Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1w6a
GeneSetHALLMARK_COMPLEMENT
Enrichment Score (ES)0.3369706
Normalized Enrichment Score (NES)1.4168786
Nominal p-value0.008403362
FDR q-value0.048494115
FWER p-Value0.364
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_COMPLEMENT   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1ADRA2BNAADRA2B
Entrez,  Source
adrenergic, alpha-2B-, receptor54.6650.0354Yes
2CCL5NACCL5
Entrez,  Source
chemokine (C-C motif) ligand 5104.4620.0694Yes
3IL6NAIL6
Entrez,  Source
interleukin 6 (interferon, beta 2)154.3830.1027Yes
4CTSSNACTSS
Entrez,  Source
cathepsin S972.9720.1196Yes
5GNGT2NAGNGT2
Entrez,  Source
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 21002.9520.1421Yes
6SERPINE1NASERPINE1
Entrez,  Source
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 11092.8400.1633Yes
7TNFAIP3NATNFAIP3
Entrez,  Source
tumor necrosis factor, alpha-induced protein 31122.8040.1847Yes
8F3NAF3
Entrez,  Source
coagulation factor III (thromboplastin, tissue factor)1842.3220.1973Yes
9PLAURNAPLAUR
Entrez,  Source
plasminogen activator, urokinase receptor1872.3080.2149Yes
10OLR1NAOLR1
Entrez,  Source
oxidised low density lipoprotein (lectin-like) receptor 12092.1710.2300Yes
11IRF1NAIRF1
Entrez,  Source
interferon regulatory factor 12521.9470.2419Yes
12DUSP5NADUSP5
Entrez,  Source
dual specificity phosphatase 52801.8140.2538Yes
13CFBNACFB
Entrez,  Source
complement factor B2821.8040.2676Yes
14PSMB9NAPSMB9
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)3251.7060.2776Yes
15SH2B3NASH2B3
Entrez,  Source
SH2B adaptor protein 33541.6080.2879Yes
16HSPA1ANAHSPA1A
Entrez,  Source
heat shock 70kDa protein 1A3701.5630.2988Yes
17PDP1NA4391.4280.3048Yes
18ERAP2NA4681.3680.3132Yes
19ITGAMNAITGAM
Entrez,  Source
integrin, alpha M (complement component 3 receptor 3 subunit)6961.1000.3051Yes
20JAK2NAJAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)7561.0450.3088Yes
21STX4NASTX4
Entrez,  Source
syntaxin 47601.0410.3166Yes
22RCE1NARCE1
Entrez,  Source
RCE1 homolog, prenyl protein peptidase (S. cerevisiae)8170.9950.3201Yes
23PRDM4NAPRDM4
Entrez,  Source
PR domain containing 48720.9600.3235Yes
24PRSS36NAPRSS36
Entrez,  Source
protease, serine, 369910.8980.3218Yes
25BRPF3NABRPF3
Entrez,  Source
bromodomain and PHD finger containing, 310040.8920.3278Yes
26MAFFNAMAFF
Entrez,  Source
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)10230.8820.3332Yes
27CASP4NACASP4
Entrez,  Source
caspase 4, apoptosis-related cysteine peptidase12760.7850.3208Yes
28DYRK2NADYRK2
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 212990.7740.3252Yes
29DOCK10NADOCK10
Entrez,  Source
dedicator of cytokinesis 1013180.7670.3297Yes
30EHD1NAEHD1
Entrez,  Source
EH-domain containing 113570.7530.3327Yes
31SRCNASRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)14690.7240.3302Yes
32RABIFNARABIF
Entrez,  Source
RAB interacting factor15180.7100.3321Yes
33PLSCR1NAPLSCR1
Entrez,  Source
phospholipid scramblase 115270.7080.3370Yes
34MMP13NAMMP13
Entrez,  Source
matrix metallopeptidase 13 (collagenase 3)16160.6840.3358No
35ZEB1NA17380.6470.3319No
36CSRP1NACSRP1
Entrez,  Source
cysteine and glycine-rich protein 117770.6370.3340No
37C4BPBNAC4BPB
Entrez,  Source
complement component 4 binding protein, beta20110.5830.3215No
38SIRT6NASIRT6
Entrez,  Source
sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)20460.5790.3234No
39LIPANALIPA
Entrez,  Source
lipase A, lysosomal acid, cholesterol esterase (Wolman disease)21490.5600.3203No
