Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1w6a
GeneSetHALLMARK_IL2_STAT5_SIGNALING
Enrichment Score (ES)0.36773172
Normalized Enrichment Score (NES)1.5385592
Nominal p-value0.0
FDR q-value0.019900953
FWER p-Value0.128
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_IL2_STAT5_SIGNALING   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1CXCL10NACXCL10
Entrez,  Source
chemokine (C-X-C motif) ligand 10164.3140.0334Yes
2IL1RL1NAIL1RL1
Entrez,  Source
interleukin 1 receptor-like 1234.1490.0662Yes
3TRAF1NATRAF1
Entrez,  Source
TNF receptor-associated factor 1883.0290.0858Yes
4NT5ENANT5E
Entrez,  Source
5'-nucleotidase, ecto (CD73)933.0000.1096Yes
5TNFRSF8NATNFRSF8
Entrez,  Source
tumor necrosis factor receptor superfamily, member 81182.7060.1295Yes
6SPRY4NASPRY4
Entrez,  Source
sprouty homolog 4 (Drosophila)1292.6320.1499Yes
7TNFRSF21NATNFRSF21
Entrez,  Source
tumor necrosis factor receptor superfamily, member 211302.6310.1710Yes
8RGS16NARGS16
Entrez,  Source
regulator of G-protein signalling 161432.5540.1905Yes
9LRIG1NALRIG1
Entrez,  Source
leucine-rich repeats and immunoglobulin-like domains 11712.3720.2076Yes
10PHLDA1NAPHLDA1
Entrez,  Source
pleckstrin homology-like domain, family A, member 11942.2570.2241Yes
11MXD1NAMXD1
Entrez,  Source
MAX dimerization protein 12561.9380.2351Yes
12PRKCHNAPRKCH
Entrez,  Source
protein kinase C, eta2641.9200.2500Yes
13IL18R1NAIL18R1
Entrez,  Source
interleukin 18 receptor 12661.8940.2651Yes
14ECM1NAECM1
Entrez,  Source
extracellular matrix protein 12891.7960.2779Yes
15CD44NACD44
Entrez,  Source
CD44 molecule (Indian blood group)3361.6590.2878Yes
16NFKBIZNANFKBIZ
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta3941.5110.2958Yes
17BCL2L1NABCL2L1
Entrez,  Source
BCL2-like 14061.4950.3070Yes
18AHNAKNAAHNAK
Entrez,  Source
AHNAK nucleoprotein (desmoyokin)4581.3930.3144Yes
19F2RL2NAF2RL2
Entrez,  Source
coagulation factor II (thrombin) receptor-like 25781.2040.3153Yes
20ODC1NAODC1
Entrez,  Source
ornithine decarboxylase 16111.1720.3224Yes
21IL4RNAIL4R
Entrez,  Source
interleukin 4 receptor7321.0630.3221Yes
22LIFNALIF
Entrez,  Source
leukemia inhibitory factor (cholinergic differentiation factor)7451.0560.3297Yes
23BATF3NA7751.0340.3359Yes
24AHRNAAHR
Entrez,  Source
aryl hydrocarbon receptor7831.0230.3436Yes
25PLAGL1NAPLAGL1
Entrez,  Source
pleiomorphic adenoma gene-like 18210.9930.3488Yes
26TTC39BNA8780.9570.3524Yes
27NOP2NA9160.9360.3572Yes
28PLECNA10140.8860.3572Yes
29MAFFNAMAFF
Entrez,  Source
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)10230.8820.3637Yes
30NRP1NANRP1
Entrez,  Source
neuropilin 111030.8500.3647Yes
31ETV4NAETV4
Entrez,  Source
ets variant gene 4 (E1A enhancer binding protein, E1AF)12310.8000.3619Yes
32EMP1NAEMP1
Entrez,  Source
epithelial membrane protein 112390.7970.3677Yes
33ITGA6NAITGA6
Entrez,  Source
integrin, alpha 613270.7640.3675No
34SYT11NASYT11
Entrez,  Source
synaptotagmin XI14560.7280.3640No
35PLSCR1NAPLSCR1
Entrez,  Source
phospholipid scramblase 115270.7080.3645No
36SLC1A5NASLC1A5
Entrez,  Source
solute carrier family 1 (neutral amino acid transporter), member 516240.6810.3630No
37PDCD2LNAPDCD2L
Entrez,  Source
programmed cell death 2-like17330.6490.3603No
38HK2NAHK2
Entrez,  Source
hexokinase 217860.6360.3616No
39COL6A1NACOL6A1
Entrez,  Source
collagen, type VI, alpha 121310.5640.3409No
40TGM2NATGM2
Entrez,  Source
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)23260.5290.3310No
