Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1gfp
GeneSetHALLMARK_HYPOXIA
Enrichment Score (ES)-0.34289345
Normalized Enrichment Score (NES)-1.366973
Nominal p-value0.01767305
FDR q-value0.091401845
FWER p-Value0.717
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_HYPOXIA   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1IL6NAIL6
Entrez,  Source
interleukin 6 (interferon, beta 2)154.3830.0285No
2CYR61NACYR61
Entrez,  Source
cysteine-rich, angiogenic inducer, 61533.4460.0491No
3ISG20NAISG20
Entrez,  Source
interferon stimulated exonuclease gene 20kDa563.4020.0719No
4CTGFNACTGF
Entrez,  Source
connective tissue growth factor693.2560.0930No
5SERPINE1NASERPINE1
Entrez,  Source
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 11092.8400.1093No
6TNFAIP3NATNFAIP3
Entrez,  Source
tumor necrosis factor, alpha-induced protein 31122.8040.1281No
7SDC4NASDC4
Entrez,  Source
syndecan 4 (amphiglycan, ryudocan)1492.5030.1424No
8F3NAF3
Entrez,  Source
coagulation factor III (thromboplastin, tissue factor)1842.3220.1556No
9PLAURNAPLAUR
Entrez,  Source
plasminogen activator, urokinase receptor1872.3080.1710No
10JUNNAJUN
Entrez,  Source
jun oncogene2361.9960.1810No
11PPP1R15ANAPPP1R15A
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 15A2861.7970.1896No
12AK4NA2911.7870.2013No
13TPBGNATPBG
Entrez,  Source
trophoblast glycoprotein3971.5080.2038No
14MT2ANAMT2A
Entrez,  Source
metallothionein 2A4081.4930.2132No
15IDSNAIDS
Entrez,  Source
iduronate 2-sulfatase (Hunter syndrome)4651.3710.2184No
16ETS1NAETS1
Entrez,  Source
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)4981.3190.2249No
17PLAC8NAPLAC8
Entrez,  Source
placenta-specific 85311.2770.2312No
18EGFRNAEGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6371.1500.2313No
19ZFP36NAZFP36
Entrez,  Source
zinc finger protein 36, C3H type, homolog (mouse)6461.1400.2384No
20TIPARPNATIPARP
Entrez,  Source
TCDD-inducible poly(ADP-ribose) polymerase6491.1380.2460No
21ANXA2NAANXA2
Entrez,  Source
annexin A26741.1190.2518No
22MAP3K1NAMAP3K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase 18220.9930.2477No
23DDIT3NADDIT3
Entrez,  Source
DNA-damage-inducible transcript 38880.9490.2494No
24STC2NASTC2
Entrez,  Source
stanniocalcin 29260.9310.2529No
25MAFFNAMAFF
Entrez,  Source
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)10230.8820.2519No
26EXT1NAEXT1
Entrez,  Source
exostoses (multiple) 112100.8080.2437No
27IER3NAIER3
Entrez,  Source
immediate early response 312720.7880.2446No
28MYH9NAMYH9
Entrez,  Source
myosin, heavy chain 9, non-muscle15900.6920.2261No
29GCNT2NAGCNT2
Entrez,  Source
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)16510.6750.2262No
30HK2NAHK2
Entrez,  Source
hexokinase 217860.6360.2207No
31PFKFB3NAPFKFB3
Entrez,  Source
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 321410.5630.1986No
32PFKPNAPFKP
Entrez,  Source
phosphofructokinase, platelet22870.5350.1916No
33CHST3NACHST3
Entrez,  Source
carbohydrate (chondroitin 6) sulfotransferase 323120.5320.1935No
34TGM2NATGM2
Entrez,  Source
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)23260.5290.1961No
35FOSL2NAFOSL2
Entrez,  Source
FOS-like antigen 225240.4970.1850No
36NR3C1NANR3C1
Entrez,  Source
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)27930.4530.1685No
37NAGKNANAGK
Entrez,  Source
N-acetylglucosamine kinase28900.4350.1644No
38ADMNAADM
Entrez,  Source
adrenomedullin30120.4190.1584No
39HSPA5NAHSPA5
Entrez,  Source
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)31610.3990.1502No
40CAV1NACAV1
Entrez,  Source
caveolin 1, caveolae protein, 22kDa34830.3560.1292No
41NDST2NANDST2
Entrez,  Source