40CEBPBNACEBPB
Entrez,  Source
CCAAT/enhancer binding protein (C/EBP), beta22200.5470.3194No
41COL4A2NACOL4A2
Entrez,  Source
collagen, type IV, alpha 222710.5380.3198No
42PPP2CBNAPPP2CB
Entrez,  Source
protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform22880.5350.3228No
43GCANAGCA
Entrez,  Source
grancalcin, EF-hand calcium binding protein23360.5270.3234No
44SERPINC1NASERPINC1
Entrez,  Source
serpin peptidase inhibitor, clade C (antithrombin), member 123580.5220.3258No
45CASP3NACASP3
Entrez,  Source
caspase 3, apoptosis-related cysteine peptidase25460.4920.3159No
46NOTCH4NANOTCH4
Entrez,  Source
Notch homolog 4 (Drosophila)26500.4760.3121No
47PFN1NAPFN1
Entrez,  Source
profilin 126910.4690.3127No
48RHOGNARHOG
Entrez,  Source
ras homolog gene family, member G (rho G)28160.4490.3071No
49RNF4NARNF4
Entrez,  Source
ring finger protein 429090.4330.3037No
50GATA3NAGATA3
Entrez,  Source
GATA binding protein 330370.4170.2976No
51HSPA5NAHSPA5
Entrez,  Source
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)31610.3990.2917No
52GNAI3NAGNAI3
Entrez,  Source
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 334390.3610.2742No
53LYNNALYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog35670.3470.2676No
54USP15NAUSP15
Entrez,  Source
ubiquitin specific peptidase 1535920.3450.2685No
55PCLONAPCLO
Entrez,  Source
piccolo (presynaptic cytomatrix protein)37020.3330.2631No
56CASP7NACASP7
Entrez,  Source
caspase 7, apoptosis-related cysteine peptidase37570.3270.2616No
57MMP14NAMMP14
Entrez,  Source
matrix metallopeptidase 14 (membrane-inserted)38700.3140.2559No
58WASNAWAS
Entrez,  Source
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)39210.3070.2546No
59CD55NACD55
Entrez,  Source
CD55 molecule, decay accelerating factor for complement (Cromer blood group)39450.3030.2552No
60PREPNAPREP
Entrez,  Source
prolyl endopeptidase40260.2940.2516No
61KIF2ANAKIF2A
Entrez,  Source
kinesin heavy chain member 2A40820.2890.2498No
62TIMP1NATIMP1
Entrez,  Source
TIMP metallopeptidase inhibitor 141240.2840.2490No
63CDK5R1NACDK5R1
Entrez,  Source
cyclin-dependent kinase 5, regulatory subunit 1 (p35)41300.2840.2508No
64DGKHNADGKH
Entrez,  Source
diacylglycerol kinase, eta41980.2780.2481No
65USP16NAUSP16
Entrez,  Source
ubiquitin specific peptidase 1642600.2710.2457No
66SCG3NASCG3
Entrez,  Source
secretogranin III43220.2630.2432No
67DOCK9NADOCK9
Entrez,  Source
dedicator of cytokinesis 949340.1990.2001No
68PLATNAPLAT
Entrez,  Source
plasminogen activator, tissue50830.1830.1907No
69ANXA5NAANXA5
Entrez,  Source
annexin A551970.1720.1837No
70SPOCK2NASPOCK2
Entrez,  Source
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 252340.1670.1824No
71GNB2NAGNB2
Entrez,  Source
guanine nucleotide binding protein (G protein), beta polypeptide 252800.1640.1804No
72PSEN1NAPSEN1
Entrez,  Source
presenilin 1 (Alzheimer disease 3)53610.1550.1757No
73F5NAF5
Entrez,  Source
coagulation factor V (proaccelerin, labile factor)53930.1510.1746No
74DUSP6NADUSP6
Entrez,  Source
dual specificity phosphatase 656140.1250.1595No
75IRF2NAIRF2
Entrez,  Source
interferon regulatory factor 257600.1110.1497No
76ACTN2NAACTN2
Entrez,  Source
actinin, alpha 258380.1030.1449No
77VCPIP1NAVCPIP1
Entrez,  Source
valosin containing protein (p97)/p47 complex interacting protein 160690.0800.1287No
78FN1NAFN1
Entrez,  Source
fibronectin 161420.0730.1240No
79PPP4CNAPPP4C
Entrez,  Source
protein phosphatase 4 (formerly X), catalytic subunit63610.0530.1085No
