Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1w6a
GeneSetHALLMARK_ESTROGEN_RESPONSE_EARLY
Enrichment Score (ES)0.30066365
Normalized Enrichment Score (NES)1.3047017
Nominal p-value0.025
FDR q-value0.09352879
FWER p-Value0.677
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_ESTROGEN_RESPONSE_EARLY   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1DHRS2NADHRS2
Entrez,  Source
dehydrogenase/reductase (SDR family) member 21022.9370.0128Yes
2SLC1A1NASLC1A1
Entrez,  Source
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 11112.8190.0317Yes
3AREGNAAREG
Entrez,  Source
amphiregulin (schwannoma-derived growth factor)1132.7700.0508Yes
4KRT13NAKRT13
Entrez,  Source
keratin 131602.4370.0643Yes
5PMAIP1NAPMAIP1
Entrez,  Source
phorbol-12-myristate-13-acetate-induced protein 11702.3730.0801Yes
6LRIG1NALRIG1
Entrez,  Source
leucine-rich repeats and immunoglobulin-like domains 11712.3720.0965Yes
7IGFBP4NAIGFBP4
Entrez,  Source
insulin-like growth factor binding protein 42671.8880.1026Yes
8CD44NACD44
Entrez,  Source
CD44 molecule (Indian blood group)3361.6590.1090Yes
9PODXLNAPODXL
Entrez,  Source
podocalyxin-like3691.5640.1175Yes
10ARNAAR
Entrez,  Source
androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease)3721.5500.1281Yes
11TPBGNATPBG
Entrez,  Source
trophoblast glycoprotein3971.5080.1368Yes
12MYBL1NAMYBL1
Entrez,  Source
v-myb myeloblastosis viral oncogene homolog (avian)-like 14941.3220.1389Yes
13MICBNAMICB
Entrez,  Source
MHC class I polypeptide-related sequence B5201.2910.1460Yes
14KLF4NAKLF4
Entrez,  Source
Kruppel-like factor 4 (gut)5661.2220.1511Yes
15IL6STNAIL6ST
Entrez,  Source
interleukin 6 signal transducer (gp130, oncostatin M receptor)6451.1420.1533Yes
16TIPARPNATIPARP
Entrez,  Source
TCDD-inducible poly(ADP-ribose) polymerase6491.1380.1610Yes
17FRKNAFRK
Entrez,  Source
fyn-related kinase6561.1350.1684Yes
18BCL11BNABCL11B
Entrez,  Source
B-cell CLL/lymphoma 11B (zinc finger protein)6581.1310.1761Yes
19CYP26B1NACYP26B1
Entrez,  Source
cytochrome P450, family 26, subfamily B, polypeptide 16591.1310.1839Yes
20KRT18NAKRT18
Entrez,  Source
keratin 186641.1270.1914Yes
21PTGESNAPTGES
Entrez,  Source
prostaglandin E synthase6901.1070.1973Yes
22FLNBNAFLNB
Entrez,  Source
filamin B, beta (actin binding protein 278)7001.0990.2042Yes
23FAM102ANAFAM102A
Entrez,  Source
family with sequence similarity 102, member A7341.0620.2091Yes
24JAK2NAJAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)7561.0450.2148Yes
25HES1NAHES1
Entrez,  Source
hairy and enhancer of split 1, (Drosophila)7641.0380.2215Yes
26KAZNNA7851.0190.2271Yes
27WWC1NAWWC1
Entrez,  Source
WW, C2 and coiled-coil domain containing 17941.0100.2335Yes
28SYBUNA8091.0000.2394Yes
29MYOFNA8710.9600.2415Yes
30ELF1NAELF1
Entrez,  Source
E74-like factor 1 (ets domain transcription factor)8750.9590.2479Yes
31RRP12NA8870.9500.2537Yes
32WFS1NAWFS1
Entrez,  Source
Wolfram syndrome 1 (wolframin)9040.9420.2590Yes
33PPIFNAPPIF
Entrez,  Source
peptidylprolyl isomerase F (cyclophilin F)9240.9310.2641Yes
34STC2NASTC2
