Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1gfp
GeneSetHALLMARK_GLYCOLYSIS
Enrichment Score (ES)-0.25410846
Normalized Enrichment Score (NES)-1.0189786
Nominal p-value0.4070122
FDR q-value0.50094146
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_GLYCOLYSIS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1CACNA1HNACACNA1H
Entrez,  Source
calcium channel, voltage-dependent, alpha 1H subunit553.4230.0283No
2ISG20NAISG20
Entrez,  Source
interferon stimulated exonuclease gene 20kDa563.4020.0604No
3GPR87NAGPR87
Entrez,  Source
G protein-coupled receptor 87783.1530.0886No
4NT5ENANT5E
Entrez,  Source
5'-nucleotidase, ecto (CD73)933.0000.1159No
5MERTKNAMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase2711.8770.1206No
6AK4NA2911.7870.1361No
7CD44NACD44
Entrez,  Source
CD44 molecule (Indian blood group)3361.6590.1485No
8TPBGNATPBG
Entrez,  Source
trophoblast glycoprotein3971.5080.1584No
9BIKNABIK
Entrez,  Source
BCL2-interacting killer (apoptosis-inducing)5121.2960.1623No
10B4GALT4NAB4GALT4
Entrez,  Source
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 45151.2960.1743No
11QSOX1NA5301.2780.1854No
12EGFRNAEGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6371.1500.1885No
13STC2NASTC2
Entrez,  Source
stanniocalcin 29260.9310.1762No
14TGFANATGFA
Entrez,  Source
transforming growth factor, alpha11210.8420.1699No
15EXT1NAEXT1
Entrez,  Source
exostoses (multiple) 112100.8080.1711No
16IER3NAIER3
Entrez,  Source
immediate early response 312720.7880.1741No
17CLN6NACLN6
Entrez,  Source
ceroid-lipofuscinosis, neuronal 6, late infantile, variant12780.7850.1811No
18POLR3KNAPOLR3K
Entrez,  Source
polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa13680.7500.1817No
19GCLCNAGCLC
Entrez,  Source
glutamate-cysteine ligase, catalytic subunit14960.7170.1792No
20FKBP4NAFKBP4
Entrez,  Source
FK506 binding protein 4, 59kDa15890.6920.1790No
21PSMC4NAPSMC4
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 416960.6590.1774No
22HK2NAHK2
Entrez,  Source
hexokinase 217860.6360.1769No
23ALG1NAALG1
Entrez,  Source
asparagine-linked glycosylation 1 homolog (S. cerevisiae, beta-1,4-mannosyltransferase)18420.6210.1787No
24FUT8NAFUT8
Entrez,  Source
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)21930.5510.1583No
25IDUANAIDUA
Entrez,  Source
iduronidase, alpha-L-22110.5480.1622No
26PMM2NAPMM2
Entrez,  Source
phosphomannomutase 222730.5370.1628No
27RARSNARARS
Entrez,  Source
arginyl-tRNA synthetase22820.5360.1673No
28PFKPNAPFKP
Entrez,  Source
phosphofructokinase, platelet22870.5350.1721No
29PPP2CBNAPPP2CB
Entrez,  Source
protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform22880.5350.1771No
30CHPF2NA26180.4820.1576No
31CAPN5NACAPN5
Entrez,  Source
calpain 530110.4200.1328No
32HSPA5NAHSPA5
Entrez,  Source
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)31610.3990.1257No
33ECDNAECD
Entrez,  Source
ecdysoneless homolog (Drosophila)33000.3820.1192No
34TXNNATXN
Entrez,  Source
thioredoxin37370.3290.0904No
35PYGBNAPYGB
Entrez,  Source
phosphorylase, glycogen; brain37610.3270.0918No
36ADORA2BNAADORA2B
Entrez,  Source