80DOCK4NADOCK4
Entrez,  Source
dedicator of cytokinesis 46917-0.0060.0679No
81USP14NAUSP14
Entrez,  Source
ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)6999-0.0140.0621No
82AKAP10NAAKAP10
Entrez,  Source
A kinase (PRKA) anchor protein 107044-0.0180.0591No
83CALM3NACALM3
Entrez,  Source
calmodulin 3 (phosphorylase kinase, delta)7094-0.0220.0556No
84CALM1NACALM1
Entrez,  Source
calmodulin 1 (phosphorylase kinase, delta)7251-0.0400.0445No
85LGMNNALGMN
Entrez,  Source
legumain7414-0.0570.0331No
86RASGRP1NARASGRP1
Entrez,  Source
RAS guanyl releasing protein 1 (calcium and DAG-regulated)7522-0.0680.0259No
87LAP3NALAP3
Entrez,  Source
leucine aminopeptidase 37558-0.0720.0238No
88MMP8NAMMP8
Entrez,  Source
matrix metallopeptidase 8 (neutrophil collagenase)7576-0.0730.0232No
89CTSBNACTSB
Entrez,  Source
cathepsin B7647-0.0790.0187No
90C2NAC2
Entrez,  Source
complement component 28029-0.117-0.0083No
91XPNPEP1NAXPNPEP1
Entrez,  Source
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble8054-0.121-0.0091No
92PLEKNAPLEK
Entrez,  Source
pleckstrin8123-0.128-0.0131No
93CDANACDA
Entrez,  Source
cytidine deaminase8171-0.133-0.0155No
94ME1NAME1
Entrez,  Source
malic enzyme 1, NADP(+)-dependent, cytosolic8293-0.146-0.0233No
95PRKCDNAPRKCD
Entrez,  Source
protein kinase C, delta8314-0.148-0.0236No
96GRB2NAGRB2
Entrez,  Source
growth factor receptor-bound protein 28662-0.186-0.0475No
97S100A13NAS100A13
Entrez,  Source
S100 calcium binding protein A138804-0.203-0.0563No
98GPD2NAGPD2
Entrez,  Source
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)8930-0.218-0.0637No
99CASP10NACASP10
Entrez,  Source
caspase 10, apoptosis-related cysteine peptidase9150-0.244-0.0779No
100ATOX1NAATOX1
Entrez,  Source
ATX1 antioxidant protein 1 homolog (yeast)9210-0.251-0.0802No
101LTA4HNALTA4H
Entrez,  Source
leukotriene A4 hydrolase9221-0.253-0.0790No
102RAF1NARAF1
Entrez,  Source
v-raf-1 murine leukemia viral oncogene homolog 19437-0.284-0.0926No
103CTSONACTSO
Entrez,  Source
cathepsin O9536-0.299-0.0974No
104ADAM9NAADAM9
Entrez,  Source
ADAM metallopeptidase domain 9 (meltrin gamma)9607-0.307-0.1002No
105APOBEC3FNAAPOBEC3F
Entrez,  Source
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F9639-0.312-0.1001No
106CTSCNACTSC
Entrez,  Source
cathepsin C9651-0.314-0.0985No
107PIK3CANAPIK3CA
Entrez,  Source
phosphoinositide-3-kinase, catalytic, alpha polypeptide9727-0.326-0.1014No
108GNB4NAGNB4
Entrez,  Source
guanine nucleotide binding protein (G protein), beta polypeptide 49772-0.332-0.1021No
109LGALS3NALGALS3
Entrez,  Source
lectin, galactoside-binding, soluble, 3 (galectin 3)9870-0.347-0.1065No
110LAMP2NALAMP2
Entrez,  Source
lysosomal-associated membrane protein 29988-0.362-0.1123No
111CD59NACD59
Entrez,  Source
CD59 molecule, complement regulatory protein10017-0.367-0.1115No
112GNAI2NAGNAI2
Entrez,  Source
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 210025-0.368-0.1092No
113CASP1NACASP1
Entrez,  Source
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)10265-0.405-0.1236No
114GMFBNAGMFB
Entrez,  Source
glia maturation factor, beta10489-0.441-0.1365No
115DGKGNADGKG
Entrez,  Source
diacylglycerol kinase, gamma 90kDa10718-0.478-0.1495No
116C9NAC9
Entrez,  Source
complement component 910832-0.499-0.1539No
117GP9NAGP9
Entrez,  Source
glycoprotein IX (platelet)10872-0.505-0.1529No
118F8NAF8
Entrez,  Source
coagulation factor VIII, procoagulant component (hemophilia A)10971-0.522-0.1561No
119CR1NACR1
Entrez,  Source
