Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1gfp
GeneSetHALLMARK_HEME_METABOLISM
Enrichment Score (ES)-0.3772507
Normalized Enrichment Score (NES)-1.5018555
Nominal p-value0.00304414
FDR q-value0.032355003
FWER p-Value0.297
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_HEME_METABOLISM   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1GCLMNAGCLM
Entrez,  Source
glutamate-cysteine ligase, modifier subunit4261.464-0.0172No
2XKNAXK
Entrez,  Source
X-linked Kx blood group (McLeod syndrome)4571.395-0.0061No
3SLC30A1NASLC30A1
Entrez,  Source
solute carrier family 30 (zinc transporter), member 14851.3340.0047No
4RHCENARHCE
Entrez,  Source
Rh blood group, CcEe antigens4891.3280.0171No
5MAP2K3NAMAP2K3
Entrez,  Source
mitogen-activated protein kinase kinase 35721.2130.0227No
6SLC7A11NASLC7A11
Entrez,  Source
solute carrier family 7, (cationic amino acid transporter, y+ system) member 115861.1980.0332No
7MPP1NAMPP1
Entrez,  Source
membrane protein, palmitoylated 1, 55kDa6051.1770.0431No
8OSBP2NAOSBP2
Entrez,  Source
oxysterol binding protein 26531.1370.0505No
9RBM38NARBM38
Entrez,  Source
RNA binding motif protein 387371.0610.0545No
10SLC10A3NASLC10A3
Entrez,  Source
solute carrier family 10 (sodium/bile acid cotransporter family), member 37711.0350.0620No
11GYPENAGYPE
Entrez,  Source
glycophorin E8730.9600.0637No
12NUDT4NANUDT4
Entrez,  Source
nudix (nucleoside diphosphate linked moiety X)-type motif 49070.9410.0703No
13SLC22A4NASLC22A4
Entrez,  Source
solute carrier family 22 (organic cation transporter), member 49610.9150.0752No
14H1F0NAH1F0
Entrez,  Source
H1 histone family, member 010020.8940.0807No
15BMP2KNABMP2K
Entrez,  Source
BMP2 inducible kinase10050.8920.0891No
16SLC25A37NASLC25A37
Entrez,  Source
solute carrier family 25, member 3710810.8580.0918No
17NEK7NANEK7
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 712280.8010.0888No
18MFHAS1NAMFHAS1
Entrez,  Source
malignant fibrous histiocytoma amplified sequence 113600.7530.0864No
19ASNSNAASNS
Entrez,  Source
asparagine synthetase14360.7350.0879No
20RHDNARHD
Entrez,  Source
Rh blood group, D antigen14530.7290.0937No
21GCLCNAGCLC
Entrez,  Source
glutamate-cysteine ligase, catalytic subunit14960.7170.0975No
22LMO2NALMO2
Entrez,  Source
LIM domain only 2 (rhombotin-like 1)16570.6730.0922No
23TMCC2NATMCC2
Entrez,  Source
transmembrane and coiled-coil domain family 218640.6150.0830No
24NFE2L1NANFE2L1
Entrez,  Source
nuclear factor (erythroid-derived 2)-like 119180.6020.0848No
25RCL1NARCL1
Entrez,  Source
RNA terminal phosphate cyclase-like 120880.5710.0779No
26ERMAPNAERMAP
Entrez,  Source
erythroblast membrane-associated protein (Scianna blood group)20900.5700.0833No
27ARL2BPNAARL2BP
Entrez,  Source
ADP-ribosylation factor-like 2 binding protein21070.5680.0875No
28KLF3NAKLF3
Entrez,  Source
Kruppel-like factor 3 (basic)22050.5490.0857No
29TOP1NATOP1
Entrez,  Source
topoisomerase (DNA) I23670.5210.0789No
30GMPSNAGMPS
