 | 0.4719 | Yes |
| 14 | HERC6 | NA | HERC6 Entrez, Source | hect domain and RLD 6 | 105 | 2.908 | 0.4985 | Yes |
| 15 | SAMD9 | NA | SAMD9 Entrez, Source | sterile alpha motif domain containing 9 | 132 | 2.619 | 0.5214 | Yes |
| 16 | WARS | NA | WARS Entrez, Source | tryptophanyl-tRNA synthetase | 167 | 2.385 | 0.5415 | Yes |
| 17 | SAMD9L | NA | SAMD9L Entrez, Source | sterile alpha motif domain containing 9-like | 210 | 2.167 | 0.5590 | Yes |
| 18 | ISG15 | NA | ISG15 Entrez, Source | ISG15 ubiquitin-like modifier | 240 | 1.980 | 0.5757 | Yes |
| 19 | IRF1 | NA | IRF1 Entrez, Source | interferon regulatory factor 1 | 252 | 1.947 | 0.5933 | Yes |
| 20 | PSMB9 | NA | PSMB9 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) | 325 | 1.706 | 0.6043 | Yes |
| 21 | UBA7 | NA | 345 | 1.631 | 0.6184 | Yes | ||
| 22 | IFI27 | NA | IFI27 Entrez, Source | interferon, alpha-inducible protein 27 | 429 | 1.453 | 0.6261 | Yes |
| 23 | TRIM26 | NA | TRIM26 Entrez, Source | tripartite motif-containing 26 | 435 | 1.437 | 0.6394 | Yes |
| 24 | TRIM21 | NA | TRIM21 Entrez, Source | tripartite motif-containing 21 | 463 | 1.374 | 0.6504 | Yes |
| 25 | USP18 | NA | USP18 Entrez, Source | ubiquitin specific peptidase 18 | 540 | 1.262 | 0.6569 | Yes |
| 26 | OAS1 | NA | OAS1 Entrez, Source | 2',5'-oligoadenylate synthetase 1, 40/46kDa | 548 | 1.258 | 0.6683 | Yes |
| 27 | NCOA7 | NA | NCOA7 Entrez, Source | nuclear receptor coactivator 7 | 573 | 1.212 | 0.6780 | Yes |
| 28 | PARP12 | NA | PARP12 Entrez, Source | poly (ADP-ribose) polymerase family, member 12 | 673 | 1.120 | 0.6814 | Yes |
| 29 | TAP1 | NA | TAP1 Entrez, Source | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 686 | 1.112 | 0.6911 | Yes |
| 30 | PARP9 | NA | PARP9 Entrez, Source | poly (ADP-ribose) polymerase family, member 9 | 709 | 1.090 | 0.6998 | Yes |
| 31 | IL4R | NA | IL4R Entrez, Source | interleukin 4 receptor | 732 | 1.063 | 0.7083 | Yes |
| 32 | IFI44L | NA | IFI44L Entrez, Source | interferon-induced protein 44-like | 735 | 1.062 | 0.7182 | Yes |
| 33 | IRF9 | NA | 738 | 1.060 | 0.7281 | Yes | ||
| 34 | ELF1 | NA | ELF1 Entrez, Source | E74-like factor 1 (ets domain transcription factor) | 875 | 0.959 | 0.7273 | No |
| 35 | NMI | NA | NMI Entrez, Source | N-myc (and STAT) interactor | 1185 | 0.817 | 0.7126 | No |
| 36 | MX1 | NA | MX1 Entrez, Source | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | 1246 | 0.795 | 0.7158 | No |
| 37 | CCRL2 | NA | CCRL2 Entrez, Source | chemokine (C-C motif) receptor-like 2 | 1408 | 0.741 | 0.7111 | No |
| 38 | PNPT1 | NA | PNPT1 Entrez, Source | polyribonucleotide nucleotidyltransferase 1 | 1526 | 0.708 | 0.7093 | No |
| 39 | PLSCR1 | NA | PLSCR1 Entrez, Source | phospholipid scramblase 1 | 1527 | 0.708 | 0.7160 | No |
| 40 | EIF2AK2 | NA | EIF2AK2 Entrez, Source | eukaryotic translation initiation factor 2-alpha kinase 2 | 1708 | 0.656 | 0.7091 | No |
| 41 | TRIM14 | NA | TRIM14 Entrez, Source | tripartite motif-containing 14 | 1934 | 0.599 | 0.6985 | No |
| 42 | SP110 | NA | SP110 Entrez, Source | SP110 nuclear body protein | 2381 | 0.520 | 0.6709 | No |
| 43 | ADAR | NA | ADAR Entrez, Source | adenosine deaminase, RNA-specific | 2817 | 0.449 | 0.6436 | No |
| 44 | HLA-C | NA | HLA-C Entrez, Source | major histocompatibility complex, class I, C | 3405 | 0.367 | 0.6043 | No |
| 45 | PSME2 | NA | PSME2 Entrez, Source | proteasome (prosome, macropain) activator subunit 2 (PA28 beta) | 3736 | 0.329 | 0.5835 | No |
| 46 | B2M | NA | B2M Entrez, Source | beta-2-microglobulin | 3752 | 0.328 | 0.5855 | No |
| 47 | TRIM5 | NA | TRIM5 Entrez, Source | tripartite motif-containing 5 | 4002 | 0.297 | 0.5702 | No |
| 48 | TMEM140 | NA | TMEM140 Entrez, Source | transmembrane protein 140 | 4385 | 0.255 | 0.5448 | No |
| 49 | RIPK2 | NA | RIPK2 Entrez, Source | receptor-interacting serine-threonine kinase 2 | 4588 | 0.233 | 0.5323 | No |
| 50 | RNF31 | NA | RNF31 Entrez, Source | ring finger protein 31 | 4751 | 0.216 | 0.5226 | No |
