Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1w6a
GeneSetHALLMARK_INFLAMMATORY_RESPONSE
Enrichment Score (ES)0.5692321
Normalized Enrichment Score (NES)2.4253445
Nominal p-value0.0
FDR q-value0.0
FWER p-Value0.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_INFLAMMATORY_RESPONSE   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1CXCL11NACXCL11
Entrez,  Source
chemokine (C-X-C motif) ligand 1114.7640.0347Yes
2IL7RNAIL7R
Entrez,  Source
interleukin 7 receptor34.6800.0688Yes
3CCL5NACCL5
Entrez,  Source
chemokine (C-C motif) ligand 5104.4620.1010Yes
4IL6NAIL6
Entrez,  Source
interleukin 6 (interferon, beta 2)154.3830.1327Yes
5CXCL10NACXCL10
Entrez,  Source
chemokine (C-X-C motif) ligand 10164.3140.1642Yes
6RTP4NARTP4
Entrez,  Source
receptor transporter protein 4903.0140.1809Yes
7CCL2NACCL2
Entrez,  Source
chemokine (C-C motif) ligand 2982.9640.2020Yes
8SERPINE1NASERPINE1
Entrez,  Source
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 11092.8400.2220Yes
9RGS16NARGS16
Entrez,  Source
regulator of G-protein signalling 161432.5540.2383Yes
10PTGER4NAPTGER4
Entrez,  Source
prostaglandin E receptor 4 (subtype EP4)1592.4500.2551Yes
11HRH1NAHRH1
Entrez,  Source
histamine receptor H11682.3810.2719Yes
12F3NAF3
Entrez,  Source
coagulation factor III (thromboplastin, tissue factor)1842.3220.2877Yes
13PLAURNAPLAUR
Entrez,  Source
plasminogen activator, urokinase receptor1872.3080.3044Yes
14OLR1NAOLR1
Entrez,  Source
oxidised low density lipoprotein (lectin-like) receptor 12092.1710.3188Yes
15BEST1NA2262.0850.3328Yes
16GNA15NAGNA15
Entrez,  Source
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)2491.9570.3455Yes
17ICAM1NAICAM1
Entrez,  Source
intercellular adhesion molecule 1 (CD54), human rhinovirus receptor2511.9520.3597Yes
18IRF1NAIRF1
Entrez,  Source
interferon regulatory factor 12521.9470.3739Yes
19MXD1NAMXD1
Entrez,  Source
MAX dimerization protein 12561.9380.3878Yes
20IL18R1NAIL18R1
Entrez,  Source
interleukin 18 receptor 12661.8940.4010Yes
21EDN1NAEDN1
Entrez,  Source
endothelin 12781.8290.4136Yes
22TLR3NATLR3
Entrez,  Source
toll-like receptor 32841.7980.4263Yes
23HBEGFNAHBEGF
Entrez,  Source
heparin-binding EGF-like growth factor3191.7130.4364Yes
24CYBBNACYBB
Entrez,  Source
cytochrome b-245, beta polypeptide (chronic granulomatous disease)3441.6310.4465Yes
25SLC31A2NASLC31A2
Entrez,  Source
solute carrier family 31 (copper transporters), member 23571.5940.4573Yes
26IL12BNAIL12B
Entrez,  Source
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)3661.5670.4681Yes
27AXLNAAXL
Entrez,  Source
AXL receptor tyrosine kinase3741.5450.4789Yes
28PDE4BNAPDE4B
Entrez,  Source
phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)3881.5230.4891Yes
29ITGA5NAITGA5
Entrez,  Source
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)3901.5190.5001Yes
30TPBGNATPBG
Entrez,  Source
trophoblast glycoprotein3971.5080.5107Yes
31IL1R1NAIL1R1
Entrez,  Source
interleukin 1 receptor, type I5601.2290.5078Yes
32IRAK2NAIRAK2
Entrez,  Source
interleukin-1 receptor-associated kinase 25821.2010.5151Yes
33EMP3NAEMP3
Entrez,  Source
epithelial membrane protein 36031.1770.5222Yes
34ITGB8NAITGB8
Entrez,  Source
integrin, beta 86281.1600.5289Yes
35IL4RNAIL4R
Entrez,  Source
interleukin 4 receptor7321.0630.5291Yes