Entrez,  Source
guanine monphosphate synthetase24070.5140.0809No
31NR3C1NANR3C1
Entrez,  Source
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)27930.4530.0571No
32SLC25A38NASLC25A38
Entrez,  Source
solute carrier family 25, member 3828520.4420.0570No
33TRIM58NATRIM58
Entrez,  Source
tripartite motif-containing 5829460.4270.0543No
34FOXJ2NAFOXJ2
Entrez,  Source
forkhead box J233850.3700.0258No
35USP15NAUSP15
Entrez,  Source
ubiquitin specific peptidase 1535920.3450.0140No
36ABCG2NAABCG2
Entrez,  Source
ATP-binding cassette, sub-family G (WHITE), member 238510.316-0.0019No
37GAPVD1NAGAPVD1
Entrez,  Source
GTPase activating protein and VPS9 domains 142470.272-0.0282No
38IGSF3NAIGSF3
Entrez,  Source
immunoglobulin superfamily, member 342590.271-0.0264No
39MINPP1NAMINPP1
Entrez,  Source
multiple inositol polyphosphate histidine phosphatase, 143520.259-0.0306No
40URODNAUROD
Entrez,  Source
uroporphyrinogen decarboxylase43650.258-0.0291No
41ANK1NAANK1
Entrez,  Source
ankyrin 1, erythrocytic45400.238-0.0395No
42MARK3NAMARK3
Entrez,  Source
MAP/microtubule affinity-regulating kinase 349320.199-0.0662No
43CASTNACAST
Entrez,  Source
calpastatin49370.199-0.0646No
44HDGFNAHDGF
Entrez,  Source
hepatoma-derived growth factor (high-mobility group protein 1-like)49660.196-0.0648No
45BTRCNABTRC
Entrez,  Source
beta-transducin repeat containing53420.158-0.0907No
46PICALMNAPICALM
Entrez,  Source
phosphatidylinositol binding clathrin assembly protein53630.154-0.0907No
47SMOXNASMOX
Entrez,  Source
spermine oxidase54120.149-0.0928No
48ISCA1NA54720.143-0.0958No
49SDCBPNASDCBP
Entrez,  Source
syndecan binding protein (syntenin)55610.133-0.1009No
50VEZF1NAVEZF1
Entrez,  Source
vascular endothelial zinc finger 156040.127-0.1028No
51RAD23ANARAD23A
Entrez,  Source
RAD23 homolog A (S. cerevisiae)56360.123-0.1039No
52CDC27NACDC27
Entrez,  Source
cell division cycle 2756380.123-0.1028No
53GLRX5NAGLRX5
Entrez,  Source
glutaredoxin 5 homolog (S. cerevisiae)56890.117-0.1053No
54CCND3NACCND3
Entrez,  Source
cyclin D357220.114-0.1066No
55TRAK2NATRAK2
Entrez,  Source
trafficking protein, kinesin binding 257400.112-0.1068No
56ATG4ANAATG4A
Entrez,  Source
ATG4 autophagy related 4 homolog A (S. cerevisiae)59480.092-0.1210No
57ENDOD1NAENDOD1
Entrez,  Source
endonuclease domain containing 161890.068-0.1379No
58DAAM1NADAAM1
Entrez,  Source
dishevelled associated activator of morphogenesis 162890.058-0.1446No
59KHNYNNA64700.041-0.1574No
60CDR2NACDR2
Entrez,  Source
cerebellar degeneration-related protein 2, 62kDa65950.029-0.1662No
61TCEA1NATCEA1
Entrez,  Source
transcription elongation factor A (SII), 166100.027-0.1670No
62ICAM4NAICAM4
Entrez,  Source
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)66480.023-0.1695No
63FN3KNAFN3K
Entrez,  Source
fructosamine 3 kinase66540.022-0.1696No
64DCUN1D1NADCUN1D1
Entrez,  Source
DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)66660.021-0.1702No
65SYNJ1NASYNJ1
Entrez,  Source
