Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | HALLMARK_IL6_JAK_STAT3_SIGNALING |
| Enrichment Score (ES) | 0.6221223 |
| Normalized Enrichment Score (NES) | 2.27196 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CXCL11 | NA | CXCL11 Entrez, Source | chemokine (C-X-C motif) ligand 11 | 1 | 4.764 | 0.0714 | Yes |
| 2 | CRLF2 | NA | CRLF2 Entrez, Source | cytokine receptor-like factor 2 | 9 | 4.480 | 0.1381 | Yes |
| 3 | IL6 | NA | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 15 | 4.383 | 0.2036 | Yes |
| 4 | CXCL10 | NA | CXCL10 Entrez, Source | chemokine (C-X-C motif) ligand 10 | 16 | 4.314 | 0.2683 | Yes |
| 5 | IL2RG | NA | IL2RG Entrez, Source | interleukin 2 receptor, gamma (severe combined immunodeficiency) | 79 | 3.132 | 0.3108 | Yes |
| 6 | TNFRSF12A | NA | TNFRSF12A Entrez, Source | tumor necrosis factor receptor superfamily, member 12A | 128 | 2.638 | 0.3469 | Yes |
| 7 | TNFRSF21 | NA | TNFRSF21 Entrez, Source | tumor necrosis factor receptor superfamily, member 21 | 130 | 2.631 | 0.3863 | Yes |
| 8 | JUN | NA | JUN Entrez, Source | jun oncogene | 236 | 1.996 | 0.4086 | Yes |
| 9 | IRF1 | NA | IRF1 Entrez, Source | interferon regulatory factor 1 | 252 | 1.947 | 0.4368 | Yes |
| 10 | IL18R1 | NA | IL18R1 Entrez, Source | interleukin 18 receptor 1 | 266 | 1.894 | 0.4642 | Yes |
| 11 | CD44 | NA | CD44 Entrez, Source | CD44 molecule (Indian blood group) | 336 | 1.659 | 0.4841 | Yes |
| 12 | CSF2RA | NA | CSF2RA Entrez, Source | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | 378 | 1.539 | 0.5042 | Yes |
| 13 | SOCS3 | NA | SOCS3 Entrez, Source | suppressor of cytokine signaling 3 | 384 | 1.526 | 0.5268 | Yes |
| 14 | IL1R1 | NA | IL1R1 Entrez, Source | interleukin 1 receptor, type I | 560 | 1.229 | 0.5325 | Yes |
| 15 | IL6ST | NA | IL6ST Entrez, Source | interleukin 6 signal transducer (gp130, oncostatin M receptor) | 645 | 1.142 | 0.5436 | Yes |
| 16 | CNTFR | NA | CNTFR Entrez, Source | ciliary neurotrophic factor receptor | 677 | 1.117 | 0.5581 | Yes |
| 17 | IL4R | NA | IL4R Entrez, Source | interleukin 4 receptor | 732 | 1.063 | 0.5701 | Yes |
| 18 | IRF9 | NA | 738 | 1.060 | 0.5857 | Yes | ||
| 19 | ACVRL1 | NA | ACVRL1 Entrez, Source | activin A receptor type II-like 1 | 1070 | 0.862 | 0.5746 | Yes |
| 20 | MYD88 | NA | MYD88 Entrez, Source | myeloid differentiation primary response gene (88) | 1072 | 0.861 | 0.5874 | Yes |
| 21 | TNFRSF1A | NA | TNFRSF1A Entrez, Source | tumor necrosis factor receptor superfamily, member 1A | 1079 | 0.859 | 0.5999 | Yes |
| 22 | EBI3 | NA | EBI3 Entrez, Source | Epstein-Barr virus induced gene 3 | 1222 | 0.803 | 0.6016 | Yes |
| 23 | LTBR | NA | LTBR Entrez, Source | lymphotoxin beta receptor (TNFR superfamily, member 3) | 1223 | 0.803 | 0.6136 | Yes |
| 24 | BAK1 | NA | BAK1 Entrez, Source | BCL2-antagonist/killer 1 | 1345 | 0.758 | 0.6162 | Yes |
| 25 | TGFB1 | NA | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 1560 | 0.700 | 0.6112 | Yes |
| 26 | STAM2 | NA | STAM2 Entrez, Source | signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 | 1605 | 0.688 | 0.6183 | Yes |
| 27 | IL15RA | NA | IL15RA Entrez, Source | interleukin 15 receptor, alpha | 1690 | 0.661 | 0.6221 | Yes |
| 28 | PTPN2 | NA | PTPN2 Entrez, Source | protein tyrosine phosphatase, non-receptor type 2 | 1867 | 0.614 | 0.6186 | No |
| 29 | IFNAR1 | NA | IFNAR1 Entrez, Source | interferon (alpha, beta and omega) receptor 1 | 2074 | 0.574 | 0.6122 | No |
| 30 | STAT3 | NA | STAT3 Entrez, Source | signal transducer and activator of transcription 3 (acute-phase response factor) | 2345 | 0.524 | 0.6005 | No |
| 31 | STAT1 | NA | STAT1 Entrez, Source | signal transducer and activator of transcription 1, 91kDa | 2374 | 0.520 | 0.6062 | No |