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 236410.3390.1200No
42NEDD4LNANEDD4L
Entrez,  Source
neural precursor cell expressed, developmentally down-regulated 4-like37810.3240.1120No
43ADORA2BNAADORA2B
Entrez,  Source
adenosine A2b receptor38030.3200.1126No
44NDST1NANDST1
Entrez,  Source
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 143690.2580.0730No
45CITED2NACITED2
Entrez,  Source
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 245080.2420.0645No
46GBE1NAGBE1
Entrez,  Source
glucan (1,4-alpha-), branching enzyme 1 (glycogen branching enzyme, Andersen disease, glycogen storage disease type IV)45450.2370.0635No
47PGM2NAPGM2
Entrez,  Source
phosphoglucomutase 247720.2140.0484No
48TPD52NATPD52
Entrez,  Source
tumor protein D5247750.2140.0497No
49KLF6NAKLF6
Entrez,  Source
Kruppel-like factor 647760.2140.0512No
50SAP30NASAP30
Entrez,  Source
Sin3A-associated protein, 30kDa48060.2110.0505No
51ATP7ANAATP7A
Entrez,  Source
ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome)48260.2080.0505No
52JMJD6NA48570.2060.0497No
53EDN2NAEDN2
Entrez,  Source
endothelin 249130.2010.0470No
54PHKG1NAPHKG1
Entrez,  Source
phosphorylase kinase, gamma 1 (muscle)49910.1930.0427No
55KLF7NAKLF7
Entrez,  Source
Kruppel-like factor 7 (ubiquitous)50290.1880.0412No
56B3GALT6NAB3GALT6
Entrez,  Source
UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 653810.1520.0166No
57CDKN1ANACDKN1A
Entrez,  Source
cyclin-dependent kinase inhibitor 1A (p21, Cip1)57070.115-0.0064No
58AMPD3NAAMPD3
Entrez,  Source
adenosine monophosphate deaminase (isoform E)58010.107-0.0125No
59HMOX1NAHMOX1
Entrez,  Source
heme oxygenase (decycling) 158040.107-0.0119No
60ALDOANAALDOA
Entrez,  Source
aldolase A, fructose-bisphosphate58800.100-0.0167No
61IGFBP3NAIGFBP3
Entrez,  Source
insulin-like growth factor binding protein 359640.091-0.0222No
62CA12NACA12
Entrez,  Source
carbonic anhydrase XII59780.090-0.0225No
63BHLHE40NA60730.080-0.0289No
64P4HA1NAP4HA1
Entrez,  Source
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I61630.071-0.0349No
65RBPJNA63110.057-0.0453No
66LDHANALDHA
Entrez,  Source
lactate dehydrogenase A64240.047-0.0532No
67COL5A1NACOL5A1
Entrez,  Source
collagen, type V, alpha 164990.039-0.0583No
68BCANNABCAN
Entrez,  Source
brevican66510.022-0.0692No
69FOXO3NA6872-0.001-0.0853No
70SIAH2NASIAH2
Entrez,  Source
seven in absentia homolog 2 (Drosophila)6918-0.006-0.0886No
71TPST2NATPST2
Entrez,  Source
tyrosylprotein sulfotransferase 26929-0.008-0.0892No
72DUSP1NADUSP1
Entrez,  Source
dual specificity phosphatase 16982-0.013-0.0929No
73FBP1NAFBP1
Entrez,  Source
fructose-1,6-bisphosphatase 17096-0.022-0.1011No
74SRPXNASRPX
Entrez,  Source
sushi-repeat-containing protein, X-linked7185-0.031-0.1073No
75ERRFI1NAERRFI1
Entrez,  Source
ERBB receptor feedback inhibitor 17234-0.037-0.1106No
76SLC6A6NASLC6A6
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter, taurine), member 67305-0.046-0.1154No
77WSB1NAWSB1
Entrez,  Source
WD repeat and SOCS box-containing 17359-0.052-0.1189No
78TESNATES
Entrez,  Source
testis derived transcript (3 LIM domains)7404-0.056-0.1217No
79STBD1NA7413-0.057-0.1219No
80PLIN2NA7654-0.080-0.1390No
81GPC1NAGPC1
Entrez,  Source
glypican 17773-0.092-0.1470No
82VEGFANA7811-0.096-0.1490No
83CASP6NACASP6
Entrez,  Source
caspase 6, apoptosis-related cysteine peptidase7942-0.108-0.1578No
84ANGPTL4NAANGPTL4
Entrez,  Source
angiopoietin-like 47970-0.111-0.1590No
85XPNPEP1NAXPNPEP1
Entrez,  Source
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble8054-0.121-0.1643No
86BTG1NABTG1
Entrez,  Source
B-cell translocation gene 1, anti-proliferative8251-0.143-0.1777No