synaptojanin 166900.018-0.1717No
66RBM5NARBM5
Entrez,  Source
RNA binding motif protein 567020.017-0.1724No
67FBXO9NAFBXO9
Entrez,  Source
F-box protein 967840.008-0.1782No
68PSMD9NAPSMD9
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 967880.008-0.1784No
69MBOAT2NAMBOAT2
Entrez,  Source
membrane bound O-acyltransferase domain containing 268320.003-0.1815No
70FOXO3NA6872-0.001-0.1843No
71AGPAT4NAAGPAT4
Entrez,  Source
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)7006-0.015-0.1939No
72LRP10NALRP10
Entrez,  Source
low density lipoprotein receptor-related protein 107078-0.021-0.1989No
73XPO7NAXPO7
Entrez,  Source
exportin 77407-0.057-0.2224No
74RIOK3NARIOK3
Entrez,  Source
RIO kinase 3 (yeast)7551-0.071-0.2322No
75CTSBNACTSB
Entrez,  Source
cathepsin B7647-0.079-0.2383No
76NCOA4NANCOA4
Entrez,  Source
nuclear receptor coactivator 47687-0.083-0.2404No
77MKRN1NAMKRN1
Entrez,  Source
makorin, ring finger protein, 17755-0.090-0.2444No
78ELL2NAELL2
Entrez,  Source
elongation factor, RNA polymerase II, 27768-0.092-0.2445No
79SLC4A1NASLC4A1
Entrez,  Source
solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)7799-0.094-0.2457No
80DCAF10NA8012-0.115-0.2602No
81ATP6V0A1NAATP6V0A1
Entrez,  Source
ATPase, H+ transporting, lysosomal V0 subunit a18071-0.123-0.2632No
82ADD1NAADD1
Entrez,  Source
adducin 1 (alpha)8140-0.130-0.2670No
83ARHGEF12NAARHGEF12
Entrez,  Source
Rho guanine nucleotide exchange factor (GEF) 128247-0.143-0.2734No
84BSGNABSG
Entrez,  Source
basigin (Ok blood group)8286-0.145-0.2748No
85SLC2A1NASLC2A1
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 18373-0.154-0.2796No
86CTNSNACTNS
Entrez,  Source
cystinosis, nephropathic8419-0.159-0.2814No
87RAP1GAPNARAP1GAP
Entrez,  Source
RAP1 GTPase activating protein8482-0.168-0.2843No
88BPGMNABPGM
Entrez,  Source
2,3-bisphosphoglycerate mutase8541-0.172-0.2869No
89CIR1NA8655-0.186-0.2934No
90UBAC1NA8718-0.193-0.2961No
91KLF1NAKLF1
Entrez,  Source
Kruppel-like factor 1 (erythroid)8778-0.200-0.2985No
92BACH1NABACH1
Entrez,  Source
BTB and CNC homology 1, basic leucine zipper transcription factor 18785-0.200-0.2970No
93E2F2NAE2F2
Entrez,  Source
E2F transcription factor 28870-0.211-0.3011No
94HMBSNAHMBS
Entrez,  Source
hydroxymethylbilane synthase8894-0.213-0.3008No
95TMEM9BNATMEM9B
Entrez,  Source
TMEM9 domain family, member B8951-0.220-0.3028No
96UROSNAUROS
Entrez,  Source
uroporphyrinogen III synthase (congenital erythropoietic porphyria)9045-0.231-0.3074No
97ACSL6NAACSL6
Entrez,  Source
acyl-CoA synthetase long-chain family member 69191-0.248-0.3156No
98SLC6A9NASLC6A9
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter, glycine), member 99214-0.252-0.3148No
99HTATIP2NAHTATIP2
Entrez,  Source
HIV-1 Tat interactive protein 2, 30kDa9240-0.255-0.3142No
100HTRA2NAHTRA2
Entrez,  Source
HtrA serine peptidase 29497-0.295-0.3302No
101SEC14L1NASEC14L1
Entrez,  Source
SEC14-like 1 (S. cerevisiae)9507-0.296-0.3280No
