Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1gfp
GeneSetHALLMARK_ESTROGEN_RESPONSE_LATE
Enrichment Score (ES)-0.4020942
Normalized Enrichment Score (NES)-1.6101794
Nominal p-value0.0
FDR q-value0.012941612
FWER p-Value0.102
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_ESTROGEN_RESPONSE_LATE   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1ACOX2NAACOX2
Entrez,  Source
acyl-Coenzyme A oxidase 2, branched chain423.7740.0231No
2ISG20NAISG20
Entrez,  Source
interferon stimulated exonuclease gene 20kDa563.4020.0457No
3DHRS2NADHRS2
Entrez,  Source
dehydrogenase/reductase (SDR family) member 21022.9370.0628No
4AREGNAAREG
Entrez,  Source
amphiregulin (schwannoma-derived growth factor)1132.7700.0813No
5KRT13NAKRT13
Entrez,  Source
keratin 131602.4370.0948No
6GJB3NAGJB3
Entrez,  Source
gap junction protein, beta 3, 31kDa (connexin 31)2431.9770.1025No
7LAMC2NALAMC2
Entrez,  Source
laminin, gamma 22601.9310.1147No
8IGFBP4NAIGFBP4
Entrez,  Source
insulin-like growth factor binding protein 42671.8880.1274No
9CD44NACD44
Entrez,  Source
CD44 molecule (Indian blood group)3361.6590.1339No
10TPBGNATPBG
Entrez,  Source
trophoblast glycoprotein3971.5080.1400No
11MICBNAMICB
Entrez,  Source
MHC class I polypeptide-related sequence B5201.2910.1400No
12KLF4NAKLF4
Entrez,  Source
Kruppel-like factor 4 (gut)5661.2220.1452No
13UGDHNAUGDH
Entrez,  Source
UDP-glucose dehydrogenase5771.2040.1528No
14IL6STNAIL6ST
Entrez,  Source
interleukin 6 signal transducer (gp130, oncostatin M receptor)6451.1420.1558No
15ZFP36NAZFP36
Entrez,  Source
zinc finger protein 36, C3H type, homolog (mouse)6461.1400.1637No
16FRKNAFRK
Entrez,  Source
fyn-related kinase6561.1350.1709No
17CYP26B1NACYP26B1
Entrez,  Source
cytochrome P450, family 26, subfamily B, polypeptide 16591.1310.1786No
18PTGESNAPTGES
Entrez,  Source
prostaglandin E synthase6901.1070.1841No
19FLNBNAFLNB
Entrez,  Source
filamin B, beta (actin binding protein 278)7001.0990.1911No
20FAM102ANAFAM102A
Entrez,  Source
family with sequence similarity 102, member A7341.0620.1960No
21JAK2NAJAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)7561.0450.2017No
22MYOFNA8710.9600.2001No
23WFS1NAWFS1
Entrez,  Source
Wolfram syndrome 1 (wolframin)9040.9420.2042No
24PPIFNAPPIF
Entrez,  Source
peptidylprolyl isomerase F (cyclophilin F)9240.9310.2093No
25CCND1NACCND1
Entrez,  Source
cyclin D110330.8770.2075No
26KCNK5NAKCNK5
Entrez,  Source
potassium channel, subfamily K, member 511060.8490.2081No
27TRIM29NATRIM29
Entrez,  Source
tripartite motif-containing 2913520.7560.1954No
28FKBP4NAFKBP4
Entrez,  Source
FK506 binding protein 4, 59kDa15890.6920.1829No
29CDC20NACDC20
Entrez,  Source
CDC20 cell division cycle 20 homolog (S. cerevisiae)15960.6890.1873No
30SFNNASFN
Entrez,  Source
stratifin17230.6520.1826No
31PRSS23NAPRSS23
Entrez,  Source
protease, serine, 2317700.6390.1837No
32SLC29A1NASLC29A1
Entrez,  Source
solute carrier family 29 (nucleoside transporters), member 123230.5290.1469No
33TFF1NATFF1
Entrez,  Source