87VHLNAVHL
Entrez,  Source
von Hippel-Lindau tumor suppressor8265-0.144-0.1777No
88ENO1NAENO1
Entrez,  Source
enolase 1, (alpha)8327-0.149-0.1811No
89SLC2A1NASLC2A1
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 18373-0.154-0.1834No
90GAPDHNAGAPDH
Entrez,  Source
glyceraldehyde-3-phosphate dehydrogenase8442-0.162-0.1872No
91STC1NASTC1
Entrez,  Source
stanniocalcin 18647-0.185-0.2009No
92GAPDHSNAGAPDHS
Entrez,  Source
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic8781-0.200-0.2093No
93GPINAGPI
Entrez,  Source
glucose phosphate isomerase9315-0.265-0.2465No
94TPI1NATPI1
Entrez,  Source
triosephosphate isomerase 19395-0.278-0.2504No
95PGAM2NAPGAM2
Entrez,  Source
phosphoglycerate mutase 2 (muscle)9462-0.288-0.2533No
96EFNA3NAEFNA3
Entrez,  Source
ephrin-A39513-0.296-0.2550No
97HDLBPNAHDLBP
Entrez,  Source
high density lipoprotein binding protein (vigilin)9545-0.300-0.2552No
98GLRXNAGLRX
Entrez,  Source
glutaredoxin (thioltransferase)9559-0.301-0.2541No
99GYS1NAGYS1
Entrez,  Source
glycogen synthase 1 (muscle)9777-0.334-0.2677No
100MIFNAMIF
Entrez,  Source
macrophage migration inhibitory factor (glycosylation-inhibiting factor)9983-0.361-0.2803No
101CXCR4NACXCR4
Entrez,  Source
chemokine (C-X-C motif) receptor 410239-0.400-0.2963No
102CSRP2NACSRP2
Entrez,  Source
cysteine and glycine-rich protein 210312-0.411-0.2987No
103RORANARORA
Entrez,  Source
RAR-related orphan receptor A10428-0.431-0.3042No
104FAM162ANA10460-0.436-0.3036No
105SLC37A4NASLC37A4
Entrez,  Source
solute carrier family 37 (glycerol-6-phosphate transporter), member 410475-0.438-0.3016No
106S100A4NAS100A4
Entrez,  Source
S100 calcium binding protein A410515-0.444-0.3015No
107INHANAINHA
Entrez,  Source
inhibin, alpha10609-0.460-0.3052No
108PGK1NAPGK1
Entrez,  Source
phosphoglycerate kinase 110801-0.493-0.3158No
109ENO2NAENO2
Entrez,  Source
enolase 2 (gamma, neuronal)10819-0.496-0.3137No
110GALK1NAGALK1
Entrez,  Source
galactokinase 110873-0.505-0.3142No
111BCL2NABCL2
Entrez,  Source
B-cell CLL/lymphoma 210892-0.508-0.3121No
112ANKZF1NAANKZF1
Entrez,  Source
ankyrin repeat and zinc finger domain containing 110946-0.518-0.3125No
113SCARB1NASCARB1
Entrez,  Source
scavenger receptor class B, member 111081-0.543-0.3186No
114HEXANAHEXA
Entrez,  Source
hexosaminidase A (alpha polypeptide)11194-0.563-0.3230No
115GRHPRNAGRHPR
Entrez,  Source
glyoxylate reductase/hydroxypyruvate reductase11352-0.594-0.3305No
116KDM3ANA11432-0.611-0.3321No
117GAANAGAA
Entrez,  Source
glucosidase, alpha; acid (Pompe disease, glycogen storage disease type II)11441-0.612-0.3286No
118UGP2NAUGP2
Entrez,  Source
UDP-glucose pyrophosphorylase 211473-0.620-0.3266No
119P4HA2NAP4HA2
Entrez,  Source
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II11494-0.623-0.3239No
120EFNA1NAEFNA1
Entrez,  Source
ephrin-A111525-0.629-0.3219No
121PAMNAPAM
Entrez,  Source
peptidylglycine alpha-amidating monooxygenase11576-0.642-0.3212No
122PGM1NAPGM1
Entrez,  Source
phosphoglucomutase 111686-0.669-0.3246No
123ZNF292NAZNF292
Entrez,  Source
zinc finger protein 29211783-0.693-0.3270No
124AKAP12NAAKAP12
Entrez,  Source
A kinase (PRKA) anchor protein (gravin) 1211847-0.711-0.3268No
125PRDX5NAPRDX5
Entrez,  Source
peroxiredoxin 511922-0.730-0.3273No
126PIM1NAPIM1
Entrez,  Source
pim-1 oncogene11968-0.744-0.3255No
127PRKCANAPRKCA
Entrez,  Source
protein kinase C, alpha12193-0.818-0.3364No
128SDC3NASDC3
Entrez,  Source
syndecan 3 (N-syndecan)12261-0.839-0.3356No
129KDELR3NAKDELR3
Entrez,  Source
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 312326-0.864-0.3345No
130SLC25A1NASLC25A1
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 112442-0.911-0.3367Yes
