Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1w6a
GeneSetHALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
Enrichment Score (ES)0.44198084
Normalized Enrichment Score (NES)1.8928576
Nominal p-value0.0
FDR q-value7.955624E-4
FWER p-Value0.004
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1IL6NAIL6
Entrez,  Source
interleukin 6 (interferon, beta 2)154.3830.0241Yes
2CYR61NACYR61
Entrez,  Source
cysteine-rich, angiogenic inducer, 61533.4460.0412Yes
3CTGFNACTGF
Entrez,  Source
connective tissue growth factor693.2560.0589Yes
4IL32NAIL32
Entrez,  Source
interleukin 32803.1220.0761Yes
5THBS1NATHBS1
Entrez,  Source
thrombospondin 1813.1200.0941Yes
6NT5ENANT5E
Entrez,  Source
5'-nucleotidase, ecto (CD73)933.0000.1105Yes
7SERPINE1NASERPINE1
Entrez,  Source
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 11092.8400.1258Yes
8TNFAIP3NATNFAIP3
Entrez,  Source
tumor necrosis factor, alpha-induced protein 31122.8040.1417Yes
9AREGNAAREG
Entrez,  Source
amphiregulin (schwannoma-derived growth factor)1132.7700.1577Yes
10TNFRSF12ANATNFRSF12A
Entrez,  Source
tumor necrosis factor receptor superfamily, member 12A1282.6380.1718Yes
11COL5A3NACOL5A3
Entrez,  Source
collagen, type V, alpha 31392.5720.1859Yes
12FGF2NAFGF2
Entrez,  Source
fibroblast growth factor 2 (basic)1462.5330.2000Yes
13SDC4NASDC4
Entrez,  Source
syndecan 4 (amphiglycan, ryudocan)1492.5030.2143Yes
14GREM1NAGREM1
Entrez,  Source
gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)1552.4740.2282Yes
15FBN2NAFBN2
Entrez,  Source
fibrillin 2 (congenital contractural arachnodactyly)1562.4730.2424Yes
16GADD45ANAGADD45A
Entrez,  Source
growth arrest and DNA-damage-inducible, alpha1612.4290.2561Yes
17DKK1NADKK1
Entrez,  Source
dickkopf homolog 1 (Xenopus laevis)1752.3530.2687Yes
18PLAURNAPLAUR
Entrez,  Source
plasminogen activator, urokinase receptor1872.3080.2811Yes
19ITGA2NAITGA2
Entrez,  Source
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)1922.2660.2939Yes
20SPOCK1NASPOCK1
Entrez,  Source
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 11932.2640.3069Yes
21LOXL1NALOXL1
Entrez,  Source
lysyl oxidase-like 12072.1890.3185Yes
22JUNNAJUN
Entrez,  Source
jun oncogene2361.9960.3280Yes
23LAMC2NALAMC2
Entrez,  Source
laminin, gamma 22601.9310.3374Yes
24IGFBP4NAIGFBP4
Entrez,  Source
insulin-like growth factor binding protein 42671.8880.3478Yes
25COL16A1NACOL16A1
Entrez,  Source
collagen, type XVI, alpha 12751.8470.3579Yes
26ECM1NAECM1
Entrez,  Source
extracellular matrix protein 12891.7960.3673Yes
27CD44NACD44
Entrez,  Source
CD44 molecule (Indian blood group)3361.6590.3735Yes
28ADAM12NAADAM12
Entrez,  Source
ADAM metallopeptidase domain 12 (meltrin alpha)3391.6520.3829Yes
29FSTL1NAFSTL1
Entrez,  Source
follistatin-like 13731.5480.3894Yes
30ITGA5NAITGA5
Entrez,  Source
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)3901.5190.3969Yes
31TAGLNNATAGLN
Entrez,  Source
transgelin4711.3610.3989Yes
32VIMNAVIM
Entrez,  Source
vimentin4861.3330.4055Yes
33SERPINE2NASERPINE2
Entrez,  Source
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 25031.3070.4119Yes
34QSOX1NA5301.2780.4173Yes
35LRRC15NALRRC15
Entrez,  Source
leucine rich repeat containing 155521.2440.4230Yes
36EMP3NAEMP3
Entrez,  Source
epithelial membrane protein 36031.1770.4261Yes
37GLIPR1NAGLIPR1
Entrez,  Source
GLI pathogenesis-related 1 (glioma)6151.1700.4320Yes
38FLNANAFLNA
Entrez,  Source
filamin A, alpha (actin binding protein 280)6401.1480.4369Yes
