Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | HALLMARK_FATTY_ACID_METABOLISM |
| Enrichment Score (ES) | -0.4416328 |
| Normalized Enrichment Score (NES) | -1.7083663 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0068544135 |
| FWER p-Value | 0.036 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CYP1A1 | NA | CYP1A1 Entrez, Source | cytochrome P450, family 1, subfamily A, polypeptide 1 | 122 | 2.664 | 0.0240 | No |
| 2 | S100A10 | NA | S100A10 Entrez, Source | S100 calcium binding protein A10 | 537 | 1.265 | 0.0094 | No |
| 3 | HSPH1 | NA | HSPH1 Entrez, Source | heat shock 105kDa/110kDa protein 1 | 541 | 1.262 | 0.0247 | No |
| 4 | UGDH | NA | UGDH Entrez, Source | UDP-glucose dehydrogenase | 577 | 1.204 | 0.0371 | No |
| 5 | ODC1 | NA | ODC1 Entrez, Source | ornithine decarboxylase 1 | 611 | 1.172 | 0.0491 | No |
| 6 | MAOA | NA | MAOA Entrez, Source | monoamine oxidase A | 855 | 0.975 | 0.0434 | No |
| 7 | CD1D | NA | CD1D Entrez, Source | CD1d molecule | 1162 | 0.827 | 0.0313 | No |
| 8 | SMS | NA | SMS Entrez, Source | spermine synthase | 1517 | 0.711 | 0.0142 | No |
| 9 | CEL | NA | CEL Entrez, Source | carboxyl ester lipase (bile salt-stimulated lipase) | 1636 | 0.677 | 0.0140 | No |
| 10 | CBR3 | NA | CBR3 Entrez, Source | carbonyl reductase 3 | 2172 | 0.557 | -0.0182 | No |
| 11 | NBN | NA | NBN Entrez, Source | nibrin | 2302 | 0.533 | -0.0210 | No |
| 12 | HSP90AA1 | NA | HSP90AA1 Entrez, Source | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 2335 | 0.527 | -0.0169 | No |
| 13 | HCCS | NA | HCCS Entrez, Source | holocytochrome c synthase (cytochrome c heme-lyase) | 2494 | 0.501 | -0.0222 | No |
| 14 | IL4I1 | NA | IL4I1 Entrez, Source | interleukin 4 induced 1 | 2740 | 0.461 | -0.0344 | No |
| 15 | CCDC58 | NA | CCDC58 Entrez, Source | coiled-coil domain containing 58 | 2869 | 0.439 | -0.0383 | No |
| 16 | ACSL4 | NA | ACSL4 Entrez, Source | acyl-CoA synthetase long-chain family member 4 | 3026 | 0.418 | -0.0445 | No |
| 17 | ALDH3A1 | NA | ALDH3A1 Entrez, Source | aldehyde dehydrogenase 3 family, memberA1 | 3480 | 0.356 | -0.0732 | No |
| 18 | HMGCS1 | NA | HMGCS1 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | 3649 | 0.338 | -0.0813 | No |
| 19 | ACSL5 | NA | ACSL5 Entrez, Source | acyl-CoA synthetase long-chain family member 5 | 4128 | 0.284 | -0.1127 | No |
| 20 | UROD | NA | UROD Entrez, Source | uroporphyrinogen decarboxylase | 4365 | 0.258 | -0.1267 | No |
| 21 | CPT1A | NA | CPT1A Entrez, Source | carnitine palmitoyltransferase 1A (liver) | 4433 | 0.250 | -0.1285 | No |
| 22 | YWHAH | NA | YWHAH Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | 4514 | 0.241 | -0.1314 | No |
| 23 | MGLL | NA | MGLL Entrez, Source | monoglyceride lipase | 4876 | 0.204 | -0.1552 | No |
| 24 | METAP1 | NA | METAP1 Entrez, Source | methionyl aminopeptidase 1 | 4944 | 0.198 | -0.1576 | No |
| 25 | PSME1 | NA | PSME1 Entrez, Source | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | 4947 | 0.197 | -0.1553 | No |
| 26 | ADSL | NA | ADSL Entrez, Source | adenylosuccinate lyase | 5112 | 0.180 | -0.1651 | No |