131IRS2NAIRS2
Entrez,  Source
insulin receptor substrate 212470-0.925-0.3325Yes
132CDKN1BNACDKN1B
Entrez,  Source
cyclin-dependent kinase inhibitor 1B (p27, Kip1)12505-0.942-0.3286Yes
133PDGFBNAPDGFB
Entrez,  Source
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)12572-0.972-0.3269Yes
134ILVBLNAILVBL
Entrez,  Source
ilvB (bacterial acetolactate synthase)-like12682-1.026-0.3279Yes
135HK1NAHK1
Entrez,  Source
hexokinase 112755-1.065-0.3260Yes
136PDK3NAPDK3
Entrez,  Source
pyruvate dehydrogenase kinase, isozyme 312825-1.102-0.3236Yes
137TGFB3NATGFB3
Entrez,  Source
transforming growth factor, beta 312913-1.157-0.3221Yes
138RRAGDNARRAGD
Entrez,  Source
Ras-related GTP binding D12945-1.181-0.3164Yes
139PDK1NAPDK1
Entrez,  Source
pyruvate dehydrogenase kinase, isozyme 112994-1.211-0.3118Yes
140SLC2A5NASLC2A5
Entrez,  Source
solute carrier family 2 (facilitated glucose/fructose transporter), member 513020-1.235-0.3052Yes
141CPNACP
Entrez,  Source
ceruloplasmin (ferroxidase)13164-1.353-0.3066Yes
142DDIT4NADDIT4
Entrez,  Source
DNA-damage-inducible transcript 413200-1.395-0.2997Yes
143LXNNALXN
Entrez,  Source
latexin13204-1.399-0.2905Yes
144SDC2NASDC2
Entrez,  Source
syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan)13234-1.433-0.2829Yes
145MXI1NAMXI1
Entrez,  Source
MAX interactor 113253-1.458-0.2744Yes
146PFKLNAPFKL
Entrez,  Source
phosphofructokinase, liver13274-1.484-0.2658Yes
147SLC2A3NASLC2A3
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 313297-1.509-0.2572Yes
148NFIL3NANFIL3
Entrez,  Source
nuclear factor, interleukin 3 regulated13322-1.542-0.2486Yes
149BNIP3LNABNIP3L
Entrez,  Source
BCL2/adenovirus E1B 19kDa interacting protein 3-like13391-1.641-0.2425Yes
150PPARGC1ANAPPARGC1A
Entrez,  Source
peroxisome proliferative activated receptor, gamma, coactivator 1, alpha13430-1.702-0.2338Yes
151PNRC1NAPNRC1
Entrez,  Source
proline-rich nuclear receptor coactivator 113437-1.721-0.2226Yes
152CDKN1CNACDKN1C
Entrez,  Source
cyclin-dependent kinase inhibitor 1C (p57, Kip2)13445-1.734-0.2114Yes
153TGFBINATGFBI
Entrez,  Source
transforming growth factor, beta-induced, 68kDa13453-1.742-0.2001Yes
154NDRG1NANDRG1
Entrez,  Source
N-myc downstream regulated gene 113498-1.810-0.1911Yes
155TMEM45ANATMEM45A
Entrez,  Source
transmembrane protein 45A13505-1.831-0.1792Yes
156VLDLRNAVLDLR
Entrez,  Source
very low density lipoprotein receptor13512-1.854-0.1671Yes
157KLHL24NAKLHL24
Entrez,  Source
kelch-like 24 (Drosophila)13525-1.883-0.1553Yes
158SULT2B1NASULT2B1
Entrez,  Source
sulfotransferase family, cytosolic, 2B, member 113538-1.902-0.1433Yes
159FOSNAFOS
Entrez,  Source
v-fos FBJ murine osteosarcoma viral oncogene homolog13543-1.911-0.1307Yes
160WISP2NAWISP2
Entrez,  Source
WNT1 inducible signaling pathway protein 213581-2.016-0.1198Yes
161ALDOCNAALDOC
Entrez,  Source
aldolase C, fructose-bisphosphate13596-2.047-0.1070Yes
162DTNANADTNA
Entrez,  Source
dystrobrevin, alpha13629-2.169-0.0947Yes
163PPP1R3CNAPPP1R3C
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 3C13630-2.169-0.0800Yes
164SELENBP1NASELENBP1
Entrez,  Source
selenium binding protein 113647-2.240-0.0661Yes
165CCNG2NACCNG2
Entrez,  Source
cyclin G213664-2.302-0.0517Yes
166LOXNALOX
Entrez,  Source
lysyl oxidase13703-2.537-0.0373Yes
167ENO3NAENO3
Entrez,  Source
enolase 3 (beta, muscle)13755-2.899-0.0215Yes
168DCNNADCN
Entrez,  Source
decorin13811-4.0270.0017Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_HYPOXIA   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_HYPOXIA: Random ES distribution   
Gene set null distribution of ES for HALLMARK_HYPOXIA