adenosine A2b receptor38030.3200.0918No
37PHKA2NAPHKA2
Entrez,  Source
phosphorylase kinase, alpha 2 (liver)38740.3130.0896No
38KIF2ANAKIF2A
Entrez,  Source
kinesin heavy chain member 2A40820.2890.0772No
39HOMER1NAHOMER1
Entrez,  Source
homer homolog 1 (Drosophila)43460.2610.0604No
40NASPNANASP
Entrez,  Source
nuclear autoantigenic sperm protein (histone-binding)43630.2590.0617No
41GYS2NAGYS2
Entrez,  Source
glycogen synthase 2 (liver)44400.2500.0584No
42CITED2NACITED2
Entrez,  Source
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 245080.2420.0558No
43CHPFNACHPF
Entrez,  Source
-45590.2360.0544No
44PGM2NAPGM2
Entrez,  Source
phosphoglucomutase 247720.2140.0409No
45SAP30NASAP30
Entrez,  Source
Sin3A-associated protein, 30kDa48060.2110.0405No
46PRPS1NAPRPS1
Entrez,  Source
phosphoribosyl pyrophosphate synthetase 148890.2020.0364No
47ME2NAME2
Entrez,  Source
malic enzyme 2, NAD(+)-dependent, mitochondrial49210.2000.0360No
48CDK1NA50060.1910.0316No
49GFPT1NAGFPT1
Entrez,  Source
glutamine-fructose-6-phosphate transaminase 151600.1750.0221No
50B3GALT6NAB3GALT6
Entrez,  Source
UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 653810.1520.0074No
51SDC1NASDC1
Entrez,  Source
syndecan 153890.1520.0083No
52AGRNNA53970.1510.0093No
53MED24NA55150.1380.0020No
54GUSBNAGUSB
Entrez,  Source
glucuronidase, beta55260.1370.0026No
55GNPDA1NAGNPDA1
Entrez,  Source
glucosamine-6-phosphate deaminase 156610.120-0.0061No
56GOT2NAGOT2
Entrez,  Source
glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)57740.109-0.0133No
57ALDOANAALDOA
Entrez,  Source
aldolase A, fructose-bisphosphate58800.100-0.0200No
58GNENAGNE
Entrez,  Source
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase59080.097-0.0211No
59METNAMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)59160.096-0.0207No
60NDST3NANDST3
Entrez,  Source
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 359170.096-0.0198No
61DEPDC1NADEPDC1
Entrez,  Source
DEP domain containing 159210.095-0.0191No
62AURKANAAURKA
Entrez,  Source
aurora kinase A59230.095-0.0183No
63IGFBP3NAIGFBP3
Entrez,  Source
insulin-like growth factor binding protein 359640.091-0.0204No
64HAX1NAHAX1
Entrez,  Source
HCLS1 associated protein X-159870.088-0.0212No
65GALENAGALE
Entrez,  Source
UDP-galactose-4-epimerase59930.088-0.0207No
66B4GALT7NAB4GALT7
Entrez,  Source
xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)60390.083-0.0232No
67VCANNA60560.081-0.0236No
68CLDN9NACLDN9
Entrez,  Source
claudin 960760.079-0.0243No
69SLC16A3NASLC16A3
Entrez,  Source
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)60770.079-0.0235No
70P4HA1NAP4HA1
Entrez,  Source
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I61630.071-0.0291No
71PGAM1NAPGAM1
Entrez,  Source
phosphoglycerate mutase 1 (brain)61910.068-0.0304No
72NSDHLNANSDHL
Entrez,  Source
NAD(P) dependent steroid dehydrogenase-like62150.065-0.0315No
73CHST1NACHST1
Entrez,  Source
carbohydrate (keratan sulfate Gal-6) sulfotransferase 163060.057-0.0375No
74GMPPBNAGMPPB
Entrez,  Source
GDP-mannose pyrophosphorylase B63320.055-0.0388No
75LDHANALDHA
Entrez,  Source