trefoil factor 1 (breast cancer, estrogen-inducible sequence expressed in)25930.4850.1306No
34LSRNALSR
Entrez,  Source
lipolysis stimulated lipoprotein receptor26390.4770.1306No
35ABHD2NAABHD2
Entrez,  Source
abhydrolase domain containing 227540.4600.1255No
36JAK1NAJAK1
Entrez,  Source
Janus kinase 1 (a protein tyrosine kinase)29270.4300.1159No
37HSPB8NAHSPB8
Entrez,  Source
heat shock 22kDa protein 830860.4100.1072No
38SLC16A1NASLC16A1
Entrez,  Source
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)31100.4070.1083No
39HSPA4LNAHSPA4L
Entrez,  Source
heat shock 70kDa protein 4-like32090.3920.1039No
40STILNASTIL
Entrez,  Source
SCL/TAL1 interrupting locus32640.3860.1026No
41CAV1NACAV1
Entrez,  Source
caveolin 1, caveolae protein, 22kDa34830.3560.0891No
42NXT1NANXT1
Entrez,  Source
NTF2-like export factor 135460.3490.0870No
43FABP5NAFABP5
Entrez,  Source
fatty acid binding protein 5 (psoriasis-associated)36700.3360.0803No
44DNAJC1NADNAJC1
Entrez,  Source
DnaJ (Hsp40) homolog, subfamily C, member 139060.3090.0653No
45FOXC1NAFOXC1
Entrez,  Source
forkhead box C140010.2970.0604No
46PERPNAPERP
Entrez,  Source
PERP, TP53 apoptosis effector42200.2750.0464No
47MOCS2NAMOCS2
Entrez,  Source
molybdenum cofactor synthesis 245150.2410.0265No
48XRCC3NAXRCC3
Entrez,  Source
X-ray repair complementing defective repair in Chinese hamster cells 346130.2300.0210No
49TFAP2CNATFAP2C
Entrez,  Source
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)54260.148-0.0373No
50CISHNACISH
Entrez,  Source
cytokine inducible SH2-containing protein55180.138-0.0430No
51RBBP8NARBBP8
Entrez,  Source
retinoblastoma binding protein 857050.116-0.0558No
52SCUBE2NASCUBE2
Entrez,  Source
signal peptide, CUB domain, EGF-like 258020.107-0.0621No
53CDH1NACDH1
Entrez,  Source
cadherin 1, type 1, E-cadherin (epithelial)58590.102-0.0655No
54PLK4NAPLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)58990.098-0.0677No
55CA12NACA12
Entrez,  Source
carbonic anhydrase XII59780.090-0.0728No
56GALENAGALE
Entrez,  Source
UDP-galactose-4-epimerase59930.088-0.0732No
57CDC6NACDC6
Entrez,  Source
CDC6 cell division cycle 6 homolog (S. cerevisiae)60050.087-0.0734No
58METTL3NAMETTL3
Entrez,  Source
methyltransferase like 361560.072-0.0839No
59FKBP5NAFKBP5
Entrez,  Source
FK506 binding protein 563090.057-0.0946No
60SLC2A8NASLC2A8
Entrez,  Source
solute carrier family 2, (facilitated glucose transporter) member 863750.051-0.0990No
61GLANAGLA
Entrez,  Source
galactosidase, alpha64730.041-0.1058No
62RAPGEFL1NARAPGEFL1
Entrez,  Source
Rap guanine nucleotide exchange factor (GEF)-like 165320.036-0.1098No
63HPRT1NAHPRT1
Entrez,  Source
hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome)67760.009-0.1275No
64SIAH2NASIAH2
Entrez,  Source
seven in absentia homolog 2 (Drosophila)6918-0.006-0.1378No
65KLK10NAKLK10
Entrez,  Source
kallikrein 106919-0.006-0.1378No
66NCOR2NANCOR2
Entrez,  Source
nuclear receptor co-repressor 27018-0.016-0.1448No
67MAPTNAMAPT
Entrez,  Source
microtubule-associated protein tau7280-0.043-0.1636No
68NAB2NANAB2
Entrez,  Source
