Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1w6a
GeneSetHALLMARK_G2M_CHECKPOINT
Enrichment Score (ES)0.30667162
Normalized Enrichment Score (NES)1.3429013
Nominal p-value0.018126888
FDR q-value0.07396633
FWER p-Value0.584
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_G2M_CHECKPOINT   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1ATF5NAATF5
Entrez,  Source
activating transcription factor 53311.683-0.0011Yes
2MT2ANAMT2A
Entrez,  Source
metallothionein 2A4081.4930.0138Yes
3ODC1NAODC1
Entrez,  Source
ornithine decarboxylase 16111.1720.0151Yes
4HSPA8NAHSPA8
Entrez,  Source
heat shock 70kDa protein 86341.1570.0294Yes
5SLC12A2NASLC12A2
Entrez,  Source
solute carrier family 12 (sodium/potassium/chloride transporters), member 26481.1390.0441Yes
6PMLNAPML
Entrez,  Source
promyelocytic leukemia7551.0460.0507Yes
7SMAD3NASMAD3
Entrez,  Source
SMAD, mothers against DPP homolog 3 (Drosophila)10250.8810.0431Yes
8CCND1NACCND1
Entrez,  Source
cyclin D110330.8770.0546Yes
9NCLNANCL
Entrez,  Source
nucleolin11070.8480.0609Yes
10NOLC1NANOLC1
Entrez,  Source
nucleolar and coiled-body phosphoprotein 111490.8300.0693Yes
11E2F4NAE2F4
Entrez,  Source
E2F transcription factor 4, p107/p130-binding11750.8220.0788Yes
12RPS6KA5NARPS6KA5
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 512120.8070.0873Yes
13ORC6NA12470.7950.0957Yes
14GSPT1NAGSPT1
Entrez,  Source
G1 to S phase transition 113750.7490.0967Yes
15DR1NADR1
Entrez,  Source
down-regulator of transcription 1, TBP-binding (negative cofactor 2)13860.7470.1062Yes
16PRMT5NAPRMT5
Entrez,  Source
protein arginine methyltransferase 514030.7420.1153Yes
17KIF23NAKIF23
Entrez,  Source
kinesin family member 2314550.7280.1215Yes
18G3BP1NA14760.7230.1300Yes
19DDX39ANA15470.7020.1345Yes
20TGFB1NATGFB1
Entrez,  Source
transforming growth factor, beta 1 (Camurati-Engelmann disease)15600.7000.1433Yes
21CDC20NACDC20
Entrez,  Source
CDC20 cell division cycle 20 homolog (S. cerevisiae)15960.6890.1502Yes
22NOTCH2NANOTCH2
Entrez,  Source
Notch homolog 2 (Drosophila)16560.6740.1551Yes
23HMGA1NAHMGA1
Entrez,  Source
high mobility group AT-hook 116620.6700.1639Yes
24RASAL2NARASAL2
Entrez,  Source
RAS protein activator like 217090.6560.1696Yes
25ORC5NA17280.6500.1772Yes
26PLK1NAPLK1
Entrez,  Source
polo-like kinase 1 (Drosophila)17740.6380.1827Yes
27BUB1NABUB1
Entrez,  Source
BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)18280.6260.1874Yes
28HIF1ANAHIF1A
Entrez,  Source
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)18710.6130.1927Yes
29UBE2SNAUBE2S
Entrez,  Source
ubiquitin-conjugating enzyme E2S19360.5990.1963Yes
30CTCFNACTCF
Entrez,  Source
CCCTC-binding factor (zinc finger protein)19390.5980.2043Yes
31CDC25ANACDC25A
Entrez,  Source
cell division cycle 25A19630.5940.2108Yes
32KPNA2NAKPNA2
Entrez,  Source
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)20970.5700.2089Yes
33SYNCRIPNASYNCRIP
Entrez,  Source
synaptotagmin binding, cytoplasmic RNA interacting protein21140.5670.2155Yes
34UPF1NAUPF1
Entrez,  Source
UPF1 regulator of nonsense transcripts homolog (yeast)21870.5530.2178Yes
35KIF20BNA22040.5500.2242Yes
36CCNFNACCNF
Entrez,  Source
cyclin F22120.5480.2312Yes