Entrez,  Source
stanniocalcin 29260.9310.2705Yes
35KRT8NAKRT8
Entrez,  Source
keratin 89490.9220.2752Yes
36CCND1NACCND1
Entrez,  Source
cyclin D110330.8770.2752Yes
37TSKUNA10380.8750.2810Yes
38GAB2NAGAB2
Entrez,  Source
GRB2-associated binding protein 210770.8600.2841Yes
39KCNK5NAKCNK5
Entrez,  Source
potassium channel, subfamily K, member 511060.8490.2879Yes
40KLF10NAKLF10
Entrez,  Source
Kruppel-like factor 1011410.8350.2912Yes
41UGCGNAUGCG
Entrez,  Source
UDP-glucose ceramide glucosyltransferase11600.8280.2956Yes
42ELOVL2NAELOVL2
Entrez,  Source
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 211700.8230.3007Yes
43MYBBP1ANAMYBBP1A
Entrez,  Source
MYB binding protein (P160) 1a14370.7350.2863No
44FKBP4NAFKBP4
Entrez,  Source
FK506 binding protein 4, 59kDa15890.6920.2800No
45SVILNASVIL
Entrez,  Source
supervillin16930.6600.2770No
46SFNNASFN
Entrez,  Source
stratifin17230.6520.2794No
47PRSS23NAPRSS23
Entrez,  Source
protease, serine, 2317700.6390.2805No
48SLC37A1NASLC37A1
Entrez,  Source
solute carrier family 37 (glycerol-3-phosphate transporter), member 120320.5810.2654No
49MAST4NAMAST4
Entrez,  Source
microtubule associated serine/threonine kinase family member 420370.5800.2691No
50TGM2NATGM2
Entrez,  Source
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)23260.5290.2517No
51THSD4NATHSD4
Entrez,  Source
thrombospondin, type I, domain containing 424450.5090.2465No
52TFF1NATFF1
Entrez,  Source
trefoil factor 1 (breast cancer, estrogen-inducible sequence expressed in)25930.4850.2391No
53MED13LNA27250.4630.2327No
54ABHD2NAABHD2
Entrez,  Source
abhydrolase domain containing 227540.4600.2339No
55INHBBNAINHBB
Entrez,  Source
inhibin, beta B (activin AB beta polypeptide)28330.4460.2312No
56HSPB8NAHSPB8
Entrez,  Source
heat shock 22kDa protein 830860.4100.2156No
57SLC16A1NASLC16A1
Entrez,  Source
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)31100.4070.2168No
58RARANARARA
Entrez,  Source
retinoic acid receptor, alpha34000.3680.1981No
59NXT1NANXT1
Entrez,  Source
NTF2-like export factor 135460.3490.1899No
60AKAP1NAAKAP1
Entrez,  Source
A kinase (PRKA) anchor protein 136040.3430.1881No
61TMEM164NATMEM164
Entrez,  Source
transmembrane protein 16436570.3370.1867No
62FOXC1NAFOXC1
Entrez,  Source
forkhead box C140010.2970.1636No
63FHL2NAFHL2
Entrez,  Source
four and a half LIM domains 241070.2860.1579No
64P2RY2NAP2RY2
Entrez,  Source
purinergic receptor P2Y, G-protein coupled, 243160.2630.1445No
65CANT1NACANT1
Entrez,  Source
calcium activated nucleotidase 143230.2630.1459No
66MREGNA48120.2100.1116No
67TFAP2CNATFAP2C
Entrez,  Source
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)54260.1480.0677No
68MED24NA55150.1380.0622No
69CISHNACISH
Entrez,  Source
cytokine inducible SH2-containing protein55180.1380.0630No
70MUC1NAMUC1
Entrez,  Source
mucin 1, cell surface associated55420.1360.0623No
71UNC119NAUNC119
Entrez,  Source
unc-119 homolog (C. elegans)56880.1170.0525No
72RBBP8NARBBP8
Entrez,  Source
retinoblastoma binding protein 857050.1160.0521No
73INPP5FNAINPP5F
Entrez,  Source