lactate dehydrogenase A64240.047-0.0451No
76COG2NACOG2
Entrez,  Source
component of oligomeric golgi complex 264760.041-0.0484No
77COL5A1NACOL5A1
Entrez,  Source
collagen, type V, alpha 164990.039-0.0496No
78PYGLNAPYGL
Entrez,  Source
phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI)66230.026-0.0584No
79PLOD2NAPLOD2
Entrez,  Source
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 266690.021-0.0615No
80CHST6NACHST6
Entrez,  Source
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 667460.013-0.0669No
81HS2ST1NAHS2ST1
Entrez,  Source
heparan sulfate 2-O-sulfotransferase 168060.006-0.0712No
82EXT2NAEXT2
Entrez,  Source
exostoses (multiple) 26963-0.011-0.0825No
83LCTNALCT
Entrez,  Source
lactase7203-0.033-0.0997No
84CENPANACENPA
Entrez,  Source
centromere protein A7370-0.053-0.1114No
85GLCENAGLCE
Entrez,  Source
UDP-glucuronic acid epimerase7385-0.054-0.1119No
86NDUFV3NANDUFV3
Entrez,  Source
NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa7412-0.057-0.1132No
87ARPP19NA7535-0.069-0.1215No
88SLC25A13NASLC25A13
Entrez,  Source
solute carrier family 25, member 13 (citrin)7684-0.083-0.1316No
89B4GALT2NAB4GALT2
Entrez,  Source
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 27763-0.091-0.1364No
90GPC1NAGPC1
Entrez,  Source
glypican 17773-0.092-0.1362No
91KIF20ANAKIF20A
Entrez,  Source
kinesin family member 20A7809-0.095-0.1379No
92VEGFANA7811-0.096-0.1371No
93CASP6NACASP6
Entrez,  Source
caspase 6, apoptosis-related cysteine peptidase7942-0.108-0.1456No
94XYLT2NAXYLT2
Entrez,  Source
xylosyltransferase II7945-0.108-0.1447No
95AGLNAAGL
Entrez,  Source
amylo-1, 6-glucosidase, 4-alpha-glucanotransferase (glycogen debranching enzyme, glycogen storage disease type III)7951-0.109-0.1440No
96ANGPTL4NAANGPTL4
Entrez,  Source
angiopoietin-like 47970-0.111-0.1443No
97HMMRNAHMMR
Entrez,  Source
hyaluronan-mediated motility receptor (RHAMM)8010-0.115-0.1461No
98ME1NAME1
Entrez,  Source
malic enzyme 1, NADP(+)-dependent, cytosolic8293-0.146-0.1653No
99ENO1NAENO1
Entrez,  Source
enolase 1, (alpha)8327-0.149-0.1664No
100ARTNNAARTN
Entrez,  Source
artemin8351-0.151-0.1666No
101STC1NASTC1
Entrez,  Source
stanniocalcin 18647-0.185-0.1865No
102IL13RA1NAIL13RA1
Entrez,  Source
interleukin 13 receptor, alpha 18682-0.188-0.1872No
103GMPPANAGMPPA
Entrez,  Source
GDP-mannose pyrophosphorylase A8693-0.190-0.1861No
104GAPDHSNAGAPDHS
Entrez,  Source
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic8781-0.200-0.1906No
105SLC35A3NASLC35A3
Entrez,  Source
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A38823-0.206-0.1917No
106COPB2NACOPB2
Entrez,  Source
coatomer protein complex, subunit beta 2 (beta prime)8908-0.215-0.1958No
107HS6ST2NAHS6ST2
Entrez,  Source
heparan sulfate 6-O-sulfotransferase 29250-0.257-0.2183No
108CHST12NACHST12
Entrez,  Source
carbohydrate (chondroitin 4) sulfotransferase 129346-0.270-0.2227No
109TPI1NATPI1
Entrez,  Source
triosephosphate isomerase 19395-0.278-0.2236No
110PGAM2NAPGAM2
Entrez,  Source
phosphoglycerate mutase 2 (muscle)9462-0.288-0.2257No
111EFNA3NAEFNA3
Entrez,  Source