37DKC1NADKC1
Entrez,  Source
dyskeratosis congenita 1, dyskerin22890.5350.2330Yes
38RAD23BNARAD23B
Entrez,  Source
RAD23 homolog B (S. cerevisiae)23190.5300.2382Yes
39TOP1NATOP1
Entrez,  Source
topoisomerase (DNA) I23670.5210.2419Yes
40POLQNAPOLQ
Entrez,  Source
polymerase (DNA directed), theta23800.5200.2481Yes
41FBXO5NAFBXO5
Entrez,  Source
F-box protein 524150.5130.2527Yes
42BCL3NABCL3
Entrez,  Source
B-cell CLL/lymphoma 324210.5120.2594Yes
43XPO1NAXPO1
Entrez,  Source
exportin 1 (CRM1 homolog, yeast)24700.5050.2628Yes
44TRAIPNATRAIP
Entrez,  Source
TRAF interacting protein25580.4910.2632Yes
45EZH2NAEZH2
Entrez,  Source
enhancer of zeste homolog 2 (Drosophila)25640.4900.2695Yes
46SLC7A1NASLC7A1
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 126770.4720.2678Yes
47INCENPNAINCENP
Entrez,  Source
inner centromere protein antigens 135/155kDa27000.4670.2726Yes
48BRCA2NABRCA2
Entrez,  Source
breast cancer 2, early onset27120.4660.2782Yes
49DBF4NADBF4
Entrez,  Source
DBF4 homolog (S. cerevisiae)27570.4590.2813Yes
50AURKBNAAURKB
Entrez,  Source
aurora kinase B28030.4510.2842Yes
51MTF2NAMTF2
Entrez,  Source
metal response element binding transcription factor 228250.4470.2888Yes
52H2AFXNAH2AFX
Entrez,  Source
H2A histone family, member X28730.4380.2914Yes
53NUP50NANUP50
Entrez,  Source
nucleoporin 50kDa29200.4320.2939Yes
54NUP98NANUP98
Entrez,  Source
nucleoporin 98kDa29740.4240.2959Yes
55E2F3NAE2F3
Entrez,  Source
E2F transcription factor 329880.4230.3007Yes
56SFPQNASFPQ
Entrez,  Source
splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated)31560.3990.2940Yes
57EWSR1NAEWSR1
Entrez,  Source
Ewing sarcoma breakpoint region 131680.3980.2986Yes
58TNPO2NATNPO2
Entrez,  Source
transportin 2 (importin 3, karyopherin beta 2b)32120.3920.3009Yes
59STILNASTIL
Entrez,  Source
SCL/TAL1 interrupting locus32640.3860.3024Yes
60SUV39H1NASUV39H1
Entrez,  Source
suppressor of variegation 3-9 homolog 1 (Drosophila)33700.3720.2999Yes
61RBL1NARBL1
Entrez,  Source
retinoblastoma-like 1 (p107)33740.3710.3047Yes
62CDC25BNACDC25B
Entrez,  Source
cell division cycle 25B34500.3600.3042Yes
63KPNB1NAKPNB1
Entrez,  Source
karyopherin (importin) beta 134840.3560.3067Yes
64RBM14NARBM14
Entrez,  Source
RNA binding motif protein 1437170.3320.2942No
65HUS1NAHUS1
Entrez,  Source
HUS1 checkpoint homolog (S. pombe)38320.3180.2902No
66CCNA2NACCNA2
Entrez,  Source
cyclin A238880.3110.2905No
67SMC1ANASMC1A
Entrez,  Source
structural maintenance of chromosomes 1A39290.3050.2917No
68CDC7NACDC7
Entrez,  Source
CDC7 cell division cycle 7 (S. cerevisiae)39880.2980.2916No
69TFDP1NATFDP1
Entrez,  Source
transcription factor Dp-141050.2860.2870No
70STAG1NASTAG1
Entrez,  Source
stromal antigen 142420.2730.2808No
71NASPNANASP
Entrez,  Source
nuclear autoantigenic sperm protein (histone-binding)43630.2590.2755No
72HMGN2NAHMGN2
Entrez,  Source
high-mobility group nucleosomal binding domain 243860.2550.2774No
73KIF11NAKIF11
Entrez,  Source
kinesin family member 1143870.2550.2809No
74CUL1NACUL1
Entrez,  Source
cullin 144030.2530.2833No
75TROAPNATROAP
Entrez,  Source
trophinin associated protein (tastin)44090.2520.2864No
76HNRNPDNA44630.2470.2859No
77SS18NASS18