NGFI-A binding protein 2 (EGR1 binding protein 2)7298-0.045-0.1646No
69RABEP1NARABEP1
Entrez,  Source
rabaptin, RAB GTPase binding effector protein 17573-0.073-0.1841No
70PRLRNAPRLR
Entrez,  Source
prolactin receptor7590-0.074-0.1848No
71PAPSS2NAPAPSS2
Entrez,  Source
3'-phosphoadenosine 5'-phosphosulfate synthase 27625-0.078-0.1867No
72SORDNASORD
Entrez,  Source
sorbitol dehydrogenase7660-0.081-0.1886No
73KIF20ANAKIF20A
Entrez,  Source
kinesin family member 20A7809-0.095-0.1988No
74CACNA2D2NACACNA2D2
Entrez,  Source
calcium channel, voltage-dependent, alpha 2/delta subunit 27839-0.098-0.2002No
75PKP3NAPKP3
Entrez,  Source
plakophilin 37914-0.105-0.2049No
76TIAM1NATIAM1
Entrez,  Source
T-cell lymphoma invasion and metastasis 17923-0.106-0.2048No
77AMFRNAAMFR
Entrez,  Source
autocrine motility factor receptor7950-0.108-0.2059No
78GINS2NAGINS2
Entrez,  Source
GINS complex subunit 2 (Psf2 homolog)8053-0.121-0.2125No
79ITPK1NAITPK1
Entrez,  Source
inositol 1,3,4-triphosphate 5/6 kinase8183-0.134-0.2211No
80HRNAHR
Entrez,  Source
hairless homolog (mouse)8330-0.150-0.2307No
81SLC26A2NASLC26A2
Entrez,  Source
solute carrier family 26 (sulfate transporter), member 28371-0.154-0.2326No
82ELOVL5NAELOVL5
Entrez,  Source
ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)8468-0.166-0.2384No
83GALNAGAL
Entrez,  Source
galanin8475-0.166-0.2377No
84PGRNAPGR
Entrez,  Source
progesterone receptor8522-0.171-0.2399No
85ATP2B4NAATP2B4
Entrez,  Source
ATPase, Ca++ transporting, plasma membrane 48524-0.171-0.2388No
86DLG5NADLG5
Entrez,  Source
discs, large homolog 5 (Drosophila)8531-0.172-0.2380No
87MESTNAMEST
Entrez,  Source
mesoderm specific transcript homolog (mouse)8549-0.173-0.2381No
88BTG3NABTG3
Entrez,  Source
BTG family, member 38698-0.191-0.2476No
89SLC1A4NASLC1A4
Entrez,  Source
solute carrier family 1 (glutamate/neutral amino acid transporter), member 49038-0.230-0.2708No
90XBP1NAXBP1
Entrez,  Source
X-box binding protein 19068-0.233-0.2713No
91SLC9A3R1NASLC9A3R1
Entrez,  Source
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 19104-0.238-0.2722No
92NRIP1NANRIP1
Entrez,  Source
nuclear receptor interacting protein 19144-0.243-0.2734No
93TOP2ANATOP2A
Entrez,  Source
topoisomerase (DNA) II alpha 170kDa9333-0.268-0.2853No
94ALDH3A2NAALDH3A2
Entrez,  Source
aldehyde dehydrogenase 3 family, member A29636-0.312-0.3052No
95NPY1RNANPY1R
Entrez,  Source
neuropeptide Y receptor Y19640-0.313-0.3033No
96PRKAR2BNAPRKAR2B
Entrez,  Source
protein kinase, cAMP-dependent, regulatory, type II, beta9706-0.322-0.3058No
97RNASEH2ANARNASEH2A
Entrez,  Source
ribonuclease H2, subunit A9811-0.338-0.3110No
98SLC27A2NASLC27A2
Entrez,  Source
solute carrier family 27 (fatty acid transporter), member 29957-0.357-0.3192No
99SLC22A5NASLC22A5
Entrez,  Source
solute carrier family 22 (organic cation transporter), member 510065-0.374-0.3244No
100MYBNAMYB
Entrez,  Source
v-myb myeloblastosis viral oncogene homolog (avian)10386-0.424-0.3449No
101CYP4F11NACYP4F11
Entrez,  Source
cytochrome P450, family 4, subfamily F, polypeptide 1110661-0.470-0.3617No