complement component (3b/4b) receptor 1 (Knops blood group)11207-0.565-0.1689No
120PCSK9NAPCSK9
Entrez,  Source
proprotein convertase subtilisin/kexin type 911328-0.591-0.1732No
121CTSDNACTSD
Entrez,  Source
cathepsin D (lysosomal aspartyl peptidase)11336-0.592-0.1691No
122FDX1NAFDX1
Entrez,  Source
ferredoxin 111459-0.616-0.1733No
123PLA2G4ANAPLA2G4A
Entrez,  Source
phospholipase A2, group IVA (cytosolic, calcium-dependent)11551-0.636-0.1751No
124KYNUNAKYNU
Entrez,  Source
kynureninase (L-kynurenine hydrolase)11707-0.673-0.1813No
125CD46NACD46
Entrez,  Source
CD46 molecule, complement regulatory protein11815-0.703-0.1837No
126HNF4ANAHNF4A
Entrez,  Source
hepatocyte nuclear factor 4, alpha11862-0.714-0.1816No
127F10NAF10
Entrez,  Source
coagulation factor X11889-0.721-0.1779No
128MMP15NAMMP15
Entrez,  Source
matrix metallopeptidase 15 (membrane-inserted)11945-0.737-0.1763No
129PIM1NAPIM1
Entrez,  Source
pim-1 oncogene11968-0.744-0.1722No
130CD36NACD36
Entrez,  Source
CD36 molecule (thrombospondin receptor)11998-0.756-0.1685No
131TIMP2NATIMP2
Entrez,  Source
TIMP metallopeptidase inhibitor 212411-0.896-0.1918No
132KCNIP2NAKCNIP2
Entrez,  Source
Kv channel interacting protein 212498-0.936-0.1909No
133PDGFBNAPDGFB
Entrez,  Source
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)12572-0.972-0.1887No
134PHEXNAPHEX
Entrez,  Source
phosphate regulating endopeptidase homolog, X-linked (hypophosphatemia, vitamin D resistant rickets)12673-1.023-0.1882No
135PRCPNAPRCP
Entrez,  Source
prolylcarboxypeptidase (angiotensinase C)12708-1.040-0.1827No
136FYNNAFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES13049-1.256-0.1979No
137CBLBNACBLB
Entrez,  Source
Cas-Br-M (murine) ecotropic retroviral transforming sequence b13073-1.275-0.1898No
138C1SNAC1S
Entrez,  Source
complement component 1, s subcomponent13114-1.307-0.1827No
139CPNACP
Entrez,  Source
ceruloplasmin (ferroxidase)13164-1.353-0.1759No
140PIK3CGNAPIK3CG
Entrez,  Source
phosphoinositide-3-kinase, catalytic, gamma polypeptide13175-1.371-0.1661No
141KLK1NAKLK1
Entrez,  Source
kallikrein 1, renal/pancreas/salivary13206-1.403-0.1575No
142CPMNACPM
Entrez,  Source
carboxypeptidase M13210-1.412-0.1469No
143C1RNAC1R
Entrez,  Source
complement component 1, r subcomponent13304-1.520-0.1421No
144SERPING1NASERPING1
Entrez,  Source
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)13330-1.553-0.1320No
145GP1BANAGP1BA
Entrez,  Source
glycoprotein Ib (platelet), alpha polypeptide13339-1.568-0.1205No
146LRP1NALRP1
Entrez,  Source
low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)13358-1.589-0.1096No
147PLGNAPLG
Entrez,  Source
plasminogen13466-1.757-0.1040No
148ANGNAANG
Entrez,  Source
angiogenin, ribonuclease, RNase A family, 513529-1.891-0.0940No
149C3NAC3
Entrez,  Source
complement component 313533-1.896-0.0797No
150KCNIP3NAKCNIP3
Entrez,  Source
Kv channel interacting protein 3, calsenilin13568-1.986-0.0669No
151CFHNACFH
Entrez,  Source
complement factor H13608-2.094-0.0537No
152CASP9NACASP9
Entrez,  Source
caspase 9, apoptosis-related cysteine peptidase13696-2.469-0.0411No
153MMP12NAMMP12
Entrez,  Source
matrix metallopeptidase 12 (macrophage elastase)13769-3.069-0.0228No
154S100A9NAS100A9
Entrez,  Source
S100 calcium binding protein A913793-3.5840.0030No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_COMPLEMENT   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_COMPLEMENT: Random ES distribution   
Gene set null distribution of ES for HALLMARK_COMPLEMENT