Entrez,  Source
synovial sarcoma translocation, chromosome 1844660.2470.2892No
78LMNB1NALMNB1
Entrez,  Source
lamin B144670.2470.2926No
79SRSF1NA45780.2350.2877No
80HIST1H2BKNAHIST1H2BK
Entrez,  Source
histone cluster 1, H2bk46600.2270.2849No
81FANCCNAFANCC
Entrez,  Source
Fanconi anemia, complementation group C46800.2250.2866No
82SRSF10NA46920.2240.2889No
83SAP30NASAP30
Entrez,  Source
Sin3A-associated protein, 30kDa48060.2110.2835No
84AMD1NAAMD1
Entrez,  Source
adenosylmethionine decarboxylase 148670.2050.2819No
85CKS1BNACKS1B
Entrez,  Source
CDC28 protein kinase regulatory subunit 1B48680.2050.2847No
86SMC2NASMC2
Entrez,  Source
structural maintenance of chromosomes 249410.1980.2822No
87CDK1NA50060.1910.2801No
88MNAT1NAMNAT1
Entrez,  Source
menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)50310.1880.2809No
89CDK4NACDK4
Entrez,  Source
cyclin-dependent kinase 450460.1870.2825No
90KIF4ANAKIF4A
Entrez,  Source
kinesin family member 4A50680.1850.2835No
91CUL3NACUL3
Entrez,  Source
cullin 350750.1840.2856No
92HIRANAHIRA
Entrez,  Source
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)50880.1830.2872No
93TPX2NATPX2
Entrez,  Source
TPX2, microtubule-associated, homolog (Xenopus laevis)50890.1830.2897No
94HNRNPUNA51000.1810.2915No
95YTHDC1NAYTHDC1
Entrez,  Source
YTH domain containing 153500.1560.2754No
96MKI67NAMKI67
Entrez,  Source
antigen identified by monoclonal antibody Ki-6753750.1530.2757No
97LBRNALBR
Entrez,  Source
lamin B receptor54000.1500.2760No
98SNRPD1NASNRPD1
Entrez,  Source
small nuclear ribonucleoprotein D1 polypeptide 16kDa54020.1500.2780No
99SQLENASQLE
Entrez,  Source
squalene epoxidase54400.1470.2773No
100UCK2NAUCK2
Entrez,  Source
uridine-cytidine kinase 255340.1360.2724No
101BUB3NABUB3
Entrez,  Source
BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)55630.1330.2721No
102KIF5BNAKIF5B
Entrez,  Source
kinesin family member 5B55680.1320.2737No
103ODF2NAODF2
Entrez,  Source
outer dense fiber of sperm tails 255950.1280.2735No
104CDC27NACDC27
Entrez,  Source
cell division cycle 2756380.1230.2721No
105TMPONATMPO
Entrez,  Source
thymopoietin56480.1220.2731No
106ESPL1NAESPL1
Entrez,  Source
extra spindle poles like 1 (S. cerevisiae)56940.1170.2714No
107CHMP1ANA57670.1100.2677No
108CKS2NACKS2
Entrez,  Source
CDC28 protein kinase regulatory subunit 257900.1080.2675No
109KIF2CNAKIF2C
Entrez,  Source
kinesin family member 2C58290.1040.2662No
110CCNT1NACCNT1
Entrez,  Source
cyclin T158810.1000.2638No
111PLK4NAPLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)58990.0980.2639No
112AURKANAAURKA
Entrez,  Source
aurora kinase A59230.0950.2635No
113CENPENACENPE
Entrez,  Source
centromere protein E, 312kDa60040.0870.2589No
114CDC6NACDC6
Entrez,  Source
CDC6 cell division cycle 6 homolog (S. cerevisiae)60050.0870.2601No
115PURANAPURA
Entrez,  Source
purine-rich element binding protein A60630.0810.2570No
116HOXC10NAHOXC10
Entrez,  Source
homeobox C1060830.0790.2567No
117BARD1NABARD1
Entrez,  Source
BRCA1 associated RING domain 161540.0720.2525No
118CHAF1ANACHAF1A
Entrez,  Source
chromatin assembly factor 1, subunit A (p150)64220.0470.2336No
119TTKNATTK
Entrez,  Source
TTK protein kinase64320.0460.2336No