| 32 | IL1B | NA | IL1B Entrez, Source | interleukin 1, beta | 2581 | 0.487 | 0.5986 | No |
| 33 | CXCL3 | NA | CXCL3 Entrez, Source | chemokine (C-X-C motif) ligand 3 | 2875 | 0.438 | 0.5839 | No |
| 34 | PTPN1 | NA | PTPN1 Entrez, Source | protein tyrosine phosphatase, non-receptor type 1 | 3057 | 0.414 | 0.5770 | No |
| 35 | IL9R | NA | IL9R Entrez, Source | interleukin 9 receptor | 3096 | 0.409 | 0.5803 | No |
| 36 | IL2RA | NA | IL2RA Entrez, Source | interleukin 2 receptor, alpha | 3404 | 0.367 | 0.5635 | No |
| 37 | FAS | NA | FAS Entrez, Source | Fas (TNF receptor superfamily, member 6) | 3457 | 0.360 | 0.5652 | No |
| 38 | IFNGR1 | NA | IFNGR1 Entrez, Source | interferon gamma receptor 1 | 4135 | 0.284 | 0.5203 | No |
| 39 | ACVR1B | NA | ACVR1B Entrez, Source | activin A receptor, type IB | 4187 | 0.279 | 0.5207 | No |
| 40 | PTPN11 | NA | PTPN11 Entrez, Source | protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) | 5619 | 0.125 | 0.4187 | No |
| 41 | HMOX1 | NA | HMOX1 Entrez, Source | heme oxygenase (decycling) 1 | 5804 | 0.107 | 0.4069 | No |
| 42 | HAX1 | NA | HAX1 Entrez, Source | HCLS1 associated protein X-1 | 5987 | 0.088 | 0.3950 | No |
| 43 | CBL | NA | CBL Entrez, Source | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 6561 | 0.031 | 0.3539 | No |
| 44 | MAP3K8 | NA | MAP3K8 Entrez, Source | mitogen-activated protein kinase kinase kinase 8 | 6608 | 0.027 | 0.3510 | No |
| 45 | IL3RA | NA | IL3RA Entrez, Source | interleukin 3 receptor, alpha (low affinity) | 6957 | -0.010 | 0.3258 | No |
| 46 | TNFRSF1B | NA | TNFRSF1B Entrez, Source | tumor necrosis factor receptor superfamily, member 1B | 7244 | -0.038 | 0.3057 | No |
| 47 | ITGB3 | NA | ITGB3 Entrez, Source | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 7628 | -0.078 | 0.2790 | No |
| 48 | IL17RA | NA | IL17RA Entrez, Source | interleukin 17 receptor A | 8245 | -0.143 | 0.2364 | No |
| 49 | GRB2 | NA | GRB2 Entrez, Source | growth factor receptor-bound protein 2 | 8662 | -0.186 | 0.2090 | No |
| 50 | IL10RB | NA | IL10RB Entrez, Source | interleukin 10 receptor, beta | 8678 | -0.188 | 0.2107 | No |
| 51 | IL13RA1 | NA | IL13RA1 Entrez, Source | interleukin 13 receptor, alpha 1 | 8682 | -0.188 | 0.2133 | No |
| 52 | IFNGR2 | NA | IFNGR2 Entrez, Source | interferon gamma receptor 2 (interferon gamma transducer 1) | 9538 | -0.299 | 0.1557 | No |
| 53 | OSMR | NA | OSMR Entrez, Source | oncostatin M receptor | 9965 | -0.359 | 0.1302 | No |
| 54 | STAT2 | NA | STAT2 Entrez, Source | signal transducer and activator of transcription 2, 113kDa | 10036 | -0.369 | 0.1306 | No |
| 55 | LEPR | NA | LEPR Entrez, Source | leptin receptor | 10086 | -0.377 | 0.1327 | No |
| 56 | INHBE | NA | INHBE Entrez, Source | inhibin, beta E | 10420 | -0.429 | 0.1150 | No |
| 57 | CD14 | NA | CD14 Entrez, Source | CD14 molecule | 11218 | -0.567 | 0.0656 | No |
| 58 | PDGFC | NA | PDGFC Entrez, Source | platelet derived growth factor C | 11490 | -0.622 | 0.0553 | No |
| 59 | CD9 | NA | CD9 Entrez, Source | CD9 molecule | 11497 | -0.623 | 0.0642 | No |
| 60 | TYK2 | NA | TYK2 Entrez, Source | tyrosine kinase 2 | 11932 | -0.735 | 0.0437 | No |
| 61 | PIM1 | NA | PIM1 Entrez, Source | pim-1 oncogene | 11968 | -0.744 | 0.0523 | No |
| 62 | CD36 | NA | CD36 Entrez, Source | CD36 molecule (thrombospondin receptor) | 11998 | -0.756 | 0.0615 | No |
| 63 | IL17RB | NA | IL17RB Entrez, Source | interleukin 17 receptor B | 12549 | -0.960 | 0.0360 | No |
| 64 | CCR1 | NA | CCR1 Entrez, Source | chemokine (C-C motif) receptor 1 | 13495 | -1.800 | -0.0056 | No |
| 65 | A2M | NA | A2M Entrez, Source | alpha-2-macroglobulin | 13580 | -2.010 | 0.0184 | No |