36LIFNALIF
Entrez,  Source
leukemia inhibitory factor (cholinergic differentiation factor)7451.0560.5360Yes
37PVRNAPVR
Entrez,  Source
poliovirus receptor7571.0450.5428Yes
38CCL22NACCL22
Entrez,  Source
chemokine (C-C motif) ligand 227581.0420.5504Yes
39AHRNAAHR
Entrez,  Source
aryl hydrocarbon receptor7831.0230.5561Yes
40LDLRNALDLR
Entrez,  Source
low density lipoprotein receptor (familial hypercholesterolemia)8031.0070.5621Yes
41IL18NAIL18
Entrez,  Source
interleukin 18 (interferon-gamma-inducing factor)8310.9880.5674Yes
42IL1ANAIL1A
Entrez,  Source
interleukin 1, alpha9770.9040.5634Yes
43NMINANMI
Entrez,  Source
N-myc (and STAT) interactor11850.8170.5542Yes
44SPHK1NASPHK1
Entrez,  Source
sphingosine kinase 111980.8140.5593Yes
45EBI3NAEBI3
Entrez,  Source
Epstein-Barr virus induced gene 312220.8030.5635Yes
46CCRL2NACCRL2
Entrez,  Source
chemokine (C-C motif) receptor-like 214080.7410.5553Yes
47NAMPTNA14390.7340.5585Yes
48NFKBIANANFKBIA
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha14840.7210.5606Yes
49RELANARELA
Entrez,  Source
v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian)15700.6980.5595Yes
50RNF144BNA15870.6920.5633Yes
51ADRM1NAADRM1
Entrez,  Source
adhesion regulating molecule 116610.6710.5629Yes
52IL15RANAIL15RA
Entrez,  Source
interleukin 15 receptor, alpha16900.6610.5657Yes
53EIF2AK2NAEIF2AK2
Entrez,  Source
eukaryotic translation initiation factor 2-alpha kinase 217080.6560.5692Yes
54HIF1ANAHIF1A
Entrez,  Source
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)18710.6130.5619No
55BDKRB1NABDKRB1
Entrez,  Source
bradykinin receptor B119930.5880.5573No
56NFKB1NANFKB1
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)20040.5850.5609No
57IFNAR1NAIFNAR1
Entrez,  Source
interferon (alpha, beta and omega) receptor 120740.5740.5600No
58ATP2B1NAATP2B1
Entrez,  Source
ATPase, Ca++ transporting, plasma membrane 121270.5650.5603No
59TAPBPNATAPBP
Entrez,  Source
TAP binding protein (tapasin)23390.5260.5488No
60IL1BNAIL1B
Entrez,  Source
interleukin 1, beta25810.4870.5347No
61SLC31A1NASLC31A1
Entrez,  Source
solute carrier family 31 (copper transporters), member 125990.4840.5370No
62SLC7A1NASLC7A1
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 126770.4720.5348No
63RHOGNARHOG
Entrez,  Source
ras homolog gene family, member G (rho G)28160.4490.5280No
64PTAFRNAPTAFR
Entrez,  Source
platelet-activating factor receptor29750.4240.5196No
65ADMNAADM
Entrez,  Source
adrenomedullin30120.4190.5200No
66TNFSF15NATNFSF15
Entrez,  Source
tumor necrosis factor (ligand) superfamily, member 1533230.3800.5001No
67CALCRLNACALCRL
Entrez,  Source
calcitonin receptor-like34310.3620.4950No
68GNAI3NAGNAI3
Entrez,  Source
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 334390.3610.4971No
69LYNNALYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog35670.3470.4903No
70ATP2A2NAATP2A2
Entrez,  Source
ATPase, Ca++ transporting, cardiac muscle, slow twitch 237680.3250.4781No
71ADORA2BNAADORA2B
Entrez,  Source
adenosine A2b receptor38030.3200.4780No
72MMP14NAMMP14
Entrez,  Source
matrix metallopeptidase 14 (membrane-inserted)38700.3140.4754No
73CD55NACD55
Entrez,  Source
CD55 molecule, decay accelerating factor for complement (Cromer blood group)39450.3030.4722No
74TIMP1NATIMP1
Entrez,  Source