inositol polyphosphate-5-phosphatase F57680.1100.0483No
74CA12NACA12
Entrez,  Source
carbonic anhydrase XII59780.0900.0337No
75BHLHE40NA60730.0800.0273No
76TBC1D30NA61680.0710.0209No
77ENDOD1NAENDOD1
Entrez,  Source
endonuclease domain containing 161890.0680.0199No
78FKBP5NAFKBP5
Entrez,  Source
FK506 binding protein 563090.0570.0116No
79GLANAGLA
Entrez,  Source
galactosidase, alpha64730.041-0.0000No
80RAPGEFL1NARAPGEFL1
Entrez,  Source
Rap guanine nucleotide exchange factor (GEF)-like 165320.036-0.0040No
81SIAH2NASIAH2
Entrez,  Source
seven in absentia homolog 2 (Drosophila)6918-0.006-0.0322No
82KLK10NAKLK10
Entrez,  Source
kallikrein 106919-0.006-0.0321No
83NCOR2NANCOR2
Entrez,  Source
nuclear receptor co-repressor 27018-0.016-0.0392No
84MAPTNAMAPT
Entrez,  Source
microtubule-associated protein tau7280-0.043-0.0580No
85SNX24NASNX24
Entrez,  Source
sorting nexing 247400-0.056-0.0663No
86RASGRP1NARASGRP1
Entrez,  Source
RAS guanyl releasing protein 1 (calcium and DAG-regulated)7522-0.068-0.0747No
87PAPSS2NAPAPSS2
Entrez,  Source
3'-phosphoadenosine 5'-phosphosulfate synthase 27625-0.078-0.0817No
88TGIF2NATGIF2
Entrez,  Source
TGFB-induced factor 2 (TALE family homeobox)7690-0.083-0.0858No
89ESRP2NA7702-0.084-0.0860No
90ABLIM1NAABLIM1
Entrez,  Source
actin binding LIM protein 17824-0.097-0.0942No
91TIAM1NATIAM1
Entrez,  Source
T-cell lymphoma invasion and metastasis 17923-0.106-0.1006No
92AMFRNAAMFR
Entrez,  Source
autocrine motility factor receptor7950-0.108-0.1018No
93TTC39ANA8130-0.129-0.1140No
94ITPK1NAITPK1
Entrez,  Source
inositol 1,3,4-triphosphate 5/6 kinase8183-0.134-0.1169No
95HRNAHR
Entrez,  Source
hairless homolog (mouse)8330-0.150-0.1265No
96SLC26A2NASLC26A2
Entrez,  Source
solute carrier family 26 (sulfate transporter), member 28371-0.154-0.1284No
97SLC2A1NASLC2A1
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 18373-0.154-0.1274No
98ELOVL5NAELOVL5
Entrez,  Source
ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)8468-0.166-0.1331No
99PGRNAPGR
Entrez,  Source
progesterone receptor8522-0.171-0.1358No
100IGF1RNAIGF1R
Entrez,  Source
insulin-like growth factor 1 receptor8663-0.186-0.1448No
101ADCY9NAADCY9
Entrez,  Source
adenylate cyclase 98752-0.197-0.1499No
102SLC1A4NASLC1A4
Entrez,  Source
solute carrier family 1 (glutamate/neutral amino acid transporter), member 49038-0.230-0.1691No
103XBP1NAXBP1
Entrez,  Source
X-box binding protein 19068-0.233-0.1697No
104SLC9A3R1NASLC9A3R1
Entrez,  Source
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 19104-0.238-0.1706No
105NRIP1NANRIP1
Entrez,  Source
nuclear receptor interacting protein 19144-0.243-0.1718No
106SEC14L2NASEC14L2
Entrez,  Source
SEC14-like 2 (S. cerevisiae)9181-0.247-0.1727No
107SLC19A2NASLC19A2
Entrez,  Source
solute carrier family 19 (thiamine transporter), member 29224-0.253-0.1740No
108KDM4BNA9383-0.276-0.1837No
109MLPHNAMLPH
Entrez,  Source
melanophilin9613-0.309-0.1983No
110NPY1RNANPY1R
Entrez,  Source
neuropeptide Y receptor Y19640-0.313-0.1980No
111MYCNAMYC
Entrez,  Source