120WRNNAWRN
Entrez,  Source
Werner syndrome65400.0340.2262No
121ILF3NAILF3
Entrez,  Source
interleukin enhancer binding factor 3, 90kDa65420.0340.2266No
122SMC4NASMC4
Entrez,  Source
structural maintenance of chromosomes 465930.0290.2233No
123TACC3NATACC3
Entrez,  Source
transforming, acidic coiled-coil containing protein 366130.0270.2223No
124PAPD7NA66630.0220.2190No
125MEIS2NAMEIS2
Entrez,  Source
Meis1, myeloid ecotropic viral integration site 1 homolog 2 (mouse)67900.0080.2099No
126RACGAP1NARACGAP1
Entrez,  Source
Rac GTPase activating protein 168650.0000.2045No
127EFNA5NAEFNA5
Entrez,  Source
ephrin-A56893-0.0030.2025No
128CBX1NACBX1
Entrez,  Source
chromobox homolog 1 (HP1 beta homolog Drosophila )6907-0.0050.2016No
129TRA2BNA6976-0.0120.1968No
130ABL1NAABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 16995-0.0140.1957No
131TLE3NATLE3
Entrez,  Source
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)7029-0.0170.1935No
132MYBL2NAMYBL2
Entrez,  Source
v-myb myeloblastosis viral oncogene homolog (avian)-like 27176-0.0300.1832No
133RPA2NARPA2
Entrez,  Source
replication protein A2, 32kDa7216-0.0350.1808No
134CENPANACENPA
Entrez,  Source
centromere protein A7370-0.0530.1703No
135SMARCC1NASMARCC1
Entrez,  Source
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 17486-0.0650.1628No
136MAPK14NAMAPK14
Entrez,  Source
mitogen-activated protein kinase 147577-0.0730.1572No
137PDS5BNA7580-0.0740.1581No
138KIF15NAKIF15
Entrez,  Source
kinesin family member 157713-0.0850.1496No
139CUL5NACUL5
Entrez,  Source
cullin 57826-0.0970.1427No
140KIF22NAKIF22
Entrez,  Source
kinesin family member 227831-0.0980.1437No
141SLC38A1NASLC38A1
Entrez,  Source
solute carrier family 38, member 17847-0.0990.1440No
142MARCKSNAMARCKS
Entrez,  Source
myristoylated alanine-rich protein kinase C substrate7910-0.1050.1409No
143MAD2L1NAMAD2L1
Entrez,  Source
MAD2 mitotic arrest deficient-like 1 (yeast)7922-0.1060.1416No
144HMMRNAHMMR
Entrez,  Source
hyaluronan-mediated motility receptor (RHAMM)8010-0.1150.1368No
145DTYMKNADTYMK
Entrez,  Source
deoxythymidylate kinase (thymidylate kinase)8050-0.1210.1356No
146GINS2NAGINS2
Entrez,  Source
GINS complex subunit 2 (Psf2 homolog)8053-0.1210.1371No
147NUMA1NANUMA1
Entrez,  Source
nuclear mitotic apparatus protein 18277-0.1450.1227No
148RAD54LNARAD54L
Entrez,  Source
RAD54-like (S. cerevisiae)8279-0.1450.1246No
149NEK2NANEK2
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 28320-0.1480.1237No
150MCM2NAMCM2
Entrez,  Source
MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)8382-0.1550.1214No
151H2AFVNAH2AFV
Entrez,  Source
H2A histone family, member V8394-0.1570.1228No
152LIG3NALIG3
Entrez,  Source
ligase III, DNA, ATP-dependent8412-0.1590.1237No
153NDC80NA8545-0.1730.1164No
154CENPFNACENPF
Entrez,  Source
centromere protein F, 350/400ka (mitosin)8548-0.1730.1186No
155HMGB3NAHMGB3
Entrez,  Source
high-mobility group box 38556-0.1740.1205No
156PRPF4BNAPRPF4B
Entrez,  Source
PRP4 pre-mRNA processing factor 4 homolog B (yeast)8636-0.1830.1172No
157ATRXNAATRX
Entrez,  Source
alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)8803-0.2030.1079No
158E2F2NAE2F2
Entrez,  Source