TIMP metallopeptidase inhibitor 141240.2840.4613No
75ACVR1BNAACVR1B
Entrez,  Source
activin A receptor, type IB41870.2790.4588No
76P2RY2NAP2RY2
Entrez,  Source
purinergic receptor P2Y, G-protein coupled, 243160.2630.4514No
77ROS1NAROS1
Entrez,  Source
v-ros UR2 sarcoma virus oncogene homolog 1 (avian)45000.2440.4398No
78NLRP3NA45070.2420.4411No
79ACVR2ANAACVR2A
Entrez,  Source
activin A receptor, type IIA45660.2350.4386No
80RIPK2NARIPK2
Entrez,  Source
receptor-interacting serine-threonine kinase 245880.2330.4388No
81KLF6NAKLF6
Entrez,  Source
Kruppel-like factor 647760.2140.4267No
82TNFRSF9NATNFRSF9
Entrez,  Source
tumor necrosis factor receptor superfamily, member 952500.1660.3933No
83SEMA4DNASEMA4D
Entrez,  Source
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D52860.1630.3920No
84GCH1NAGCH1
Entrez,  Source
GTP cyclohydrolase 1 (dopa-responsive dystonia)53040.1610.3919No
85PSEN1NAPSEN1
Entrez,  Source
presenilin 1 (Alzheimer disease 3)53610.1550.3890No
86IL15NAIL15
Entrez,  Source
interleukin 1554950.1400.3803No
87CDKN1ANACDKN1A
Entrez,  Source
cyclin-dependent kinase inhibitor 1A (p21, Cip1)57070.1150.3657No
88METNAMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)59160.0960.3512No
89EREGNAEREG
Entrez,  Source
epiregulin59540.0920.3492No
90ABI1NAABI1
Entrez,  Source
abl-interactor 161190.0750.3377No
91P2RX4NAP2RX4
Entrez,  Source
purinergic receptor P2X, ligand-gated ion channel, 464410.0450.3146No
92NMUR1NANMUR1
Entrez,  Source
neuromedin U receptor 165840.0300.3044No
93ICAM4NAICAM4
Entrez,  Source
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)66480.0230.3000No
94MEFVNAMEFV
Entrez,  Source
Mediterranean fever66980.0170.2965No
95GPR132NAGPR132
Entrez,  Source
G protein-coupled receptor 13267830.0080.2905No
96SGMS2NA68330.0030.2869No
97LAMP3NALAMP3
Entrez,  Source
lysosomal-associated membrane protein 37144-0.0270.2645No
98HAS2NAHAS2
Entrez,  Source
hyaluronan synthase 27222-0.0350.2591No
99TNFRSF1BNATNFRSF1B
Entrez,  Source
tumor necrosis factor receptor superfamily, member 1B7244-0.0380.2578No
100FZD5NAFZD5
Entrez,  Source
frizzled homolog 5 (Drosophila)7372-0.0530.2490No
101RASGRP1NARASGRP1
Entrez,  Source
RAS guanyl releasing protein 1 (calcium and DAG-regulated)7522-0.0680.2386No
102ITGB3NAITGB3
Entrez,  Source
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)7628-0.0780.2315No
103ATP2C1NAATP2C1
Entrez,  Source
ATPase, Ca++ transporting, type 2C, member 17646-0.0790.2308No
104PCDH7NAPCDH7
Entrez,  Source
BH-protocadherin (brain-heart)7917-0.1060.2119No
105SCN1BNASCN1B
Entrez,  Source
sodium channel, voltage-gated, type I, beta8060-0.1210.2024No
106IL18RAPNAIL18RAP
Entrez,  Source
interleukin 18 receptor accessory protein8072-0.1230.2025No
107SLC4A4NASLC4A4
Entrez,  Source
solute carrier family 4, sodium bicarbonate cotransporter, member 48280-0.1450.1884No
108LPAR1NA8547-0.1730.1702No
109ICOSLGNAICOSLG
Entrez,  Source
inducible T-cell co-stimulator ligand8708-0.1920.1599No
110IL2RBNAIL2RB
Entrez,  Source
interleukin 2 receptor, beta8981-0.2230.1417No
111C3AR1NAC3AR1
Entrez,  Source
complement component 3a receptor 19205-0.2500.1272No
112RAF1NARAF1
Entrez,  Source
v-raf-1 murine leukemia viral oncogene homolog 19437-0.2840.1124No
113IFNGR2NAIFNGR2
Entrez,  Source