41PNPNA23330.5270.3348No
42SERPINC1NASERPINC1
Entrez,  Source
serpin peptidase inhibitor, clade C (antithrombin), member 123580.5220.3372No
43CASP3NACASP3
Entrez,  Source
caspase 3, apoptosis-related cysteine peptidase25460.4920.3275No
44TWSG1NATWSG1
Entrez,  Source
twisted gastrulation homolog 1 (Drosophila)27060.4670.3196No
45SOCS2NASOCS2
Entrez,  Source
suppressor of cytokine signaling 227130.4660.3229No
46PRNPNAPRNP
Entrez,  Source
prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)27890.4530.3210No
47HUWE1NAHUWE1
Entrez,  Source
HECT, UBA and WWE domain containing 128740.4380.3184No
48ARL4ANAARL4A
Entrez,  Source
ADP-ribosylation factor-like 4A29010.4340.3200No
49GPR83NAGPR83
Entrez,  Source
G protein-coupled receptor 8330540.4140.3122No
50POU2F1NAPOU2F1
Entrez,  Source
POU domain, class 2, transcription factor 131420.4020.3090No
51IL2RANAIL2RA
Entrez,  Source
interleukin 2 receptor, alpha34040.3670.2929No
52ITIH5NAITIH5
Entrez,  Source
inter-alpha (globulin) inhibitor H536140.3430.2803No
53FAM126BNAFAM126B
Entrez,  Source
family with sequence similarity 126, member B37440.3280.2735No
54UMPSNAUMPS
Entrez,  Source
uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase)39170.3070.2634No
55MAPKAPK2NAMAPKAPK2
Entrez,  Source
mitogen-activated protein kinase-activated protein kinase 240030.2960.2596No
56IFNGR1NAIFNGR1
Entrez,  Source
interferon gamma receptor 141350.2840.2523No
57PUS1NAPUS1
Entrez,  Source
pseudouridylate synthase 143080.2640.2418No
58SYNGR2NASYNGR2
Entrez,  Source
synaptogyrin 243980.2530.2373No
59CKAP4NACKAP4
Entrez,  Source
cytoskeleton-associated protein 444910.2450.2326No
60GADD45BNAGADD45B
Entrez,  Source
growth arrest and DNA-damage-inducible, beta45060.2420.2335No
61KLF6NAKLF6
Entrez,  Source
Kruppel-like factor 647760.2140.2155No
62PTRH2NAPTRH2
Entrez,  Source
peptidyl-tRNA hydrolase 251260.1790.1914No
63TNFRSF9NATNFRSF9
Entrez,  Source
tumor necrosis factor receptor superfamily, member 952500.1660.1838No
64SPRED2NASPRED2
Entrez,  Source
sprouty-related, EVH1 domain containing 252550.1660.1848No
65IKZF4NAIKZF4
Entrez,  Source
IKAROS family zinc finger 4 (Eos)53020.1610.1827No
66RNH1NARNH1
Entrez,  Source
ribonuclease/angiogenin inhibitor 153690.1540.1792No
67CISHNACISH
Entrez,  Source
cytokine inducible SH2-containing protein55180.1380.1694No
68UCK2NAUCK2
Entrez,  Source
uridine-cytidine kinase 255340.1360.1694No
69MUC1NAMUC1
Entrez,  Source
mucin 1, cell surface associated55420.1360.1700No
70LCLAT1NA56300.1230.1646No
71CCND3NACCND3
Entrez,  Source
cyclin D357220.1140.1589No
72FAHNAFAH
Entrez,  Source
fumarylacetoacetate hydrolase (fumarylacetoacetase)58190.1050.1527No
73CDC6NACDC6
Entrez,  Source
CDC6 cell division cycle 6 homolog (S. cerevisiae)60050.0870.1399No
74BHLHE40NA60730.0800.1356No
75PRAF2NAPRAF2
Entrez,  Source
PRA1 domain family, member 261300.0740.1321No
76P4HA1NAP4HA1
Entrez,  Source
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I61630.0710.1303No
77AHCYNAAHCY
Entrez,  Source
S-adenosylhomocysteine hydrolase63970.0500.1137No
78P2RX4NAP2RX4
Entrez,  Source
purinergic receptor P2X, ligand-gated ion channel, 464410.0450.1109No
79FGL2NAFGL2
Entrez,  Source
fibrinogen-like 264690.0410.1093No
80GSTO1NAGSTO1
Entrez,  Source
glutathione S-transferase omega 165490.0330.1038No
81MAP3K8NAMAP3K8
Entrez,  Source
mitogen-activated protein kinase kinase kinase 866080.0270.0997No
82ENPP1NAENPP1
Entrez,  Source
ectonucleotide pyrophosphatase/phosphodiesterase 166260.0260.0987No