39NID2NANID2
Entrez,  Source
nidogen 2 (osteonidogen)6601.1310.4420Yes
40PVRNAPVR
Entrez,  Source
poliovirus receptor7571.0450.4410No
41TGFB1NATGFB1
Entrez,  Source
transforming growth factor, beta 1 (Camurati-Engelmann disease)15600.7000.3864No
42ANPEPNAANPEP
Entrez,  Source
alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150)16320.6790.3851No
43NOTCH2NANOTCH2
Entrez,  Source
Notch homolog 2 (Drosophila)16560.6740.3873No
44MYLKNAMYLK
Entrez,  Source
myosin, light chain kinase18060.6320.3800No
45PFN2NAPFN2
Entrez,  Source
profilin 221740.5570.3564No
46COL4A2NACOL4A2
Entrez,  Source
collagen, type IV, alpha 222710.5380.3524No
47TPM1NATPM1
Entrez,  Source
tropomyosin 1 (alpha)22980.5340.3536No
48TGM2NATGM2
Entrez,  Source
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)23260.5290.3547No
49COL4A1NACOL4A1
Entrez,  Source
collagen, type IV, alpha 124080.5140.3517No
50BDNFNABDNF
Entrez,  Source
brain-derived neurotrophic factor24650.5060.3505No
51TGFBR3NATGFBR3
Entrez,  Source
transforming growth factor, beta receptor III (betaglycan, 300kDa)25470.4920.3474No
52MMP2NAMMP2
Entrez,  Source
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)26630.4730.3418No
53SERPINH1NASERPINH1
Entrez,  Source
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)27360.4620.3392No
54TPM4NATPM4
Entrez,  Source
tropomyosin 429170.4320.3285No
55SAT1NASAT1
Entrez,  Source
spermidine/spermine N1-acetyltransferase 129430.4280.3291No
56WNT5ANAWNT5A
Entrez,  Source
wingless-type MMTV integration site family, member 5A29630.4250.3302No
57CAP2NACAP2
Entrez,  Source
CAP, adenylate cyclase-associated protein, 2 (yeast)33400.3770.3048No
58FASNAFAS
Entrez,  Source
Fas (TNF receptor superfamily, member 6)34570.3600.2984No
59SLIT3NASLIT3
Entrez,  Source
slit homolog 3 (Drosophila)34910.3550.2981No
60OXTRNAOXTR
Entrez,  Source
oxytocin receptor36360.3390.2895No
61FOXC2NAFOXC2
Entrez,  Source
forkhead box C2 (MFH-1, mesenchyme forkhead 1)36760.3350.2886No
62MMP14NAMMP14
Entrez,  Source
matrix metallopeptidase 14 (membrane-inserted)38700.3140.2763No
63FBN1NAFBN1
Entrez,  Source
fibrillin 139820.2980.2699No
64MGPNAMGP
Entrez,  Source
matrix Gla protein40710.2910.2651No
65TIMP1NATIMP1
Entrez,  Source
TIMP metallopeptidase inhibitor 141240.2840.2629No
66MSX1NAMSX1
Entrez,  Source
msh homeobox homolog 1 (Drosophila)42650.2710.2542No
67TNCNATNC
Entrez,  Source
tenascin C (hexabrachion)44570.2480.2417No
68GADD45BNAGADD45B
Entrez,  Source
growth arrest and DNA-damage-inducible, beta45060.2420.2396No
69TPM2NATPM2
Entrez,  Source
tropomyosin 2 (beta)46140.2300.2331No
70ECM2NAECM2
Entrez,  Source
extracellular matrix protein 2, female organ and adipocyte specific46460.2290.2321No
71MATN2NAMATN2
Entrez,  Source
matrilin 246500.2280.2332No
72PPIBNAPPIB
Entrez,  Source
peptidylprolyl isomerase B (cyclophilin B)49330.1990.2138No
73MATN3NAMATN3
Entrez,  Source
matrilin 353430.1580.1848No
74SDC1NASDC1
Entrez,  Source
syndecan 153890.1520.1823No
75IL15NAIL15
Entrez,  Source
interleukin 1554950.1400.1755No
76COL11A1NACOL11A1
Entrez,  Source
collagen, type XI, alpha 157340.1130.1587No
77TIMP3NATIMP3
Entrez,  Source
TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)57860.1080.1556No
78PDLIM4NAPDLIM4
Entrez,  Source
PDZ and LIM domain 459420.0930.1448No
79IGFBP3NAIGFBP3
Entrez,  Source
insulin-like growth factor binding protein 359640.0910.1438No
80VCANNA60560.0810.1376No
81FN1NAFN1
Entrez,  Source