102ETFBNAETFB
Entrez,  Source
electron-transfer-flavoprotein, beta polypeptide10709-0.477-0.3618No
103MAPK13NAMAPK13
Entrez,  Source
mitogen-activated protein kinase 1310850-0.502-0.3686No
104BCL2NABCL2
Entrez,  Source
B-cell CLL/lymphoma 210892-0.508-0.3680No
105CHPT1NACHPT1
Entrez,  Source
choline phosphotransferase 110893-0.508-0.3645No
106PLA2G16NA10896-0.508-0.3611No
107TPD52L1NATPD52L1
Entrez,  Source
tumor protein D52-like 110974-0.522-0.3632No
108TSTA3NATSTA3
Entrez,  Source
tissue specific transplantation antigen P35B10993-0.527-0.3608No
109DCXRNADCXR
Entrez,  Source
dicarbonyl/L-xylulose reductase11049-0.537-0.3611No
110SCARB1NASCARB1
Entrez,  Source
scavenger receptor class B, member 111081-0.543-0.3596No
111PLAC1NAPLAC1
Entrez,  Source
placenta-specific 111100-0.546-0.3572No
112RAB31NARAB31
Entrez,  Source
RAB31, member RAS oncogene family11358-0.595-0.3718No
113CD9NACD9
Entrez,  Source
CD9 molecule11497-0.623-0.3776No
114AGR2NAAGR2
Entrez,  Source
anterior gradient 2 homolog (Xenopus laevis)11544-0.634-0.3766No
115TOB1NATOB1
Entrez,  Source
transducer of ERBB2, 111787-0.694-0.3895No
116COX6CNACOX6C
Entrez,  Source
cytochrome c oxidase subunit VIc11796-0.698-0.3852No
117FDFT1NAFDFT1
Entrez,  Source
farnesyl-diphosphate farnesyltransferase 111896-0.723-0.3875No
118ARL3NAARL3
Entrez,  Source
ADP-ribosylation factor-like 312097-0.785-0.3967Yes
119UNC13BNAUNC13B
Entrez,  Source
unc-13 homolog B (C. elegans)12115-0.791-0.3924Yes
120DHCR7NADHCR7
Entrez,  Source
7-dehydrocholesterol reductase12147-0.804-0.3891Yes
121SNX10NASNX10
Entrez,  Source
sorting nexin 1012283-0.848-0.3931Yes
122HOMER2NAHOMER2
Entrez,  Source
homer homolog 2 (Drosophila)12321-0.861-0.3898Yes
123CELSR2NACELSR2
Entrez,  Source
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)12334-0.868-0.3847Yes
124EMP2NAEMP2
Entrez,  Source
epithelial membrane protein 212400-0.890-0.3833Yes
125AFF1NAAFF1
Entrez,  Source
AF4/FMR2 family, member 112402-0.891-0.3772Yes
126TSTNATST
Entrez,  Source
thiosulfate sulfurtransferase (rhodanese)12431-0.907-0.3729Yes
127BLVRBNABLVRB
Entrez,  Source
biliverdin reductase B (flavin reductase (NADPH))12510-0.944-0.3721Yes
128SCNN1ANASCNN1A
Entrez,  Source
sodium channel, nonvoltage-gated 1 alpha12518-0.947-0.3660Yes
129IL17RBNAIL17RB
Entrez,  Source
interleukin 17 receptor B12549-0.960-0.3616Yes
130SGK1NA12552-0.961-0.3551Yes
131DYNLT3NADYNLT3
Entrez,  Source
dynein, light chain, Tctex-type 312595-0.978-0.3514Yes
132LLGL2NALLGL2
Entrez,  Source
lethal giant larvae homolog 2 (Drosophila)12647-1.008-0.3481Yes
133TSPAN13NATSPAN13
Entrez,  Source
tetraspanin 1312693-1.032-0.3442Yes
134CLIC3NACLIC3
Entrez,  Source
chloride intracellular channel 312752-1.064-0.3411Yes
135PTPN6NAPTPN6
Entrez,  Source
protein tyrosine phosphatase, non-receptor type 612791-1.084-0.3364Yes
136SEMA3BNASEMA3B
Entrez,  Source
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B12853-1.122-0.3331Yes
137FGFR3NAFGFR3
Entrez,  Source
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)12973-1.198-0.3335Yes