ephrin-A39513-0.296-0.2266No
112PAXIP1NAPAXIP1
Entrez,  Source
PAX interacting (with transcription-activation domain) protein 19525-0.298-0.2246No
113HDLBPNAHDLBP
Entrez,  Source
high density lipoprotein binding protein (vigilin)9545-0.300-0.2232No
114GLRXNAGLRX
Entrez,  Source
glutaredoxin (thioltransferase)9559-0.301-0.2213No
115FBP2NAFBP2
Entrez,  Source
fructose-1,6-bisphosphatase 29701-0.321-0.2286No
116DLDNADLD
Entrez,  Source
dihydrolipoamide dehydrogenase9719-0.325-0.2267No
117GALK2NAGALK2
Entrez,  Source
galactokinase 29758-0.330-0.2264No
118GYS1NAGYS1
Entrez,  Source
glycogen synthase 1 (muscle)9777-0.334-0.2246No
119B3GAT3NAB3GAT3
Entrez,  Source
beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)9824-0.340-0.2247No
120PKP2NAPKP2
Entrez,  Source
plakophilin 29920-0.353-0.2284No
121MIFNAMIF
Entrez,  Source
macrophage migration inhibitory factor (glycosylation-inhibiting factor)9983-0.361-0.2295No
122TALDO1NATALDO1
Entrez,  Source
transaldolase 110011-0.366-0.2280No
123B3GNT3NAB3GNT3
Entrez,  Source
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 310042-0.371-0.2267No
124PLOD1NAPLOD1
Entrez,  Source
procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 110170-0.389-0.2323No
125ELF3NAELF3
Entrez,  Source
E74-like factor 3 (ets domain transcription factor, epithelial-specific )10193-0.393-0.2302No
126GOT1NAGOT1
Entrez,  Source
glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)10200-0.395-0.2270No
127CXCR4NACXCR4
Entrez,  Source
chemokine (C-X-C motif) receptor 410239-0.400-0.2260No
128RPENARPE
Entrez,  Source
ribulose-5-phosphate-3-epimerase10446-0.434-0.2370No
129FAM162ANA10460-0.436-0.2338No
130SLC37A4NASLC37A4
Entrez,  Source
solute carrier family 37 (glycerol-6-phosphate transporter), member 410475-0.438-0.2307No
131MDH2NAMDH2
Entrez,  Source
malate dehydrogenase 2, NAD (mitochondrial)10593-0.456-0.2349No
132PGK1NAPGK1
Entrez,  Source
phosphoglycerate kinase 110801-0.493-0.2455No
133ENO2NAENO2
Entrez,  Source
enolase 2 (gamma, neuronal)10819-0.496-0.2420No
134GALK1NAGALK1
Entrez,  Source
galactokinase 110873-0.505-0.2411No
135SDHCNASDHC
Entrez,  Source
succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa10930-0.514-0.2404No
136ANKZF1NAANKZF1
Entrez,  Source
ankyrin repeat and zinc finger domain containing 110946-0.518-0.2366No
137ALDH9A1NAALDH9A1
Entrez,  Source
aldehyde dehydrogenase 9 family, member A110955-0.519-0.2323No
138TSTA3NATSTA3
Entrez,  Source
tissue specific transplantation antigen P35B10993-0.527-0.2300No
139PGLSNAPGLS
Entrez,  Source
6-phosphogluconolactonase11095-0.545-0.2323No
140NANPNANANP
Entrez,  Source
N-acetylneuraminic acid phosphatase11393-0.603-0.2483Yes
141UGP2NAUGP2
Entrez,  Source
UDP-glucose pyrophosphorylase 211473-0.620-0.2483Yes
142P4HA2NAP4HA2
Entrez,  Source
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II11494-0.623-0.2438Yes
143DSC2NADSC2
Entrez,  Source
desmocollin 211532-0.630-0.2406Yes
144PAMNAPAM
Entrez,  Source
peptidylglycine alpha-amidating monooxygenase11576-0.642-0.2377Yes
145B4GALT1NAB4GALT1
Entrez,  Source
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 111626-0.655-0.2351Yes