102ADIPOR1NAADIPOR1
Entrez,  Source
adiponectin receptor 19625-0.310-0.3336No
103BLVRANABLVRA
Entrez,  Source
biliverdin reductase A9761-0.331-0.3403No
104FBXO34NAFBXO34
Entrez,  Source
F-box protein 349768-0.332-0.3376No
105PIGQNAPIGQ
Entrez,  Source
phosphatidylinositol glycan anchor biosynthesis, class Q9808-0.338-0.3372No
106EPB41NAEPB41
Entrez,  Source
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)9814-0.339-0.3343No
107NARFNANARF
Entrez,  Source
nuclear prelamin A recognition factor9819-0.339-0.3314No
108CLIC2NACLIC2
Entrez,  Source
chloride intracellular channel 29862-0.346-0.3312No
109TAL1NATAL1
Entrez,  Source
T-cell acute lymphocytic leukemia 19909-0.351-0.3312No
110LAMP2NALAMP2
Entrez,  Source
lysosomal-associated membrane protein 29988-0.362-0.3334No
111GDE1NA9994-0.363-0.3303No
112HIST1H4CNAHIST1H4C
Entrez,  Source
histone cluster 1, H4c10010-0.365-0.3280No
113TNRC6BNATNRC6B
Entrez,  Source
trinucleotide repeat containing 6B10081-0.376-0.3295No
114FBXO7NAFBXO7
Entrez,  Source
F-box protein 710303-0.410-0.3417No
115PQLC1NAPQLC1
Entrez,  Source
PQ loop repeat containing 110447-0.434-0.3481No
116LPIN2NALPIN2
Entrez,  Source
lipin 210517-0.444-0.3489No
117PRDX2NAPRDX2
Entrez,  Source
peroxiredoxin 210666-0.471-0.3552No
118OPTNNAOPTN
Entrez,  Source
optineurin10676-0.473-0.3514No
119EZH1NAEZH1
Entrez,  Source
enhancer of zeste homolog 1 (Drosophila)10779-0.490-0.3542No
120HEBP1NAHEBP1
Entrez,  Source
heme binding protein 110927-0.513-0.3600No
121TFRCNATFRC
Entrez,  Source
transferrin receptor (p90, CD71)10954-0.519-0.3570No
122EIF2AK1NAEIF2AK1
Entrez,  Source
eukaryotic translation initiation factor 2-alpha kinase 110960-0.520-0.3524No
123PGLSNAPGLS
Entrez,  Source
6-phosphogluconolactonase11095-0.545-0.3570No
124UCP2NAUCP2
Entrez,  Source
uncoupling protein 2 (mitochondrial, proton carrier)11373-0.598-0.3715Yes
125PPP2R5BNAPPP2R5B
Entrez,  Source
protein phosphatase 2, regulatory subunit B (B56), beta isoform11415-0.608-0.3688Yes
126CLCN3NACLCN3
Entrez,  Source
chloride channel 311420-0.608-0.3632Yes
127SPTA1NASPTA1
Entrez,  Source
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)11486-0.621-0.3621Yes
128P4HA2NAP4HA2
Entrez,  Source
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II11494-0.623-0.3566Yes
129SLC11A2NASLC11A2
Entrez,  Source
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 211514-0.626-0.3521Yes
130FAM46CNAFAM46C
Entrez,  Source
family with sequence similarity 46, member C11751-0.685-0.3628Yes
131EPORNAEPOR
Entrez,  Source
erythropoietin receptor11843-0.711-0.3627Yes
132HAGHNAHAGH
Entrez,  Source
hydroxyacylglutathione hydrolase11999-0.756-0.3668Yes
133CCDC28ANACCDC28A
Entrez,  Source
coiled-coil domain containing 28A12085-0.781-0.3656Yes
134RNF19ANA12132-0.797-0.3613Yes
135RNF123NARNF123
Entrez,  Source
ring finger protein 12312136-0.798-0.3539Yes
136MARCH2NAMARCH2
Entrez,  Source
membrane-associated ring finger (C3HC4) 212250-0.836-0.3542Yes