| 27 | PTS | NA | PTS Entrez, Source | 6-pyruvoyltetrahydropterin synthase | 5188 | 0.172 | -0.1684 | No |
| 28 | DLST | NA | DLST Entrez, Source | dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) | 5346 | 0.157 | -0.1779 | No |
| 29 | PTPRG | NA | PTPRG Entrez, Source | protein tyrosine phosphatase, receptor type, G | 5692 | 0.117 | -0.2017 | No |
| 30 | ALDOA | NA | ALDOA Entrez, Source | aldolase A, fructose-bisphosphate | 5880 | 0.100 | -0.2141 | No |
| 31 | HSD17B10 | NA | 6177 | 0.069 | -0.2349 | No | ||
| 32 | NSDHL | NA | NSDHL Entrez, Source | NAD(P) dependent steroid dehydrogenase-like | 6215 | 0.065 | -0.2367 | No |
| 33 | RETSAT | NA | RETSAT Entrez, Source | retinol saturase (all-trans-retinol 13,14-reductase) | 6362 | 0.053 | -0.2467 | No |
| 34 | LDHA | NA | LDHA Entrez, Source | lactate dehydrogenase A | 6424 | 0.047 | -0.2506 | No |
| 35 | CBR1 | NA | CBR1 Entrez, Source | carbonyl reductase 1 | 6498 | 0.039 | -0.2555 | No |
| 36 | NTHL1 | NA | NTHL1 Entrez, Source | nth endonuclease III-like 1 (E. coli) | 6667 | 0.021 | -0.2675 | No |
| 37 | UBE2L6 | NA | UBE2L6 Entrez, Source | ubiquitin-conjugating enzyme E2L 6 | 6768 | 0.010 | -0.2746 | No |
| 38 | CYP4A11 | NA | CYP4A11 Entrez, Source | cytochrome P450, family 4, subfamily A, polypeptide 11 | 6797 | 0.007 | -0.2766 | No |
| 39 | RAP1GDS1 | NA | RAP1GDS1 Entrez, Source | RAP1, GTP-GDP dissociation stimulator 1 | 6810 | 0.006 | -0.2774 | No |
| 40 | GLUL | NA | GLUL Entrez, Source | glutamate-ammonia ligase (glutamine synthetase) | 7897 | -0.104 | -0.3554 | No |
| 41 | DHCR24 | NA | DHCR24 Entrez, Source | 24-dehydrocholesterol reductase | 8270 | -0.144 | -0.3808 | No |
| 42 | ME1 | NA | ME1 Entrez, Source | malic enzyme 1, NADP(+)-dependent, cytosolic | 8293 | -0.146 | -0.3806 | No |
| 43 | ELOVL5 | NA | ELOVL5 Entrez, Source | ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast) | 8468 | -0.166 | -0.3912 | No |
| 44 | PRDX6 | NA | PRDX6 Entrez, Source | peroxiredoxin 6 | 8585 | -0.178 | -0.3975 | No |
| 45 | ACAA1 | NA | ACAA1 Entrez, Source | acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase) | 8688 | -0.190 | -0.4026 | No |
| 46 | RDH11 | NA | RDH11 Entrez, Source | retinol dehydrogenase 11 (all-trans/9-cis/11-cis) | 8706 | -0.192 | -0.4015 | No |
| 47 | ADIPOR2 | NA | ADIPOR2 Entrez, Source | adiponectin receptor 2 | 8728 | -0.194 | -0.4006 | No |
| 48 | CRYZ | NA | CRYZ Entrez, Source | crystallin, zeta (quinone reductase) | 8732 | -0.195 | -0.3984 | No |
| 49 | GAPDHS | NA | GAPDHS Entrez, Source | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic | 8781 | -0.200 | -0.3994 | No |
| 50 | MLYCD | NA | MLYCD Entrez, Source | malonyl-CoA decarboxylase | 8788 | -0.201 | -0.3974 | No |
| 51 | APEX1 | NA | APEX1 Entrez, Source | APEX nuclease (multifunctional DNA repair enzyme) 1 | 8798 | -0.203 | -0.3956 | No |
| 52 | VNN1 | NA | VNN1 Entrez, Source | vanin 1 | 8859 | -0.209 | -0.3974 | No |
| 53 | GPD2 | NA | GPD2 Entrez, Source | glycerol-3-phosphate dehydrogenase 2 (mitochondrial) | 8930 | -0.218 | -0.3998 | No |
| 54 | INMT | NA | INMT Entrez, Source | indolethylamine N-methyltransferase | 8946 | -0.220 | -0.3982 | No |