83IFITM3NAIFITM3
Entrez,  Source
interferon induced transmembrane protein 3 (1-8U)66940.0180.0939No
84PTCH1NAPTCH1
Entrez,  Source
patched homolog 1 (Drosophila)67090.0160.0930No
85PHTF2NAPHTF2
Entrez,  Source
putative homeodomain transcription factor 26914-0.0060.0782No
86IL3RANAIL3RA
Entrez,  Source
interleukin 3 receptor, alpha (low affinity)6957-0.0100.0752No
87ITGAVNAITGAV
Entrez,  Source
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)7059-0.0190.0679No
88ITGAENAITGAE
Entrez,  Source
integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)7153-0.0280.0614No
89TNFRSF1BNATNFRSF1B
Entrez,  Source
tumor necrosis factor receptor superfamily, member 1B7244-0.0380.0551No
90BMPR2NABMPR2
Entrez,  Source
bone morphogenetic protein receptor, type II (serine/threonine kinase)7601-0.0750.0297No
91IRF6NAIRF6
Entrez,  Source
interferon regulatory factor 67610-0.0760.0297No
92IGF2RNAIGF2R
Entrez,  Source
insulin-like growth factor 2 receptor7634-0.0780.0286No
93PLIN2NA7654-0.0800.0279No
94TIAM1NATIAM1
Entrez,  Source
T-cell lymphoma invasion and metastasis 17923-0.1060.0091No
95TLR7NATLR7
Entrez,  Source
toll-like receptor 77976-0.1110.0062No
96SNX14NASNX14
Entrez,  Source
sorting nexin 148228-0.140-0.0110No
97NCOA3NANCOA3
Entrez,  Source
nuclear receptor coactivator 38237-0.142-0.0104No
98CD81NACD81
Entrez,  Source
CD81 molecule8271-0.144-0.0117No
99GPR65NAGPR65
Entrez,  Source
G protein-coupled receptor 658400-0.157-0.0198No
100SLC39A8NASLC39A8
Entrez,  Source
solute carrier family 39 (zinc transporter), member 88483-0.168-0.0245No
101CAPN3NACAPN3
Entrez,  Source
calpain 3, (p94)8493-0.168-0.0238No
102SNX9NASNX9
Entrez,  Source
sorting nexin 98502-0.169-0.0230No
103WLSNA8511-0.170-0.0222No
104CDCP1NACDCP1
Entrez,  Source
CUB domain containing protein 18609-0.180-0.0279No
105IGF1RNAIGF1R
Entrez,  Source
insulin-like growth factor 1 receptor8663-0.186-0.0303No
106IRF4NAIRF4
Entrez,  Source
interferon regulatory factor 48687-0.189-0.0304No
107CCND2NACCND2
Entrez,  Source
cyclin D28965-0.222-0.0489No
108IL2RBNAIL2RB
Entrez,  Source
interleukin 2 receptor, beta8981-0.223-0.0482No
109XBP1NAXBP1
Entrez,  Source
X-box binding protein 19068-0.233-0.0526No
110CCNE1NACCNE1
Entrez,  Source
cyclin E19355-0.272-0.0714No
111CAPGNACAPG
Entrez,  Source
capping protein (actin filament), gelsolin-like9453-0.286-0.0762No
112CDC42SE2NACDC42SE2
Entrez,  Source
CDC42 small effector 29514-0.296-0.0782No
113GALMNAGALM
Entrez,  Source
galactose mutarotase (aldose 1-epimerase)9554-0.301-0.0786No
114MYO1ENAMYO1E
Entrez,  Source
myosin IE9562-0.302-0.0767No
115SHENASHE
Entrez,  Source
Src homology 2 domain containing E9682-0.318-0.0829No
116MYCNAMYC
Entrez,  Source
v-myc myelocytomatosis viral oncogene homolog (avian)9860-0.346-0.0930No
117AGERNAAGER
Entrez,  Source
advanced glycosylation end product-specific receptor9868-0.346-0.0908No
118ADAM19NAADAM19
Entrez,  Source
ADAM metallopeptidase domain 19 (meltrin beta)9951-0.356-0.0939No
119SLC29A2NASLC29A2
Entrez,  Source
solute carrier family 29 (nucleoside transporters), member 210245-0.402-0.1121No
120SCN9ANASCN9A
Entrez,  Source
sodium channel, voltage-gated, type IX, alpha10369-0.420-0.1177No
121RORANARORA
Entrez,  Source
RAR-related orphan receptor A10428-0.431-0.1185No
122DCPSNADCPS
Entrez,  Source
decapping enzyme, scavenger10492-0.441-0.1196No
123S100A1NAS100A1
Entrez,  Source
S100 calcium binding protein A110539-0.448-0.1194No