138ADD3NAADD3
Entrez,  Source
adducin 3 (gamma)13003-1.217-0.3271Yes
139PDZK1NAPDZK1
Entrez,  Source
PDZ domain containing 113026-1.237-0.3202Yes
140BAG1NABAG1
Entrez,  Source
BCL2-associated athanogene13066-1.272-0.3142Yes
141SLC7A5NASLC7A5
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 513086-1.288-0.3067Yes
142IMPA2NAIMPA2
Entrez,  Source
inositol(myo)-1(or 4)-monophosphatase 213093-1.294-0.2981Yes
143ANXA9NAANXA9
Entrez,  Source
annexin A913127-1.317-0.2914Yes
144FARP1NAFARP1
Entrez,  Source
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)13153-1.343-0.2839Yes
145CKBNACKB
Entrez,  Source
creatine kinase, brain13162-1.352-0.2751Yes
146ABCA3NAABCA3
Entrez,  Source
ATP-binding cassette, sub-family A (ABC1), member 313179-1.375-0.2668Yes
147PTGER3NAPTGER3
Entrez,  Source
prostaglandin E receptor 3 (subtype EP3)13180-1.375-0.2573Yes
148TMPRSS3NATMPRSS3
Entrez,  Source
transmembrane protease, serine 313240-1.440-0.2516Yes
149ALDH3B1NAALDH3B1
Entrez,  Source
aldehyde dehydrogenase 3 family, member B113265-1.473-0.2431Yes
150PDCD4NAPDCD4
Entrez,  Source
programmed cell death 4 (neoplastic transformation inhibitor)13296-1.508-0.2349Yes
151OPN3NAOPN3
Entrez,  Source
opsin 3 (encephalopsin, panopsin)13338-1.567-0.2270Yes
152DUSP2NADUSP2
Entrez,  Source
dual specificity phosphatase 213368-1.602-0.2180Yes
153ST6GALNAC2NAST6GALNAC2
Entrez,  Source
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 213384-1.630-0.2078Yes
154IDH2NAIDH2
Entrez,  Source
isocitrate dehydrogenase 2 (NADP+), mitochondrial13440-1.724-0.1999Yes
155CCNA1NACCNA1
Entrez,  Source
cyclin A113467-1.757-0.1896Yes
156RPS6KA2NARPS6KA2
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 213473-1.764-0.1777Yes
157PLXNB1NAPLXNB1
Entrez,  Source
plexin B113494-1.800-0.1667Yes
158SULT2B1NASULT2B1
Entrez,  Source
sulfotransferase family, cytosolic, 2B, member 113538-1.902-0.1567Yes
159FOSNAFOS
Entrez,  Source
v-fos FBJ murine osteosarcoma viral oncogene homolog13543-1.911-0.1437Yes
160ST14NAST14
Entrez,  Source
suppression of tumorigenicity 14 (colon carcinoma)13551-1.938-0.1308Yes
161WISP2NAWISP2
Entrez,  Source
WNT1 inducible signaling pathway protein 213581-2.016-0.1189Yes
162DNAJC12NADNAJC12
Entrez,  Source
DnaJ (Hsp40) homolog, subfamily C, member 1213631-2.172-0.1074Yes
163TNNC1NATNNC1
Entrez,  Source
troponin C type 1 (slow)13657-2.279-0.0935Yes
164ASS1NAASS1
Entrez,  Source
argininosuccinate synthetase 113675-2.361-0.0783Yes
165ID2NAID2
Entrez,  Source
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein13694-2.466-0.0626Yes
166IGSF1NAIGSF1
Entrez,  Source
immunoglobulin superfamily, member 113697-2.473-0.0456Yes
167S100A9NAS100A9
Entrez,  Source
S100 calcium binding protein A913793-3.584-0.0277Yes
168OLFM1NAOLFM1
Entrez,  Source
olfactomedin 113822-4.4120.0009Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_ESTROGEN_RESPONSE_LATE   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_ESTROGEN_RESPONSE_LATE: Random ES distribution   
Gene set null distribution of ES for HALLMARK_ESTROGEN_RESPONSE_LATE