interferon gamma receptor 2 (interferon gamma transducer 1)9538-0.2990.1073No
114MYCNAMYC
Entrez,  Source
v-myc myelocytomatosis viral oncogene homolog (avian)9860-0.3460.0864No
115OSMRNAOSMR
Entrez,  Source
oncostatin M receptor9965-0.3590.0814No
116CX3CL1NACX3CL1
Entrez,  Source
chemokine (C-X3-C motif) ligand 110321-0.4120.0585No
117P2RX7NAP2RX7
Entrez,  Source
purinergic receptor P2X, ligand-gated ion channel, 710404-0.4270.0556No
118CD70NA10418-0.4290.0578No
119PTPRENAPTPRE
Entrez,  Source
protein tyrosine phosphatase, receptor type, E10421-0.4300.0608No
120KIF1BNAKIF1B
Entrez,  Source
kinesin family member 1B10440-0.4330.0626No
121GABBR1NAGABBR1
Entrez,  Source
gamma-aminobutyric acid (GABA) B receptor, 110444-0.4340.0656No
122SLC1A2NASLC1A2
Entrez,  Source
solute carrier family 1 (glial high affinity glutamate transporter), member 210573-0.4540.0596No
123TNFSF9NATNFSF9
Entrez,  Source
tumor necrosis factor (ligand) superfamily, member 910580-0.4550.0624No
124CXCR6NACXCR6
Entrez,  Source
chemokine (C-X-C motif) receptor 610630-0.4640.0622No
125SLC28A2NASLC28A2
Entrez,  Source
solute carrier family 28 (sodium-coupled nucleoside transporter), member 210635-0.4650.0654No
126IL10NAIL10
Entrez,  Source
interleukin 1010658-0.4690.0672No
127OPRK1NAOPRK1
Entrez,  Source
opioid receptor, kappa 110795-0.4920.0608No
128BST2NABST2
Entrez,  Source
bone marrow stromal cell antigen 210820-0.4960.0627No
129SRINASRI
Entrez,  Source
sorcin10970-0.5220.0556No
130CD14NACD14
Entrez,  Source
CD14 molecule11218-0.5670.0417No
131SCARF1NASCARF1
Entrez,  Source
scavenger receptor class F, member 111261-0.5770.0429No
132FFAR2NAFFAR2
Entrez,  Source
free fatty acid receptor 211349-0.5940.0408No
133CD82NACD82
Entrez,  Source
CD82 molecule11402-0.6060.0415No
134DCBLD2NADCBLD2
Entrez,  Source
discoidin, CUB and LCCL domain containing 211464-0.6170.0415No
135SLC11A2NASLC11A2
Entrez,  Source
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 211514-0.6260.0425No
136LY6ENALY6E
Entrez,  Source
lymphocyte antigen 6 complex, locus E11565-0.6390.0435No
137ABCA1NAABCA1
Entrez,  Source
ATP-binding cassette, sub-family A (ABC1), member 111871-0.7160.0265No
138TLR1NATLR1
Entrez,  Source
toll-like receptor 111940-0.7360.0269No
139TNFSF10NATNFSF10
Entrez,  Source
tumor necrosis factor (ligand) superfamily, member 1012683-1.028-0.0198No
140KCNJ2NAKCNJ2
Entrez,  Source
potassium inwardly-rectifying channel, subfamily J, member 212759-1.067-0.0175No
141IFITM1NAIFITM1
Entrez,  Source
interferon induced transmembrane protein 1 (9-27)13029-1.239-0.0281No
142SLC7A2NASLC7A2
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 213262-1.470-0.0343No
143GP1BANAGP1BA
Entrez,  Source
glycoprotein Ib (platelet), alpha polypeptide13339-1.568-0.0284No
144CCR7NACCR7
Entrez,  Source
chemokine (C-C motif) receptor 713458-1.749-0.0243No
145STAB1NASTAB1
Entrez,  Source
stabilin 113598-2.061-0.0194No
146BTG2NABTG2
Entrez,  Source
BTG family, member 213659-2.285-0.0071No
147C5AR1NAC5AR1
Entrez,  Source
complement component 5a receptor 113729-2.7090.0077No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_INFLAMMATORY_RESPONSE   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_INFLAMMATORY_RESPONSE: Random ES distribution   
Gene set null distribution of ES for HALLMARK_INFLAMMATORY_RESPONSE