137DCAF11NA12327-0.864-0.3515Yes
138AQP3NAAQP3
Entrez,  Source
aquaporin 3 (Gill blood group)12436-0.910-0.3508Yes
139BLVRBNABLVRB
Entrez,  Source
biliverdin reductase B (flavin reductase (NADPH))12510-0.944-0.3471Yes
140PDZK1IP1NAPDZK1IP1
Entrez,  Source
PDZK1 interacting protein 112677-1.025-0.3495Yes
141SLC6A8NASLC6A8
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter, creatine), member 812717-1.043-0.3424Yes
142PPOXNAPPOX
Entrez,  Source
protoporphyrinogen oxidase12743-1.059-0.3341Yes
143ABCB6NAABCB6
Entrez,  Source
ATP-binding cassette, sub-family B (MDR/TAP), member 612794-1.086-0.3274Yes
144GYPANAGYPA
Entrez,  Source
glycophorin A (MNS blood group)12849-1.120-0.3207Yes
145TFDP2NATFDP2
Entrez,  Source
transcription factor Dp-2 (E2F dimerization partner 2)12943-1.181-0.3162Yes
146FECHNAFECH
Entrez,  Source
ferrochelatase (protoporphyria)12946-1.182-0.3051Yes
147SPTBNASPTB
Entrez,  Source
spectrin, beta, erythrocytic (includes spherocytosis, clinical type I)12980-1.200-0.2960Yes
148ALADNAALAD
Entrez,  Source
aminolevulinate, delta-, dehydratase13113-1.307-0.2932Yes
149TNS1NATNS1
Entrez,  Source
tensin 113195-1.388-0.2859Yes
150MOSPD1NAMOSPD1
Entrez,  Source
motile sperm domain containing 113217-1.418-0.2739Yes
151MXI1NAMXI1
Entrez,  Source
MAX interactor 113253-1.458-0.2626Yes
152KAT2BNA13263-1.472-0.2492Yes
153ALDH6A1NAALDH6A1
Entrez,  Source
aldehyde dehydrogenase 6 family, member A113276-1.487-0.2359Yes
154CPOXNACPOX
Entrez,  Source
coproporphyrinogen oxidase13319-1.535-0.2243Yes
155NNTNANNT
Entrez,  Source
nicotinamide nucleotide transhydrogenase13325-1.547-0.2099Yes
156SIDT2NASIDT2
Entrez,  Source
SID1 transmembrane family, member 213355-1.585-0.1969Yes
157BNIP3LNABNIP3L
Entrez,  Source
BCL2/adenovirus E1B 19kDa interacting protein 3-like13391-1.641-0.1838Yes
158SNCANASNCA
Entrez,  Source
synuclein, alpha (non A4 component of amyloid precursor)13431-1.703-0.1705Yes
159CATNACAT
Entrez,  Source
catalase13474-1.769-0.1566Yes
160MGST3NAMGST3
Entrez,  Source
microsomal glutathione S-transferase 313497-1.809-0.1410Yes
161YPEL5NAYPEL5
Entrez,  Source
yippee-like 5 (Drosophila)13501-1.821-0.1238Yes
162C3NAC3
Entrez,  Source
complement component 313533-1.896-0.1080Yes
163NFE2NANFE2
Entrez,  Source
nuclear factor (erythroid-derived 2), 45kDa13627-2.165-0.0942Yes
164MOCOSNAMOCOS
Entrez,  Source
molybdenum cofactor sulfurase13638-2.208-0.0739Yes
165PCNAPC
Entrez,  Source
pyruvate carboxylase13641-2.224-0.0528Yes
166SELENBP1NASELENBP1
Entrez,  Source
selenium binding protein 113647-2.240-0.0318Yes
167BTG2NABTG2
Entrez,  Source
BTG family, member 213659-2.285-0.0108Yes
168BCAMNABCAM
Entrez,  Source
basal cell adhesion molecule (Lutheran blood group)13693-2.4660.0103Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_HEME_METABOLISM   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_HEME_METABOLISM: Random ES distribution   
Gene set null distribution of ES for HALLMARK_HEME_METABOLISM