| 55 | PCBD1 | NA | PCBD1 Entrez, Source | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) | 8982 | -0.224 | -0.3980 | No |
| 56 | BMPR1B | NA | BMPR1B Entrez, Source | bone morphogenetic protein receptor, type IB | 9027 | -0.229 | -0.3983 | No |
| 57 | UROS | NA | UROS Entrez, Source | uroporphyrinogen III synthase (congenital erythropoietic porphyria) | 9045 | -0.231 | -0.3967 | No |
| 58 | HSDL2 | NA | HSDL2 Entrez, Source | hydroxysteroid dehydrogenase like 2 | 9176 | -0.247 | -0.4032 | No |
| 59 | CPT2 | NA | CPT2 Entrez, Source | carnitine palmitoyltransferase II | 9235 | -0.255 | -0.4043 | No |
| 60 | SUCLA2 | NA | SUCLA2 Entrez, Source | succinate-CoA ligase, ADP-forming, beta subunit | 9278 | -0.260 | -0.4041 | No |
| 61 | SERINC1 | NA | SERINC1 Entrez, Source | serine incorporator 1 | 9305 | -0.264 | -0.4028 | No |
| 62 | NCAPH2 | NA | NCAPH2 Entrez, Source | non-SMC condensin II complex, subunit H2 | 9413 | -0.281 | -0.4071 | No |
| 63 | LGALS1 | NA | LGALS1 Entrez, Source | lectin, galactoside-binding, soluble, 1 (galectin 1) | 9431 | -0.283 | -0.4048 | No |
| 64 | IDH3G | NA | IDH3G Entrez, Source | isocitrate dehydrogenase 3 (NAD+) gamma | 9487 | -0.293 | -0.4052 | No |
| 65 | ALDH3A2 | NA | ALDH3A2 Entrez, Source | aldehyde dehydrogenase 3 family, member A2 | 9636 | -0.312 | -0.4122 | No |
| 66 | FH | NA | FH Entrez, Source | fumarate hydratase | 9680 | -0.318 | -0.4114 | No |
| 67 | DLD | NA | DLD Entrez, Source | dihydrolipoamide dehydrogenase | 9719 | -0.325 | -0.4102 | No |
| 68 | BLVRA | NA | BLVRA Entrez, Source | biliverdin reductase A | 9761 | -0.331 | -0.4091 | No |
| 69 | PDHA1 | NA | PDHA1 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 1 | 9820 | -0.339 | -0.4091 | No |
| 70 | MIF | NA | MIF Entrez, Source | macrophage migration inhibitory factor (glycosylation-inhibiting factor) | 9983 | -0.361 | -0.4165 | No |
| 71 | HIBCH | NA | HIBCH Entrez, Source | 3-hydroxyisobutyryl-Coenzyme A hydrolase | 9987 | -0.362 | -0.4122 | No |
| 72 | SLC22A5 | NA | SLC22A5 Entrez, Source | solute carrier family 22 (organic cation transporter), member 5 | 10065 | -0.374 | -0.4132 | No |
| 73 | ECI2 | NA | 10219 | -0.397 | -0.4195 | No | ||
| 74 | ACADVL | NA | ACADVL Entrez, Source | acyl-Coenzyme A dehydrogenase, very long chain | 10279 | -0.407 | -0.4188 | No |
| 75 | MDH2 | NA | MDH2 Entrez, Source | malate dehydrogenase 2, NAD (mitochondrial) | 10593 | -0.456 | -0.4360 | Yes |
| 76 | ACAA2 | NA | ACAA2 Entrez, Source | acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) | 10640 | -0.466 | -0.4336 | Yes |
| 77 | HSD17B11 | NA | 10655 | -0.468 | -0.4288 | Yes | ||
| 78 | EPHX1 | NA | EPHX1 Entrez, Source | epoxide hydrolase 1, microsomal (xenobiotic) | 10704 | -0.476 | -0.4265 | Yes |
| 79 | EHHADH | NA | EHHADH Entrez, Source | enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase | 10749 | -0.483 | -0.4237 | Yes |
| 80 | SUCLG2 | NA | SUCLG2 Entrez, Source | succinate-CoA ligase, GDP-forming, beta subunit | 10808 | -0.494 | -0.4218 | Yes |