146BPNT1NABPNT1
Entrez,  Source
3'(2'), 5'-bisphosphate nucleotidase 111648-0.659-0.2304Yes
147PPIANAPPIA
Entrez,  Source
peptidylprolyl isomerase A (cyclophilin A)11715-0.675-0.2289Yes
148SOD1NASOD1
Entrez,  Source
superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))11746-0.684-0.2246Yes
149ZNF292NAZNF292
Entrez,  Source
zinc finger protein 29211783-0.693-0.2207Yes
150AKR1A1NAAKR1A1
Entrez,  Source
aldo-keto reductase family 1, member A1 (aldehyde reductase)11855-0.713-0.2192Yes
151STMN1NASTMN1
Entrez,  Source
stathmin 1/oncoprotein 1811874-0.717-0.2137Yes
152ALDH7A1NAALDH7A1
Entrez,  Source
aldehyde dehydrogenase 7 family, member A112010-0.760-0.2165Yes
153RBCK1NARBCK1
Entrez,  Source
RanBP-type and C3HC4-type zinc finger containing 112175-0.813-0.2208Yes
154SLC25A10NASLC25A10
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 1012255-0.837-0.2187Yes
155SDC3NASDC3
Entrez,  Source
syndecan 3 (N-syndecan)12261-0.839-0.2111Yes
156KDELR3NAKDELR3
Entrez,  Source
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 312326-0.864-0.2077Yes
157SRD5A3NA12416-0.900-0.2057Yes
158MDH1NAMDH1
Entrez,  Source
malate dehydrogenase 1, NAD (soluble)12448-0.914-0.1993Yes
159IRS2NAIRS2
Entrez,  Source
insulin receptor substrate 212470-0.925-0.1921Yes
160SPAG4NASPAG4
Entrez,  Source
sperm associated antigen 412704-1.038-0.1994Yes
161ABCB6NAABCB6
Entrez,  Source
ATP-binding cassette, sub-family B (MDR/TAP), member 612794-1.086-0.1957Yes
162MPINAMPI
Entrez,  Source
mannose phosphate isomerase12806-1.094-0.1861Yes
163PDK3NAPDK3
Entrez,  Source
pyruvate dehydrogenase kinase, isozyme 312825-1.102-0.1771Yes
164RRAGDNARRAGD
Entrez,  Source
Ras-related GTP binding D12945-1.181-0.1746Yes
165IDH1NAIDH1
Entrez,  Source
isocitrate dehydrogenase 1 (NADP+), soluble13083-1.285-0.1725Yes
166AK3NAAK3
Entrez,  Source
adenylate kinase 313165-1.356-0.1657Yes
167DDIT4NADDIT4
Entrez,  Source
DNA-damage-inducible transcript 413200-1.395-0.1550Yes
168SDC2NASDC2
Entrez,  Source
syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan)13234-1.433-0.1439Yes
169MXI1NAMXI1
Entrez,  Source
MAX interactor 113253-1.458-0.1314Yes
170EGLN3NAEGLN3
Entrez,  Source
egl nine homolog 3 (C. elegans)13293-1.506-0.1201Yes
171G6PDNAG6PD
Entrez,  Source
glucose-6-phosphate dehydrogenase13294-1.507-0.1059Yes
172LHPPNALHPP
Entrez,  Source
-13422-1.687-0.0992Yes
173TGFBINATGFBI
Entrez,  Source
transforming growth factor, beta-induced, 68kDa13453-1.742-0.0850Yes
174VLDLRNAVLDLR
Entrez,  Source
very low density lipoprotein receptor13512-1.854-0.0718Yes
175ANGNAANG
Entrez,  Source
angiogenin, ribonuclease, RNase A family, 513529-1.891-0.0551Yes
176CTHNACTH
Entrez,  Source
cystathionase (cystathionine gamma-lyase)13546-1.929-0.0380Yes
177PCNAPC
Entrez,  Source
pyruvate carboxylase13641-2.224-0.0239Yes
178DCNNADCN
Entrez,  Source
decorin13811-4.0270.0017Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_GLYCOLYSIS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_GLYCOLYSIS: Random ES distribution   
Gene set null distribution of ES for HALLMARK_GLYCOLYSIS