v-myc myelocytomatosis viral oncogene homolog (avian)9860-0.346-0.2117No
112SLC27A2NASLC27A2
Entrez,  Source
solute carrier family 27 (fatty acid transporter), member 29957-0.357-0.2162No
113ADCY1NAADCY1
Entrez,  Source
adenylate cyclase 1 (brain)9975-0.360-0.2150No
114SLC22A5NASLC22A5
Entrez,  Source
solute carrier family 22 (organic cation transporter), member 510065-0.374-0.2189No
115KRT15NAKRT15
Entrez,  Source
keratin 1510080-0.376-0.2173No
116GREB1NAGREB1
Entrez,  Source
-10178-0.391-0.2218No
117ELF3NAELF3
Entrez,  Source
E74-like factor 3 (ets domain transcription factor, epithelial-specific )10193-0.393-0.2201No
118MYBNAMYB
Entrez,  Source
v-myb myeloblastosis viral oncogene homolog (avian)10386-0.424-0.2312No
119ASB13NAASB13
Entrez,  Source
ankyrin repeat and SOCS box-containing 1310587-0.456-0.2427No
120RAB17NARAB17
Entrez,  Source
RAB17, member RAS oncogene family10675-0.473-0.2458No
121NADSYN1NANADSYN1
Entrez,  Source
NAD synthetase 110861-0.503-0.2558No
122BCL2NABCL2
Entrez,  Source
B-cell CLL/lymphoma 210892-0.508-0.2545No
123CHPT1NACHPT1
Entrez,  Source
choline phosphotransferase 110893-0.508-0.2510No
124PLA2G16NA10896-0.508-0.2476No
125PEX11ANAPEX11A
Entrez,  Source
peroxisomal biogenesis factor 11A10928-0.514-0.2464No
126MPPED2NAMPPED2
Entrez,  Source
metallophosphoesterase domain containing 210952-0.518-0.2445No
127TPD52L1NATPD52L1
Entrez,  Source
tumor protein D52-like 110974-0.522-0.2424No
128SCARB1NASCARB1
Entrez,  Source
scavenger receptor class B, member 111081-0.543-0.2464No
129GFRA1NAGFRA1
Entrez,  Source
GDNF family receptor alpha 111173-0.559-0.2492No
130RAB31NARAB31
Entrez,  Source
RAB31, member RAS oncogene family11358-0.595-0.2586No
131FASNNAFASN
Entrez,  Source
fatty acid synthase11589-0.645-0.2709No
132B4GALT1NAB4GALT1
Entrez,  Source
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 111626-0.655-0.2690No
133RHODNARHOD
Entrez,  Source
ras homolog gene family, member D11722-0.676-0.2713No
134NAV2NANAV2
Entrez,  Source
neuron navigator 211729-0.678-0.2671No
135ZNF185NAZNF185
Entrez,  Source
zinc finger protein 185 (LIM domain)11756-0.686-0.2642No
136TOB1NATOB1
Entrez,  Source
transducer of ERBB2, 111787-0.694-0.2616No
137FDFT1NAFDFT1
Entrez,  Source
farnesyl-diphosphate farnesyltransferase 111896-0.723-0.2645No
138GJA1NAGJA1
Entrez,  Source
gap junction protein, alpha 1, 43kDa (connexin 43)12003-0.758-0.2671No
139CELSR1NACELSR1
Entrez,  Source
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)12032-0.765-0.2638No
140ARL3NAARL3
Entrez,  Source
ADP-ribosylation factor-like 312097-0.785-0.2631No
141DHCR7NADHCR7
Entrez,  Source
7-dehydrocholesterol reductase12147-0.804-0.2611No
142CELSR2NACELSR2
Entrez,  Source
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)12334-0.868-0.2687No
143DEPTORNA12384-0.886-0.2662No
144SYT12NASYT12
Entrez,  Source
synaptotagmin XII12399-0.890-0.2611No
145AFF1NAAFF1
Entrez,  Source
AF4/FMR2 family, member 112402-0.891-0.2550No
146AQP3NAAQP3
Entrez,  Source
aquaporin 3 (Gill blood group)12436-0.910-0.2512No
147BLVRBNABLVRB
Entrez,  Source
biliverdin reductase B (flavin reductase (NADPH))12510-0.944-0.2500No
148SCNN1ANASCNN1A
Entrez,  Source
sodium channel, nonvoltage-gated 1 alpha12518-0.947-0.2440No
149IL17RBNAIL17RB
Entrez,  Source
interleukin 17 receptor B12549-0.960-0.2395No
150DYNLT3NADYNLT3
Entrez,  Source
dynein, light chain, Tctex-type 312595-0.978-0.2360No
151ABATNAABAT
Entrez,  Source
4-aminobutyrate aminotransferase12624-0.996-0.2312No
152CLIC3NACLIC3
Entrez,  Source
chloride intracellular channel 312752-1.064-0.2331No
153SEMA3BNASEMA3B
Entrez,  Source
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B12853-1.122-0.2327No
154ADD3NAADD3
Entrez,  Source
adducin 3 (gamma)13003-1.217-0.2352No
155PDZK1NAPDZK1
Entrez,  Source
PDZ domain containing 113026-1.237-0.2283No
156BAG1NABAG1
Entrez,  Source
BCL2-associated athanogene13066-1.272-0.2223No
157SLC7A5NASLC7A5
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 513086-1.288-0.2148No
158CBFA2T3NACBFA2T3
Entrez,  Source
core-binding factor, runt domain, alpha subunit 2; translocated to, 313105-1.300-0.2071No
159ANXA9NAANXA9
Entrez,  Source
annexin A913127-1.317-0.1996No
160FARP1NAFARP1
Entrez,  Source
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)13153-1.343-0.1921No
161ABCA3NAABCA3
Entrez,  Source
ATP-binding cassette, sub-family A (ABC1), member 313179-1.375-0.1844No
162TMPRSS3NATMPRSS3
Entrez,  Source
transmembrane protease, serine 313240-1.440-0.1789No
163RHOBTB3NARHOBTB3
Entrez,  Source
Rho-related BTB domain containing 313260-1.466-0.1701No
164SLC7A2NASLC7A2
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 213262-1.470-0.1600No
165ALDH3B1NAALDH3B1
Entrez,  Source
aldehyde dehydrogenase 3 family, member B113265-1.473-0.1500No
166OPN3NAOPN3
Entrez,  Source
opsin 3 (encephalopsin, panopsin)13338-1.567-0.1444No
167DHRS3NADHRS3
Entrez,  Source
dehydrogenase/reductase (SDR family) member 313396-1.646-0.1372No
168RPS6KA2NARPS6KA2
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 213473-1.764-0.1306No
169SH3BP5NASH3BP5
Entrez,  Source
SH3-domain binding protein 5 (BTK-associated)13503-1.825-0.1201No
170SULT2B1NASULT2B1
Entrez,  Source
sulfotransferase family, cytosolic, 2B, member 113538-1.902-0.1094No
171FOSNAFOS
Entrez,  Source
v-fos FBJ murine osteosarcoma viral oncogene homolog13543-1.911-0.0965No
172SLC39A6NASLC39A6
Entrez,  Source
solute carrier family 39 (zinc transporter), member 613549-1.935-0.0835No
173WISP2NAWISP2
Entrez,  Source
WNT1 inducible signaling pathway protein 213581-2.016-0.0718No
174DLC1NADLC1
Entrez,  Source
deleted in liver cancer 113650-2.246-0.0613No
175CLDN7NACLDN7
Entrez,  Source
claudin 713774-3.160-0.0484No
176REEP1NAREEP1
Entrez,  Source
receptor accessory protein 113779-3.207-0.0266No
177OLFM1NAOLFM1
Entrez,  Source
olfactomedin 113822-4.4120.0009No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_ESTROGEN_RESPONSE_EARLY   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_ESTROGEN_RESPONSE_EARLY: Random ES distribution   
Gene set null distribution of ES for HALLMARK_ESTROGEN_RESPONSE_EARLY