| 81 | ENO2 | NA | ENO2 Entrez, Source | enolase 2 (gamma, neuronal) | 10819 | -0.496 | -0.4165 | Yes |
| 82 | SDHC | NA | SDHC Entrez, Source | succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa | 10930 | -0.514 | -0.4181 | Yes |
| 83 | ALDH9A1 | NA | ALDH9A1 Entrez, Source | aldehyde dehydrogenase 9 family, member A1 | 10955 | -0.519 | -0.4135 | Yes |
| 84 | FABP2 | NA | FABP2 Entrez, Source | fatty acid binding protein 2, intestinal | 10994 | -0.527 | -0.4097 | Yes |
| 85 | H2AFZ | NA | H2AFZ Entrez, Source | H2A histone family, member Z | 11093 | -0.545 | -0.4102 | Yes |
| 86 | AQP7 | NA | AQP7 Entrez, Source | aquaporin 7 | 11110 | -0.547 | -0.4046 | Yes |
| 87 | GABARAPL1 | NA | GABARAPL1 Entrez, Source | GABA(A) receptor-associated protein like 1 | 11242 | -0.573 | -0.4071 | Yes |
| 88 | HADHB | NA | HADHB Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit | 11304 | -0.585 | -0.4043 | Yes |
| 89 | D2HGDH | NA | D2HGDH Entrez, Source | D-2-hydroxyglutarate dehydrogenase | 11305 | -0.585 | -0.3971 | Yes |
| 90 | GRHPR | NA | GRHPR Entrez, Source | glyoxylate reductase/hydroxypyruvate reductase | 11352 | -0.594 | -0.3931 | Yes |
| 91 | ERP29 | NA | ERP29 Entrez, Source | endoplasmic reticulum protein 29 | 11394 | -0.603 | -0.3887 | Yes |
| 92 | HADH | NA | HADH Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase | 11456 | -0.615 | -0.3855 | Yes |
| 93 | ACOX1 | NA | ACOX1 Entrez, Source | acyl-Coenzyme A oxidase 1, palmitoyl | 11472 | -0.619 | -0.3790 | Yes |
| 94 | BPHL | NA | BPHL Entrez, Source | biphenyl hydrolase-like (serine hydrolase; breast epithelial mucin-associated antigen) | 11508 | -0.625 | -0.3738 | Yes |
| 95 | HSD17B7 | NA | HSD17B7 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 7 | 11557 | -0.637 | -0.3694 | Yes |
| 96 | FASN | NA | FASN Entrez, Source | fatty acid synthase | 11589 | -0.645 | -0.3637 | Yes |
| 97 | OSTC | NA | 11635 | -0.658 | -0.3589 | Yes | ||
| 98 | GCDH | NA | GCDH Entrez, Source | glutaryl-Coenzyme A dehydrogenase | 11682 | -0.668 | -0.3540 | Yes |
| 99 | HSD17B4 | NA | HSD17B4 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 4 | 11867 | -0.715 | -0.3586 | Yes |
| 100 | ECHS1 | NA | ECHS1 Entrez, Source | enoyl Coenzyme A hydratase, short chain, 1, mitochondrial | 11963 | -0.742 | -0.3564 | Yes |
| 101 | CD36 | NA | CD36 Entrez, Source | CD36 molecule (thrombospondin receptor) | 11998 | -0.756 | -0.3495 | Yes |
| 102 | SUCLG1 | NA | SUCLG1 Entrez, Source | succinate-CoA ligase, GDP-forming, alpha subunit | 12083 | -0.781 | -0.3460 | Yes |
| 103 | ACADM | NA | ACADM Entrez, Source | acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain | 12101 | -0.786 | -0.3376 | Yes |
| 104 | ECI1 | NA | 12174 | -0.813 | -0.3328 | Yes | ||
| 105 | ACO2 | NA | ACO2 Entrez, Source | aconitase 2, mitochondrial | 12178 | -0.814 | -0.3229 | Yes |
| 106 | SDHD | NA | SDHD Entrez, Source | succinate dehydrogenase complex, subunit D, integral membrane protein | 12186 | -0.815 | -0.3134 | Yes |
| 107 | PDHB | NA | PDHB Entrez, Source | pyruvate dehydrogenase (lipoamide) beta | 12302 | -0.852 | -0.3113 | Yes |