| 51 | PSME1 | NA | PSME1 Entrez, Source | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | 4947 | 0.197 | 0.5103 | No |
| 52 | CASP8 | NA | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 5043 | 0.187 | 0.5051 | No |
| 53 | PSMA3 | NA | PSMA3 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 3 | 5405 | 0.150 | 0.4803 | No |
| 54 | IL15 | NA | IL15 Entrez, Source | interleukin 15 | 5495 | 0.140 | 0.4752 | No |
| 55 | IRF2 | NA | IRF2 Entrez, Source | interferon regulatory factor 2 | 5760 | 0.111 | 0.4570 | No |
| 56 | OGFR | NA | OGFR Entrez, Source | opioid growth factor receptor | 5997 | 0.087 | 0.4407 | No |
| 57 | NUB1 | NA | NUB1 Entrez, Source | negative regulator of ubiquitin-like proteins 1 | 6556 | 0.032 | 0.4004 | No |
| 58 | IFITM3 | NA | IFITM3 Entrez, Source | interferon induced transmembrane protein 3 (1-8U) | 6694 | 0.018 | 0.3906 | No |
| 59 | UBE2L6 | NA | UBE2L6 Entrez, Source | ubiquitin-conjugating enzyme E2L 6 | 6768 | 0.010 | 0.3854 | No |
| 60 | SLC25A28 | NA | SLC25A28 Entrez, Source | solute carrier family 25, member 28 | 6848 | 0.002 | 0.3797 | No |
| 61 | LAMP3 | NA | LAMP3 Entrez, Source | lysosomal-associated membrane protein 3 | 7144 | -0.027 | 0.3585 | No |
| 62 | CNP | NA | CNP Entrez, Source | 2',3'-cyclic nucleotide 3' phosphodiesterase | 7460 | -0.063 | 0.3361 | No |
| 63 | PROCR | NA | PROCR Entrez, Source | protein C receptor, endothelial (EPCR) | 7498 | -0.066 | 0.3341 | No |
| 64 | TRIM25 | NA | TRIM25 Entrez, Source | tripartite motif-containing 25 | 7512 | -0.068 | 0.3338 | No |
| 65 | LAP3 | NA | LAP3 Entrez, Source | leucine aminopeptidase 3 | 7558 | -0.072 | 0.3312 | No |
| 66 | LPAR6 | NA | 8066 | -0.122 | 0.2955 | No | ||
| 67 | IFI35 | NA | IFI35 Entrez, Source | interferon-induced protein 35 | 8748 | -0.197 | 0.2478 | No |
| 68 | TXNIP | NA | TXNIP Entrez, Source | thioredoxin interacting protein | 8817 | -0.205 | 0.2448 | No |
| 69 | PARP14 | NA | PARP14 Entrez, Source | poly (ADP-ribose) polymerase family, member 14 | 8880 | -0.212 | 0.2423 | No |
| 70 | LGALS3BP | NA | LGALS3BP Entrez, Source | lectin, galactoside-binding, soluble, 3 binding protein | 9055 | -0.232 | 0.2318 | No |
| 71 | TRAFD1 | NA | TRAFD1 Entrez, Source | TRAF-type zinc finger domain containing 1 | 9619 | -0.310 | 0.1938 | No |
| 72 | STAT2 | NA | STAT2 Entrez, Source | signal transducer and activator of transcription 2, 113kDa | 10036 | -0.369 | 0.1671 | No |
| 73 | CASP1 | NA | CASP1 Entrez, Source | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 10265 | -0.405 | 0.1543 | No |
| 74 | IFI30 | NA | IFI30 Entrez, Source | interferon, gamma-inducible protein 30 | 10399 | -0.427 | 0.1487 | No |
| 75 | EPSTI1 | NA | EPSTI1 Entrez, Source | epithelial stromal interaction 1 (breast) | 10657 | -0.469 | 0.1345 | No |
| 76 | PSMB8 | NA | PSMB8 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) | 10667 | -0.471 | 0.1383 | No |
| 77 | MOV10 | NA | MOV10 Entrez, Source | Mov10, Moloney leukemia virus 10, homolog (mouse) | 10682 | -0.473 | 0.1417 | No |
| 78 | BST2 | NA | BST2 Entrez, Source | bone marrow stromal cell antigen 2 | 10820 | -0.496 | 0.1365 | No |
| 79 | FAM46A | NA | FAM46A Entrez, Source | family with sequence similarity 46, member A | 11379 | -0.599 | 0.1016 | No |
| 80 | LY6E | NA | LY6E Entrez, Source | lymphocyte antigen 6 complex, locus E | 11565 | -0.639 | 0.0942 | No |
| 81 | IFITM2 | NA | IFITM2 Entrez, Source | interferon induced transmembrane protein 2 (1-8D) | 11878 | -0.718 | 0.0783 | No |
| 82 | CD47 | NA | CD47 Entrez, Source | CD47 molecule | 12103 | -0.788 | 0.0695 | No |
| 83 | GBP4 | NA | GBP4 Entrez, Source | guanylate binding protein 4 | 12904 | -1.153 | 0.0222 | No |
| 84 | IFITM1 | NA | IFITM1 Entrez, Source | interferon induced transmembrane protein 1 (9-27) | 13029 | -1.239 | 0.0249 | No |
| 85 | C1S | NA | C1S Entrez, Source | complement component 1, s subcomponent | 13114 | -1.307 | 0.0312 | No |
| 86 | GBP2 | NA | GBP2 Entrez, Source | guanylate binding protein 2, interferon-inducible | 13642 | -2.224 | 0.0140 | No |