E2F transcription factor 28870-0.2110.1059No
159PAFAH1B1NAPAFAH1B1
Entrez,  Source
platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa8914-0.2150.1057No
160DMDNADMD
Entrez,  Source
dystrophin (muscular dystrophy, Duchenne and Becker types)8927-0.2170.1078No
161CDKN2CNACDKN2C
Entrez,  Source
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)8975-0.2230.1075No
162SRSF2NA9135-0.2410.0991No
163CHEK1NACHEK1
Entrez,  Source
CHK1 checkpoint homolog (S. pombe)9140-0.2420.1022No
164BIRC5NABIRC5
Entrez,  Source
baculoviral IAP repeat-containing 5 (survivin)9183-0.2480.1025No
165POLA2NAPOLA2
Entrez,  Source
polymerase (DNA directed), alpha 2 (70kD subunit)9324-0.2670.0959No
166TOP2ANATOP2A
Entrez,  Source
topoisomerase (DNA) II alpha 170kDa9333-0.2680.0990No
167POLENAPOLE
Entrez,  Source
polymerase (DNA directed), epsilon9401-0.2790.0979No
168CASP8AP2NACASP8AP2
Entrez,  Source
CASP8 associated protein 29532-0.2990.0925No
169MEIS1NAMEIS1
Entrez,  Source
Meis1, myeloid ecotropic viral integration site 1 homolog (mouse)9635-0.3120.0893No
170MYCNAMYC
Entrez,  Source
v-myc myelocytomatosis viral oncogene homolog (avian)9860-0.3460.0776No
171MCM6NAMCM6
Entrez,  Source
MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)9910-0.3510.0789No
172PRIM2NA10064-0.3740.0728No
173MCM3NAMCM3
Entrez,  Source
MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)10230-0.3990.0662No
174CCNB2NACCNB2
Entrez,  Source
cyclin B210443-0.4340.0566No
175PRC1NAPRC1
Entrez,  Source
protein regulator of cytokinesis 110560-0.4510.0543No
176PTTG1NAPTTG1
Entrez,  Source
pituitary tumor-transforming 110586-0.4560.0587No
177CDKN3NACDKN3
Entrez,  Source
cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)10665-0.4700.0595No
178EXO1NAEXO1
Entrez,  Source
exonuclease 110782-0.4900.0577No
179ARID4ANAARID4A
Entrez,  Source
AT rich interactive domain 4A (RBP1-like)10878-0.5060.0577No
180H2AFZNAH2AFZ
Entrez,  Source
H2A histone family, member Z11093-0.5450.0495No
181PBKNAPBK
Entrez,  Source
PDZ binding kinase11280-0.5810.0439No
182RAD21NARAD21
Entrez,  Source
RAD21 homolog (S. pombe)11353-0.5950.0468No
183MCM5NAMCM5
Entrez,  Source
MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)11408-0.6070.0511No
184EGFNAEGF
Entrez,  Source
epidermal growth factor (beta-urogastrone)11460-0.6160.0559No
185KATNA1NAKATNA1
Entrez,  Source
katanin p60 (ATPase-containing) subunit A 111520-0.6270.0602No
186CDC45NA11553-0.6370.0666No
187CUL4ANACUL4A
Entrez,  Source
cullin 4A11708-0.6730.0645No
188STMN1NASTMN1
Entrez,  Source
stathmin 1/oncoprotein 1811874-0.7170.0623No
189CDKN1BNACDKN1B
Entrez,  Source
cyclin-dependent kinase inhibitor 1B (p27, Kip1)12505-0.9420.0291No
190E2F1NAE2F1
Entrez,  Source
E2F transcription factor 112754-1.0650.0255No
191FOXN3NA12848-1.1200.0341No
192SLC7A5NASLC7A5
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 513086-1.2880.0344No
193NUSAP1NANUSAP1
Entrez,  Source
nucleolar and spindle associated protein 113270-1.4800.0413No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_G2M_CHECKPOINT   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_G2M_CHECKPOINT: Random ES distribution   
Gene set null distribution of ES for HALLMARK_G2M_CHECKPOINT