| 108 | ACOT2 | NA | ACOT2 Entrez, Source | acyl-CoA thioesterase 2 | 12350 | -0.874 | -0.3039 | Yes |
| 109 | ETFDH | NA | ETFDH Entrez, Source | electron-transferring-flavoprotein dehydrogenase | 12412 | -0.897 | -0.2973 | Yes |
| 110 | ACOT8 | NA | ACOT8 Entrez, Source | acyl-CoA thioesterase 8 | 12438 | -0.910 | -0.2879 | Yes |
| 111 | MDH1 | NA | MDH1 Entrez, Source | malate dehydrogenase 1, NAD (soluble) | 12448 | -0.914 | -0.2772 | Yes |
| 112 | HMGCL | NA | HMGCL Entrez, Source | 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) | 12509 | -0.943 | -0.2700 | Yes |
| 113 | AUH | NA | AUH Entrez, Source | AU RNA binding protein/enoyl-Coenzyme A hydratase | 12524 | -0.949 | -0.2593 | Yes |
| 114 | MCEE | NA | MCEE Entrez, Source | methylmalonyl CoA epimerase | 12681 | -1.026 | -0.2580 | Yes |
| 115 | AOC3 | NA | AOC3 Entrez, Source | amine oxidase, copper containing 3 (vascular adhesion protein 1) | 12711 | -1.041 | -0.2473 | Yes |
| 116 | ACAT2 | NA | ACAT2 Entrez, Source | acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) | 12819 | -1.099 | -0.2415 | Yes |
| 117 | SDHA | NA | SDHA Entrez, Source | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) | 12856 | -1.123 | -0.2303 | Yes |
| 118 | DECR1 | NA | DECR1 Entrez, Source | 2,4-dienoyl CoA reductase 1, mitochondrial | 12865 | -1.131 | -0.2169 | Yes |
| 119 | ACADS | NA | ACADS Entrez, Source | acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain | 12961 | -1.190 | -0.2091 | Yes |
| 120 | PPARA | NA | PPARA Entrez, Source | peroxisome proliferative activated receptor, alpha | 12967 | -1.194 | -0.1948 | Yes |
| 121 | GPD1 | NA | GPD1 Entrez, Source | glycerol-3-phosphate dehydrogenase 1 (soluble) | 13037 | -1.246 | -0.1844 | Yes |
| 122 | IDI1 | NA | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 13058 | -1.264 | -0.1703 | Yes |
| 123 | IDH1 | NA | IDH1 Entrez, Source | isocitrate dehydrogenase 1 (NADP+), soluble | 13083 | -1.285 | -0.1561 | Yes |
| 124 | ACSM3 | NA | ACSM3 Entrez, Source | acyl-CoA synthetase medium-chain family member 3 | 13112 | -1.305 | -0.1421 | Yes |
| 125 | ALAD | NA | ALAD Entrez, Source | aminolevulinate, delta-, dehydratase | 13113 | -1.307 | -0.1260 | Yes |
| 126 | CRAT | NA | CRAT Entrez, Source | carnitine acetyltransferase | 13125 | -1.314 | -0.1105 | Yes |
| 127 | BCKDHB | NA | BCKDHB Entrez, Source | branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease) | 13135 | -1.324 | -0.0948 | Yes |
| 128 | CPOX | NA | CPOX Entrez, Source | coproporphyrinogen oxidase | 13319 | -1.535 | -0.0892 | Yes |
| 129 | ECH1 | NA | ECH1 Entrez, Source | enoyl Coenzyme A hydratase 1, peroxisomal | 13349 | -1.579 | -0.0719 | Yes |
| 130 | TP53INP2 | NA | TP53INP2 Entrez, Source | tumor protein p53 inducible nuclear protein 2 | 13504 | -1.830 | -0.0605 | Yes |
| 131 | REEP6 | NA | REEP6 Entrez, Source | receptor accessory protein 6 | 13536 | -1.900 | -0.0393 | Yes |
| 132 | ACSL1 | NA | ACSL1 Entrez, Source | acyl-CoA synthetase long-chain family member 1 | 13590 | -2.037 | -0.0181 | Yes |
| 133 | ENO3 | NA | ENO3 Entrez, Source | enolase 3 (beta, muscle) | 13755 | -2.899 | 0.0058 | Yes |