fibronectin 161420.0730.1318No
82LAMA2NALAMA2
Entrez,  Source
laminin, alpha 2 (merosin, congenital muscular dystrophy)64200.0470.1118No
83COL5A1NACOL5A1
Entrez,  Source
collagen, type V, alpha 164990.0390.1063No
84FSTL3NAFSTL3
Entrez,  Source
follistatin-like 3 (secreted glycoprotein)65030.0390.1063No
85CALUNACALU
Entrez,  Source
calumenin65550.0320.1028No
86PLOD2NAPLOD2
Entrez,  Source
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 266690.0210.0947No
87LOXL2NALOXL2
Entrez,  Source
lysyl oxidase-like 267820.0080.0865No
88LAMC1NALAMC1
Entrez,  Source
laminin, gamma 1 (formerly LAMB2)68620.0010.0807No
89ITGAVNAITGAV
Entrez,  Source
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)7059-0.0190.0665No
90CDH6NACDH6
Entrez,  Source
cadherin 6, type 2, K-cadherin (fetal kidney)7111-0.0240.0629No
91LAMA1NALAMA1
Entrez,  Source
laminin, alpha 17314-0.0460.0484No
92ITGB3NAITGB3
Entrez,  Source
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)7628-0.0780.0260No
93GPC1NAGPC1
Entrez,  Source
glypican 17773-0.0920.0160No
94MCM7NAMCM7
Entrez,  Source
MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)7810-0.0960.0139No
95VEGFANA7811-0.0960.0145No
96COL6A3NACOL6A3
Entrez,  Source
collagen, type VI, alpha 37823-0.0970.0142No
97DSTNADST
Entrez,  Source
dystonin7838-0.0980.0138No
98ITGB5NAITGB5
Entrez,  Source
integrin, beta 57873-0.1020.0119No
99PLOD3NAPLOD3
Entrez,  Source
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 38282-0.145-0.0171No
100SGCBNASGCB
Entrez,  Source
sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)8307-0.147-0.0181No
101ABI3BPNAABI3BP
Entrez,  Source
ABI gene family, member 3 (NESH) binding protein8530-0.171-0.0333No
102MESTNAMEST
Entrez,  Source
mesoderm specific transcript homolog (mouse)8549-0.173-0.0336No
103COL12A1NACOL12A1
Entrez,  Source
collagen, type XII, alpha 18733-0.195-0.0459No
104SNTB1NASNTB1
Entrez,  Source
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)8892-0.213-0.0562No
105FERMT2NA9218-0.252-0.0785No
106LGALS1NALGALS1
Entrez,  Source
lectin, galactoside-binding, soluble, 1 (galectin 1)9431-0.283-0.0924No
107VCAM1NAVCAM1
Entrez,  Source
vascular cell adhesion molecule 19432-0.284-0.0908No
108CAPGNACAPG
Entrez,  Source
capping protein (actin filament), gelsolin-like9453-0.286-0.0906No
109SGCDNASGCD
Entrez,  Source
sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)9478-0.290-0.0907No
110PCOLCE2NAPCOLCE2
Entrez,  Source
procollagen C-endopeptidase enhancer 29509-0.296-0.0911No
111CD59NACD59
Entrez,  Source
CD59 molecule, complement regulatory protein10017-0.367-0.1261No
112SCG2NASCG2
Entrez,  Source
secretogranin II (chromogranin C)10108-0.379-0.1305No
113PLOD1NAPLOD1
Entrez,  Source
procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 110170-0.389-0.1327No
114COPANACOPA
Entrez,  Source
coatomer protein complex, subunit alpha10173-0.389-0.1306No
115CALD1NACALD1
Entrez,  Source
caldesmon 110212-0.396-0.1311No
116NNMTNANNMT
Entrez,  Source
nicotinamide N-methyltransferase10394-0.426-0.1419No
117ITGB1NAITGB1
Entrez,  Source
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)10722-0.479-0.1631No
118ENO2NAENO2
Entrez,  Source
enolase 2 (gamma, neuronal)10819-0.496-0.1672No
119SGCGNASGCG
Entrez,  Source
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)10836-0.500-0.1655No
120PMP22NAPMP22
Entrez,  Source
peripheral myelin protein 2211186-0.562-0.1878No
121SPARCNASPARC
Entrez,  Source