124IL10NAIL10
Entrez,  Source
interleukin 1010658-0.469-0.1242No
125SERPINB6NASERPINB6
Entrez,  Source
serpin peptidase inhibitor, clade B (ovalbumin), member 610728-0.480-0.1254No
126AMACRNAAMACR
Entrez,  Source
alpha-methylacyl-CoA racemase10776-0.488-0.1250No
127NCS1NA10809-0.494-0.1233No
128LRRC8CNALRRC8C
Entrez,  Source
leucine rich repeat containing 8 family, member C10875-0.506-0.1240No
129RABGAP1LNARABGAP1L
Entrez,  Source
RAB GTPase activating protein 1-like10883-0.507-0.1205No
130BCL2NABCL2
Entrez,  Source
B-cell CLL/lymphoma 210892-0.508-0.1170No
131ST3GAL4NAST3GAL4
Entrez,  Source
ST3 beta-galactoside alpha-2,3-sialyltransferase 410998-0.528-0.1205No
132DENND5ANA11166-0.557-0.1282No
133GABARAPL1NAGABARAPL1
Entrez,  Source
GABA(A) receptor-associated protein like 111242-0.573-0.1291No
134SWAP70NASWAP70
Entrez,  Source
-11296-0.584-0.1283No
135MYO1CNAMYO1C
Entrez,  Source
myosin IC11467-0.618-0.1358No
136CYFIP1NACYFIP1
Entrez,  Source
cytoplasmic FMR1 interacting protein 111517-0.627-0.1343No
137FURINNAFURIN
Entrez,  Source
furin (paired basic amino acid cleaving enzyme)11593-0.646-0.1346No
138FLT3LGNAFLT3LG
Entrez,  Source
fms-related tyrosine kinase 3 ligand11849-0.712-0.1476No
139ANXA4NAANXA4
Entrez,  Source
annexin A411851-0.712-0.1419No
140IKZF2NAIKZF2
Entrez,  Source
IKAROS family zinc finger 2 (Helios)11870-0.716-0.1375No
141HIPK2NAHIPK2
Entrez,  Source
homeodomain interacting protein kinase 211948-0.738-0.1372No
142PIM1NAPIM1
Entrez,  Source
pim-1 oncogene11968-0.744-0.1327No
143TNFSF10NATNFSF10
Entrez,  Source
tumor necrosis factor (ligand) superfamily, member 1012683-1.028-0.1766No
144GPX4NAGPX4
Entrez,  Source
glutathione peroxidase 4 (phospholipid hydroperoxidase)12713-1.042-0.1704No
145GBP4NAGBP4
Entrez,  Source
guanylate binding protein 412904-1.153-0.1751No
146RRAGDNARRAGD
Entrez,  Source
Ras-related GTP binding D12945-1.181-0.1685No
147RHOBNARHOB
Entrez,  Source
ras homolog gene family, member B13181-1.375-0.1747No
148MAP6NAMAP6
Entrez,  Source
microtubule-associated protein 613225-1.426-0.1664No
149SLC2A3NASLC2A3
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 313297-1.509-0.1595No
150NFIL3NANFIL3
Entrez,  Source
nuclear factor, interleukin 3 regulated13322-1.542-0.1489No
151SH3BGRL2NASH3BGRL2
Entrez,  Source
SH3 domain binding glutamic acid-rich protein like 213348-1.578-0.1381No
152APLP1NAAPLP1
Entrez,  Source
amyloid beta (A4) precursor-like protein 113366-1.597-0.1265No
153SMPDL3ANASMPDL3A
Entrez,  Source
sphingomyelin phosphodiesterase, acid-like 3A13381-1.627-0.1145No
154DHRS3NADHRS3
Entrez,  Source
dehydrogenase/reductase (SDR family) member 313396-1.646-0.1023No
155BMP2NABMP2
Entrez,  Source
bone morphogenetic protein 213439-1.723-0.0916No
156CDKN1CNACDKN1C
Entrez,  Source
cyclin-dependent kinase inhibitor 1C (p57, Kip2)13445-1.734-0.0781No
157NDRG1NANDRG1
Entrez,  Source
N-myc downstream regulated gene 113498-1.810-0.0674No
158CTSZNACTSZ
Entrez,  Source
cathepsin Z13523-1.878-0.0541No
159CD83NACD83
Entrez,  Source
CD83 molecule13621-2.139-0.0440No
160ENO3NAENO3
Entrez,  Source
enolase 3 (beta, muscle)13755-2.899-0.0305No
161ALCAMNAALCAM
Entrez,  Source
activated leukocyte cell adhesion molecule13826-4.5190.0006No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_IL2_STAT5_SIGNALING   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_IL2_STAT5_SIGNALING: Random ES distribution   
Gene set null distribution of ES for HALLMARK_IL2_STAT5_SIGNALING