secreted protein, acidic, cysteine-rich (osteonectin)11483-0.621-0.2059No
122BMP1NABMP1
Entrez,  Source
bone morphogenetic protein 111506-0.624-0.2039No
123COL7A1NACOL7A1
Entrez,  Source
collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive)11828-0.705-0.2233No
124FBLN1NAFBLN1
Entrez,  Source
fibulin 111872-0.716-0.2224No
125GJA1NAGJA1
Entrez,  Source
gap junction protein, alpha 1, 43kDa (connexin 43)12003-0.758-0.2275No
126BASP1NABASP1
Entrez,  Source
brain abundant, membrane attached signal protein 112020-0.762-0.2243No
127GAS1NAGAS1
Entrez,  Source
growth arrest-specific 112432-0.908-0.2491No
128GEMNAGEM
Entrez,  Source
GTP binding protein overexpressed in skeletal muscle12453-0.919-0.2453No
129PMEPA1NA12482-0.930-0.2420No
130CADM1NA12545-0.959-0.2410No
131COL5A2NACOL5A2
Entrez,  Source
collagen, type V, alpha 212707-1.040-0.2468No
132SLC6A8NASLC6A8
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter, creatine), member 812717-1.043-0.2414No
133SNAI2NASNAI2
Entrez,  Source
snail homolog 2 (Drosophila)12785-1.082-0.2401No
134FUCA1NAFUCA1
Entrez,  Source
fucosidase, alpha-L- 1, tissue12896-1.146-0.2416No
135CRLF1NACRLF1
Entrez,  Source
cytokine receptor-like factor 112905-1.154-0.2355No
136PCOLCENAPCOLCE
Entrez,  Source
procollagen C-endopeptidase enhancer12918-1.162-0.2297No
137WIPF1NAWIPF1
Entrez,  Source
WAS/WASL interacting protein family, member 113077-1.280-0.2339No
138LAMA3NALAMA3
Entrez,  Source
laminin, alpha 313132-1.319-0.2303No
139EFEMP2NAEFEMP2
Entrez,  Source
EGF-containing fibulin-like extracellular matrix protein 213134-1.323-0.2227No
140RHOBNARHOB
Entrez,  Source
ras homolog gene family, member B13181-1.375-0.2182No
141ACTA2NAACTA2
Entrez,  Source
actin, alpha 2, smooth muscle, aorta13216-1.418-0.2125No
142HTRA1NAHTRA1
Entrez,  Source
HtrA serine peptidase 113310-1.528-0.2105No
143FBLN2NAFBLN2
Entrez,  Source
fibulin 213333-1.556-0.2032No
144PDGFRBNAPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide13337-1.562-0.1944No
145LRP1NALRP1
Entrez,  Source
low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)13358-1.589-0.1867No
146APLP1NAAPLP1
Entrez,  Source
amyloid beta (A4) precursor-like protein 113366-1.597-0.1780No
147TGFBINATGFBI
Entrez,  Source
transforming growth factor, beta-induced, 68kDa13453-1.742-0.1743No
148DAB2NADAB2
Entrez,  Source
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)13564-1.978-0.1710No
149FAPNAFAP
Entrez,  Source
fibroblast activation protein, alpha13603-2.081-0.1618No
150ID2NAID2
Entrez,  Source
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein13694-2.466-0.1542No
151LUMNALUM
Entrez,  Source
lumican13701-2.519-0.1401No
152LOXNALOX
Entrez,  Source
lysyl oxidase13703-2.537-0.1256No
153COL1A1NACOL1A1
Entrez,  Source
collagen, type I, alpha 113723-2.670-0.1116No
154EDIL3NAEDIL3
Entrez,  Source
EGF-like repeats and discoidin I-like domains 313726-2.687-0.0963No
155FBLN5NAFBLN5
Entrez,  Source
fibulin 513742-2.810-0.0812No
156FMODNAFMOD
Entrez,  Source
fibromodulin13770-3.089-0.0654No
157COL3A1NACOL3A1
Entrez,  Source
collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant)13796-3.638-0.0463No
158DCNNADCN
Entrez,  Source
decorin13811-4.027-0.0242No
159MFAP5NAMFAP5
Entrez,  Source
microfibrillar associated protein 513824-4.4850.0007No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION: Random ES distribution   
Gene set null distribution of ES for HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION